Vacuolar 14 Fab1-binding region/Vacuolar protein 14 C-terminal Fig4p binding, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar 14 Fab1-binding region/Vacuolar protein 14 C-terminal Fig4p binding, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IA32_LEIDO

TriTrypDb:

LdBPK_141550.1 , LdCL_140021400 , LDHU3_14.1930

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005942	phosphatidylinositol 3-kinase complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0035032	phosphatidylinositol 3-kinase complex, class III	4	11
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	11
GO:0070772	PAS complex	5	11
GO:0098796	membrane protein complex	2	11
GO:1902494	catalytic complex	2	11
GO:1990234	transferase complex	3	11
GO:0005737	cytoplasm	2	1
GO:0010008	endosome membrane	5	1
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0031090	organelle membrane	3	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IA32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IA32

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0006644	phospholipid metabolic process	4	11
GO:0006650	glycerophospholipid metabolic process	5	11
GO:0006661	phosphatidylinositol biosynthetic process	6	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	11
GO:0008654	phospholipid biosynthetic process	5	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0019637	organophosphate metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0045017	glycerolipid biosynthetic process	4	11
GO:0046474	glycerophospholipid biosynthetic process	5	11
GO:0046486	glycerolipid metabolic process	4	11
GO:0046488	phosphatidylinositol metabolic process	6	11
GO:0071704	organic substance metabolic process	2	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0009893	positive regulation of metabolic process	4	1
GO:0010562	positive regulation of phosphorus metabolic process	6	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0033674	positive regulation of kinase activity	6	1
GO:0042325	regulation of phosphorylation	7	1
GO:0042327	positive regulation of phosphorylation	8	1
GO:0043085	positive regulation of catalytic activity	4	1
GO:0043549	regulation of kinase activity	5	1
GO:0044093	positive regulation of molecular function	3	1
GO:0045937	positive regulation of phosphate metabolic process	7	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0050794	regulation of cellular process	3	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051338	regulation of transferase activity	4	1
GO:0051347	positive regulation of transferase activity	5	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.330
CLV_C14_Caspase3-7	327	331	PF00656	0.523
CLV_C14_Caspase3-7	350	354	PF00656	0.514
CLV_C14_Caspase3-7	530	534	PF00656	0.222
CLV_NRD_NRD_1	10	12	PF00675	0.522
CLV_NRD_NRD_1	459	461	PF00675	0.424
CLV_NRD_NRD_1	466	468	PF00675	0.376
CLV_NRD_NRD_1	526	528	PF00675	0.406
CLV_NRD_NRD_1	566	568	PF00675	0.323
CLV_NRD_NRD_1	636	638	PF00675	0.293
CLV_NRD_NRD_1	69	71	PF00675	0.301
CLV_PCSK_FUR_1	149	153	PF00082	0.403
CLV_PCSK_KEX2_1	151	153	PF00082	0.357
CLV_PCSK_KEX2_1	459	461	PF00082	0.424
CLV_PCSK_KEX2_1	466	468	PF00082	0.376
CLV_PCSK_KEX2_1	526	528	PF00082	0.421
CLV_PCSK_KEX2_1	566	568	PF00082	0.323
CLV_PCSK_KEX2_1	636	638	PF00082	0.293
CLV_PCSK_KEX2_1	69	71	PF00082	0.281
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.357
CLV_PCSK_PC7_1	522	528	PF00082	0.406
CLV_PCSK_SKI1_1	11	15	PF00082	0.461
CLV_PCSK_SKI1_1	151	155	PF00082	0.302
CLV_PCSK_SKI1_1	216	220	PF00082	0.476
CLV_PCSK_SKI1_1	235	239	PF00082	0.201
CLV_PCSK_SKI1_1	365	369	PF00082	0.452
CLV_PCSK_SKI1_1	503	507	PF00082	0.311
CLV_PCSK_SKI1_1	522	526	PF00082	0.146
CLV_PCSK_SKI1_1	527	531	PF00082	0.387
CLV_Separin_Metazoa	121	125	PF03568	0.406
DEG_APCC_DBOX_1	364	372	PF00400	0.439
DEG_APCC_DBOX_1	69	77	PF00400	0.298
DEG_MDM2_SWIB_1	293	301	PF02201	0.427
DOC_CYCLIN_RxL_1	232	241	PF00134	0.354
DOC_MAPK_gen_1	636	643	PF00069	0.412
DOC_MAPK_gen_1	69	76	PF00069	0.324
DOC_MAPK_MEF2A_6	408	415	PF00069	0.388
DOC_MAPK_MEF2A_6	481	488	PF00069	0.406
DOC_MAPK_MEF2A_6	499	508	PF00069	0.334
DOC_MAPK_MEF2A_6	636	645	PF00069	0.488
DOC_MAPK_NFAT4_5	408	416	PF00069	0.388
DOC_MAPK_RevD_3	553	567	PF00069	0.323
DOC_PP2B_LxvP_1	219	222	PF13499	0.372
DOC_PP2B_LxvP_1	622	625	PF13499	0.279
DOC_USP7_MATH_1	205	209	PF00917	0.507
DOC_USP7_MATH_1	240	244	PF00917	0.504
DOC_USP7_MATH_1	347	351	PF00917	0.452
DOC_USP7_MATH_1	395	399	PF00917	0.507
DOC_USP7_MATH_1	87	91	PF00917	0.406
DOC_WW_Pin1_4	625	630	PF00397	0.289
LIG_14-3-3_CanoR_1	134	142	PF00244	0.382
LIG_14-3-3_CanoR_1	170	178	PF00244	0.442
LIG_14-3-3_CanoR_1	256	260	PF00244	0.439
LIG_14-3-3_CanoR_1	32	40	PF00244	0.484
LIG_14-3-3_CanoR_1	408	412	PF00244	0.428
LIG_14-3-3_CanoR_1	466	472	PF00244	0.468
LIG_14-3-3_CanoR_1	490	498	PF00244	0.406
LIG_14-3-3_CanoR_1	601	605	PF00244	0.324
LIG_14-3-3_CanoR_1	62	68	PF00244	0.415
LIG_14-3-3_CanoR_1	670	679	PF00244	0.391
LIG_Actin_WH2_2	200	218	PF00022	0.477
LIG_Actin_WH2_2	352	367	PF00022	0.410
LIG_Actin_WH2_2	458	474	PF00022	0.339
LIG_Actin_WH2_2	46	64	PF00022	0.441
LIG_Actin_WH2_2	485	501	PF00022	0.403
LIG_Actin_WH2_2	585	603	PF00022	0.403
LIG_AP2alpha_1	135	139	PF02296	0.403
LIG_APCC_ABBA_1	304	309	PF00400	0.452
LIG_BIR_III_2	106	110	PF00653	0.403
LIG_BRCT_BRCA1_1	593	597	PF00533	0.324
LIG_Clathr_ClatBox_1	644	648	PF01394	0.450
LIG_deltaCOP1_diTrp_1	129	135	PF00928	0.323
LIG_eIF4E_1	547	553	PF01652	0.403
LIG_eIF4E_1	618	624	PF01652	0.460
LIG_eIF4E_1	68	74	PF01652	0.412
LIG_FHA_1	31	37	PF00498	0.446
LIG_FHA_1	408	414	PF00498	0.372
LIG_FHA_1	563	569	PF00498	0.406
LIG_FHA_1	614	620	PF00498	0.409
LIG_FHA_1	62	68	PF00498	0.481
LIG_FHA_1	640	646	PF00498	0.493
LIG_FHA_2	161	167	PF00498	0.330
LIG_FHA_2	265	271	PF00498	0.429
LIG_FHA_2	320	326	PF00498	0.383
LIG_FHA_2	338	344	PF00498	0.455
LIG_FHA_2	512	518	PF00498	0.284
LIG_FHA_2	528	534	PF00498	0.281
LIG_GBD_Chelix_1	504	512	PF00786	0.406
LIG_GBD_Chelix_1	613	621	PF00786	0.403
LIG_LIR_Gen_1	117	128	PF02991	0.437
LIG_LIR_Gen_1	136	146	PF02991	0.313
LIG_LIR_Gen_1	180	189	PF02991	0.355
LIG_LIR_Gen_1	246	254	PF02991	0.483
LIG_LIR_Gen_1	385	394	PF02991	0.329
LIG_LIR_Gen_1	438	448	PF02991	0.317
LIG_LIR_Gen_1	536	543	PF02991	0.382
LIG_LIR_Gen_1	581	589	PF02991	0.387
LIG_LIR_Gen_1	594	605	PF02991	0.231
LIG_LIR_Gen_1	616	625	PF02991	0.409
LIG_LIR_Gen_1	628	638	PF02991	0.245
LIG_LIR_LC3C_4	196	201	PF02991	0.609
LIG_LIR_Nem_3	117	123	PF02991	0.380
LIG_LIR_Nem_3	136	142	PF02991	0.313
LIG_LIR_Nem_3	180	184	PF02991	0.354
LIG_LIR_Nem_3	246	252	PF02991	0.484
LIG_LIR_Nem_3	34	40	PF02991	0.421
LIG_LIR_Nem_3	385	389	PF02991	0.319
LIG_LIR_Nem_3	438	443	PF02991	0.320
LIG_LIR_Nem_3	514	518	PF02991	0.303
LIG_LIR_Nem_3	536	541	PF02991	0.328
LIG_LIR_Nem_3	581	585	PF02991	0.371
LIG_LIR_Nem_3	594	600	PF02991	0.212
LIG_LIR_Nem_3	616	621	PF02991	0.387
LIG_LIR_Nem_3	628	634	PF02991	0.214
LIG_LIR_Nem_3	667	671	PF02991	0.391
LIG_NRBOX	233	239	PF00104	0.361
LIG_NRBOX	383	389	PF00104	0.434
LIG_NRBOX	444	450	PF00104	0.454
LIG_NRBOX	616	622	PF00104	0.403
LIG_NRBOX	92	98	PF00104	0.406
LIG_Pex14_1	131	135	PF04695	0.323
LIG_Pex14_2	135	139	PF04695	0.274
LIG_Pex14_2	293	297	PF04695	0.426
LIG_SH2_CRK	547	551	PF00017	0.279
LIG_SH2_CRK	631	635	PF00017	0.310
LIG_SH2_NCK_1	547	551	PF00017	0.279
LIG_SH2_PTP2	582	585	PF00017	0.395
LIG_SH2_PTP2	618	621	PF00017	0.468
LIG_SH2_STAP1	681	685	PF00017	0.530
LIG_SH2_STAT5	192	195	PF00017	0.538
LIG_SH2_STAT5	582	585	PF00017	0.401
LIG_SH2_STAT5	618	621	PF00017	0.458
LIG_SH2_STAT5	671	674	PF00017	0.454
LIG_SH3_3	81	87	PF00018	0.403
LIG_SUMO_SIM_anti_2	366	373	PF11976	0.430
LIG_SUMO_SIM_anti_2	385	391	PF11976	0.318
LIG_SUMO_SIM_anti_2	46	52	PF11976	0.538
LIG_SUMO_SIM_par_1	193	202	PF11976	0.592
LIG_SUMO_SIM_par_1	347	353	PF11976	0.471
LIG_SUMO_SIM_par_1	366	373	PF11976	0.247
LIG_TRAF2_1	340	343	PF00917	0.463
LIG_TRAF2_1	375	378	PF00917	0.479
LIG_TRAF2_1	673	676	PF00917	0.511
LIG_WRC_WIRS_1	178	183	PF05994	0.401
MOD_CK1_1	171	177	PF00069	0.500
MOD_CK1_1	183	189	PF00069	0.364
MOD_CK1_1	243	249	PF00069	0.373
MOD_CK1_1	264	270	PF00069	0.461
MOD_CK1_1	30	36	PF00069	0.535
MOD_CK1_1	493	499	PF00069	0.417
MOD_CK1_1	578	584	PF00069	0.298
MOD_CK1_1	595	601	PF00069	0.298
MOD_CK2_1	160	166	PF00069	0.357
MOD_CK2_1	319	325	PF00069	0.380
MOD_CK2_1	337	343	PF00069	0.292
MOD_CK2_1	363	369	PF00069	0.419
MOD_CK2_1	470	476	PF00069	0.418
MOD_CK2_1	511	517	PF00069	0.284
MOD_CK2_1	670	676	PF00069	0.418
MOD_GlcNHglycan	170	173	PF01048	0.485
MOD_GlcNHglycan	195	198	PF01048	0.573
MOD_GlcNHglycan	263	266	PF01048	0.528
MOD_GlcNHglycan	286	289	PF01048	0.499
MOD_GlcNHglycan	355	358	PF01048	0.544
MOD_GlcNHglycan	372	375	PF01048	0.376
MOD_GlcNHglycan	472	475	PF01048	0.451
MOD_GlcNHglycan	593	597	PF01048	0.369
MOD_GlcNHglycan	662	666	PF01048	0.500
MOD_GlcNHglycan	672	675	PF01048	0.449
MOD_GSK3_1	133	140	PF00069	0.407
MOD_GSK3_1	160	167	PF00069	0.383
MOD_GSK3_1	257	264	PF00069	0.494
MOD_GSK3_1	27	34	PF00069	0.440
MOD_GSK3_1	3	10	PF00069	0.555
MOD_GSK3_1	325	332	PF00069	0.497
MOD_GSK3_1	591	598	PF00069	0.403
MOD_N-GLC_1	190	195	PF02516	0.431
MOD_N-GLC_1	243	248	PF02516	0.519
MOD_NEK2_1	164	169	PF00069	0.494
MOD_NEK2_1	226	231	PF00069	0.421
MOD_NEK2_1	238	243	PF00069	0.308
MOD_NEK2_1	319	324	PF00069	0.469
MOD_NEK2_1	363	368	PF00069	0.436
MOD_NEK2_1	370	375	PF00069	0.499
MOD_NEK2_1	511	516	PF00069	0.304
MOD_NEK2_1	537	542	PF00069	0.365
MOD_NEK2_1	562	567	PF00069	0.421
MOD_NEK2_1	592	597	PF00069	0.409
MOD_NEK2_1	60	65	PF00069	0.375
MOD_NEK2_1	600	605	PF00069	0.298
MOD_NEK2_1	613	618	PF00069	0.208
MOD_NEK2_1	7	12	PF00069	0.473
MOD_PIKK_1	205	211	PF00454	0.501
MOD_PIKK_1	257	263	PF00454	0.488
MOD_PIKK_1	31	37	PF00454	0.449
MOD_PKA_2	133	139	PF00069	0.403
MOD_PKA_2	255	261	PF00069	0.375
MOD_PKA_2	31	37	PF00069	0.474
MOD_PKA_2	407	413	PF00069	0.427
MOD_PKA_2	422	428	PF00069	0.334
MOD_PKA_2	600	606	PF00069	0.324
MOD_PKA_2	61	67	PF00069	0.399
MOD_Plk_1	324	330	PF00069	0.368
MOD_Plk_1	376	382	PF00069	0.335
MOD_Plk_1	575	581	PF00069	0.403
MOD_Plk_1	592	598	PF00069	0.403
MOD_Plk_2-3	325	331	PF00069	0.342
MOD_Plk_4	180	186	PF00069	0.375
MOD_Plk_4	376	382	PF00069	0.493
MOD_Plk_4	537	543	PF00069	0.316
MOD_Plk_4	578	584	PF00069	0.302
MOD_Plk_4	600	606	PF00069	0.296
MOD_Plk_4	613	619	PF00069	0.262
MOD_Plk_4	639	645	PF00069	0.469
MOD_ProDKin_1	625	631	PF00069	0.289
TRG_DiLeu_BaEn_1	439	444	PF01217	0.415
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.249
TRG_DiLeu_BaLyEn_6	444	449	PF01217	0.444
TRG_ENDOCYTIC_2	120	123	PF00928	0.373
TRG_ENDOCYTIC_2	37	40	PF00928	0.470
TRG_ENDOCYTIC_2	547	550	PF00928	0.284
TRG_ENDOCYTIC_2	582	585	PF00928	0.371
TRG_ENDOCYTIC_2	618	621	PF00928	0.431
TRG_ENDOCYTIC_2	631	634	PF00928	0.206
TRG_ER_diArg_1	289	292	PF00400	0.445
TRG_ER_diArg_1	458	460	PF00400	0.424
TRG_ER_diArg_1	465	467	PF00400	0.376
TRG_ER_diArg_1	525	527	PF00400	0.406
TRG_ER_diArg_1	566	568	PF00400	0.323
TRG_ER_diArg_1	636	638	PF00400	0.297
TRG_ER_diArg_1	68	70	PF00400	0.301
TRG_NES_CRM1_1	296	309	PF08389	0.462
TRG_NES_CRM1_1	497	509	PF08389	0.421
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	566	570	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC70	Leptomonas seymouri	61%	99%
A0A0S4IRF4	Bodo saltans	26%	100%
A0A1X0NNZ5	Trypanosomatidae	30%	99%
A0A422N3V6	Trypanosoma rangeli	30%	99%
A4H7W5	Leishmania braziliensis	84%	100%
A4HW92	Leishmania infantum	100%	100%
C9ZSR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	99%
E9APZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QFI8	Leishmania major	94%	100%
Q9ZU97	Arabidopsis thaliana	27%	92%
V5AVZ7	Trypanosoma cruzi	31%	99%