LeishMANIAdb
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Ethanolamine-phosphate cytidylyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ethanolamine-phosphate cytidylyltransferase
Gene product:
cholinephosphate cytidylyltransferase A, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IA23_LEIDO
TriTrypDb:
LdBPK_181310.1 , LdCL_180018400 , LDHU3_18.1670
Length:
589

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, cholinephosphate cytidylyltransferase A

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0005737 cytoplasm 2 1
GO:0005829 cytosol 2 1

Expansion

Sequence features

A0A3Q8IA23
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IA23

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 12
GO:0006644 phospholipid metabolic process 4 12
GO:0006646 phosphatidylethanolamine biosynthetic process 6 12
GO:0006650 glycerophospholipid metabolic process 5 12
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0008152 metabolic process 1 12
GO:0008610 lipid biosynthetic process 4 12
GO:0008654 phospholipid biosynthetic process 5 12
GO:0009058 biosynthetic process 2 12
GO:0009987 cellular process 1 12
GO:0019637 organophosphate metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044249 cellular biosynthetic process 3 12
GO:0044255 cellular lipid metabolic process 3 12
GO:0045017 glycerolipid biosynthetic process 4 12
GO:0046337 phosphatidylethanolamine metabolic process 6 12
GO:0046474 glycerophospholipid biosynthetic process 5 12
GO:0046486 glycerolipid metabolic process 4 12
GO:0071704 organic substance metabolic process 2 12
GO:0090407 organophosphate biosynthetic process 4 12
GO:1901576 organic substance biosynthetic process 3 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004306 ethanolamine-phosphate cytidylyltransferase activity 6 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016779 nucleotidyltransferase activity 4 12
GO:0016780 phosphotransferase activity, for other substituted phosphate groups 4 12
GO:0070567 cytidylyltransferase activity 5 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 584 588 PF00656 0.740
CLV_NRD_NRD_1 199 201 PF00675 0.329
CLV_NRD_NRD_1 388 390 PF00675 0.271
CLV_NRD_NRD_1 542 544 PF00675 0.311
CLV_NRD_NRD_1 577 579 PF00675 0.524
CLV_PCSK_KEX2_1 199 201 PF00082 0.303
CLV_PCSK_KEX2_1 388 390 PF00082 0.271
CLV_PCSK_KEX2_1 479 481 PF00082 0.231
CLV_PCSK_KEX2_1 542 544 PF00082 0.311
CLV_PCSK_PC1ET2_1 479 481 PF00082 0.231
CLV_PCSK_SKI1_1 134 138 PF00082 0.447
CLV_PCSK_SKI1_1 202 206 PF00082 0.304
CLV_PCSK_SKI1_1 303 307 PF00082 0.533
CLV_PCSK_SKI1_1 436 440 PF00082 0.262
DEG_APCC_DBOX_1 302 310 PF00400 0.385
DEG_SCF_FBW7_1 550 557 PF00400 0.613
DOC_CKS1_1 431 436 PF01111 0.528
DOC_CKS1_1 530 535 PF01111 0.535
DOC_CKS1_1 551 556 PF01111 0.620
DOC_MAPK_gen_1 332 342 PF00069 0.506
DOC_MAPK_gen_1 388 396 PF00069 0.550
DOC_MAPK_HePTP_8 236 248 PF00069 0.298
DOC_MAPK_MEF2A_6 220 227 PF00069 0.411
DOC_MAPK_MEF2A_6 239 248 PF00069 0.298
DOC_MAPK_MEF2A_6 303 310 PF00069 0.358
DOC_MAPK_MEF2A_6 338 345 PF00069 0.445
DOC_MAPK_MEF2A_6 36 45 PF00069 0.558
DOC_MAPK_MEF2A_6 460 469 PF00069 0.498
DOC_MAPK_MEF2A_6 517 525 PF00069 0.455
DOC_MAPK_NFAT4_5 220 228 PF00069 0.411
DOC_MAPK_NFAT4_5 338 346 PF00069 0.439
DOC_MAPK_RevD_3 373 389 PF00069 0.315
DOC_PP1_RVXF_1 27 34 PF00149 0.613
DOC_PP1_SILK_1 544 549 PF00149 0.482
DOC_PP2B_LxvP_1 156 159 PF13499 0.513
DOC_PP2B_LxvP_1 427 430 PF13499 0.495
DOC_PP2B_LxvP_1 53 56 PF13499 0.526
DOC_USP7_MATH_1 146 150 PF00917 0.324
DOC_USP7_MATH_1 568 572 PF00917 0.570
DOC_USP7_UBL2_3 265 269 PF12436 0.635
DOC_USP7_UBL2_3 334 338 PF12436 0.521
DOC_WW_Pin1_4 430 435 PF00397 0.526
DOC_WW_Pin1_4 503 508 PF00397 0.431
DOC_WW_Pin1_4 529 534 PF00397 0.551
DOC_WW_Pin1_4 550 555 PF00397 0.625
LIG_14-3-3_CanoR_1 171 181 PF00244 0.326
LIG_14-3-3_CanoR_1 199 207 PF00244 0.495
LIG_14-3-3_CanoR_1 213 219 PF00244 0.438
LIG_14-3-3_CanoR_1 29 34 PF00244 0.519
LIG_14-3-3_CanoR_1 44 53 PF00244 0.551
LIG_14-3-3_CanoR_1 566 573 PF00244 0.578
LIG_14-3-3_CanoR_1 578 585 PF00244 0.581
LIG_Actin_WH2_2 91 106 PF00022 0.686
LIG_BIR_II_1 1 5 PF00653 0.647
LIG_BRCT_BRCA1_1 7 11 PF00533 0.517
LIG_Clathr_ClatBox_1 375 379 PF01394 0.281
LIG_EH1_1 285 293 PF00400 0.411
LIG_EH1_1 414 422 PF00400 0.478
LIG_eIF4E_1 337 343 PF01652 0.478
LIG_eIF4E_1 415 421 PF01652 0.506
LIG_FHA_1 159 165 PF00498 0.482
LIG_FHA_1 173 179 PF00498 0.204
LIG_FHA_1 26 32 PF00498 0.562
LIG_FHA_1 317 323 PF00498 0.336
LIG_FHA_1 45 51 PF00498 0.418
LIG_FHA_1 551 557 PF00498 0.541
LIG_FHA_2 10 16 PF00498 0.534
LIG_FHA_2 224 230 PF00498 0.300
LIG_FHA_2 483 489 PF00498 0.431
LIG_FHA_2 530 536 PF00498 0.505
LIG_FHA_2 582 588 PF00498 0.631
LIG_IRF3_LxIS_1 181 187 PF10401 0.414
LIG_LIR_Apic_2 477 481 PF02991 0.535
LIG_LIR_Apic_2 528 533 PF02991 0.432
LIG_LIR_Apic_2 535 541 PF02991 0.493
LIG_LIR_Gen_1 160 167 PF02991 0.433
LIG_LIR_Gen_1 209 219 PF02991 0.471
LIG_LIR_Gen_1 283 294 PF02991 0.322
LIG_LIR_Gen_1 324 333 PF02991 0.318
LIG_LIR_Gen_1 359 367 PF02991 0.336
LIG_LIR_LC3C_4 319 322 PF02991 0.411
LIG_LIR_Nem_3 160 166 PF02991 0.493
LIG_LIR_Nem_3 209 214 PF02991 0.450
LIG_LIR_Nem_3 238 244 PF02991 0.248
LIG_LIR_Nem_3 283 289 PF02991 0.321
LIG_LIR_Nem_3 324 328 PF02991 0.363
LIG_LIR_Nem_3 35 41 PF02991 0.550
LIG_LIR_Nem_3 359 364 PF02991 0.386
LIG_LIR_Nem_3 534 540 PF02991 0.504
LIG_LIR_Nem_3 76 80 PF02991 0.552
LIG_NRBOX 178 184 PF00104 0.300
LIG_NRBOX 286 292 PF00104 0.331
LIG_NRBOX 398 404 PF00104 0.530
LIG_NRBOX 60 66 PF00104 0.567
LIG_PDZ_Class_3 584 589 PF00595 0.651
LIG_Pex14_2 38 42 PF04695 0.526
LIG_PTB_Apo_2 267 274 PF02174 0.630
LIG_PTB_Apo_2 72 79 PF02174 0.542
LIG_PTB_Phospho_1 267 273 PF10480 0.629
LIG_PTB_Phospho_1 72 78 PF10480 0.535
LIG_SH2_CRK 317 321 PF00017 0.280
LIG_SH2_CRK 337 341 PF00017 0.580
LIG_SH2_CRK 361 365 PF00017 0.282
LIG_SH2_CRK 478 482 PF00017 0.535
LIG_SH2_CRK 530 534 PF00017 0.456
LIG_SH2_CRK 538 542 PF00017 0.464
LIG_SH2_CRK 71 75 PF00017 0.483
LIG_SH2_GRB2like 518 521 PF00017 0.535
LIG_SH2_NCK_1 530 534 PF00017 0.431
LIG_SH2_SRC 415 418 PF00017 0.490
LIG_SH2_STAP1 425 429 PF00017 0.495
LIG_SH2_STAT5 163 166 PF00017 0.420
LIG_SH2_STAT5 241 244 PF00017 0.333
LIG_SH2_STAT5 273 276 PF00017 0.554
LIG_SH2_STAT5 277 280 PF00017 0.519
LIG_SH2_STAT5 354 357 PF00017 0.579
LIG_SH2_STAT5 381 384 PF00017 0.523
LIG_SH2_STAT5 415 418 PF00017 0.466
LIG_SH2_STAT5 498 501 PF00017 0.535
LIG_SH3_1 548 554 PF00018 0.596
LIG_SH3_3 501 507 PF00018 0.456
LIG_SH3_3 548 554 PF00018 0.613
LIG_SH3_5 159 163 PF00018 0.443
LIG_SUMO_SIM_anti_2 177 183 PF11976 0.418
LIG_SUMO_SIM_anti_2 285 291 PF11976 0.397
LIG_SUMO_SIM_anti_2 327 332 PF11976 0.391
LIG_SUMO_SIM_anti_2 362 369 PF11976 0.311
LIG_SUMO_SIM_par_1 181 187 PF11976 0.299
LIG_SUMO_SIM_par_1 247 253 PF11976 0.411
LIG_SUMO_SIM_par_1 318 324 PF11976 0.301
LIG_SUMO_SIM_par_1 374 379 PF11976 0.324
LIG_SUMO_SIM_par_1 419 424 PF11976 0.470
LIG_TRAF2_1 12 15 PF00917 0.550
LIG_TRAF2_1 485 488 PF00917 0.429
LIG_TRFH_1 353 357 PF08558 0.360
LIG_TYR_ITIM 315 320 PF00017 0.331
LIG_TYR_ITIM 516 521 PF00017 0.535
LIG_UBA3_1 305 312 PF00899 0.334
LIG_UBA3_1 330 338 PF00899 0.515
LIG_WRC_WIRS_1 322 327 PF05994 0.281
MOD_CDK_SPxK_1 430 436 PF00069 0.528
MOD_CK1_1 149 155 PF00069 0.287
MOD_CK1_1 203 209 PF00069 0.522
MOD_CK1_1 282 288 PF00069 0.283
MOD_CK1_1 32 38 PF00069 0.507
MOD_CK1_1 359 365 PF00069 0.238
MOD_CK1_1 506 512 PF00069 0.458
MOD_CK1_1 569 575 PF00069 0.651
MOD_CK2_1 223 229 PF00069 0.300
MOD_CK2_1 482 488 PF00069 0.419
MOD_CK2_1 9 15 PF00069 0.543
MOD_GlcNHglycan 122 125 PF01048 0.469
MOD_GlcNHglycan 148 151 PF01048 0.324
MOD_GlcNHglycan 202 205 PF01048 0.303
MOD_GSK3_1 145 152 PF00069 0.447
MOD_GSK3_1 209 216 PF00069 0.493
MOD_GSK3_1 21 28 PF00069 0.553
MOD_GSK3_1 405 412 PF00069 0.486
MOD_GSK3_1 44 51 PF00069 0.633
MOD_GSK3_1 5 12 PF00069 0.532
MOD_GSK3_1 529 536 PF00069 0.531
MOD_GSK3_1 546 553 PF00069 0.489
MOD_GSK3_1 556 563 PF00069 0.526
MOD_GSK3_1 577 584 PF00069 0.658
MOD_N-GLC_1 258 263 PF02516 0.378
MOD_NEK2_1 184 189 PF00069 0.339
MOD_NEK2_1 223 228 PF00069 0.273
MOD_NEK2_1 423 428 PF00069 0.483
MOD_NEK2_1 5 10 PF00069 0.638
MOD_NEK2_1 64 69 PF00069 0.476
MOD_NEK2_1 73 78 PF00069 0.490
MOD_PIKK_1 356 362 PF00454 0.437
MOD_PKA_2 279 285 PF00069 0.431
MOD_PKA_2 43 49 PF00069 0.609
MOD_PKA_2 577 583 PF00069 0.674
MOD_PKB_1 200 208 PF00069 0.581
MOD_PKB_1 564 572 PF00069 0.556
MOD_Plk_1 113 119 PF00069 0.669
MOD_Plk_1 169 175 PF00069 0.425
MOD_Plk_1 282 288 PF00069 0.280
MOD_Plk_1 421 427 PF00069 0.475
MOD_Plk_1 5 11 PF00069 0.535
MOD_Plk_1 569 575 PF00069 0.675
MOD_Plk_2-3 581 587 PF00069 0.627
MOD_Plk_4 113 119 PF00069 0.669
MOD_Plk_4 174 180 PF00069 0.278
MOD_Plk_4 223 229 PF00069 0.272
MOD_Plk_4 250 256 PF00069 0.279
MOD_Plk_4 282 288 PF00069 0.317
MOD_Plk_4 29 35 PF00069 0.520
MOD_Plk_4 316 322 PF00069 0.288
MOD_Plk_4 359 365 PF00069 0.261
MOD_Plk_4 398 404 PF00069 0.484
MOD_Plk_4 409 415 PF00069 0.468
MOD_Plk_4 5 11 PF00069 0.535
MOD_Plk_4 533 539 PF00069 0.523
MOD_Plk_4 556 562 PF00069 0.498
MOD_Plk_4 73 79 PF00069 0.599
MOD_ProDKin_1 430 436 PF00069 0.528
MOD_ProDKin_1 503 509 PF00069 0.431
MOD_ProDKin_1 529 535 PF00069 0.551
MOD_ProDKin_1 550 556 PF00069 0.622
MOD_SUMO_rev_2 571 580 PF00179 0.693
TRG_DiLeu_BaEn_1 14 19 PF01217 0.544
TRG_DiLeu_BaEn_1 283 288 PF01217 0.328
TRG_DiLeu_BaLyEn_6 461 466 PF01217 0.431
TRG_ENDOCYTIC_2 163 166 PF00928 0.477
TRG_ENDOCYTIC_2 241 244 PF00928 0.313
TRG_ENDOCYTIC_2 317 320 PF00928 0.301
TRG_ENDOCYTIC_2 337 340 PF00928 0.630
TRG_ENDOCYTIC_2 361 364 PF00928 0.276
TRG_ENDOCYTIC_2 518 521 PF00928 0.531
TRG_ENDOCYTIC_2 537 540 PF00928 0.425
TRG_ENDOCYTIC_2 71 74 PF00928 0.468
TRG_ENDOCYTIC_2 77 80 PF00928 0.528
TRG_ER_diArg_1 199 202 PF00400 0.536
TRG_ER_diArg_1 388 390 PF00400 0.472
TRG_ER_diArg_1 541 543 PF00400 0.496

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I259 Leptomonas seymouri 78% 100%
A0A0S4JNN5 Bodo saltans 47% 100%
A0A1X0P717 Trypanosomatidae 62% 100%
A0A422P0J5 Trypanosoma rangeli 61% 100%
A4H9L4 Leishmania braziliensis 92% 99%
A4HY04 Leishmania infantum 100% 100%
D0A5A2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 57% 100%
E9ARR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4QDQ6 Leishmania major 96% 100%
V5BEI8 Trypanosoma cruzi 59% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS