Ethanolamine-phosphate cytidylyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cholinephosphate cytidylyltransferase A, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IA23_LEIDO

TriTrypDb:

LdBPK_181310.1 , LdCL_180018400 , LDHU3_18.1670

Length:

589

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, cholinephosphate cytidylyltransferase A

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

A0A3Q8IA23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IA23

Function

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Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006646	phosphatidylethanolamine biosynthetic process	6	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004306	ethanolamine-phosphate cytidylyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	12
GO:0070567	cytidylyltransferase activity	5	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	584	588	PF00656	0.740
CLV_NRD_NRD_1	199	201	PF00675	0.329
CLV_NRD_NRD_1	388	390	PF00675	0.271
CLV_NRD_NRD_1	542	544	PF00675	0.311
CLV_NRD_NRD_1	577	579	PF00675	0.524
CLV_PCSK_KEX2_1	199	201	PF00082	0.303
CLV_PCSK_KEX2_1	388	390	PF00082	0.271
CLV_PCSK_KEX2_1	479	481	PF00082	0.231
CLV_PCSK_KEX2_1	542	544	PF00082	0.311
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.231

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I259	Leptomonas seymouri	78%	100%
A0A0S4JNN5	Bodo saltans	47%	100%
A0A1X0P717	Trypanosomatidae	62%	100%
A0A422P0J5	Trypanosoma rangeli	61%	100%
A4H9L4	Leishmania braziliensis	92%	99%
A4HY04	Leishmania infantum	100%	100%
D0A5A2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9ARR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QDQ6	Leishmania major	96%	100%
V5BEI8	Trypanosoma cruzi	59%	100%

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