AATF protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AATF protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IA20_LEIDO

TriTrypDb:

LdBPK_200930.1 , LdCL_200014000 , LDHU3_20.1140

Length:

601

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	6
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	7
GO:0005730	nucleolus	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8IA20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IA20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.797
CLV_C14_Caspase3-7	187	191	PF00656	0.635
CLV_C14_Caspase3-7	284	288	PF00656	0.451
CLV_C14_Caspase3-7	346	350	PF00656	0.265
CLV_C14_Caspase3-7	50	54	PF00656	0.751
CLV_C14_Caspase3-7	63	67	PF00656	0.617
CLV_NRD_NRD_1	176	178	PF00675	0.724
CLV_NRD_NRD_1	18	20	PF00675	0.654
CLV_NRD_NRD_1	193	195	PF00675	0.545
CLV_NRD_NRD_1	197	199	PF00675	0.494
CLV_NRD_NRD_1	225	227	PF00675	0.591
CLV_NRD_NRD_1	440	442	PF00675	0.309
CLV_NRD_NRD_1	529	531	PF00675	0.368
CLV_NRD_NRD_1	556	558	PF00675	0.393
CLV_NRD_NRD_1	81	83	PF00675	0.774
CLV_PCSK_FUR_1	194	198	PF00082	0.648
CLV_PCSK_KEX2_1	195	197	PF00082	0.544
CLV_PCSK_KEX2_1	20	22	PF00082	0.578
CLV_PCSK_KEX2_1	225	227	PF00082	0.564
CLV_PCSK_KEX2_1	529	531	PF00082	0.298
CLV_PCSK_KEX2_1	81	83	PF00082	0.680
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.525
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.639
CLV_PCSK_PC7_1	525	531	PF00082	0.289
CLV_PCSK_SKI1_1	197	201	PF00082	0.624
CLV_PCSK_SKI1_1	309	313	PF00082	0.388
CLV_PCSK_SKI1_1	328	332	PF00082	0.362
CLV_PCSK_SKI1_1	33	37	PF00082	0.742
CLV_PCSK_SKI1_1	405	409	PF00082	0.350
CLV_PCSK_SKI1_1	547	551	PF00082	0.384
CLV_PCSK_SKI1_1	597	601	PF00082	0.507
CLV_Separin_Metazoa	526	530	PF03568	0.368
DEG_COP1_1	409	418	PF00400	0.343
DEG_SPOP_SBC_1	272	276	PF00917	0.586
DOC_CYCLIN_RxL_1	325	335	PF00134	0.388
DOC_CYCLIN_RxL_1	541	554	PF00134	0.326
DOC_MAPK_gen_1	388	397	PF00069	0.390
DOC_MAPK_gen_1	405	415	PF00069	0.389
DOC_MAPK_gen_1	475	485	PF00069	0.480
DOC_PP1_RVXF_1	574	581	PF00149	0.288
DOC_PP2B_LxvP_1	413	416	PF13499	0.466
DOC_PP4_FxxP_1	580	583	PF00568	0.308
DOC_USP7_MATH_1	104	108	PF00917	0.707
DOC_USP7_MATH_1	272	276	PF00917	0.660
DOC_USP7_MATH_1	343	347	PF00917	0.370
DOC_USP7_MATH_1	383	387	PF00917	0.490
DOC_USP7_MATH_1	494	498	PF00917	0.522
DOC_USP7_MATH_1	533	537	PF00917	0.350
DOC_USP7_MATH_1	589	593	PF00917	0.358
DOC_USP7_UBL2_3	94	98	PF12436	0.808
DOC_WW_Pin1_4	124	129	PF00397	0.540
LIG_14-3-3_CanoR_1	19	24	PF00244	0.535
LIG_14-3-3_CanoR_1	225	231	PF00244	0.677
LIG_14-3-3_CanoR_1	257	265	PF00244	0.609
LIG_BIR_III_4	148	152	PF00653	0.684
LIG_BIR_III_4	190	194	PF00653	0.705
LIG_BRCT_BRCA1_1	66	70	PF00533	0.658
LIG_eIF4E_1	325	331	PF01652	0.417
LIG_eIF4E_1	438	444	PF01652	0.334
LIG_FHA_1	206	212	PF00498	0.589
LIG_FHA_1	289	295	PF00498	0.552
LIG_FHA_1	315	321	PF00498	0.417
LIG_FHA_2	201	207	PF00498	0.540
LIG_FHA_2	24	30	PF00498	0.571
LIG_FHA_2	282	288	PF00498	0.454
LIG_FHA_2	407	413	PF00498	0.423
LIG_FHA_2	432	438	PF00498	0.350
LIG_FHA_2	494	500	PF00498	0.609
LIG_LIR_Gen_1	362	372	PF02991	0.420
LIG_LIR_Gen_1	59	70	PF02991	0.669
LIG_LIR_Nem_3	136	142	PF02991	0.533
LIG_LIR_Nem_3	362	368	PF02991	0.420
LIG_LIR_Nem_3	417	421	PF02991	0.258
LIG_LIR_Nem_3	59	65	PF02991	0.635
LIG_NRBOX	307	313	PF00104	0.398
LIG_PCNA_yPIPBox_3	363	376	PF02747	0.420
LIG_SH2_CRK	302	306	PF00017	0.274
LIG_SH2_NCK_1	380	384	PF00017	0.393
LIG_SH2_NCK_1	518	522	PF00017	0.475
LIG_SH2_SRC	51	54	PF00017	0.708
LIG_SH2_SRC	518	521	PF00017	0.462
LIG_SH2_STAP1	207	211	PF00017	0.558
LIG_SH2_STAP1	326	330	PF00017	0.302
LIG_SH2_STAT5	207	210	PF00017	0.448
LIG_SH3_3	579	585	PF00018	0.217
LIG_TRAF2_1	162	165	PF00917	0.629
MOD_CK1_1	102	108	PF00069	0.752
MOD_CK1_1	12	18	PF00069	0.693
MOD_CK1_1	271	277	PF00069	0.641
MOD_CK1_1	283	289	PF00069	0.642
MOD_CK1_1	399	405	PF00069	0.265
MOD_CK1_1	414	420	PF00069	0.175
MOD_CK1_1	467	473	PF00069	0.632
MOD_CK2_1	115	121	PF00069	0.593
MOD_CK2_1	19	25	PF00069	0.638
MOD_CK2_1	200	206	PF00069	0.549
MOD_CK2_1	414	420	PF00069	0.381
MOD_CK2_1	533	539	PF00069	0.350
MOD_CK2_1	84	90	PF00069	0.626
MOD_Cter_Amidation	192	195	PF01082	0.597
MOD_Cter_Amidation	439	442	PF01082	0.217
MOD_GlcNHglycan	102	105	PF01048	0.792
MOD_GlcNHglycan	234	237	PF01048	0.658
MOD_GlcNHglycan	270	273	PF01048	0.694
MOD_GlcNHglycan	275	278	PF01048	0.692
MOD_GlcNHglycan	33	36	PF01048	0.600
MOD_GlcNHglycan	385	388	PF01048	0.385
MOD_GlcNHglycan	399	402	PF01048	0.469
MOD_GlcNHglycan	447	450	PF01048	0.568
MOD_GlcNHglycan	466	469	PF01048	0.598
MOD_GlcNHglycan	495	499	PF01048	0.552
MOD_GlcNHglycan	7	10	PF01048	0.589
MOD_GlcNHglycan	86	89	PF01048	0.751
MOD_GSK3_1	19	26	PF00069	0.554
MOD_GSK3_1	268	275	PF00069	0.654
MOD_GSK3_1	314	321	PF00069	0.425
MOD_GSK3_1	359	366	PF00069	0.416
MOD_GSK3_1	395	402	PF00069	0.426
MOD_GSK3_1	467	474	PF00069	0.524
MOD_GSK3_1	5	12	PF00069	0.605
MOD_GSK3_1	77	84	PF00069	0.773
MOD_GSK3_1	99	106	PF00069	0.759
MOD_LATS_1	491	497	PF00433	0.600
MOD_N-GLC_1	212	217	PF02516	0.497
MOD_N-GLC_1	4	9	PF02516	0.690
MOD_N-GLC_1	478	483	PF02516	0.532
MOD_NEK2_1	115	120	PF00069	0.543
MOD_NEK2_1	224	229	PF00069	0.678
MOD_NEK2_1	23	28	PF00069	0.434
MOD_NEK2_1	256	261	PF00069	0.614
MOD_NEK2_1	31	36	PF00069	0.570
MOD_NEK2_1	4	9	PF00069	0.618
MOD_NEK2_2	326	331	PF00069	0.470
MOD_PIKK_1	256	262	PF00454	0.578
MOD_PIKK_1	281	287	PF00454	0.695
MOD_PIKK_1	533	539	PF00454	0.481
MOD_PKA_1	19	25	PF00069	0.539
MOD_PKA_1	81	87	PF00069	0.716
MOD_PKA_2	224	230	PF00069	0.631
MOD_PKA_2	256	262	PF00069	0.578
MOD_PKA_2	390	396	PF00069	0.284
MOD_PKA_2	561	567	PF00069	0.283
MOD_PKA_2	77	83	PF00069	0.612
MOD_PKA_2	9	15	PF00069	0.633
MOD_Plk_1	115	121	PF00069	0.543
MOD_Plk_1	205	211	PF00069	0.590
MOD_Plk_1	411	417	PF00069	0.241
MOD_Plk_1	478	484	PF00069	0.532
MOD_Plk_4	259	265	PF00069	0.528
MOD_Plk_4	375	381	PF00069	0.376
MOD_Plk_4	9	15	PF00069	0.713
MOD_ProDKin_1	124	130	PF00069	0.537
MOD_SUMO_for_1	407	410	PF00179	0.430
MOD_SUMO_rev_2	116	125	PF00179	0.672
MOD_SUMO_rev_2	206	216	PF00179	0.592
MOD_SUMO_rev_2	283	291	PF00179	0.574
MOD_SUMO_rev_2	495	502	PF00179	0.490
MOD_SUMO_rev_2	536	542	PF00179	0.350
TRG_DiLeu_BaEn_4	245	251	PF01217	0.558
TRG_ENDOCYTIC_2	302	305	PF00928	0.286
TRG_ENDOCYTIC_2	365	368	PF00928	0.417
TRG_ENDOCYTIC_2	418	421	PF00928	0.370
TRG_ER_diArg_1	109	112	PF00400	0.680
TRG_ER_diArg_1	194	197	PF00400	0.604
TRG_ER_diArg_1	224	226	PF00400	0.599
TRG_ER_diArg_1	306	309	PF00400	0.289
TRG_ER_diArg_1	528	530	PF00400	0.368
TRG_NLS_Bipartite_1	177	199	PF00514	0.512
TRG_NLS_MonoCore_2	193	198	PF00514	0.546
TRG_NLS_MonoExtC_3	193	198	PF00514	0.570
TRG_NLS_MonoExtC_3	404	410	PF00514	0.419
TRG_NLS_MonoExtN_4	17	23	PF00514	0.574
TRG_NLS_MonoExtN_4	194	199	PF00514	0.538
TRG_NLS_MonoExtN_4	403	409	PF00514	0.349
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	328	333	PF00026	0.145
TRG_Pf-PMV_PEXEL_1	441	445	PF00026	0.642

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5P4	Leptomonas seymouri	60%	99%
A0A0S4JJ09	Bodo saltans	31%	100%
A0A1X0NXQ8	Trypanosomatidae	38%	100%
A0A3R7KQ11	Trypanosoma rangeli	40%	100%
A4HYT4	Leishmania infantum	99%	100%
C9ZIB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AIE3	Leishmania braziliensis	78%	100%
E9AUN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QCV4	Leishmania major	91%	99%
V5BQR9	Trypanosoma cruzi	37%	100%