Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IA19_LEIDO

TriTrypDb:

LdBPK_150580.1 , LdCL_150010900 , LDHU3_15.0730

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IA19

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IA19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.650
CLV_C14_Caspase3-7	395	399	PF00656	0.531
CLV_NRD_NRD_1	139	141	PF00675	0.586
CLV_NRD_NRD_1	2	4	PF00675	0.586
CLV_NRD_NRD_1	242	244	PF00675	0.590
CLV_NRD_NRD_1	245	247	PF00675	0.511
CLV_NRD_NRD_1	341	343	PF00675	0.517
CLV_NRD_NRD_1	403	405	PF00675	0.545
CLV_NRD_NRD_1	537	539	PF00675	0.498
CLV_PCSK_FUR_1	243	247	PF00082	0.611
CLV_PCSK_KEX2_1	139	141	PF00082	0.518
CLV_PCSK_KEX2_1	242	244	PF00082	0.585
CLV_PCSK_KEX2_1	245	247	PF00082	0.516
CLV_PCSK_KEX2_1	341	343	PF00082	0.517
CLV_PCSK_KEX2_1	403	405	PF00082	0.545
CLV_PCSK_KEX2_1	500	502	PF00082	0.602
CLV_PCSK_KEX2_1	539	541	PF00082	0.504
CLV_PCSK_PC1ET2_1	500	502	PF00082	0.467
CLV_PCSK_PC1ET2_1	539	541	PF00082	0.504
CLV_PCSK_SKI1_1	139	143	PF00082	0.544
CLV_PCSK_SKI1_1	217	221	PF00082	0.655
CLV_PCSK_SKI1_1	296	300	PF00082	0.455
CLV_PCSK_SKI1_1	458	462	PF00082	0.415
CLV_PCSK_SKI1_1	48	52	PF00082	0.639
CLV_PCSK_SKI1_1	6	10	PF00082	0.633
DEG_APCC_DBOX_1	252	260	PF00400	0.466
DEG_APCC_KENBOX_2	492	496	PF00400	0.436
DEG_Nend_Nbox_1	1	3	PF02207	0.529
DEG_SPOP_SBC_1	143	147	PF00917	0.570
DEG_SPOP_SBC_1	195	199	PF00917	0.601
DEG_SPOP_SBC_1	233	237	PF00917	0.663
DEG_SPOP_SBC_1	529	533	PF00917	0.540
DOC_CYCLIN_yCln2_LP_2	210	216	PF00134	0.562
DOC_MAPK_gen_1	169	178	PF00069	0.477
DOC_MAPK_gen_1	3	12	PF00069	0.482
DOC_MAPK_gen_1	32	42	PF00069	0.532
DOC_MAPK_gen_1	403	409	PF00069	0.544
DOC_MAPK_MEF2A_6	3	12	PF00069	0.482
DOC_PP1_RVXF_1	515	521	PF00149	0.445
DOC_PP2B_LxvP_1	210	213	PF13499	0.570
DOC_PP2B_LxvP_1	409	412	PF13499	0.600
DOC_USP7_MATH_1	116	120	PF00917	0.442
DOC_USP7_MATH_1	143	147	PF00917	0.613
DOC_USP7_MATH_1	194	198	PF00917	0.594
DOC_USP7_MATH_1	414	418	PF00917	0.535
DOC_USP7_MATH_1	529	533	PF00917	0.614
DOC_USP7_MATH_1	86	90	PF00917	0.551
DOC_USP7_UBL2_3	179	183	PF12436	0.459
DOC_USP7_UBL2_3	51	55	PF12436	0.623
DOC_USP7_UBL2_3	99	103	PF12436	0.478
DOC_WW_Pin1_4	407	412	PF00397	0.587
LIG_14-3-3_CanoR_1	217	226	PF00244	0.557
LIG_14-3-3_CanoR_1	231	241	PF00244	0.596
LIG_14-3-3_CanoR_1	294	299	PF00244	0.455
LIG_BRCT_BRCA1_1	356	360	PF00533	0.551
LIG_Clathr_ClatBox_1	464	468	PF01394	0.454
LIG_FHA_1	129	135	PF00498	0.524
LIG_FHA_1	236	242	PF00498	0.660
LIG_FHA_1	31	37	PF00498	0.492
LIG_FHA_1	7	13	PF00498	0.474
LIG_FHA_2	309	315	PF00498	0.499
LIG_FHA_2	316	322	PF00498	0.589
LIG_FHA_2	531	537	PF00498	0.500
LIG_LIR_Gen_1	421	429	PF02991	0.518
LIG_LIR_Nem_3	379	385	PF02991	0.509
LIG_LIR_Nem_3	421	426	PF02991	0.515
LIG_PCNA_yPIPBox_3	112	121	PF02747	0.462
LIG_PCNA_yPIPBox_3	179	193	PF02747	0.419
LIG_SH2_CRK	382	386	PF00017	0.515
LIG_SH2_CRK	97	101	PF00017	0.448
LIG_SH2_STAT5	308	311	PF00017	0.438
LIG_SH3_2	411	416	PF14604	0.538
LIG_SH3_3	238	244	PF00018	0.653
LIG_SH3_3	405	411	PF00018	0.719
LIG_SUMO_SIM_anti_2	173	180	PF11976	0.471
LIG_SUMO_SIM_par_1	173	180	PF11976	0.450
LIG_SUMO_SIM_par_1	463	468	PF11976	0.496
LIG_TRAF2_1	28	31	PF00917	0.511
LIG_TRAF2_1	333	336	PF00917	0.402
LIG_WRC_WIRS_1	216	221	PF05994	0.525
LIG_WRC_WIRS_1	415	420	PF05994	0.507
MOD_CK1_1	147	153	PF00069	0.573
MOD_CK1_1	215	221	PF00069	0.577
MOD_CK1_1	232	238	PF00069	0.573
MOD_CK1_1	486	492	PF00069	0.537
MOD_CK1_1	532	538	PF00069	0.557
MOD_CK1_1	70	76	PF00069	0.586
MOD_CK2_1	194	200	PF00069	0.602
MOD_CK2_1	308	314	PF00069	0.433
MOD_CK2_1	315	321	PF00069	0.440
MOD_CK2_1	418	424	PF00069	0.532
MOD_CK2_1	528	534	PF00069	0.491
MOD_CK2_1	77	83	PF00069	0.602
MOD_GlcNHglycan	146	149	PF01048	0.577
MOD_GlcNHglycan	158	161	PF01048	0.625
MOD_GlcNHglycan	220	223	PF01048	0.601
MOD_GlcNHglycan	256	259	PF01048	0.528
MOD_GlcNHglycan	288	291	PF01048	0.555
MOD_GlcNHglycan	355	359	PF01048	0.594
MOD_GlcNHglycan	362	365	PF01048	0.557
MOD_GlcNHglycan	370	373	PF01048	0.488
MOD_GlcNHglycan	448	451	PF01048	0.487
MOD_GlcNHglycan	485	488	PF01048	0.570
MOD_GlcNHglycan	505	508	PF01048	0.315
MOD_GlcNHglycan	55	58	PF01048	0.578
MOD_GlcNHglycan	70	73	PF01048	0.547
MOD_GlcNHglycan	74	77	PF01048	0.651
MOD_GlcNHglycan	79	82	PF01048	0.517
MOD_GlcNHglycan	89	92	PF01048	0.389
MOD_GSK3_1	139	146	PF00069	0.531
MOD_GSK3_1	208	215	PF00069	0.701
MOD_GSK3_1	229	236	PF00069	0.612
MOD_GSK3_1	297	304	PF00069	0.449
MOD_GSK3_1	354	361	PF00069	0.545
MOD_GSK3_1	414	421	PF00069	0.706
MOD_GSK3_1	479	486	PF00069	0.611
MOD_GSK3_1	528	535	PF00069	0.578
MOD_GSK3_1	66	73	PF00069	0.624
MOD_GSK3_1	82	89	PF00069	0.461
MOD_N-GLC_1	67	72	PF02516	0.534
MOD_NEK2_1	12	17	PF00069	0.478
MOD_NEK2_1	177	182	PF00069	0.434
MOD_NEK2_1	286	291	PF00069	0.553
MOD_NEK2_1	313	318	PF00069	0.432
MOD_NEK2_1	360	365	PF00069	0.580
MOD_NEK2_1	418	423	PF00069	0.506
MOD_PIKK_1	12	18	PF00454	0.484
MOD_PIKK_1	30	36	PF00454	0.388
MOD_PKA_1	139	145	PF00069	0.506
MOD_PKA_2	139	145	PF00069	0.506
MOD_PKA_2	254	260	PF00069	0.466
MOD_PKA_2	286	292	PF00069	0.508
MOD_PKB_1	501	509	PF00069	0.429
MOD_Plk_1	6	12	PF00069	0.481
MOD_Plk_4	308	314	PF00069	0.452
MOD_Plk_4	486	492	PF00069	0.557
MOD_ProDKin_1	407	413	PF00069	0.586
MOD_SUMO_for_1	298	301	PF00179	0.450
MOD_SUMO_rev_2	124	134	PF00179	0.547
TRG_DiLeu_BaEn_1	133	138	PF01217	0.518
TRG_DiLeu_BaEn_1	173	178	PF01217	0.469
TRG_DiLeu_BaEn_4	173	179	PF01217	0.539
TRG_DiLeu_LyEn_5	133	138	PF01217	0.541
TRG_ENDOCYTIC_2	382	385	PF00928	0.516
TRG_ENDOCYTIC_2	423	426	PF00928	0.440
TRG_ENDOCYTIC_2	97	100	PF00928	0.451
TRG_ER_diArg_1	138	140	PF00400	0.585
TRG_ER_diArg_1	168	171	PF00400	0.505
TRG_ER_diArg_1	241	243	PF00400	0.596
TRG_ER_diArg_1	244	246	PF00400	0.538
TRG_ER_diArg_1	340	342	PF00400	0.521
TRG_ER_diArg_1	402	404	PF00400	0.549
TRG_NLS_MonoExtC_3	498	503	PF00514	0.423
TRG_NLS_MonoExtN_4	499	504	PF00514	0.424
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	268	273	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	420	424	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	6	11	PF00026	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I948	Leptomonas seymouri	44%	87%
A4H828	Leishmania braziliensis	70%	100%
A4HWF4	Leishmania infantum	100%	100%
E9AQ53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QFC9	Leishmania major	92%	100%