Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IA15_LEIDO

TriTrypDb:

LdBPK_181180.1 , LdCL_180017000 , LDHU3_18.1500

Length:

202

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IA15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IA15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	154	156	PF00675	0.515
CLV_NRD_NRD_1	171	173	PF00675	0.488
CLV_PCSK_KEX2_1	153	155	PF00082	0.528
DEG_Nend_UBRbox_2	1	3	PF02207	0.517
DOC_CDC14_PxL_1	28	36	PF14671	0.436
DOC_MAPK_DCC_7	189	197	PF00069	0.622
DOC_MAPK_gen_1	153	161	PF00069	0.516
DOC_PP1_RVXF_1	91	98	PF00149	0.519
DOC_PP2B_LxvP_1	185	188	PF13499	0.621
DOC_PP4_FxxP_1	4	7	PF00568	0.476
DOC_USP7_MATH_1	30	34	PF00917	0.447
DOC_USP7_MATH_1	77	81	PF00917	0.445
LIG_deltaCOP1_diTrp_1	100	105	PF00928	0.427
LIG_LIR_Apic_2	2	7	PF02991	0.486
LIG_Pex14_2	145	149	PF04695	0.558
LIG_Pex14_2	24	28	PF04695	0.511
LIG_PTB_Apo_2	145	152	PF02174	0.648
LIG_SH2_GRB2like	120	123	PF00017	0.509
LIG_SH2_GRB2like	146	149	PF00017	0.561
LIG_SH2_NCK_1	120	124	PF00017	0.518
LIG_SH2_SRC	120	123	PF00017	0.509
LIG_SH2_STAT5	96	99	PF00017	0.506
LIG_SUMO_SIM_par_1	157	163	PF11976	0.664
LIG_TRAF2_1	33	36	PF00917	0.540
MOD_CK2_1	30	36	PF00069	0.533
MOD_GlcNHglycan	79	82	PF01048	0.481
MOD_GSK3_1	177	184	PF00069	0.576
MOD_N-GLC_1	147	152	PF02516	0.546
MOD_NEK2_1	110	115	PF00069	0.436
MOD_NEK2_2	69	74	PF00069	0.501
MOD_Plk_1	147	153	PF00069	0.543
MOD_Plk_1	180	186	PF00069	0.681
MOD_Plk_1	69	75	PF00069	0.402
MOD_Plk_2-3	177	183	PF00069	0.641
MOD_Plk_4	79	85	PF00069	0.430
TRG_ENDOCYTIC_2	146	149	PF00928	0.561
TRG_ER_diArg_1	152	155	PF00400	0.535
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMB7	Leptomonas seymouri	87%	100%
A0A0S4JNP2	Bodo saltans	75%	100%
A0A1X0P7B0	Trypanosomatidae	81%	97%
A4H9M7	Leishmania braziliensis	96%	100%
A4HXZ1	Leishmania infantum	100%	100%
D0A5B7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	98%
E9ARQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4QDS5	Leishmania major	100%	100%