Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IA12_LEIDO

TriTrypDb:

LdBPK_150110.1 , LdCL_150006000 , LDHU3_15.0140

Length:

797

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8IA12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IA12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.583
CLV_NRD_NRD_1	105	107	PF00675	0.758
CLV_NRD_NRD_1	231	233	PF00675	0.663
CLV_NRD_NRD_1	257	259	PF00675	0.431
CLV_NRD_NRD_1	387	389	PF00675	0.435
CLV_NRD_NRD_1	526	528	PF00675	0.348
CLV_NRD_NRD_1	759	761	PF00675	0.451
CLV_NRD_NRD_1	777	779	PF00675	0.550
CLV_PCSK_FUR_1	106	110	PF00082	0.514
CLV_PCSK_FUR_1	385	389	PF00082	0.422
CLV_PCSK_KEX2_1	105	107	PF00082	0.765
CLV_PCSK_KEX2_1	108	110	PF00082	0.679
CLV_PCSK_KEX2_1	257	259	PF00082	0.413
CLV_PCSK_KEX2_1	387	389	PF00082	0.404
CLV_PCSK_KEX2_1	526	528	PF00082	0.381
CLV_PCSK_KEX2_1	692	694	PF00082	0.663
CLV_PCSK_KEX2_1	759	761	PF00082	0.451
CLV_PCSK_KEX2_1	777	779	PF00082	0.652
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.570
CLV_PCSK_PC1ET2_1	692	694	PF00082	0.663
CLV_PCSK_SKI1_1	232	236	PF00082	0.719
CLV_PCSK_SKI1_1	388	392	PF00082	0.434
CLV_PCSK_SKI1_1	576	580	PF00082	0.491
CLV_PCSK_SKI1_1	616	620	PF00082	0.374
CLV_PCSK_SKI1_1	78	82	PF00082	0.550
CLV_Separin_Metazoa	774	778	PF03568	0.535
DEG_APCC_DBOX_1	306	314	PF00400	0.427
DEG_APCC_DBOX_1	615	623	PF00400	0.387
DEG_MDM2_SWIB_1	295	302	PF02201	0.483
DEG_Nend_UBRbox_1	1	4	PF02207	0.736
DEG_SCF_FBW7_1	555	562	PF00400	0.482
DEG_SCF_FBW7_1	577	583	PF00400	0.358
DOC_CKS1_1	380	385	PF01111	0.453
DOC_CKS1_1	577	582	PF01111	0.413
DOC_CYCLIN_RxL_1	613	623	PF00134	0.435
DOC_MAPK_HePTP_8	635	647	PF00069	0.430
DOC_MAPK_MEF2A_6	638	647	PF00069	0.497
DOC_PP1_RVXF_1	416	423	PF00149	0.412
DOC_PP1_RVXF_1	552	558	PF00149	0.518
DOC_PP2B_LxvP_1	511	514	PF13499	0.398
DOC_PP4_FxxP_1	393	396	PF00568	0.400
DOC_PP4_FxxP_1	735	738	PF00568	0.614
DOC_USP7_MATH_1	140	144	PF00917	0.444
DOC_USP7_MATH_1	224	228	PF00917	0.717
DOC_USP7_MATH_1	27	31	PF00917	0.522
DOC_USP7_MATH_1	326	330	PF00917	0.626
DOC_USP7_MATH_1	356	360	PF00917	0.682
DOC_USP7_MATH_1	364	368	PF00917	0.614
DOC_USP7_MATH_1	547	551	PF00917	0.472
DOC_USP7_MATH_1	580	584	PF00917	0.510
DOC_USP7_MATH_1	596	600	PF00917	0.281
DOC_USP7_MATH_1	705	709	PF00917	0.593
DOC_USP7_MATH_1	782	786	PF00917	0.582
DOC_USP7_MATH_1	88	92	PF00917	0.702
DOC_USP7_UBL2_3	686	690	PF12436	0.679
DOC_WW_Pin1_4	359	364	PF00397	0.721
DOC_WW_Pin1_4	379	384	PF00397	0.493
DOC_WW_Pin1_4	426	431	PF00397	0.397
DOC_WW_Pin1_4	450	455	PF00397	0.376
DOC_WW_Pin1_4	543	548	PF00397	0.470
DOC_WW_Pin1_4	555	560	PF00397	0.538
DOC_WW_Pin1_4	568	573	PF00397	0.445
DOC_WW_Pin1_4	576	581	PF00397	0.367
DOC_WW_Pin1_4	675	680	PF00397	0.649
DOC_WW_Pin1_4	734	739	PF00397	0.607
DOC_WW_Pin1_4	90	95	PF00397	0.679
LIG_14-3-3_CanoR_1	167	175	PF00244	0.407
LIG_14-3-3_CanoR_1	323	331	PF00244	0.591
LIG_14-3-3_CanoR_1	616	622	PF00244	0.469
LIG_14-3-3_CanoR_1	78	83	PF00244	0.650
LIG_Actin_WH2_2	271	289	PF00022	0.423
LIG_Actin_WH2_2	310	325	PF00022	0.586
LIG_AP2alpha_2	159	161	PF02296	0.459
LIG_BRCT_BRCA1_1	533	537	PF00533	0.466
LIG_CaM_IQ_9	711	727	PF13499	0.440
LIG_CtBP_PxDLS_1	482	486	PF00389	0.513
LIG_deltaCOP1_diTrp_1	296	299	PF00928	0.390
LIG_deltaCOP1_diTrp_1	494	497	PF00928	0.454
LIG_FHA_1	188	194	PF00498	0.431
LIG_FHA_1	209	215	PF00498	0.596
LIG_FHA_1	395	401	PF00498	0.463
LIG_FHA_1	464	470	PF00498	0.438
LIG_FHA_1	486	492	PF00498	0.558
LIG_FHA_1	506	512	PF00498	0.346
LIG_FHA_1	544	550	PF00498	0.388
LIG_FHA_1	589	595	PF00498	0.382
LIG_FHA_1	613	619	PF00498	0.492
LIG_FHA_1	712	718	PF00498	0.616
LIG_FHA_1	763	769	PF00498	0.510
LIG_FHA_1	84	90	PF00498	0.778
LIG_FHA_2	112	118	PF00498	0.645
LIG_FHA_2	478	484	PF00498	0.428
LIG_FHA_2	502	508	PF00498	0.447
LIG_LIR_Gen_1	148	158	PF02991	0.438
LIG_LIR_Gen_1	266	275	PF02991	0.531
LIG_LIR_Gen_1	296	304	PF02991	0.402
LIG_LIR_Gen_1	374	383	PF02991	0.488
LIG_LIR_Gen_1	453	464	PF02991	0.365
LIG_LIR_Gen_1	531	540	PF02991	0.510
LIG_LIR_Gen_1	591	596	PF02991	0.343
LIG_LIR_Nem_3	113	119	PF02991	0.508
LIG_LIR_Nem_3	148	153	PF02991	0.496
LIG_LIR_Nem_3	159	164	PF02991	0.379
LIG_LIR_Nem_3	296	302	PF02991	0.405
LIG_LIR_Nem_3	374	379	PF02991	0.560
LIG_LIR_Nem_3	389	393	PF02991	0.370
LIG_LIR_Nem_3	429	435	PF02991	0.330
LIG_LIR_Nem_3	453	459	PF02991	0.346
LIG_LIR_Nem_3	531	536	PF02991	0.572
LIG_LIR_Nem_3	542	548	PF02991	0.344
LIG_LIR_Nem_3	644	649	PF02991	0.352
LIG_MAD2	418	426	PF02301	0.326
LIG_MYND_1	426	430	PF01753	0.396
LIG_NRBOX	617	623	PF00104	0.297
LIG_Pex14_2	295	299	PF04695	0.451
LIG_SH2_CRK	533	537	PF00017	0.577
LIG_SH2_NCK_1	116	120	PF00017	0.486
LIG_SH2_NCK_1	533	537	PF00017	0.466
LIG_SH2_PTP2	519	522	PF00017	0.462
LIG_SH2_SRC	116	119	PF00017	0.430
LIG_SH2_STAP1	533	537	PF00017	0.580
LIG_SH2_STAP1	551	555	PF00017	0.228
LIG_SH2_STAT3	435	438	PF00017	0.472
LIG_SH2_STAT5	309	312	PF00017	0.312
LIG_SH2_STAT5	398	401	PF00017	0.347
LIG_SH2_STAT5	456	459	PF00017	0.334
LIG_SH2_STAT5	519	522	PF00017	0.383
LIG_SH2_STAT5	569	572	PF00017	0.464
LIG_SH2_STAT5	65	68	PF00017	0.546
LIG_SH2_STAT5	786	789	PF00017	0.519
LIG_SH3_2	380	385	PF14604	0.453
LIG_SH3_2	405	410	PF14604	0.448
LIG_SH3_3	190	196	PF00018	0.470
LIG_SH3_3	209	215	PF00018	0.437
LIG_SH3_3	240	246	PF00018	0.539
LIG_SH3_3	377	383	PF00018	0.541
LIG_SH3_3	402	408	PF00018	0.526
LIG_SH3_3	560	566	PF00018	0.442
LIG_SH3_3	740	746	PF00018	0.581
LIG_Sin3_3	409	416	PF02671	0.446
LIG_SUMO_SIM_anti_2	32	37	PF11976	0.632
LIG_SUMO_SIM_anti_2	617	623	PF11976	0.357
LIG_SUMO_SIM_par_1	250	256	PF11976	0.483
LIG_SUMO_SIM_par_1	300	305	PF11976	0.407
LIG_SUMO_SIM_par_1	309	314	PF11976	0.245
LIG_SUMO_SIM_par_1	617	623	PF11976	0.537
LIG_TRAF2_1	290	293	PF00917	0.459
LIG_TRFH_1	376	380	PF08558	0.359
LIG_TYR_ITSM	112	119	PF00017	0.516
LIG_WRC_WIRS_1	456	461	PF05994	0.476
LIG_WRC_WIRS_1	621	626	PF05994	0.410
MOD_CDK_SPxK_1	379	385	PF00069	0.455
MOD_CDK_SPxxK_3	90	97	PF00069	0.592
MOD_CK1_1	145	151	PF00069	0.608
MOD_CK1_1	187	193	PF00069	0.542
MOD_CK1_1	29	35	PF00069	0.533
MOD_CK1_1	324	330	PF00069	0.603
MOD_CK1_1	359	365	PF00069	0.671
MOD_CK1_1	441	447	PF00069	0.461
MOD_CK1_1	455	461	PF00069	0.399
MOD_CK1_1	503	509	PF00069	0.539
MOD_CK1_1	620	626	PF00069	0.459
MOD_CK1_1	660	666	PF00069	0.607
MOD_CK1_1	708	714	PF00069	0.451
MOD_CK2_1	38	44	PF00069	0.592
MOD_CK2_1	462	468	PF00069	0.523
MOD_CK2_1	477	483	PF00069	0.329
MOD_CK2_1	701	707	PF00069	0.629
MOD_Cter_Amidation	103	106	PF01082	0.760
MOD_GlcNHglycan	149	153	PF01048	0.569
MOD_GlcNHglycan	215	218	PF01048	0.696
MOD_GlcNHglycan	312	316	PF01048	0.377
MOD_GlcNHglycan	324	327	PF01048	0.501
MOD_GlcNHglycan	366	369	PF01048	0.666
MOD_GlcNHglycan	445	448	PF01048	0.460
MOD_GlcNHglycan	450	453	PF01048	0.499
MOD_GlcNHglycan	533	536	PF01048	0.592
MOD_GlcNHglycan	638	641	PF01048	0.378
MOD_GlcNHglycan	694	698	PF01048	0.672
MOD_GlcNHglycan	703	706	PF01048	0.587
MOD_GSK3_1	162	169	PF00069	0.397
MOD_GSK3_1	187	194	PF00069	0.526
MOD_GSK3_1	22	29	PF00069	0.726
MOD_GSK3_1	311	318	PF00069	0.536
MOD_GSK3_1	322	329	PF00069	0.617
MOD_GSK3_1	448	455	PF00069	0.397
MOD_GSK3_1	501	508	PF00069	0.406
MOD_GSK3_1	531	538	PF00069	0.515
MOD_GSK3_1	543	550	PF00069	0.368
MOD_GSK3_1	555	562	PF00069	0.458
MOD_GSK3_1	576	583	PF00069	0.460
MOD_GSK3_1	671	678	PF00069	0.629
MOD_GSK3_1	701	708	PF00069	0.546
MOD_GSK3_1	74	81	PF00069	0.620
MOD_LATS_1	498	504	PF00433	0.438
MOD_N-GLC_1	372	377	PF02516	0.508
MOD_NEK2_1	162	167	PF00069	0.483
MOD_NEK2_1	191	196	PF00069	0.515
MOD_NEK2_1	271	276	PF00069	0.405
MOD_NEK2_1	295	300	PF00069	0.425
MOD_NEK2_1	31	36	PF00069	0.653
MOD_NEK2_1	322	327	PF00069	0.593
MOD_NEK2_1	391	396	PF00069	0.407
MOD_NEK2_1	399	404	PF00069	0.348
MOD_NEK2_1	412	417	PF00069	0.409
MOD_NEK2_1	448	453	PF00069	0.550
MOD_NEK2_1	485	490	PF00069	0.564
MOD_NEK2_1	509	514	PF00069	0.435
MOD_NEK2_1	89	94	PF00069	0.748
MOD_NEK2_2	38	43	PF00069	0.568
MOD_NEK2_2	474	479	PF00069	0.359
MOD_OFUCOSY	593	598	PF10250	0.410
MOD_PIKK_1	168	174	PF00454	0.369
MOD_PIKK_1	356	362	PF00454	0.717
MOD_PIKK_1	483	489	PF00454	0.500
MOD_PIKK_1	580	586	PF00454	0.466
MOD_PIKK_1	657	663	PF00454	0.668
MOD_PIKK_1	705	711	PF00454	0.638
MOD_PKA_2	166	172	PF00069	0.403
MOD_PKA_2	224	230	PF00069	0.676
MOD_PKA_2	322	328	PF00069	0.592
MOD_PKA_2	74	80	PF00069	0.633
MOD_Plk_1	112	118	PF00069	0.566
MOD_Plk_1	148	154	PF00069	0.518
MOD_Plk_1	295	301	PF00069	0.476
MOD_Plk_1	372	378	PF00069	0.444
MOD_Plk_1	752	758	PF00069	0.490
MOD_Plk_4	31	37	PF00069	0.662
MOD_Plk_4	38	44	PF00069	0.385
MOD_Plk_4	394	400	PF00069	0.397
MOD_Plk_4	452	458	PF00069	0.498
MOD_Plk_4	617	623	PF00069	0.460
MOD_Plk_4	782	788	PF00069	0.502
MOD_ProDKin_1	359	365	PF00069	0.720
MOD_ProDKin_1	379	385	PF00069	0.496
MOD_ProDKin_1	426	432	PF00069	0.395
MOD_ProDKin_1	450	456	PF00069	0.374
MOD_ProDKin_1	543	549	PF00069	0.466
MOD_ProDKin_1	555	561	PF00069	0.547
MOD_ProDKin_1	568	574	PF00069	0.440
MOD_ProDKin_1	576	582	PF00069	0.368
MOD_ProDKin_1	675	681	PF00069	0.649
MOD_ProDKin_1	734	740	PF00069	0.603
MOD_ProDKin_1	90	96	PF00069	0.679
TRG_DiLeu_BaEn_1	374	379	PF01217	0.571
TRG_DiLeu_BaEn_2	730	736	PF01217	0.533
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.525
TRG_DiLeu_BaLyEn_6	573	578	PF01217	0.421
TRG_ENDOCYTIC_2	116	119	PF00928	0.478
TRG_ENDOCYTIC_2	182	185	PF00928	0.295
TRG_ENDOCYTIC_2	268	271	PF00928	0.371
TRG_ENDOCYTIC_2	456	459	PF00928	0.334
TRG_ENDOCYTIC_2	518	521	PF00928	0.365
TRG_ENDOCYTIC_2	533	536	PF00928	0.516
TRG_ER_diArg_1	385	388	PF00400	0.440
TRG_ER_diArg_1	424	427	PF00400	0.530
TRG_ER_diArg_1	526	529	PF00400	0.440
TRG_ER_diArg_1	758	760	PF00400	0.462
TRG_ER_diArg_1	776	778	PF00400	0.542
TRG_Pf-PMV_PEXEL_1	479	483	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCR8	Leptomonas seymouri	50%	98%
A0A0S4KHH2	Bodo saltans	29%	92%
A0A1X0NTL8	Trypanosomatidae	40%	100%
A0A422NS84	Trypanosoma rangeli	36%	100%
A4H7Y1	Leishmania braziliensis	74%	100%
A4HWA8	Leishmania infantum	100%	100%
C9ZNU4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AQ08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4QFH3	Leishmania major	93%	100%
V5AWK1	Trypanosoma cruzi	35%	96%