Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IA11_LEIDO

TriTrypDb:

LdBPK_200750.1 , LdCL_200012200 , LDHU3_20.0900

Length:

1339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0000123	histone acetyltransferase complex	4	1
GO:0000124	SAGA complex	4	1
GO:0031248	protein acetyltransferase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0070461	SAGA-type complex	5	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902493	acetyltransferase complex	4	1
GO:1902494	catalytic complex	2	1
GO:1905368	peptidase complex	3	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A0A3Q8IA11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003712	transcription coregulator activity	2	1
GO:0140110	transcription regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	486	490	PF00656	0.647
CLV_C14_Caspase3-7	559	563	PF00656	0.754
CLV_NRD_NRD_1	1112	1114	PF00675	0.743
CLV_NRD_NRD_1	126	128	PF00675	0.503
CLV_NRD_NRD_1	241	243	PF00675	0.627
CLV_NRD_NRD_1	301	303	PF00675	0.387
CLV_NRD_NRD_1	36	38	PF00675	0.482
CLV_NRD_NRD_1	44	46	PF00675	0.480
CLV_NRD_NRD_1	587	589	PF00675	0.634
CLV_NRD_NRD_1	590	592	PF00675	0.632
CLV_NRD_NRD_1	594	596	PF00675	0.639
CLV_NRD_NRD_1	609	611	PF00675	0.573
CLV_NRD_NRD_1	672	674	PF00675	0.581
CLV_NRD_NRD_1	679	681	PF00675	0.611
CLV_NRD_NRD_1	720	722	PF00675	0.646
CLV_PCSK_FUR_1	166	170	PF00082	0.525
CLV_PCSK_FUR_1	588	592	PF00082	0.632
CLV_PCSK_KEX2_1	1112	1114	PF00082	0.743
CLV_PCSK_KEX2_1	126	128	PF00082	0.480
CLV_PCSK_KEX2_1	168	170	PF00082	0.678
CLV_PCSK_KEX2_1	241	243	PF00082	0.740
CLV_PCSK_KEX2_1	301	303	PF00082	0.387
CLV_PCSK_KEX2_1	36	38	PF00082	0.482
CLV_PCSK_KEX2_1	44	46	PF00082	0.480
CLV_PCSK_KEX2_1	587	589	PF00082	0.634
CLV_PCSK_KEX2_1	590	592	PF00082	0.632
CLV_PCSK_KEX2_1	593	595	PF00082	0.639
CLV_PCSK_KEX2_1	672	674	PF00082	0.581
CLV_PCSK_KEX2_1	679	681	PF00082	0.611
CLV_PCSK_KEX2_1	720	722	PF00082	0.646
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.480
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.678
CLV_PCSK_PC1ET2_1	720	722	PF00082	0.625
CLV_PCSK_PC7_1	590	596	PF00082	0.636
CLV_PCSK_SKI1_1	44	48	PF00082	0.483
CLV_PCSK_SKI1_1	545	549	PF00082	0.645
CLV_PCSK_SKI1_1	573	577	PF00082	0.729
CLV_PCSK_SKI1_1	642	646	PF00082	0.442
CLV_PCSK_SKI1_1	680	684	PF00082	0.641
CLV_PCSK_SKI1_1	852	856	PF00082	0.657
DEG_COP1_1	261	270	PF00400	0.692
DOC_CKS1_1	267	272	PF01111	0.661
DOC_CYCLIN_yCln2_LP_2	364	370	PF00134	0.346
DOC_CYCLIN_yCln2_LP_2	854	860	PF00134	0.656
DOC_MAPK_DCC_7	360	370	PF00069	0.346
DOC_MAPK_gen_1	414	422	PF00069	0.369
DOC_PP2B_LxvP_1	196	199	PF13499	0.598
DOC_PP2B_LxvP_1	216	219	PF13499	0.541
DOC_PP2B_LxvP_1	265	268	PF13499	0.705
DOC_PP2B_LxvP_1	854	857	PF13499	0.668
DOC_PP2B_LxvP_1	956	959	PF13499	0.495
DOC_PP4_FxxP_1	312	315	PF00568	0.506
DOC_PP4_FxxP_1	55	58	PF00568	0.468
DOC_USP7_MATH_1	112	116	PF00917	0.468
DOC_USP7_MATH_1	1189	1193	PF00917	0.630
DOC_USP7_MATH_1	1237	1241	PF00917	0.635
DOC_USP7_MATH_1	1242	1246	PF00917	0.647
DOC_USP7_MATH_1	201	205	PF00917	0.599
DOC_USP7_MATH_1	236	240	PF00917	0.556
DOC_USP7_MATH_1	560	564	PF00917	0.723
DOC_USP7_MATH_1	575	579	PF00917	0.565
DOC_USP7_MATH_1	583	587	PF00917	0.622
DOC_USP7_MATH_1	617	621	PF00917	0.625
DOC_USP7_MATH_1	84	88	PF00917	0.623
DOC_USP7_MATH_1	848	852	PF00917	0.454
DOC_USP7_MATH_1	904	908	PF00917	0.584
DOC_USP7_MATH_1	959	963	PF00917	0.631
DOC_USP7_UBL2_3	164	168	PF12436	0.533
DOC_USP7_UBL2_3	174	178	PF12436	0.577
DOC_USP7_UBL2_3	545	549	PF12436	0.645
DOC_WW_Pin1_4	1166	1171	PF00397	0.659
DOC_WW_Pin1_4	178	183	PF00397	0.694
DOC_WW_Pin1_4	214	219	PF00397	0.617
DOC_WW_Pin1_4	249	254	PF00397	0.709
DOC_WW_Pin1_4	266	271	PF00397	0.520
DOC_WW_Pin1_4	289	294	PF00397	0.583
DOC_WW_Pin1_4	389	394	PF00397	0.566
DOC_WW_Pin1_4	76	81	PF00397	0.506
DOC_WW_Pin1_4	892	897	PF00397	0.604
DOC_WW_Pin1_4	96	101	PF00397	0.562
LIG_14-3-3_CanoR_1	1168	1174	PF00244	0.729
LIG_14-3-3_CanoR_1	207	216	PF00244	0.586
LIG_14-3-3_CanoR_1	565	570	PF00244	0.679
LIG_14-3-3_CanoR_1	610	617	PF00244	0.665
LIG_14-3-3_CanoR_1	852	857	PF00244	0.658
LIG_BIR_III_2	574	578	PF00653	0.665
LIG_BRCT_BRCA1_1	115	119	PF00533	0.481
LIG_BRCT_BRCA1_1	1325	1329	PF00533	0.565
LIG_BRCT_BRCA1_1	372	376	PF00533	0.347
LIG_eIF4E_1	359	365	PF01652	0.401
LIG_eIF4E_1	400	406	PF01652	0.484
LIG_FHA_1	148	154	PF00498	0.467
LIG_FHA_1	24	30	PF00498	0.516
LIG_FHA_1	462	468	PF00498	0.507
LIG_FHA_1	59	65	PF00498	0.627
LIG_FHA_1	77	83	PF00498	0.432
LIG_FHA_2	1261	1267	PF00498	0.600
LIG_FHA_2	464	470	PF00498	0.500
LIG_FHA_2	484	490	PF00498	0.515
LIG_FHA_2	534	540	PF00498	0.547
LIG_FHA_2	565	571	PF00498	0.724
LIG_FHA_2	613	619	PF00498	0.559
LIG_FHA_2	76	82	PF00498	0.512
LIG_IBAR_NPY_1	1281	1283	PF08397	0.718
LIG_IBAR_NPY_1	999	1001	PF08397	0.474
LIG_Integrin_RGD_1	512	514	PF01839	0.710
LIG_LIR_Apic_2	310	315	PF02991	0.508
LIG_LIR_Gen_1	1284	1292	PF02991	0.585
LIG_LIR_Gen_1	292	303	PF02991	0.479
LIG_LIR_Gen_1	348	359	PF02991	0.364
LIG_LIR_Gen_1	650	661	PF02991	0.466
LIG_LIR_Nem_3	1284	1288	PF02991	0.654
LIG_LIR_Nem_3	292	298	PF02991	0.523
LIG_LIR_Nem_3	348	354	PF02991	0.371
LIG_LIR_Nem_3	358	364	PF02991	0.347
LIG_LIR_Nem_3	650	656	PF02991	0.458
LIG_MAD2	852	860	PF02301	0.653
LIG_MLH1_MIPbox_1	1325	1329	PF16413	0.565
LIG_MYND_1	222	226	PF01753	0.646
LIG_PCNA_yPIPBox_3	421	433	PF02747	0.409
LIG_Pex14_2	351	355	PF04695	0.421
LIG_PTB_Apo_2	1328	1335	PF02174	0.483
LIG_PTB_Apo_2	394	401	PF02174	0.406
LIG_PTB_Phospho_1	394	400	PF10480	0.410
LIG_REV1ctd_RIR_1	1332	1339	PF16727	0.448
LIG_SH2_CRK	1187	1191	PF00017	0.695
LIG_SH2_CRK	912	916	PF00017	0.520
LIG_SH2_CRK	997	1001	PF00017	0.624
LIG_SH2_GRB2like	997	1000	PF00017	0.511
LIG_SH2_NCK_1	1187	1191	PF00017	0.711
LIG_SH2_NCK_1	155	159	PF00017	0.614
LIG_SH2_NCK_1	912	916	PF00017	0.520
LIG_SH2_PTP2	844	847	PF00017	0.476
LIG_SH2_SRC	838	841	PF00017	0.353
LIG_SH2_STAP1	1283	1287	PF00017	0.631
LIG_SH2_STAT3	1049	1052	PF00017	0.646
LIG_SH2_STAT5	308	311	PF00017	0.403
LIG_SH2_STAT5	380	383	PF00017	0.353
LIG_SH2_STAT5	54	57	PF00017	0.476
LIG_SH2_STAT5	838	841	PF00017	0.396
LIG_SH2_STAT5	844	847	PF00017	0.422
LIG_SH2_STAT5	868	871	PF00017	0.510
LIG_SH2_STAT5	928	931	PF00017	0.594
LIG_SH3_3	101	107	PF00018	0.590
LIG_SH3_3	1180	1186	PF00018	0.665
LIG_SH3_3	1191	1197	PF00018	0.630
LIG_SH3_3	1270	1276	PF00018	0.597
LIG_SH3_3	215	221	PF00018	0.613
LIG_SH3_3	264	270	PF00018	0.643
LIG_SH3_3	287	293	PF00018	0.665
LIG_SH3_3	322	328	PF00018	0.571
LIG_SH3_3	387	393	PF00018	0.573
LIG_SH3_3	501	507	PF00018	0.591
LIG_SH3_3	749	755	PF00018	0.609
LIG_SH3_3	842	848	PF00018	0.450
LIG_SH3_3	854	860	PF00018	0.532
LIG_SH3_3	866	872	PF00018	0.510
LIG_SH3_3	893	899	PF00018	0.591
LIG_SH3_3	966	972	PF00018	0.590
LIG_SH3_4	506	513	PF00018	0.667
LIG_SUMO_SIM_par_1	462	469	PF11976	0.506
LIG_TRAF2_1	1071	1074	PF00917	0.589
LIG_TRAF2_1	682	685	PF00917	0.618
LIG_TRAF2_1	715	718	PF00917	0.660
LIG_TYR_ITIM	842	847	PF00017	0.534
LIG_UBA3_1	639	645	PF00899	0.434
LIG_WW_2	1196	1199	PF00397	0.696
MOD_CDK_SPK_2	178	183	PF00069	0.630
MOD_CK1_1	122	128	PF00069	0.596
MOD_CK1_1	1225	1231	PF00069	0.656
MOD_CK1_1	1245	1251	PF00069	0.492
MOD_CK1_1	146	152	PF00069	0.614
MOD_CK1_1	206	212	PF00069	0.726
MOD_CK1_1	280	286	PF00069	0.668
MOD_CK1_1	288	294	PF00069	0.515
MOD_CK1_1	310	316	PF00069	0.391
MOD_CK1_1	460	466	PF00069	0.518
MOD_CK1_1	578	584	PF00069	0.632
MOD_CK1_1	586	592	PF00069	0.647
MOD_CK1_1	75	81	PF00069	0.637
MOD_CK1_1	83	89	PF00069	0.636
MOD_CK1_1	96	102	PF00069	0.479
MOD_CK1_1	962	968	PF00069	0.655
MOD_CK2_1	1225	1231	PF00069	0.781
MOD_CK2_1	288	294	PF00069	0.544
MOD_CK2_1	612	618	PF00069	0.570
MOD_CK2_1	622	628	PF00069	0.426
MOD_CK2_1	675	681	PF00069	0.584
MOD_Cter_Amidation	239	242	PF01082	0.597
MOD_Cter_Amidation	299	302	PF01082	0.372
MOD_GlcNHglycan	100	103	PF01048	0.693
MOD_GlcNHglycan	115	118	PF01048	0.446
MOD_GlcNHglycan	1164	1167	PF01048	0.688
MOD_GlcNHglycan	1178	1181	PF01048	0.648
MOD_GlcNHglycan	120	124	PF01048	0.525
MOD_GlcNHglycan	1227	1230	PF01048	0.694
MOD_GlcNHglycan	1234	1237	PF01048	0.593
MOD_GlcNHglycan	1239	1242	PF01048	0.576
MOD_GlcNHglycan	1244	1247	PF01048	0.541
MOD_GlcNHglycan	1256	1259	PF01048	0.490
MOD_GlcNHglycan	156	159	PF01048	0.676
MOD_GlcNHglycan	237	241	PF01048	0.572
MOD_GlcNHglycan	244	247	PF01048	0.660
MOD_GlcNHglycan	279	282	PF01048	0.695
MOD_GlcNHglycan	469	473	PF01048	0.583
MOD_GlcNHglycan	530	533	PF01048	0.726
MOD_GlcNHglycan	578	581	PF01048	0.626
MOD_GlcNHglycan	625	628	PF01048	0.611
MOD_GlcNHglycan	783	786	PF01048	0.564
MOD_GlcNHglycan	81	85	PF01048	0.648
MOD_GlcNHglycan	885	888	PF01048	0.583
MOD_GlcNHglycan	890	893	PF01048	0.644
MOD_GlcNHglycan	95	98	PF01048	0.515
MOD_GlcNHglycan	961	964	PF01048	0.636
MOD_GSK3_1	1162	1169	PF00069	0.661
MOD_GSK3_1	1221	1228	PF00069	0.668
MOD_GSK3_1	1237	1244	PF00069	0.647
MOD_GSK3_1	1277	1284	PF00069	0.639
MOD_GSK3_1	1323	1330	PF00069	0.690
MOD_GSK3_1	143	150	PF00069	0.399
MOD_GSK3_1	202	209	PF00069	0.610
MOD_GSK3_1	285	292	PF00069	0.535
MOD_GSK3_1	310	317	PF00069	0.448
MOD_GSK3_1	375	382	PF00069	0.361
MOD_GSK3_1	457	464	PF00069	0.665
MOD_GSK3_1	483	490	PF00069	0.593
MOD_GSK3_1	560	567	PF00069	0.784
MOD_GSK3_1	652	659	PF00069	0.477
MOD_GSK3_1	71	78	PF00069	0.508
MOD_GSK3_1	781	788	PF00069	0.537
MOD_GSK3_1	80	87	PF00069	0.530
MOD_GSK3_1	813	820	PF00069	0.649
MOD_GSK3_1	823	830	PF00069	0.536
MOD_GSK3_1	848	855	PF00069	0.502
MOD_GSK3_1	883	890	PF00069	0.576
MOD_GSK3_1	89	96	PF00069	0.491
MOD_N-GLC_1	1225	1230	PF02516	0.729
MOD_N-GLC_1	1242	1247	PF02516	0.565
MOD_N-GLC_1	248	253	PF02516	0.768
MOD_N-GLC_1	258	263	PF02516	0.584
MOD_N-GLC_1	39	44	PF02516	0.482
MOD_N-GLC_1	565	570	PF02516	0.681
MOD_N-GLC_1	59	64	PF02516	0.479
MOD_N-GLC_1	675	680	PF02516	0.723
MOD_N-GLC_1	75	80	PF02516	0.524
MOD_N-GLC_1	89	94	PF02516	0.446
MOD_N-GLC_2	340	342	PF02516	0.481
MOD_NEK2_1	113	118	PF00069	0.557
MOD_NEK2_1	1204	1209	PF00069	0.688
MOD_NEK2_1	13	18	PF00069	0.555
MOD_NEK2_1	147	152	PF00069	0.447
MOD_NEK2_1	176	181	PF00069	0.562
MOD_NEK2_1	277	282	PF00069	0.661
MOD_NEK2_1	370	375	PF00069	0.347
MOD_NEK2_1	381	386	PF00069	0.419
MOD_NEK2_1	39	44	PF00069	0.461
MOD_NEK2_1	443	448	PF00069	0.565
MOD_NEK2_1	461	466	PF00069	0.398
MOD_NEK2_1	493	498	PF00069	0.665
MOD_NEK2_1	675	680	PF00069	0.605
MOD_NEK2_1	697	702	PF00069	0.614
MOD_NEK2_1	781	786	PF00069	0.563
MOD_NEK2_1	91	96	PF00069	0.614
MOD_NEK2_1	978	983	PF00069	0.585
MOD_NEK2_2	307	312	PF00069	0.392
MOD_NEK2_2	617	622	PF00069	0.508
MOD_NEK2_2	652	657	PF00069	0.458
MOD_NEK2_2	84	89	PF00069	0.670
MOD_NMyristoyl	1	7	PF02799	0.502
MOD_OFUCOSY	305	311	PF10250	0.389
MOD_PIKK_1	1085	1091	PF00454	0.513
MOD_PIKK_1	1213	1219	PF00454	0.628
MOD_PIKK_1	1323	1329	PF00454	0.578
MOD_PIKK_1	156	162	PF00454	0.450
MOD_PIKK_1	209	215	PF00454	0.606
MOD_PIKK_1	375	381	PF00454	0.356
MOD_PIKK_1	737	743	PF00454	0.653
MOD_PIKK_1	858	864	PF00454	0.559
MOD_PIKK_1	922	928	PF00454	0.523
MOD_PIKK_1	938	944	PF00454	0.470
MOD_PK_1	169	175	PF00069	0.625
MOD_PKA_1	241	247	PF00069	0.762
MOD_PKA_2	206	212	PF00069	0.580
MOD_PKA_2	241	247	PF00069	0.759
MOD_PKA_2	564	570	PF00069	0.676
MOD_PKA_2	586	592	PF00069	0.703
MOD_PKA_2	609	615	PF00069	0.541
MOD_Plk_1	143	149	PF00069	0.446
MOD_Plk_1	258	264	PF00069	0.719
MOD_Plk_1	461	467	PF00069	0.512
MOD_Plk_1	565	571	PF00069	0.549
MOD_Plk_1	59	65	PF00069	0.602
MOD_Plk_1	617	623	PF00069	0.644
MOD_Plk_2-3	685	691	PF00069	0.717
MOD_Plk_4	1190	1196	PF00069	0.664
MOD_Plk_4	143	149	PF00069	0.459
MOD_Plk_4	370	376	PF00069	0.347
MOD_Plk_4	381	387	PF00069	0.425
MOD_Plk_4	489	495	PF00069	0.648
MOD_Plk_4	617	623	PF00069	0.513
MOD_Plk_4	656	662	PF00069	0.476
MOD_Plk_4	697	703	PF00069	0.609
MOD_Plk_4	904	910	PF00069	0.608
MOD_ProDKin_1	1166	1172	PF00069	0.659
MOD_ProDKin_1	178	184	PF00069	0.695
MOD_ProDKin_1	214	220	PF00069	0.612
MOD_ProDKin_1	249	255	PF00069	0.706
MOD_ProDKin_1	266	272	PF00069	0.519
MOD_ProDKin_1	289	295	PF00069	0.579
MOD_ProDKin_1	389	395	PF00069	0.563
MOD_ProDKin_1	76	82	PF00069	0.507
MOD_ProDKin_1	892	898	PF00069	0.600
MOD_ProDKin_1	96	102	PF00069	0.558
MOD_SUMO_rev_2	324	333	PF00179	0.594
MOD_SUMO_rev_2	352	362	PF00179	0.355
MOD_SUMO_rev_2	570	578	PF00179	0.698
TRG_DiLeu_BaEn_1	1073	1078	PF01217	0.626
TRG_DiLeu_BaEn_2	365	371	PF01217	0.346
TRG_DiLeu_BaEn_4	1073	1079	PF01217	0.629
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.622
TRG_DiLeu_BaLyEn_6	790	795	PF01217	0.563
TRG_DiLeu_LyEn_5	425	430	PF01217	0.457
TRG_ENDOCYTIC_2	1065	1068	PF00928	0.685
TRG_ENDOCYTIC_2	1187	1190	PF00928	0.695
TRG_ENDOCYTIC_2	133	136	PF00928	0.484
TRG_ENDOCYTIC_2	359	362	PF00928	0.397
TRG_ENDOCYTIC_2	400	403	PF00928	0.373
TRG_ENDOCYTIC_2	653	656	PF00928	0.575
TRG_ENDOCYTIC_2	844	847	PF00928	0.422
TRG_ENDOCYTIC_2	945	948	PF00928	0.610
TRG_ER_diArg_1	1112	1114	PF00400	0.568
TRG_ER_diArg_1	301	304	PF00400	0.384
TRG_ER_diArg_1	35	37	PF00400	0.484
TRG_ER_diArg_1	44	46	PF00400	0.480
TRG_ER_diArg_1	587	590	PF00400	0.633
TRG_ER_diArg_1	591	594	PF00400	0.636
TRG_NES_CRM1_1	419	431	PF08389	0.522
TRG_NLS_Bipartite_1	587	601	PF00514	0.631
TRG_NLS_MonoExtN_4	594	601	PF00514	0.628
TRG_NLS_MonoExtN_4	720	725	PF00514	0.642
TRG_Pf-PMV_PEXEL_1	1079	1083	PF00026	0.649
TRG_Pf-PMV_PEXEL_1	421	425	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	673	677	PF00026	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZR7	Leptomonas seymouri	46%	100%
A4HYP3	Leishmania infantum	100%	100%
E9AIC5	Leishmania braziliensis	71%	95%
E9AUL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QCX2	Leishmania major	91%	99%