RWD_domain-containing_protein/GeneDB:LmjF.20.0540

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RWD domain-containing protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IA02_LEIDO

TriTrypDb:

LdBPK_200610.1 , LdCL_200010800 , LDHU3_20.0730

Length:

232

Annotations

Annotations by Jardim et al.

Membrane associated proteins, RWD domain-containing Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005844	polysome	3	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3Q8IA02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IA02

Function

Biological processes
Term	Name	Level	Count
GO:0002181	cytoplasmic translation	5	1
GO:0006412	translation	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043043	peptide biosynthetic process	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0043604	amide biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.577
CLV_NRD_NRD_1	160	162	PF00675	0.562
CLV_NRD_NRD_1	74	76	PF00675	0.236
CLV_PCSK_KEX2_1	123	125	PF00082	0.524
CLV_PCSK_KEX2_1	134	136	PF00082	0.666
CLV_PCSK_KEX2_1	74	76	PF00082	0.236
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.666
CLV_PCSK_SKI1_1	153	157	PF00082	0.512
CLV_PCSK_SKI1_1	177	181	PF00082	0.630
DOC_CYCLIN_RxL_1	150	160	PF00134	0.538
DOC_MAPK_gen_1	171	181	PF00069	0.688
DOC_PP2B_PxIxI_1	142	148	PF00149	0.609
DOC_PP4_MxPP_1	1	4	PF00568	0.616
DOC_USP7_UBL2_3	176	180	PF12436	0.541
LIG_14-3-3_CanoR_1	24	32	PF00244	0.501
LIG_14-3-3_CanoR_1	47	53	PF00244	0.482
LIG_CaM_NSCaTE_8	192	199	PF13499	0.578
LIG_deltaCOP1_diTrp_1	200	204	PF00928	0.548
LIG_FHA_1	134	140	PF00498	0.603
LIG_FHA_1	142	148	PF00498	0.536
LIG_FHA_1	150	156	PF00498	0.440
LIG_FHA_1	80	86	PF00498	0.552
LIG_FHA_2	37	43	PF00498	0.453
LIG_FHA_2	86	92	PF00498	0.519
LIG_LIR_Gen_1	198	208	PF02991	0.558
LIG_LIR_Gen_1	20	30	PF02991	0.501
LIG_LIR_Nem_3	198	204	PF02991	0.544
LIG_LIR_Nem_3	20	25	PF02991	0.501
LIG_PTB_Apo_2	212	219	PF02174	0.622
LIG_Rb_pABgroove_1	13	21	PF01858	0.467
LIG_SH2_STAT5	32	35	PF00017	0.561
LIG_SUMO_SIM_anti_2	97	103	PF11976	0.445
LIG_SUMO_SIM_par_1	63	68	PF11976	0.523
LIG_TRAF2_1	112	115	PF00917	0.645
LIG_TRAF2_1	138	141	PF00917	0.701
LIG_TRAF2_1	53	56	PF00917	0.501
LIG_TRAF2_1	88	91	PF00917	0.520
LIG_WW_1	29	32	PF00397	0.467
MOD_CK1_1	184	190	PF00069	0.579
MOD_CK1_1	195	201	PF00069	0.598
MOD_CK2_1	36	42	PF00069	0.507
MOD_CK2_1	84	90	PF00069	0.531
MOD_GlcNHglycan	181	184	PF01048	0.598
MOD_GlcNHglycan	186	189	PF01048	0.542
MOD_GlcNHglycan	197	200	PF01048	0.471
MOD_GlcNHglycan	59	62	PF01048	0.354
MOD_GSK3_1	28	35	PF00069	0.475
MOD_NEK2_2	192	197	PF00069	0.543
MOD_PIKK_1	36	42	PF00454	0.501
MOD_PKA_2	23	29	PF00069	0.501
MOD_Plk_1	192	198	PF00069	0.544
MOD_Plk_2-3	217	223	PF00069	0.611
MOD_Plk_2-3	23	29	PF00069	0.529
MOD_Plk_4	94	100	PF00069	0.462
MOD_SUMO_rev_2	110	119	PF00179	0.530
MOD_SUMO_rev_2	173	179	PF00179	0.522
TRG_DiLeu_BaEn_1	117	122	PF01217	0.641
TRG_ENDOCYTIC_2	22	25	PF00928	0.483
TRG_ER_diArg_1	122	124	PF00400	0.619
TRG_ER_diArg_1	74	76	PF00400	0.436
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.676

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILT1	Leptomonas seymouri	76%	100%
A0A0S4IZT9	Bodo saltans	50%	97%
A0A1X0NWI2	Trypanosomatidae	58%	97%
A0A422NCD6	Trypanosoma rangeli	51%	100%
A4HYQ7	Leishmania infantum	100%	100%
C9ZI71	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AIB1	Leishmania braziliensis	85%	100%
E9AUJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QCY6	Leishmania major	95%	100%
Q99ND9	Rattus norvegicus	30%	95%
Q9CQK7	Mus musculus	29%	95%
Q9H446	Homo sapiens	30%	95%