Fatty acid desaturase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

delta-6 fatty acid desaturase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I9Z6_LEIDO

TriTrypDb:

LdBPK_141420.1 , LdCL_140020100 , LDHU3_14.1770

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3Q8I9Z6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9Z6

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	1
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.517
CLV_NRD_NRD_1	373	375	PF00675	0.298
CLV_NRD_NRD_1	410	412	PF00675	0.433
CLV_NRD_NRD_1	50	52	PF00675	0.278
CLV_PCSK_FUR_1	408	412	PF00082	0.397
CLV_PCSK_KEX2_1	128	130	PF00082	0.517
CLV_PCSK_KEX2_1	410	412	PF00082	0.489
CLV_PCSK_KEX2_1	49	51	PF00082	0.280
CLV_PCSK_KEX2_1	89	91	PF00082	0.317
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.489
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.317
CLV_PCSK_PC7_1	406	412	PF00082	0.380
CLV_PCSK_SKI1_1	109	113	PF00082	0.312
CLV_PCSK_SKI1_1	20	24	PF00082	0.381
CLV_PCSK_SKI1_1	254	258	PF00082	0.309
CLV_PCSK_SKI1_1	380	384	PF00082	0.328
CLV_PCSK_SKI1_1	6	10	PF00082	0.364
DEG_MDM2_SWIB_1	337	345	PF02201	0.528
DOC_CYCLIN_RxL_1	159	172	PF00134	0.476
DOC_MAPK_gen_1	128	135	PF00069	0.277
DOC_MAPK_gen_1	159	169	PF00069	0.473
DOC_MAPK_gen_1	254	264	PF00069	0.500
DOC_MAPK_gen_1	5	11	PF00069	0.558
DOC_MAPK_MEF2A_6	109	118	PF00069	0.359
DOC_MAPK_MEF2A_6	198	206	PF00069	0.277
DOC_MAPK_MEF2A_6	208	217	PF00069	0.270
DOC_MAPK_MEF2A_6	257	266	PF00069	0.504
DOC_MAPK_RevD_3	114	129	PF00069	0.336
DOC_PP2B_LxvP_1	202	205	PF13499	0.252
LIG_14-3-3_CanoR_1	254	264	PF00244	0.491
LIG_14-3-3_CanoR_1	380	385	PF00244	0.503
LIG_14-3-3_CterR_2	411	414	PF00244	0.654
LIG_BIR_II_1	1	5	PF00653	0.574
LIG_BRCT_BRCA1_1	308	312	PF00533	0.438
LIG_BRCT_BRCA1_1	333	337	PF00533	0.516
LIG_CaM_NSCaTE_8	104	111	PF13499	0.338
LIG_FHA_1	113	119	PF00498	0.271
LIG_FHA_1	16	22	PF00498	0.506
LIG_FHA_1	256	262	PF00498	0.470
LIG_FHA_2	387	393	PF00498	0.488
LIG_Integrin_isoDGR_2	36	38	PF01839	0.347
LIG_LIR_Apic_2	58	63	PF02991	0.582
LIG_LIR_Gen_1	121	131	PF02991	0.363
LIG_LIR_Gen_1	385	395	PF02991	0.490
LIG_LIR_Gen_1	82	91	PF02991	0.485
LIG_LIR_Nem_3	121	126	PF02991	0.357
LIG_LIR_Nem_3	383	387	PF02991	0.477
LIG_LIR_Nem_3	41	47	PF02991	0.463
LIG_LIR_Nem_3	80	84	PF02991	0.476
LIG_PCNA_PIPBox_1	294	303	PF02747	0.331
LIG_Pex14_2	224	228	PF04695	0.310
LIG_Pex14_2	240	244	PF04695	0.196
LIG_Pex14_2	337	341	PF04695	0.528
LIG_PTB_Apo_2	181	188	PF02174	0.328
LIG_PTB_Apo_2	238	245	PF02174	0.326
LIG_PTB_Phospho_1	181	187	PF10480	0.328
LIG_SH2_CRK	272	276	PF00017	0.418
LIG_SH2_CRK	366	370	PF00017	0.470
LIG_SH2_CRK	387	391	PF00017	0.568
LIG_SH2_CRK	60	64	PF00017	0.590
LIG_SH2_GRB2like	192	195	PF00017	0.252
LIG_SH2_SRC	187	190	PF00017	0.328
LIG_SH2_STAP1	123	127	PF00017	0.468
LIG_SH2_STAP1	366	370	PF00017	0.522
LIG_SH2_STAP1	81	85	PF00017	0.558
LIG_SH2_STAT3	219	222	PF00017	0.217
LIG_SH2_STAT5	107	110	PF00017	0.312
LIG_SH2_STAT5	131	134	PF00017	0.304
LIG_SH2_STAT5	187	190	PF00017	0.265
LIG_SH2_STAT5	192	195	PF00017	0.238
LIG_SH2_STAT5	219	222	PF00017	0.245
LIG_SH2_STAT5	225	228	PF00017	0.272
LIG_SH2_STAT5	301	304	PF00017	0.284
LIG_SH2_STAT5	368	371	PF00017	0.453
LIG_SH2_STAT5	384	387	PF00017	0.460
LIG_SH2_STAT5	84	87	PF00017	0.463
LIG_SUMO_SIM_anti_2	17	25	PF11976	0.516
LIG_SUMO_SIM_par_1	7	12	PF11976	0.553
LIG_SxIP_EBH_1	206	216	PF03271	0.328
LIG_SxIP_EBH_1	263	273	PF03271	0.344
LIG_TRAF2_1	389	392	PF00917	0.565
LIG_TYR_ITIM	270	275	PF00017	0.418
LIG_TYR_ITIM	302	307	PF00017	0.391
LIG_TYR_ITSM	383	390	PF00017	0.477
LIG_UBA3_1	239	247	PF00899	0.414
LIG_WRC_WIRS_1	395	400	PF05994	0.530
MOD_CK1_1	177	183	PF00069	0.323
MOD_CK1_1	80	86	PF00069	0.512
MOD_CK2_1	386	392	PF00069	0.579
MOD_CK2_1	68	74	PF00069	0.591
MOD_CK2_1	80	86	PF00069	0.539
MOD_GlcNHglycan	210	213	PF01048	0.528
MOD_GSK3_1	131	138	PF00069	0.281
MOD_GSK3_1	382	389	PF00069	0.516
MOD_NEK2_1	112	117	PF00069	0.274
MOD_NEK2_1	174	179	PF00069	0.315
MOD_NEK2_1	255	260	PF00069	0.497
MOD_NEK2_1	279	284	PF00069	0.330
MOD_NEK2_1	306	311	PF00069	0.273
MOD_NEK2_1	382	387	PF00069	0.482
MOD_NEK2_1	394	399	PF00069	0.478
MOD_OFUCOSY	285	291	PF10250	0.454
MOD_OFUCOSY	329	335	PF10250	0.328
MOD_PIKK_1	167	173	PF00454	0.326
MOD_PIKK_1	255	261	PF00454	0.509
MOD_Plk_1	38	44	PF00069	0.501
MOD_Plk_2-3	7	13	PF00069	0.558
MOD_Plk_4	112	118	PF00069	0.299
MOD_Plk_4	121	127	PF00069	0.380
MOD_Plk_4	131	137	PF00069	0.274
MOD_Plk_4	265	271	PF00069	0.344
MOD_Plk_4	68	74	PF00069	0.625
MOD_Plk_4	80	86	PF00069	0.541
TRG_DiLeu_BaEn_1	19	24	PF01217	0.524
TRG_DiLeu_BaEn_1	251	256	PF01217	0.528
TRG_DiLeu_BaLyEn_6	202	207	PF01217	0.252
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.473
TRG_DiLeu_LyEn_5	251	256	PF01217	0.522
TRG_ENDOCYTIC_2	105	108	PF00928	0.315
TRG_ENDOCYTIC_2	123	126	PF00928	0.365
TRG_ENDOCYTIC_2	225	228	PF00928	0.309
TRG_ENDOCYTIC_2	272	275	PF00928	0.418
TRG_ENDOCYTIC_2	304	307	PF00928	0.289
TRG_ENDOCYTIC_2	366	369	PF00928	0.438
TRG_ENDOCYTIC_2	387	390	PF00928	0.494
TRG_ENDOCYTIC_2	84	87	PF00928	0.463
TRG_ER_diArg_1	127	129	PF00400	0.323
TRG_ER_diArg_1	49	51	PF00400	0.494
TRG_ER_diLys_1	410	414	PF00400	0.695
TRG_NES_CRM1_1	137	151	PF08389	0.303

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0C5PRW9	Tachysurus fulvidraco	23%	93%
A0A0N1HZP4	Leptomonas seymouri	83%	100%
A0A0N1IMB2	Leptomonas seymouri	22%	100%
A0A0N1PAQ6	Leptomonas seymouri	25%	99%
A0A0S4IVF3	Bodo saltans	50%	97%
A0A0S4KLP1	Bodo saltans	22%	100%
A0A1X0NMZ1	Trypanosomatidae	23%	100%
A0A1X0NPK3	Trypanosomatidae	21%	99%
A0A1X0P7J5	Trypanosomatidae	57%	97%
A0A3Q8IK71	Leishmania donovani	24%	100%
A0A3S5H618	Leishmania donovani	23%	99%
A0A422NCE1	Trypanosoma rangeli	56%	97%
A0PJ29	Rebecca salina	36%	93%
A4H558	Leishmania braziliensis	23%	100%
A4H7V4	Leishmania braziliensis	85%	100%
A4HQL7	Leishmania braziliensis	25%	100%
A4HTD5	Leishmania infantum	23%	100%
A4HW80	Leishmania infantum	100%	100%
A4IFP3	Bos taurus	24%	93%
A4KDP0	Rebecca salina	23%	97%
A8MWK0	Homo sapiens	23%	86%
A9SIZ6	Physcomitrium patens	26%	86%
B2KKL4	Siganus canaliculatus	23%	93%
D0A3D4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
D8X2C5	Siganus canaliculatus	23%	93%
E9AI08	Leishmania infantum	25%	100%
E9ALC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9APY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AUD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	99%
G5EG11	Caenorhabditis elegans	22%	93%
I2CYZ4	Chlamydomonas reinhardtii	28%	80%
O04353	Borago officinalis	23%	92%
O74212	Mortierella alpina	25%	93%
O95864	Homo sapiens	20%	93%
O96099	Dictyostelium discoideum	25%	89%
Q08871	Synechocystis sp. (strain PCC 6803 / Kazusa)	29%	100%
Q0VAX3	Mus musculus	21%	85%
Q1ZXQ5	Dictyostelium discoideum	26%	90%
Q2HWK7	Chlamydomonas reinhardtii	25%	87%
Q43469	Helianthus annuus	21%	90%
Q4Q058	Leishmania major	24%	100%
Q4QFK0	Leishmania major	95%	100%
Q4QIH7	Leishmania major	24%	100%
Q6DDK2	Xenopus laevis	22%	93%
Q6VPV2	Diacronema lutheri	38%	93%
Q6WNG7	Euglena gracilis	28%	77%
Q8K1P9	Rattus norvegicus	24%	92%
Q920L1	Mus musculus	23%	93%
Q920R3	Rattus norvegicus	21%	93%
Q9DEX7	Danio rerio	23%	93%
Q9JJE7	Mus musculus	24%	92%
Q9LEM9	Ceratodon purpureus	25%	80%
Q9LEN0	Ceratodon purpureus	26%	86%
Q9Y1W0	Dictyostelium discoideum	24%	89%
Q9Y5Q0	Homo sapiens	24%	93%
Q9ZRP7	Arabidopsis thaliana	23%	92%