Zn-finger in Ran binding protein and others/FYVE zinc finger containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zn-finger in Ran binding protein and others/FYVE zinc finger, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I9Y5_LEIDO

TriTrypDb:

LdBPK_180610.1 , LdCL_180011000 , LDHU3_18.0790

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I9Y5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9Y5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	243	245	PF00675	0.521
CLV_NRD_NRD_1	254	256	PF00675	0.511
CLV_NRD_NRD_1	518	520	PF00675	0.388
CLV_NRD_NRD_1	580	582	PF00675	0.323
CLV_NRD_NRD_1	630	632	PF00675	0.600
CLV_PCSK_FUR_1	241	245	PF00082	0.509
CLV_PCSK_KEX2_1	243	245	PF00082	0.521
CLV_PCSK_KEX2_1	469	471	PF00082	0.676
CLV_PCSK_KEX2_1	528	530	PF00082	0.423
CLV_PCSK_KEX2_1	580	582	PF00082	0.346
CLV_PCSK_KEX2_1	630	632	PF00082	0.697
CLV_PCSK_PC1ET2_1	469	471	PF00082	0.676
CLV_PCSK_PC1ET2_1	528	530	PF00082	0.423
DEG_APCC_DBOX_1	232	240	PF00400	0.480
DEG_APCC_DBOX_1	270	278	PF00400	0.383
DEG_COP1_1	348	356	PF00400	0.572
DEG_MDM2_SWIB_1	376	384	PF02201	0.553
DEG_Nend_UBRbox_3	1	3	PF02207	0.674
DEG_SPOP_SBC_1	121	125	PF00917	0.798
DEG_SPOP_SBC_1	196	200	PF00917	0.637
DOC_CKS1_1	127	132	PF01111	0.811
DOC_CYCLIN_RxL_1	238	251	PF00134	0.531
DOC_MAPK_gen_1	238	248	PF00069	0.528
DOC_PP4_FxxP_1	27	30	PF00568	0.711
DOC_PP4_FxxP_1	513	516	PF00568	0.383
DOC_USP7_MATH_1	121	125	PF00917	0.806
DOC_USP7_MATH_1	222	226	PF00917	0.690
DOC_USP7_MATH_1	312	316	PF00917	0.784
DOC_USP7_MATH_1	345	349	PF00917	0.531
DOC_USP7_MATH_1	414	418	PF00917	0.653
DOC_USP7_MATH_1	426	430	PF00917	0.734
DOC_USP7_MATH_1	456	460	PF00917	0.483
DOC_USP7_MATH_1	593	597	PF00917	0.391
DOC_USP7_MATH_1	68	72	PF00917	0.653
DOC_USP7_UBL2_3	393	397	PF12436	0.571
DOC_USP7_UBL2_3	624	628	PF12436	0.552
DOC_WW_Pin1_4	108	113	PF00397	0.738
DOC_WW_Pin1_4	114	119	PF00397	0.619
DOC_WW_Pin1_4	123	128	PF00397	0.555
DOC_WW_Pin1_4	199	204	PF00397	0.660
DOC_WW_Pin1_4	310	315	PF00397	0.821
DOC_WW_Pin1_4	354	359	PF00397	0.619
DOC_WW_Pin1_4	371	376	PF00397	0.534
LIG_14-3-3_CanoR_1	286	292	PF00244	0.566
LIG_BIR_III_2	411	415	PF00653	0.642
LIG_EVH1_2	118	122	PF00568	0.637
LIG_FHA_1	408	414	PF00498	0.660
LIG_FHA_1	574	580	PF00498	0.441
LIG_IBAR_NPY_1	2	4	PF08397	0.665
LIG_LIR_Apic_2	111	116	PF02991	0.562
LIG_LIR_Apic_2	24	30	PF02991	0.711
LIG_LIR_Apic_2	262	266	PF02991	0.365
LIG_LIR_Apic_2	510	516	PF02991	0.383
LIG_LIR_Apic_2	596	601	PF02991	0.383
LIG_LIR_Gen_1	50	58	PF02991	0.767
LIG_LIR_Gen_1	573	579	PF02991	0.441
LIG_LIR_Nem_3	50	54	PF02991	0.705
LIG_LIR_Nem_3	573	578	PF02991	0.383
LIG_LYPXL_yS_3	155	158	PF13949	0.671
LIG_MYND_1	134	138	PF01753	0.655
LIG_Pex14_2	376	380	PF04695	0.559
LIG_SH2_CRK	100	104	PF00017	0.700
LIG_SH2_CRK	113	117	PF00017	0.500
LIG_SH2_CRK	177	181	PF00017	0.593
LIG_SH2_CRK	289	293	PF00017	0.625
LIG_SH2_CRK	51	55	PF00017	0.707
LIG_SH2_CRK	598	602	PF00017	0.505
LIG_SH2_NCK_1	289	293	PF00017	0.629
LIG_SH2_NCK_1	58	62	PF00017	0.753
LIG_SH2_PTP2	5	8	PF00017	0.609
LIG_SH2_STAP1	533	537	PF00017	0.585
LIG_SH2_STAT3	422	425	PF00017	0.574
LIG_SH2_STAT5	289	292	PF00017	0.631
LIG_SH2_STAT5	5	8	PF00017	0.577
LIG_SH2_STAT5	589	592	PF00017	0.323
LIG_SH3_1	113	119	PF00018	0.790
LIG_SH3_3	113	119	PF00018	0.721
LIG_SH3_3	124	130	PF00018	0.601
LIG_SH3_3	132	138	PF00018	0.605
LIG_SH3_3	153	159	PF00018	0.700
LIG_SH3_3	162	168	PF00018	0.725
LIG_SH3_3	206	212	PF00018	0.759
LIG_SH3_3	295	301	PF00018	0.658
LIG_SH3_3	3	9	PF00018	0.658
LIG_SH3_3	385	391	PF00018	0.456
LIG_SH3_3	40	46	PF00018	0.722
LIG_SH3_3	410	416	PF00018	0.729
LIG_SH3_3	429	435	PF00018	0.638
LIG_SxIP_EBH_1	347	357	PF03271	0.602
LIG_TRAF2_1	227	230	PF00917	0.572
LIG_TRAF2_1	546	549	PF00917	0.676
LIG_WRC_WIRS_1	267	272	PF05994	0.373
LIG_WRC_WIRS_1	442	447	PF05994	0.509
LIG_WW_1	48	51	PF00397	0.693
LIG_WW_2	432	435	PF00397	0.610
MOD_CK1_1	123	129	PF00069	0.745
MOD_CK1_1	17	23	PF00069	0.774
MOD_CK1_1	199	205	PF00069	0.672
MOD_CK1_1	417	423	PF00069	0.683
MOD_CK1_1	441	447	PF00069	0.455
MOD_CK1_1	475	481	PF00069	0.717
MOD_CK1_1	483	489	PF00069	0.683
MOD_CK1_1	501	507	PF00069	0.445
MOD_CK1_1	596	602	PF00069	0.464
MOD_CK2_1	224	230	PF00069	0.679
MOD_CK2_1	561	567	PF00069	0.383
MOD_Cter_Amidation	517	520	PF01082	0.383
MOD_GlcNHglycan	108	111	PF01048	0.751
MOD_GlcNHglycan	203	206	PF01048	0.725
MOD_GlcNHglycan	219	222	PF01048	0.685
MOD_GlcNHglycan	226	229	PF01048	0.598
MOD_GlcNHglycan	293	296	PF01048	0.627
MOD_GlcNHglycan	348	351	PF01048	0.580
MOD_GlcNHglycan	358	361	PF01048	0.695
MOD_GlcNHglycan	399	402	PF01048	0.581
MOD_GlcNHglycan	419	422	PF01048	0.716
MOD_GlcNHglycan	428	431	PF01048	0.674
MOD_GlcNHglycan	449	452	PF01048	0.476
MOD_GlcNHglycan	458	461	PF01048	0.550
MOD_GlcNHglycan	485	488	PF01048	0.669
MOD_GlcNHglycan	490	494	PF01048	0.616
MOD_GlcNHglycan	59	62	PF01048	0.707
MOD_GlcNHglycan	81	84	PF01048	0.683
MOD_GSK3_1	122	129	PF00069	0.740
MOD_GSK3_1	191	198	PF00069	0.721
MOD_GSK3_1	287	294	PF00069	0.600
MOD_GSK3_1	352	359	PF00069	0.588
MOD_GSK3_1	371	378	PF00069	0.517
MOD_GSK3_1	441	448	PF00069	0.504
MOD_GSK3_1	497	504	PF00069	0.653
MOD_GSK3_1	596	603	PF00069	0.402
MOD_GSK3_1	79	86	PF00069	0.670
MOD_N-GLC_1	404	409	PF02516	0.525
MOD_N-GLC_1	596	601	PF02516	0.397
MOD_N-GLC_1	79	84	PF02516	0.740
MOD_N-GLC_2	569	571	PF02516	0.332
MOD_NEK2_1	122	127	PF00069	0.688
MOD_NEK2_1	195	200	PF00069	0.578
MOD_NEK2_1	281	286	PF00069	0.391
MOD_NEK2_1	436	441	PF00069	0.570
MOD_NEK2_1	445	450	PF00069	0.549
MOD_NEK2_2	266	271	PF00069	0.360
MOD_NEK2_2	83	88	PF00069	0.693
MOD_PIKK_1	312	318	PF00454	0.685
MOD_PIKK_1	501	507	PF00454	0.526
MOD_PKA_1	497	503	PF00069	0.615
MOD_PKA_2	17	23	PF00069	0.774
MOD_PKA_2	346	352	PF00069	0.571
MOD_PKA_2	483	489	PF00069	0.753
MOD_Plk_1	445	451	PF00069	0.555
MOD_Plk_1	561	567	PF00069	0.383
MOD_Plk_1	596	602	PF00069	0.402
MOD_Plk_1	83	89	PF00069	0.744
MOD_Plk_2-3	561	567	PF00069	0.383
MOD_Plk_4	191	197	PF00069	0.591
MOD_Plk_4	509	515	PF00069	0.383
MOD_Plk_4	83	89	PF00069	0.744
MOD_ProDKin_1	108	114	PF00069	0.739
MOD_ProDKin_1	123	129	PF00069	0.557
MOD_ProDKin_1	199	205	PF00069	0.662
MOD_ProDKin_1	310	316	PF00069	0.816
MOD_ProDKin_1	354	360	PF00069	0.622
MOD_ProDKin_1	371	377	PF00069	0.573
MOD_SUMO_for_1	277	280	PF00179	0.383
MOD_SUMO_for_1	546	549	PF00179	0.605
MOD_SUMO_rev_2	490	500	PF00179	0.781
MOD_SUMO_rev_2	621	626	PF00179	0.518
TRG_DiLeu_BaEn_4	229	235	PF01217	0.612
TRG_ENDOCYTIC_2	155	158	PF00928	0.671
TRG_ENDOCYTIC_2	51	54	PF00928	0.704
TRG_ER_diArg_1	240	243	PF00400	0.528
TRG_ER_diArg_1	579	581	PF00400	0.383
TRG_ER_diArg_1	630	632	PF00400	0.643
TRG_NES_CRM1_1	237	251	PF08389	0.531
TRG_NLS_MonoExtC_3	626	631	PF00514	0.620
TRG_NLS_MonoExtN_4	624	631	PF00514	0.612
TRG_Pf-PMV_PEXEL_1	244	249	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2D5	Leptomonas seymouri	56%	100%
A4H9G8	Leishmania braziliensis	80%	100%
A4HXT6	Leishmania infantum	100%	100%
C9ZZX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ARJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4QDY1	Leishmania major	92%	99%