Elongation of fatty acids protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fatty acid elongase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I9X8_LEIDO

TriTrypDb:

LdBPK_140740.1 , LdCL_140012800 , LDHU3_14.0970

Length:

335

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 61
NetGPI	no	yes: 0, no: 61

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	55
GO:0110165	cellular anatomical entity	1	57
GO:0005737	cytoplasm	2	2

Expansion

Sequence features

A0A3Q8I9X8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9X8

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	62
GO:0006629	lipid metabolic process	3	62
GO:0006631	fatty acid metabolic process	4	62
GO:0006633	fatty acid biosynthetic process	5	62
GO:0008152	metabolic process	1	62
GO:0008610	lipid biosynthetic process	4	62
GO:0009058	biosynthetic process	2	62
GO:0009987	cellular process	1	62
GO:0016053	organic acid biosynthetic process	4	62
GO:0019752	carboxylic acid metabolic process	5	62
GO:0032787	monocarboxylic acid metabolic process	6	62
GO:0043436	oxoacid metabolic process	4	62
GO:0044237	cellular metabolic process	2	62
GO:0044238	primary metabolic process	2	62
GO:0044249	cellular biosynthetic process	3	62
GO:0044255	cellular lipid metabolic process	3	62
GO:0044281	small molecule metabolic process	2	62
GO:0044283	small molecule biosynthetic process	3	62
GO:0046394	carboxylic acid biosynthetic process	5	62
GO:0071704	organic substance metabolic process	2	62
GO:0072330	monocarboxylic acid biosynthetic process	6	62
GO:1901576	organic substance biosynthetic process	3	62
GO:0000038	very long-chain fatty acid metabolic process	5	7
GO:0006643	membrane lipid metabolic process	4	7
GO:0006665	sphingolipid metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0019367	fatty acid elongation, saturated fatty acid	7	7
GO:0019368	fatty acid elongation, unsaturated fatty acid	7	7
GO:0030148	sphingolipid biosynthetic process	5	7
GO:0030497	fatty acid elongation	6	7
GO:0034625	fatty acid elongation, monounsaturated fatty acid	8	7
GO:0034626	fatty acid elongation, polyunsaturated fatty acid	8	7
GO:0042761	very long-chain fatty acid biosynthetic process	6	7
GO:0046467	membrane lipid biosynthetic process	4	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901566	organonitrogen compound biosynthetic process	4	7
GO:0001676	long-chain fatty acid metabolic process	5	1
GO:0042759	long-chain fatty acid biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	62
GO:0004312	fatty acid synthase activity	5	62
GO:0009922	fatty acid elongase activity	6	62
GO:0016740	transferase activity	2	62
GO:0016746	acyltransferase activity	3	62
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	62
GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity	5	62

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	202	204	PF00675	0.254
CLV_NRD_NRD_1	290	292	PF00675	0.485
CLV_NRD_NRD_1	333	335	PF00675	0.500
CLV_PCSK_KEX2_1	290	292	PF00082	0.406
CLV_PCSK_KEX2_1	323	325	PF00082	0.525
CLV_PCSK_KEX2_1	332	334	PF00082	0.517
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.419
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.525
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.503
CLV_PCSK_SKI1_1	292	296	PF00082	0.283
CLV_PCSK_SKI1_1	82	86	PF00082	0.505
DEG_Nend_Nbox_1	1	3	PF02207	0.385
DOC_CYCLIN_RxL_1	289	297	PF00134	0.663
DOC_CYCLIN_RxL_1	79	88	PF00134	0.304
DOC_CYCLIN_yClb5_NLxxxL_5	54	63	PF00134	0.478
DOC_MAPK_gen_1	148	154	PF00069	0.442
DOC_MAPK_MEF2A_6	207	215	PF00069	0.439
DOC_PP1_RVXF_1	147	154	PF00149	0.448
DOC_PP2B_LxvP_1	24	27	PF13499	0.321
DOC_PP2B_LxvP_1	39	42	PF13499	0.267
DOC_USP7_MATH_1	316	320	PF00917	0.570
LIG_14-3-3_CanoR_1	312	320	PF00244	0.758
LIG_APCC_ABBA_1	223	228	PF00400	0.201
LIG_BIR_III_2	315	319	PF00653	0.568
LIG_BRCT_BRCA1_1	263	267	PF00533	0.301
LIG_EH_1	2	6	PF12763	0.285
LIG_EH1_1	157	165	PF00400	0.313
LIG_EH1_1	184	192	PF00400	0.306
LIG_FHA_1	139	145	PF00498	0.295
LIG_FHA_1	159	165	PF00498	0.285
LIG_FHA_1	97	103	PF00498	0.296
LIG_GBD_Chelix_1	29	37	PF00786	0.282
LIG_Integrin_RGD_1	12	14	PF01839	0.587
LIG_LIR_Gen_1	140	151	PF02991	0.286
LIG_LIR_Gen_1	214	223	PF02991	0.388
LIG_LIR_Gen_1	31	42	PF02991	0.289
LIG_LIR_Nem_3	105	110	PF02991	0.272
LIG_LIR_Nem_3	140	146	PF02991	0.307
LIG_LIR_Nem_3	189	195	PF02991	0.317
LIG_LIR_Nem_3	199	205	PF02991	0.463
LIG_LIR_Nem_3	214	218	PF02991	0.356
LIG_LIR_Nem_3	227	233	PF02991	0.297
LIG_LIR_Nem_3	258	263	PF02991	0.281
LIG_LIR_Nem_3	79	84	PF02991	0.277
LIG_Pex14_2	126	130	PF04695	0.397
LIG_Pex14_2	263	267	PF04695	0.298
LIG_Pex14_2	81	85	PF04695	0.330
LIG_SH2_CRK	107	111	PF00017	0.232
LIG_SH2_PTP2	205	208	PF00017	0.526
LIG_SH2_STAP1	170	174	PF00017	0.293
LIG_SH2_STAP1	268	272	PF00017	0.469
LIG_SH2_STAT5	165	168	PF00017	0.316
LIG_SH2_STAT5	192	195	PF00017	0.318
LIG_SH2_STAT5	205	208	PF00017	0.465
LIG_SH2_STAT5	230	233	PF00017	0.332
LIG_SH2_STAT5	236	239	PF00017	0.272
LIG_SH2_STAT5	259	262	PF00017	0.303
LIG_SH2_STAT5	271	274	PF00017	0.451
LIG_SH2_STAT5	34	37	PF00017	0.287
LIG_SH2_STAT5	40	43	PF00017	0.296
LIG_SH2_STAT5	7	10	PF00017	0.324
LIG_SH2_STAT5	75	78	PF00017	0.306
LIG_SH3_1	205	211	PF00018	0.537
LIG_SH3_3	205	211	PF00018	0.439
LIG_SUMO_SIM_anti_2	28	34	PF11976	0.254
LIG_UBA3_1	129	134	PF00899	0.327
LIG_WRC_WIRS_1	212	217	PF05994	0.388
MOD_CK1_1	244	250	PF00069	0.290
MOD_CK1_1	270	276	PF00069	0.427
MOD_CK1_1	28	34	PF00069	0.386
MOD_CK1_1	284	290	PF00069	0.632
MOD_CK1_1	308	314	PF00069	0.724
MOD_CK1_1	66	72	PF00069	0.322
MOD_CK1_1	87	93	PF00069	0.251
MOD_Cter_Amidation	274	277	PF01082	0.208
MOD_GlcNHglycan	174	177	PF01048	0.456
MOD_GlcNHglycan	237	240	PF01048	0.440
MOD_GlcNHglycan	282	286	PF01048	0.534
MOD_GSK3_1	224	231	PF00069	0.286
MOD_GSK3_1	80	87	PF00069	0.266
MOD_GSK3_1	92	99	PF00069	0.283
MOD_N-GLC_1	244	249	PF02516	0.457
MOD_N-GLC_1	92	97	PF02516	0.539
MOD_NEK2_1	102	107	PF00069	0.256
MOD_NEK2_1	130	135	PF00069	0.308
MOD_NEK2_1	138	143	PF00069	0.321
MOD_NEK2_1	172	177	PF00069	0.282
MOD_NEK2_1	196	201	PF00069	0.358
MOD_NEK2_1	235	240	PF00069	0.282
MOD_NEK2_1	255	260	PF00069	0.298
MOD_NEK2_1	267	272	PF00069	0.277
MOD_NEK2_1	294	299	PF00069	0.675
MOD_NEK2_1	63	68	PF00069	0.308
MOD_NEK2_2	98	103	PF00069	0.274
MOD_PKA_2	311	317	PF00069	0.555
MOD_Plk_1	87	93	PF00069	0.314
MOD_Plk_2-3	305	311	PF00069	0.544
MOD_Plk_4	102	108	PF00069	0.260
MOD_Plk_4	158	164	PF00069	0.316
MOD_Plk_4	186	192	PF00069	0.307
MOD_Plk_4	228	234	PF00069	0.296
MOD_Plk_4	25	31	PF00069	0.317
MOD_Plk_4	255	261	PF00069	0.290
MOD_Plk_4	267	273	PF00069	0.290
MOD_Plk_4	316	322	PF00069	0.745
MOD_Plk_4	63	69	PF00069	0.316
MOD_Plk_4	80	86	PF00069	0.251
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.472
TRG_DiLeu_BaLyEn_6	290	295	PF01217	0.506
TRG_ENDOCYTIC_2	107	110	PF00928	0.276
TRG_ENDOCYTIC_2	157	160	PF00928	0.306
TRG_ENDOCYTIC_2	192	195	PF00928	0.305
TRG_ENDOCYTIC_2	259	262	PF00928	0.292
TRG_ENDOCYTIC_2	34	37	PF00928	0.293
TRG_ENDOCYTIC_2	74	77	PF00928	0.331
TRG_ER_diArg_1	291	294	PF00400	0.701
TRG_NLS_Bipartite_1	276	295	PF00514	0.670
TRG_NLS_MonoCore_2	289	294	PF00514	0.679
TRG_NLS_MonoExtN_4	290	295	PF00514	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0C5PHQ7	Tachysurus fulvidraco	22%	100%
A0A0N0P5E5	Leptomonas seymouri	40%	100%
A0A0N0P7D1	Leptomonas seymouri	66%	100%
A0A0N0P7D6	Leptomonas seymouri	31%	100%
A0A0N0P7R2	Leptomonas seymouri	62%	100%
A0A0N1HZJ8	Leptomonas seymouri	40%	100%
A0A0N1I9H5	Leptomonas seymouri	33%	100%
A0A0N1ILQ4	Leptomonas seymouri	41%	100%
A0A0N1IM10	Leptomonas seymouri	30%	100%
A0A0N1PDR8	Leptomonas seymouri	41%	100%
A0A0S4IS29	Bodo saltans	49%	100%
A0A0S4IVJ6	Bodo saltans	36%	100%
A0A0S4IVS6	Bodo saltans	41%	100%
A0A0S4IW98	Bodo saltans	46%	100%
A0A1X0NNK7	Trypanosomatidae	46%	100%
A0A1X0NNL0	Trypanosomatidae	33%	100%
A0A1X0NNM4	Trypanosomatidae	35%	100%
A0A1X0NNM5	Trypanosomatidae	52%	100%
A0A1X0NP89	Trypanosomatidae	42%	100%
A0A3Q8I8T7	Leishmania donovani	31%	100%
A0A3Q8I9T2	Leishmania donovani	33%	100%
A0A3Q8I9U9	Leishmania donovani	41%	100%
A0A3Q8IC05	Leishmania donovani	42%	100%
A0A3Q8ID51	Leishmania donovani	30%	84%
A0A3Q8IIA9	Leishmania donovani	36%	100%
A0A3Q8IT78	Leishmania donovani	24%	88%
A0A3R7KG78	Trypanosoma rangeli	50%	100%
A0A3R7MJR2	Trypanosoma rangeli	40%	100%
A0A3R7NSQ3	Trypanosoma rangeli	38%	100%
A0A3S5H6R7	Leishmania donovani	32%	100%
A0A3S5H6R8	Leishmania donovani	35%	100%
A0A3S7WSY8	Leishmania donovani	32%	100%
A0A3S7WSZ1	Leishmania donovani	59%	100%
A0A3S7WT03	Leishmania donovani	65%	100%
A0A3S7WT16	Leishmania donovani	49%	100%
A0A422NNP1	Trypanosoma rangeli	52%	100%
A1L3X0	Homo sapiens	27%	100%
A4H7M2	Leishmania braziliensis	33%	95%
A4H7M3	Leishmania braziliensis	31%	97%
A4H7M4	Leishmania braziliensis	35%	97%
A4H7M5	Leishmania braziliensis	34%	95%
A4H7M6	Leishmania braziliensis	55%	96%
A4H7M7	Leishmania braziliensis	46%	100%
A4H7M8	Leishmania braziliensis	30%	100%
A4H7M9	Leishmania braziliensis	32%	100%
A4H7N0	Leishmania braziliensis	39%	96%
A4HKA3	Leishmania braziliensis	26%	100%
A4HW07	Leishmania infantum	32%	100%
A4HW08	Leishmania infantum	32%	98%
A4HW09	Leishmania infantum	35%	98%
A4HW10	Leishmania infantum	35%	95%
A4HW12	Leishmania infantum	98%	100%
A4HW13	Leishmania infantum	41%	100%
A4HW14	Leishmania infantum	51%	100%
A4HW15	Leishmania infantum	33%	100%
A4HW16	Leishmania infantum	31%	100%
A4HW17	Leishmania infantum	31%	100%
A4HW18	Leishmania infantum	41%	100%
A4I7T3	Leishmania infantum	24%	100%
C9ZT13	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
C9ZT15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
C9ZT16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D4ADY9	Rattus norvegicus	27%	100%
E8NHR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E8NHR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E8NHR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AGL0	Leishmania infantum	65%	100%
E9AGL2	Leishmania infantum	59%	100%
E9APQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9APQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9APR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9APR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	98%
E9APR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	95%
E9APR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
E9APR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
E9APR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9APR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9APR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9APR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9APR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
G5EEE5	Caenorhabditis elegans	30%	100%
O35949	Mus musculus	33%	100%
P49191	Caenorhabditis elegans	34%	100%
Q03574	Caenorhabditis elegans	29%	100%
Q20300	Caenorhabditis elegans	30%	100%
Q20303	Caenorhabditis elegans	34%	100%
Q2KJD9	Bos taurus	25%	100%
Q4Q5G6	Leishmania major	25%	100%
Q4QFQ9	Leishmania major	40%	97%
Q4QFR0	Leishmania major	32%	100%
Q4QFR1	Leishmania major	31%	100%
Q4QFR2	Leishmania major	32%	100%
Q4QFR3	Leishmania major	51%	100%
Q4QFR4	Leishmania major	39%	100%
Q4QFR5	Leishmania major	90%	100%
Q4QFR6	Leishmania major	62%	99%
Q4QFR7	Leishmania major	39%	100%
Q4QFR8	Leishmania major	36%	97%
Q4QFR9	Leishmania major	32%	100%
Q4QFS0	Leishmania major	33%	100%
Q4QJ85	Leishmania major	28%	100%
Q4R516	Macaca fascicularis	23%	100%
Q5M8U1	Xenopus tropicalis	24%	100%
Q5ZJR8	Gallus gallus	33%	100%
Q6PC64	Danio rerio	33%	100%
Q7LKX0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	92%
Q8BHI7	Mus musculus	25%	100%
Q920L5	Mus musculus	33%	100%
Q920L6	Rattus norvegicus	33%	100%
Q920L7	Rattus norvegicus	25%	100%
Q9EQC4	Mus musculus	28%	100%
Q9H5J4	Homo sapiens	32%	100%
Q9HB03	Homo sapiens	33%	100%
Q9JLJ5	Mus musculus	25%	100%
Q9NYP7	Homo sapiens	23%	100%
Q9UTF7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
Q9VV87	Drosophila melanogaster	32%	100%
Q9XVQ9	Caenorhabditis elegans	31%	100%
V5BE99	Trypanosoma cruzi	46%	100%
V5BIX9	Trypanosoma cruzi	37%	100%
V5BND3	Trypanosoma cruzi	54%	100%
V5DF68	Trypanosoma cruzi	37%	100%