Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I9X0_LEIDO

TriTrypDb:

LdBPK_141430.1 , LdCL_140020200 , LDHU3_14.1780

Length:

622

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	4
GO:0005868	cytoplasmic dynein complex	4	4
GO:0005874	microtubule	6	4
GO:0005875	microtubule associated complex	2	4
GO:0030286	dynein complex	3	4
GO:0032991	protein-containing complex	1	4
GO:0099080	supramolecular complex	2	4
GO:0099081	supramolecular polymer	3	4
GO:0099512	supramolecular fiber	4	4
GO:0099513	polymeric cytoskeletal fiber	5	4
GO:0110165	cellular anatomical entity	1	4
GO:1902494	catalytic complex	2	4

Expansion

Sequence features

A0A3Q8I9X0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9X0

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	4
GO:0007018	microtubule-based movement	3	4
GO:0009987	cellular process	1	4

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	4
GO:0005488	binding	1	4
GO:0005524	ATP binding	5	4
GO:0017076	purine nucleotide binding	4	4
GO:0030554	adenyl nucleotide binding	5	4
GO:0032553	ribonucleotide binding	3	4
GO:0032555	purine ribonucleotide binding	4	4
GO:0032559	adenyl ribonucleotide binding	5	4
GO:0035639	purine ribonucleoside triphosphate binding	4	4
GO:0036094	small molecule binding	2	4
GO:0043167	ion binding	2	4
GO:0043168	anion binding	3	4
GO:0097159	organic cyclic compound binding	2	4
GO:0097367	carbohydrate derivative binding	2	4
GO:1901265	nucleoside phosphate binding	3	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.757
CLV_C14_Caspase3-7	212	216	PF00656	0.727
CLV_C14_Caspase3-7	563	567	PF00656	0.776
CLV_MEL_PAP_1	467	473	PF00089	0.623
CLV_NRD_NRD_1	102	104	PF00675	0.546
CLV_NRD_NRD_1	134	136	PF00675	0.571
CLV_NRD_NRD_1	237	239	PF00675	0.476
CLV_NRD_NRD_1	308	310	PF00675	0.503
CLV_NRD_NRD_1	85	87	PF00675	0.469
CLV_PCSK_KEX2_1	102	104	PF00082	0.453
CLV_PCSK_KEX2_1	134	136	PF00082	0.571
CLV_PCSK_KEX2_1	237	239	PF00082	0.476
CLV_PCSK_KEX2_1	308	310	PF00082	0.503
CLV_PCSK_KEX2_1	85	87	PF00082	0.470
CLV_PCSK_KEX2_1	97	99	PF00082	0.449
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.463
CLV_PCSK_PC7_1	98	104	PF00082	0.534
CLV_PCSK_SKI1_1	237	241	PF00082	0.397
CLV_PCSK_SKI1_1	461	465	PF00082	0.509
CLV_PCSK_SKI1_1	8	12	PF00082	0.566
CLV_PCSK_SKI1_1	86	90	PF00082	0.535
DEG_APCC_DBOX_1	441	449	PF00400	0.520
DEG_APCC_DBOX_1	460	468	PF00400	0.278
DEG_SPOP_SBC_1	335	339	PF00917	0.496
DEG_SPOP_SBC_1	349	353	PF00917	0.566
DEG_SPOP_SBC_1	375	379	PF00917	0.525
DOC_CKS1_1	228	233	PF01111	0.657
DOC_CKS1_1	576	581	PF01111	0.691
DOC_CYCLIN_RxL_1	406	416	PF00134	0.553
DOC_CYCLIN_RxL_1	97	109	PF00134	0.488
DOC_CYCLIN_yCln2_LP_2	428	434	PF00134	0.500
DOC_MAPK_gen_1	39	47	PF00069	0.714
DOC_MAPK_gen_1	439	448	PF00069	0.537
DOC_MAPK_HePTP_8	424	436	PF00069	0.501
DOC_MAPK_MEF2A_6	357	365	PF00069	0.623
DOC_MAPK_MEF2A_6	427	436	PF00069	0.504
DOC_PP1_RVXF_1	100	107	PF00149	0.530
DOC_PP2B_LxvP_1	428	431	PF13499	0.561
DOC_PP2B_LxvP_1	70	73	PF13499	0.687
DOC_PP4_FxxP_1	365	368	PF00568	0.631
DOC_PP4_FxxP_1	380	383	PF00568	0.621
DOC_USP7_MATH_1	10	14	PF00917	0.665
DOC_USP7_MATH_1	164	168	PF00917	0.693
DOC_USP7_MATH_1	2	6	PF00917	0.775
DOC_USP7_MATH_1	335	339	PF00917	0.628
DOC_USP7_MATH_1	349	353	PF00917	0.550
DOC_USP7_MATH_1	38	42	PF00917	0.755
DOC_USP7_MATH_1	46	50	PF00917	0.711
DOC_USP7_MATH_1	463	467	PF00917	0.407
DOC_USP7_MATH_1	509	513	PF00917	0.584
DOC_WW_Pin1_4	227	232	PF00397	0.675
DOC_WW_Pin1_4	31	36	PF00397	0.767
DOC_WW_Pin1_4	557	562	PF00397	0.783
DOC_WW_Pin1_4	575	580	PF00397	0.625
DOC_WW_Pin1_4	603	608	PF00397	0.566
LIG_14-3-3_CanoR_1	173	179	PF00244	0.597
LIG_14-3-3_CanoR_1	222	229	PF00244	0.763
LIG_14-3-3_CanoR_1	28	38	PF00244	0.596
LIG_14-3-3_CanoR_1	381	389	PF00244	0.637
LIG_14-3-3_CanoR_1	442	446	PF00244	0.545
LIG_14-3-3_CanoR_1	470	474	PF00244	0.623
LIG_14-3-3_CanoR_1	519	527	PF00244	0.542
LIG_14-3-3_CanoR_1	570	579	PF00244	0.695
LIG_Actin_WH2_2	421	437	PF00022	0.581
LIG_BRCT_BRCA1_1	223	227	PF00533	0.768
LIG_BRCT_BRCA1_1	351	355	PF00533	0.663
LIG_BRCT_BRCA1_1	376	380	PF00533	0.571
LIG_BRCT_BRCA1_2	351	357	PF00533	0.570
LIG_Clathr_ClatBox_1	267	271	PF01394	0.392
LIG_EH_1	488	492	PF12763	0.517
LIG_eIF4E_1	260	266	PF01652	0.358
LIG_eIF4E_1	482	488	PF01652	0.637
LIG_FHA_1	345	351	PF00498	0.580
LIG_FHA_1	377	383	PF00498	0.580
LIG_FHA_2	140	146	PF00498	0.647
LIG_FHA_2	397	403	PF00498	0.410
LIG_FHA_2	557	563	PF00498	0.731
LIG_FHA_2	569	575	PF00498	0.706
LIG_LIR_Apic_2	362	368	PF02991	0.632
LIG_LIR_Apic_2	377	383	PF02991	0.621
LIG_LIR_Gen_1	283	294	PF02991	0.511
LIG_LIR_Nem_3	283	289	PF02991	0.505
LIG_PTB_Apo_2	486	493	PF02174	0.545
LIG_PTB_Phospho_1	486	492	PF10480	0.546
LIG_SH2_CRK	194	198	PF00017	0.533
LIG_SH2_GRB2like	482	485	PF00017	0.704
LIG_SH2_SRC	194	197	PF00017	0.535
LIG_SH2_SRC	260	263	PF00017	0.376
LIG_SH2_SRC	482	485	PF00017	0.704
LIG_SH2_STAP1	194	198	PF00017	0.533
LIG_SH2_STAP1	482	486	PF00017	0.668
LIG_SH2_STAT3	196	199	PF00017	0.540
LIG_SH2_STAT3	589	592	PF00017	0.579
LIG_SH2_STAT5	196	199	PF00017	0.524
LIG_SH2_STAT5	260	263	PF00017	0.557
LIG_SH2_STAT5	284	287	PF00017	0.430
LIG_SH2_STAT5	292	295	PF00017	0.406
LIG_SH2_STAT5	498	501	PF00017	0.382
LIG_SH2_STAT5	589	592	PF00017	0.579
LIG_SH3_3	32	38	PF00018	0.751
LIG_SH3_3	550	556	PF00018	0.719
LIG_SH3_3	573	579	PF00018	0.703
LIG_SH3_5	256	260	PF00018	0.392
LIG_SUMO_SIM_anti_2	262	269	PF11976	0.379
LIG_SUMO_SIM_anti_2	536	542	PF11976	0.442
LIG_SUMO_SIM_par_1	265	271	PF11976	0.390
LIG_TRAF2_1	315	318	PF00917	0.538
LIG_TRAF2_1	606	609	PF00917	0.713
LIG_TYR_ITIM	192	197	PF00017	0.540
LIG_WW_3	36	40	PF00397	0.724
MOD_CK1_1	187	193	PF00069	0.630
MOD_CK1_1	216	222	PF00069	0.594
MOD_CK1_1	273	279	PF00069	0.516
MOD_CK1_1	31	37	PF00069	0.761
MOD_CK1_1	336	342	PF00069	0.686
MOD_CK1_1	351	357	PF00069	0.613
MOD_CK1_1	385	391	PF00069	0.563
MOD_CK1_1	41	47	PF00069	0.682
MOD_CK1_1	441	447	PF00069	0.488
MOD_CK1_1	466	472	PF00069	0.530
MOD_CK1_1	512	518	PF00069	0.573
MOD_CK1_1	557	563	PF00069	0.804
MOD_CK1_1	77	83	PF00069	0.648
MOD_CK2_1	284	290	PF00069	0.518
MOD_CK2_1	396	402	PF00069	0.480
MOD_CK2_1	545	551	PF00069	0.599
MOD_CK2_1	556	562	PF00069	0.759
MOD_CK2_1	568	574	PF00069	0.676
MOD_CK2_1	603	609	PF00069	0.751
MOD_Cter_Amidation	95	98	PF01082	0.426
MOD_GlcNHglycan	166	169	PF01048	0.666
MOD_GlcNHglycan	189	192	PF01048	0.631
MOD_GlcNHglycan	211	214	PF01048	0.679
MOD_GlcNHglycan	215	218	PF01048	0.673
MOD_GlcNHglycan	223	226	PF01048	0.641
MOD_GlcNHglycan	262	265	PF01048	0.543
MOD_GlcNHglycan	338	341	PF01048	0.697
MOD_GlcNHglycan	384	387	PF01048	0.614
MOD_GlcNHglycan	415	418	PF01048	0.593
MOD_GlcNHglycan	484	487	PF01048	0.624
MOD_GlcNHglycan	504	507	PF01048	0.243
MOD_GlcNHglycan	521	524	PF01048	0.460
MOD_GlcNHglycan	599	602	PF01048	0.693
MOD_GlcNHglycan	8	11	PF01048	0.671
MOD_GlcNHglycan	94	97	PF01048	0.466
MOD_GSK3_1	2	9	PF00069	0.718
MOD_GSK3_1	209	216	PF00069	0.677
MOD_GSK3_1	217	224	PF00069	0.695
MOD_GSK3_1	27	34	PF00069	0.750
MOD_GSK3_1	270	277	PF00069	0.496
MOD_GSK3_1	329	336	PF00069	0.598
MOD_GSK3_1	340	347	PF00069	0.706
MOD_GSK3_1	349	356	PF00069	0.726
MOD_GSK3_1	37	44	PF00069	0.708
MOD_GSK3_1	411	418	PF00069	0.566
MOD_GSK3_1	539	546	PF00069	0.420
MOD_GSK3_1	557	564	PF00069	0.717
MOD_GSK3_1	77	84	PF00069	0.671
MOD_GSK3_1	92	99	PF00069	0.383
MOD_N-GLC_1	375	380	PF02516	0.641
MOD_N-GLC_1	509	514	PF02516	0.612
MOD_NEK2_1	232	237	PF00069	0.573
MOD_NEK2_1	296	301	PF00069	0.597
MOD_NEK2_1	334	339	PF00069	0.610
MOD_NEK2_1	413	418	PF00069	0.631
MOD_NEK2_1	438	443	PF00069	0.508
MOD_NEK2_1	544	549	PF00069	0.666
MOD_NEK2_1	597	602	PF00069	0.676
MOD_NEK2_1	6	11	PF00069	0.705
MOD_NEK2_2	581	586	PF00069	0.615
MOD_PIKK_1	217	223	PF00454	0.697
MOD_PIKK_1	447	453	PF00454	0.500
MOD_PIKK_1	46	52	PF00454	0.767
MOD_PIKK_1	608	614	PF00454	0.660
MOD_PIKK_1	77	83	PF00454	0.679
MOD_PKA_1	237	243	PF00069	0.513
MOD_PKA_2	172	178	PF00069	0.695
MOD_PKA_2	221	227	PF00069	0.767
MOD_PKA_2	237	243	PF00069	0.295
MOD_PKA_2	27	33	PF00069	0.770
MOD_PKA_2	38	44	PF00069	0.736
MOD_PKA_2	405	411	PF00069	0.504
MOD_PKA_2	438	444	PF00069	0.470
MOD_PKA_2	469	475	PF00069	0.621
MOD_PKA_2	569	575	PF00069	0.711
MOD_Plk_1	273	279	PF00069	0.494
MOD_Plk_1	375	381	PF00069	0.595
MOD_Plk_1	509	515	PF00069	0.614
MOD_Plk_4	441	447	PF00069	0.439
MOD_Plk_4	564	570	PF00069	0.726
MOD_ProDKin_1	227	233	PF00069	0.665
MOD_ProDKin_1	31	37	PF00069	0.761
MOD_ProDKin_1	557	563	PF00069	0.783
MOD_ProDKin_1	575	581	PF00069	0.620
MOD_ProDKin_1	603	609	PF00069	0.566
MOD_SUMO_rev_2	318	327	PF00179	0.551
TRG_DiLeu_BaEn_1	420	425	PF01217	0.584
TRG_ENDOCYTIC_2	194	197	PF00928	0.535
TRG_ENDOCYTIC_2	286	289	PF00928	0.384
TRG_ENDOCYTIC_2	492	495	PF00928	0.385
TRG_ER_diArg_1	102	104	PF00400	0.531
TRG_ER_diArg_1	134	136	PF00400	0.571
TRG_ER_diArg_1	236	238	PF00400	0.475
TRG_ER_diArg_1	307	309	PF00400	0.503
TRG_ER_diArg_1	85	87	PF00400	0.469
TRG_Pf-PMV_PEXEL_1	588	592	PF00026	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAQ5	Leptomonas seymouri	58%	100%
A0A1X0NMR8	Trypanosomatidae	28%	100%
A0A422NDE3	Trypanosoma rangeli	27%	87%
A4H7V5	Leishmania braziliensis	77%	100%
A4HW81	Leishmania infantum	99%	100%
D0A9A0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9APY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QFJ9	Leishmania major	92%	100%
V5BID0	Trypanosoma cruzi	27%	100%