Stearic acid desaturase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

stearic acid desaturase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I9W7_LEIDO

TriTrypDb:

LdBPK_140520.1 , LdCL_140010600 , LDHU3_14.0720

Length:

467

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0031090	organelle membrane	3	2

Expansion

Sequence features

A0A3Q8I9W7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9W7

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	16
GO:0006629	lipid metabolic process	3	16
GO:0006631	fatty acid metabolic process	4	16
GO:0006633	fatty acid biosynthetic process	5	16
GO:0006636	unsaturated fatty acid biosynthetic process	6	16
GO:0008152	metabolic process	1	16
GO:0008610	lipid biosynthetic process	4	16
GO:0009058	biosynthetic process	2	16
GO:0009987	cellular process	1	16
GO:0016053	organic acid biosynthetic process	4	16
GO:0019752	carboxylic acid metabolic process	5	16
GO:0032787	monocarboxylic acid metabolic process	6	16
GO:0033559	unsaturated fatty acid metabolic process	5	16
GO:0043436	oxoacid metabolic process	4	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0044249	cellular biosynthetic process	3	16
GO:0044255	cellular lipid metabolic process	3	16
GO:0044281	small molecule metabolic process	2	16
GO:0044283	small molecule biosynthetic process	3	16
GO:0046394	carboxylic acid biosynthetic process	5	16
GO:0071704	organic substance metabolic process	2	16
GO:0072330	monocarboxylic acid biosynthetic process	6	16
GO:1901576	organic substance biosynthetic process	3	16

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0004768	stearoyl-CoA 9-desaturase activity	6	16
GO:0005488	binding	1	7
GO:0016215	acyl-CoA desaturase activity	5	16
GO:0016491	oxidoreductase activity	2	16
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	16
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	4	16
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0005506	iron ion binding	6	2
GO:0046914	transition metal ion binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.455
CLV_NRD_NRD_1	141	143	PF00675	0.228
CLV_NRD_NRD_1	178	180	PF00675	0.255
CLV_NRD_NRD_1	323	325	PF00675	0.408
CLV_NRD_NRD_1	356	358	PF00675	0.351
CLV_NRD_NRD_1	462	464	PF00675	0.392
CLV_PCSK_KEX2_1	141	143	PF00082	0.308
CLV_PCSK_KEX2_1	461	463	PF00082	0.395
CLV_PCSK_SKI1_1	216	220	PF00082	0.343
CLV_PCSK_SKI1_1	357	361	PF00082	0.350
CLV_PCSK_SKI1_1	396	400	PF00082	0.261
CLV_PCSK_SKI1_1	405	409	PF00082	0.282
DEG_APCC_DBOX_1	422	430	PF00400	0.407
DEG_MDM2_SWIB_1	210	217	PF02201	0.303
DEG_MDM2_SWIB_1	35	42	PF02201	0.505
DEG_Nend_Nbox_1	1	3	PF02207	0.687
DOC_CDC14_PxL_1	44	52	PF14671	0.418
DOC_CYCLIN_RxL_1	354	363	PF00134	0.477
DOC_CYCLIN_yCln2_LP_2	369	375	PF00134	0.501
DOC_CYCLIN_yCln2_LP_2	58	64	PF00134	0.513
DOC_MAPK_DCC_7	423	431	PF00069	0.407
DOC_MAPK_gen_1	461	467	PF00069	0.594
DOC_MAPK_MEF2A_6	170	177	PF00069	0.455
DOC_MAPK_MEF2A_6	423	431	PF00069	0.407
DOC_PP1_RVXF_1	382	389	PF00149	0.591
DOC_PP2B_LxvP_1	336	339	PF13499	0.598
DOC_PP2B_LxvP_1	58	61	PF13499	0.466
DOC_USP7_MATH_1	164	168	PF00917	0.455
DOC_USP7_MATH_1	248	252	PF00917	0.517
DOC_WW_Pin1_4	244	249	PF00397	0.522
LIG_14-3-3_CanoR_1	304	310	PF00244	0.567
LIG_14-3-3_CanoR_1	59	65	PF00244	0.275
LIG_14-3-3_CanoR_1	88	95	PF00244	0.488
LIG_BRCT_BRCA1_1	250	254	PF00533	0.428
LIG_Clathr_ClatBox_1	359	363	PF01394	0.488
LIG_deltaCOP1_diTrp_1	204	211	PF00928	0.284
LIG_FHA_1	187	193	PF00498	0.303
LIG_FHA_1	75	81	PF00498	0.375
LIG_FHA_1	8	14	PF00498	0.679
LIG_FHA_2	131	137	PF00498	0.470
LIG_FHA_2	199	205	PF00498	0.303
LIG_FHA_2	245	251	PF00498	0.470
LIG_FHA_2	306	312	PF00498	0.542
LIG_LIR_Gen_1	157	166	PF02991	0.485
LIG_LIR_Gen_1	251	259	PF02991	0.464
LIG_LIR_Gen_1	286	296	PF02991	0.576
LIG_LIR_Gen_1	343	353	PF02991	0.549
LIG_LIR_Gen_1	63	72	PF02991	0.236
LIG_LIR_Gen_1	83	94	PF02991	0.281
LIG_LIR_LC3C_4	171	175	PF02991	0.455
LIG_LIR_Nem_3	147	152	PF02991	0.524
LIG_LIR_Nem_3	157	161	PF02991	0.468
LIG_LIR_Nem_3	251	257	PF02991	0.484
LIG_LIR_Nem_3	261	266	PF02991	0.464
LIG_LIR_Nem_3	286	291	PF02991	0.494
LIG_LIR_Nem_3	294	298	PF02991	0.467
LIG_LIR_Nem_3	343	349	PF02991	0.538
LIG_LIR_Nem_3	63	67	PF02991	0.236
LIG_LIR_Nem_3	83	89	PF02991	0.301
LIG_NRBOX	49	55	PF00104	0.303
LIG_PDZ_Class_2	462	467	PF00595	0.594
LIG_Pex14_1	103	107	PF04695	0.484
LIG_Pex14_1	205	209	PF04695	0.270
LIG_Pex14_1	214	218	PF04695	0.323
LIG_Pex14_1	39	43	PF04695	0.303
LIG_Pex14_1	69	73	PF04695	0.303
LIG_Pex14_2	210	214	PF04695	0.430
LIG_Pex14_2	291	295	PF04695	0.497
LIG_Pex14_2	35	39	PF04695	0.513
LIG_SH2_CRK	158	162	PF00017	0.494
LIG_SH2_CRK	86	90	PF00017	0.484
LIG_SH2_GRB2like	263	266	PF00017	0.470
LIG_SH2_SRC	43	46	PF00017	0.478
LIG_SH2_STAT3	266	269	PF00017	0.428
LIG_SH2_STAT5	130	133	PF00017	0.470
LIG_SH2_STAT5	181	184	PF00017	0.544
LIG_SH2_STAT5	289	292	PF00017	0.579
LIG_SH2_STAT5	365	368	PF00017	0.544
LIG_SH2_STAT5	402	405	PF00017	0.459
LIG_SH2_STAT5	425	428	PF00017	0.532
LIG_SH2_STAT5	43	46	PF00017	0.412
LIG_SH3_1	371	377	PF00018	0.561
LIG_SH3_3	371	377	PF00018	0.574
LIG_SUMO_SIM_par_1	365	370	PF11976	0.543
LIG_TRAF2_1	21	24	PF00917	0.649
LIG_WRC_WIRS_1	292	297	PF05994	0.502
MOD_CK1_1	12	18	PF00069	0.653
MOD_CK1_1	440	446	PF00069	0.641
MOD_CK2_1	12	18	PF00069	0.677
MOD_CK2_1	198	204	PF00069	0.303
MOD_CK2_1	440	446	PF00069	0.619
MOD_CMANNOS	211	214	PF00535	0.352
MOD_Cter_Amidation	322	325	PF01082	0.287
MOD_Cter_Amidation	355	358	PF01082	0.362
MOD_GlcNHglycan	440	443	PF01048	0.439
MOD_GlcNHglycan	446	450	PF01048	0.404
MOD_GSK3_1	226	233	PF00069	0.336
MOD_GSK3_1	244	251	PF00069	0.417
MOD_GSK3_1	384	391	PF00069	0.389
MOD_GSK3_1	417	424	PF00069	0.526
MOD_GSK3_1	9	16	PF00069	0.675
MOD_NEK2_1	113	118	PF00069	0.472
MOD_NEK2_1	144	149	PF00069	0.470
MOD_NEK2_1	169	174	PF00069	0.428
MOD_NEK2_1	226	231	PF00069	0.343
MOD_NEK2_1	236	241	PF00069	0.465
MOD_NEK2_1	291	296	PF00069	0.499
MOD_NEK2_1	438	443	PF00069	0.528
MOD_NEK2_1	62	67	PF00069	0.289
MOD_NEK2_1	9	14	PF00069	0.670
MOD_PKA_1	384	390	PF00069	0.534
MOD_Plk_4	169	175	PF00069	0.562
MOD_Plk_4	248	254	PF00069	0.475
MOD_Plk_4	291	297	PF00069	0.620
MOD_Plk_4	9	15	PF00069	0.661
MOD_ProDKin_1	244	250	PF00069	0.522
MOD_SUMO_for_1	21	24	PF00179	0.630
MOD_SUMO_rev_2	12	21	PF00179	0.603
MOD_SUMO_rev_2	163	172	PF00179	0.428
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.373
TRG_ENDOCYTIC_2	158	161	PF00928	0.506
TRG_ENDOCYTIC_2	289	292	PF00928	0.488
TRG_ENDOCYTIC_2	37	40	PF00928	0.608
TRG_ENDOCYTIC_2	86	89	PF00928	0.470
TRG_ER_diArg_1	460	463	PF00400	0.595
TRG_Pf-PMV_PEXEL_1	324	328	PF00026	0.370

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCI5	Leptomonas seymouri	46%	100%
A0A0S4KNP4	Bodo saltans	42%	100%
A0A1X0NW01	Trypanosomatidae	46%	100%
A0A3Q8IBJ0	Leishmania donovani	46%	100%
A0A3R7MEL0	Trypanosoma rangeli	47%	100%
A4H6I1	Leishmania braziliensis	84%	100%
A4HDT6	Leishmania braziliensis	46%	100%
A4HVZ3	Leishmania infantum	100%	100%
A4I134	Leishmania infantum	46%	100%
C9ZW73	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9APP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AX71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
G5ED44	Caenorhabditis elegans	29%	100%
O44390	Trichoplusia ni	31%	100%
O94523	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	97%
P21147	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	92%
Q12618	Ajellomyces capsulatus	36%	98%
Q4QAA5	Leishmania major	44%	100%
Q4QFT4	Leishmania major	96%	100%
Q6US81	Spodoptera littoralis	31%	100%