LeishMANIAdb
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Choline transporter-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Choline transporter-like protein
Gene product:
Plasma-membrane choline transporter, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8I9V7_LEIDO
TriTrypDb:
LdBPK_140380.1 , LdCL_140008800 , LDHU3_14.0480
Length:
607

Annotations

LeishMANIAdb annotations

Highly homologous to other eukaryotic choline transporters. The protein family expanded in parazitic kinetoplastids.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 15
GO:0016020 membrane 2 15
GO:0110165 cellular anatomical entity 1 15
GO:0005737 cytoplasm 2 1
GO:0020016 ciliary pocket 2 1

Expansion

Sequence features

A0A3Q8I9V7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9V7

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0009987 cellular process 1 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0055085 transmembrane transport 2 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 15
GO:0022857 transmembrane transporter activity 2 15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 443 447 PF00656 0.436
CLV_NRD_NRD_1 317 319 PF00675 0.209
CLV_NRD_NRD_1 595 597 PF00675 0.417
CLV_PCSK_KEX2_1 317 319 PF00082 0.209
CLV_PCSK_KEX2_1 595 597 PF00082 0.411
CLV_PCSK_SKI1_1 320 324 PF00082 0.290
CLV_PCSK_SKI1_1 81 85 PF00082 0.387
DEG_SPOP_SBC_1 231 235 PF00917 0.347
DEG_SPOP_SBC_1 303 307 PF00917 0.415
DEG_SPOP_SBC_1 413 417 PF00917 0.318
DEG_SPOP_SBC_1 441 445 PF00917 0.424
DOC_CYCLIN_RxL_1 248 258 PF00134 0.486
DOC_CYCLIN_RxL_1 317 326 PF00134 0.493
DOC_CYCLIN_yCln2_LP_2 197 203 PF00134 0.409
DOC_MAPK_gen_1 317 327 PF00069 0.492
DOC_PP1_RVXF_1 221 228 PF00149 0.261
DOC_PP1_RVXF_1 249 256 PF00149 0.486
DOC_PP2B_LxvP_1 197 200 PF13499 0.401
DOC_PP2B_PxIxI_1 363 369 PF00149 0.243
DOC_PP4_FxxP_1 552 555 PF00568 0.405
DOC_SPAK_OSR1_1 435 439 PF12202 0.436
DOC_USP7_MATH_1 168 172 PF00917 0.496
DOC_USP7_MATH_1 203 207 PF00917 0.438
DOC_USP7_MATH_1 259 263 PF00917 0.273
DOC_USP7_MATH_1 311 315 PF00917 0.546
DOC_USP7_MATH_1 330 334 PF00917 0.163
DOC_USP7_MATH_1 429 433 PF00917 0.313
DOC_USP7_MATH_1 517 521 PF00917 0.350
DOC_USP7_MATH_1 555 559 PF00917 0.313
DOC_WW_Pin1_4 207 212 PF00397 0.526
DOC_WW_Pin1_4 287 292 PF00397 0.243
DOC_WW_Pin1_4 551 556 PF00397 0.216
LIG_14-3-3_CanoR_1 17 27 PF00244 0.621
LIG_14-3-3_CanoR_1 301 309 PF00244 0.450
LIG_14-3-3_CanoR_1 317 323 PF00244 0.517
LIG_14-3-3_CanoR_1 412 421 PF00244 0.268
LIG_14-3-3_CanoR_1 442 451 PF00244 0.487
LIG_14-3-3_CanoR_1 48 56 PF00244 0.626
LIG_Actin_WH2_2 169 186 PF00022 0.328
LIG_BIR_II_1 1 5 PF00653 0.821
LIG_BRCT_BRCA1_1 264 268 PF00533 0.277
LIG_BRCT_BRCA1_1 280 284 PF00533 0.381
LIG_BRCT_BRCA1_1 332 336 PF00533 0.273
LIG_BRCT_BRCA1_1 500 504 PF00533 0.427
LIG_BRCT_BRCA1_1 548 552 PF00533 0.457
LIG_deltaCOP1_diTrp_1 103 107 PF00928 0.597
LIG_deltaCOP1_diTrp_1 114 121 PF00928 0.459
LIG_EH1_1 119 127 PF00400 0.190
LIG_EH1_1 541 549 PF00400 0.351
LIG_eIF4E_1 240 246 PF01652 0.318
LIG_FHA_1 231 237 PF00498 0.299
LIG_FHA_1 288 294 PF00498 0.345
LIG_FHA_1 304 310 PF00498 0.464
LIG_FHA_1 38 44 PF00498 0.590
LIG_FHA_1 489 495 PF00498 0.450
LIG_FHA_1 507 513 PF00498 0.293
LIG_FHA_1 526 532 PF00498 0.230
LIG_FHA_1 560 566 PF00498 0.493
LIG_FHA_2 140 146 PF00498 0.304
LIG_FHA_2 21 27 PF00498 0.611
LIG_FHA_2 441 447 PF00498 0.476
LIG_FHA_2 62 68 PF00498 0.615
LIG_GBD_Chelix_1 125 133 PF00786 0.228
LIG_LIR_Apic_2 549 555 PF02991 0.407
LIG_LIR_Gen_1 114 124 PF02991 0.450
LIG_LIR_Gen_1 281 292 PF02991 0.234
LIG_LIR_Gen_1 333 344 PF02991 0.371
LIG_LIR_Gen_1 432 441 PF02991 0.300
LIG_LIR_Gen_1 448 459 PF02991 0.362
LIG_LIR_Gen_1 490 500 PF02991 0.501
LIG_LIR_Gen_1 501 512 PF02991 0.481
LIG_LIR_Gen_1 562 572 PF02991 0.492
LIG_LIR_Gen_1 580 590 PF02991 0.487
LIG_LIR_Nem_3 114 119 PF02991 0.453
LIG_LIR_Nem_3 265 271 PF02991 0.334
LIG_LIR_Nem_3 281 287 PF02991 0.448
LIG_LIR_Nem_3 333 339 PF02991 0.367
LIG_LIR_Nem_3 415 421 PF02991 0.325
LIG_LIR_Nem_3 432 436 PF02991 0.309
LIG_LIR_Nem_3 448 454 PF02991 0.539
LIG_LIR_Nem_3 490 495 PF02991 0.464
LIG_LIR_Nem_3 501 507 PF02991 0.431
LIG_LIR_Nem_3 550 556 PF02991 0.364
LIG_LIR_Nem_3 562 567 PF02991 0.449
LIG_LIR_Nem_3 577 581 PF02991 0.481
LIG_LYPXL_yS_3 363 366 PF13949 0.273
LIG_NRBOX 282 288 PF00104 0.277
LIG_NRBOX 522 528 PF00104 0.243
LIG_PCNA_yPIPBox_3 251 264 PF02747 0.426
LIG_Pex14_1 116 120 PF04695 0.333
LIG_Pex14_2 500 504 PF04695 0.468
LIG_SH2_CRK 240 244 PF00017 0.353
LIG_SH2_CRK 472 476 PF00017 0.468
LIG_SH2_CRK 553 557 PF00017 0.353
LIG_SH2_CRK 582 586 PF00017 0.511
LIG_SH2_GRB2like 468 471 PF00017 0.468
LIG_SH2_NCK_1 553 557 PF00017 0.353
LIG_SH2_SRC 158 161 PF00017 0.339
LIG_SH2_SRC 484 487 PF00017 0.489
LIG_SH2_STAP1 39 43 PF00017 0.647
LIG_SH2_STAP1 582 586 PF00017 0.507
LIG_SH2_STAT3 249 252 PF00017 0.486
LIG_SH2_STAT3 296 299 PF00017 0.330
LIG_SH2_STAT3 468 471 PF00017 0.404
LIG_SH2_STAT5 28 31 PF00017 0.637
LIG_SH2_STAT5 296 299 PF00017 0.278
LIG_SH2_STAT5 39 42 PF00017 0.560
LIG_SH2_STAT5 394 397 PF00017 0.293
LIG_SH2_STAT5 468 471 PF00017 0.453
LIG_SH2_STAT5 484 487 PF00017 0.496
LIG_SH2_STAT5 564 567 PF00017 0.404
LIG_SH2_STAT5 592 595 PF00017 0.595
LIG_SH3_3 31 37 PF00018 0.571
LIG_SH3_3 399 405 PF00018 0.250
LIG_SUMO_SIM_anti_2 145 150 PF11976 0.357
LIG_SUMO_SIM_anti_2 312 317 PF11976 0.450
LIG_SUMO_SIM_par_1 522 528 PF11976 0.354
LIG_TYR_ITIM 238 243 PF00017 0.342
LIG_TYR_ITIM 361 366 PF00017 0.243
LIG_TYR_ITIM 551 556 PF00017 0.353
LIG_Vh1_VBS_1 367 385 PF01044 0.342
LIG_WRC_WIRS_1 430 435 PF05994 0.273
MOD_CK1_1 2 8 PF00069 0.650
MOD_CK1_1 206 212 PF00069 0.486
MOD_CK1_1 262 268 PF00069 0.366
MOD_CK1_1 326 332 PF00069 0.381
MOD_CK1_1 417 423 PF00069 0.302
MOD_CK1_1 50 56 PF00069 0.649
MOD_CK1_1 554 560 PF00069 0.348
MOD_CK2_1 574 580 PF00069 0.528
MOD_CK2_1 97 103 PF00069 0.646
MOD_GlcNHglycan 257 260 PF01048 0.320
MOD_GlcNHglycan 264 267 PF01048 0.365
MOD_GlcNHglycan 328 331 PF01048 0.314
MOD_GlcNHglycan 357 360 PF01048 0.444
MOD_GlcNHglycan 378 381 PF01048 0.234
MOD_GlcNHglycan 500 503 PF01048 0.242
MOD_GlcNHglycan 519 522 PF01048 0.260
MOD_GlcNHglycan 52 55 PF01048 0.546
MOD_GlcNHglycan 95 98 PF01048 0.427
MOD_GSK3_1 203 210 PF00069 0.467
MOD_GSK3_1 227 234 PF00069 0.378
MOD_GSK3_1 255 262 PF00069 0.353
MOD_GSK3_1 326 333 PF00069 0.344
MOD_GSK3_1 413 420 PF00069 0.293
MOD_GSK3_1 437 444 PF00069 0.456
MOD_GSK3_1 46 53 PF00069 0.776
MOD_GSK3_1 525 532 PF00069 0.356
MOD_GSK3_1 542 549 PF00069 0.272
MOD_GSK3_1 551 558 PF00069 0.302
MOD_GSK3_1 597 604 PF00069 0.539
MOD_GSK3_1 88 95 PF00069 0.591
MOD_N-GLC_1 18 23 PF02516 0.459
MOD_NEK2_1 20 25 PF00069 0.614
MOD_NEK2_1 255 260 PF00069 0.368
MOD_NEK2_1 304 309 PF00069 0.504
MOD_NEK2_1 323 328 PF00069 0.368
MOD_NEK2_1 352 357 PF00069 0.335
MOD_NEK2_1 437 442 PF00069 0.525
MOD_NEK2_1 542 547 PF00069 0.353
MOD_NEK2_1 574 579 PF00069 0.489
MOD_NEK2_1 92 97 PF00069 0.611
MOD_NEK2_2 168 173 PF00069 0.380
MOD_NEK2_2 559 564 PF00069 0.488
MOD_NEK2_2 88 93 PF00069 0.575
MOD_PIKK_1 590 596 PF00454 0.529
MOD_PKA_2 411 417 PF00069 0.281
MOD_PKA_2 441 447 PF00069 0.503
MOD_PKA_2 47 53 PF00069 0.651
MOD_Plk_1 597 603 PF00069 0.535
MOD_Plk_4 232 238 PF00069 0.391
MOD_Plk_4 259 265 PF00069 0.362
MOD_Plk_4 278 284 PF00069 0.369
MOD_Plk_4 304 310 PF00069 0.533
MOD_Plk_4 311 317 PF00069 0.496
MOD_Plk_4 344 350 PF00069 0.354
MOD_Plk_4 389 395 PF00069 0.327
MOD_Plk_4 39 45 PF00069 0.587
MOD_Plk_4 422 428 PF00069 0.301
MOD_Plk_4 429 435 PF00069 0.304
MOD_Plk_4 488 494 PF00069 0.510
MOD_Plk_4 542 548 PF00069 0.338
MOD_Plk_4 559 565 PF00069 0.414
MOD_Plk_4 597 603 PF00069 0.535
MOD_ProDKin_1 207 213 PF00069 0.520
MOD_ProDKin_1 287 293 PF00069 0.243
MOD_ProDKin_1 551 557 PF00069 0.216
TRG_DiLeu_BaEn_1 490 495 PF01217 0.493
TRG_DiLeu_BaLyEn_6 288 293 PF01217 0.273
TRG_DiLeu_BaLyEn_6 347 352 PF01217 0.198
TRG_ENDOCYTIC_2 214 217 PF00928 0.444
TRG_ENDOCYTIC_2 240 243 PF00928 0.358
TRG_ENDOCYTIC_2 363 366 PF00928 0.398
TRG_ENDOCYTIC_2 472 475 PF00928 0.461
TRG_ENDOCYTIC_2 553 556 PF00928 0.372
TRG_ENDOCYTIC_2 564 567 PF00928 0.476
TRG_ENDOCYTIC_2 582 585 PF00928 0.511
TRG_ER_diArg_1 107 110 PF00400 0.612
TRG_ER_diArg_1 316 318 PF00400 0.534
TRG_Pf-PMV_PEXEL_1 435 439 PF00026 0.331

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PA24 Leptomonas seymouri 55% 100%
A0A0S4KHP0 Bodo saltans 32% 100%
A0A3R7MAJ2 Trypanosoma rangeli 29% 100%
A0A3S7XAV8 Leishmania donovani 34% 100%
A4H7J7 Leishmania braziliensis 77% 100%
A4HP90 Leishmania braziliensis 36% 100%
A4HVY0 Leishmania infantum 99% 100%
A4IDJ5 Leishmania infantum 34% 100%
D0A391 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
E9APN1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9ASZ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
Q4Q1K0 Leishmania major 34% 100%
Q4QFU7 Leishmania major 93% 100%
Q75EG5 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 27% 100%
Q870V7 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS