Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I9T9_LEIDO

TriTrypDb:

LdBPK_140100.1 , LdCL_140005900 , LDHU3_14.0120

Length:

1029

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I9T9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9T9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.609
CLV_NRD_NRD_1	22	24	PF00675	0.704
CLV_NRD_NRD_1	222	224	PF00675	0.598
CLV_NRD_NRD_1	233	235	PF00675	0.480
CLV_NRD_NRD_1	355	357	PF00675	0.668
CLV_NRD_NRD_1	46	48	PF00675	0.772
CLV_NRD_NRD_1	507	509	PF00675	0.542
CLV_NRD_NRD_1	548	550	PF00675	0.519
CLV_NRD_NRD_1	818	820	PF00675	0.514
CLV_NRD_NRD_1	909	911	PF00675	0.661
CLV_NRD_NRD_1	932	934	PF00675	0.515
CLV_NRD_NRD_1	977	979	PF00675	0.445
CLV_PCSK_FUR_1	505	509	PF00082	0.528
CLV_PCSK_KEX2_1	178	180	PF00082	0.694
CLV_PCSK_KEX2_1	202	204	PF00082	0.650
CLV_PCSK_KEX2_1	222	224	PF00082	0.309
CLV_PCSK_KEX2_1	46	48	PF00082	0.772
CLV_PCSK_KEX2_1	507	509	PF00082	0.508
CLV_PCSK_KEX2_1	80	82	PF00082	0.633
CLV_PCSK_KEX2_1	818	820	PF00082	0.514
CLV_PCSK_KEX2_1	909	911	PF00082	0.687
CLV_PCSK_KEX2_1	977	979	PF00082	0.534
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.650
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.606
CLV_PCSK_SKI1_1	203	207	PF00082	0.575
CLV_PCSK_SKI1_1	324	328	PF00082	0.647
CLV_PCSK_SKI1_1	367	371	PF00082	0.675
CLV_PCSK_SKI1_1	384	388	PF00082	0.466
CLV_PCSK_SKI1_1	400	404	PF00082	0.433
CLV_PCSK_SKI1_1	47	51	PF00082	0.679
CLV_PCSK_SKI1_1	557	561	PF00082	0.603
CLV_PCSK_SKI1_1	571	575	PF00082	0.413
CLV_PCSK_SKI1_1	659	663	PF00082	0.517
CLV_PCSK_SKI1_1	674	678	PF00082	0.563
CLV_PCSK_SKI1_1	788	792	PF00082	0.421
CLV_PCSK_SKI1_1	818	822	PF00082	0.478
CLV_PCSK_SKI1_1	901	905	PF00082	0.507
CLV_PCSK_SKI1_1	922	926	PF00082	0.556
DEG_APCC_DBOX_1	817	825	PF00400	0.526
DEG_APCC_DBOX_1	855	863	PF00400	0.496
DEG_Kelch_Keap1_1	472	477	PF01344	0.534
DEG_SPOP_SBC_1	38	42	PF00917	0.799
DEG_SPOP_SBC_1	579	583	PF00917	0.516
DEG_SPOP_SBC_1	702	706	PF00917	0.502
DOC_CKS1_1	647	652	PF01111	0.638
DOC_CKS1_1	753	758	PF01111	0.561
DOC_CYCLIN_RxL_1	381	389	PF00134	0.579
DOC_CYCLIN_RxL_1	397	407	PF00134	0.480
DOC_MAPK_DCC_7	165	175	PF00069	0.548
DOC_MAPK_gen_1	165	175	PF00069	0.490
DOC_MAPK_gen_1	232	242	PF00069	0.592
DOC_MAPK_gen_1	46	53	PF00069	0.656
DOC_MAPK_gen_1	818	826	PF00069	0.535
DOC_MAPK_gen_1	909	916	PF00069	0.703
DOC_MAPK_MEF2A_6	168	177	PF00069	0.493
DOC_MAPK_MEF2A_6	234	242	PF00069	0.644
DOC_MAPK_MEF2A_6	883	892	PF00069	0.461
DOC_PP1_RVXF_1	1011	1018	PF00149	0.657
DOC_PP1_RVXF_1	920	927	PF00149	0.523
DOC_PP4_FxxP_1	920	923	PF00568	0.449
DOC_USP7_MATH_1	1021	1025	PF00917	0.746
DOC_USP7_MATH_1	28	32	PF00917	0.691
DOC_USP7_MATH_1	38	42	PF00917	0.756
DOC_USP7_MATH_1	404	408	PF00917	0.692
DOC_USP7_MATH_1	430	434	PF00917	0.680
DOC_USP7_MATH_1	437	441	PF00917	0.546
DOC_USP7_MATH_1	465	469	PF00917	0.555
DOC_USP7_MATH_1	579	583	PF00917	0.640
DOC_USP7_MATH_1	601	605	PF00917	0.627
DOC_USP7_MATH_1	803	807	PF00917	0.539
DOC_USP7_MATH_1	938	942	PF00917	0.515
DOC_USP7_UBL2_3	135	139	PF12436	0.629
DOC_WW_Pin1_4	159	164	PF00397	0.545
DOC_WW_Pin1_4	433	438	PF00397	0.643
DOC_WW_Pin1_4	646	651	PF00397	0.654
DOC_WW_Pin1_4	752	757	PF00397	0.457
DOC_WW_Pin1_4	788	793	PF00397	0.519
DOC_WW_Pin1_4	829	834	PF00397	0.577
LIG_14-3-3_CanoR_1	288	294	PF00244	0.589
LIG_14-3-3_CanoR_1	335	343	PF00244	0.658
LIG_14-3-3_CanoR_1	367	376	PF00244	0.588
LIG_14-3-3_CanoR_1	557	565	PF00244	0.656
LIG_14-3-3_CanoR_1	600	610	PF00244	0.591
LIG_14-3-3_CanoR_1	618	622	PF00244	0.353
LIG_14-3-3_CanoR_1	71	77	PF00244	0.738
LIG_14-3-3_CanoR_1	767	774	PF00244	0.659
LIG_14-3-3_CanoR_1	869	876	PF00244	0.566
LIG_14-3-3_CanoR_1	883	892	PF00244	0.368
LIG_14-3-3_CanoR_1	909	916	PF00244	0.689
LIG_14-3-3_CanoR_1	933	942	PF00244	0.568
LIG_14-3-3_CanoR_1	993	1001	PF00244	0.506
LIG_Actin_WH2_2	493	509	PF00022	0.536
LIG_Actin_WH2_2	552	568	PF00022	0.638
LIG_Actin_WH2_2	658	676	PF00022	0.589
LIG_APCC_ABBA_1	953	958	PF00400	0.392
LIG_BIR_II_1	1	5	PF00653	0.633
LIG_BRCT_BRCA1_1	613	617	PF00533	0.657
LIG_BRCT_BRCA1_1	705	709	PF00533	0.494
LIG_BRCT_BRCA1_1	916	920	PF00533	0.647
LIG_CaM_IQ_9	195	211	PF13499	0.662
LIG_Clathr_ClatBox_1	50	54	PF01394	0.659
LIG_eIF4E_1	280	286	PF01652	0.638
LIG_eIF4E_1	317	323	PF01652	0.665
LIG_eIF4E_1	85	91	PF01652	0.554
LIG_FHA_1	129	135	PF00498	0.486
LIG_FHA_1	293	299	PF00498	0.542
LIG_FHA_1	30	36	PF00498	0.775
LIG_FHA_1	364	370	PF00498	0.605
LIG_FHA_1	581	587	PF00498	0.752
LIG_FHA_1	689	695	PF00498	0.468
LIG_FHA_1	703	709	PF00498	0.403
LIG_FHA_1	753	759	PF00498	0.561
LIG_FHA_1	815	821	PF00498	0.511
LIG_FHA_1	889	895	PF00498	0.455
LIG_FHA_1	919	925	PF00498	0.595
LIG_FHA_1	957	963	PF00498	0.469
LIG_FHA_1	996	1002	PF00498	0.512
LIG_FHA_2	146	152	PF00498	0.499
LIG_FHA_2	323	329	PF00498	0.689
LIG_FHA_2	38	44	PF00498	0.778
LIG_FHA_2	691	697	PF00498	0.574
LIG_FHA_2	893	899	PF00498	0.523
LIG_IBAR_NPY_1	186	188	PF08397	0.563
LIG_LIR_Apic_2	393	398	PF02991	0.614
LIG_LIR_Apic_2	431	437	PF02991	0.670
LIG_LIR_Apic_2	917	923	PF02991	0.464
LIG_LIR_Gen_1	17	26	PF02991	0.727
LIG_LIR_Gen_1	377	387	PF02991	0.671
LIG_LIR_Gen_1	477	487	PF02991	0.423
LIG_LIR_Gen_1	683	694	PF02991	0.537
LIG_LIR_Gen_1	891	897	PF02991	0.277
LIG_LIR_Gen_1	952	961	PF02991	0.419
LIG_LIR_Nem_3	17	22	PF02991	0.687
LIG_LIR_Nem_3	377	382	PF02991	0.614
LIG_LIR_Nem_3	460	466	PF02991	0.582
LIG_LIR_Nem_3	477	482	PF02991	0.263
LIG_LIR_Nem_3	683	689	PF02991	0.551
LIG_LIR_Nem_3	706	712	PF02991	0.420
LIG_LIR_Nem_3	722	728	PF02991	0.377
LIG_LIR_Nem_3	852	858	PF02991	0.438
LIG_LIR_Nem_3	952	956	PF02991	0.395
LIG_PCNA_yPIPBox_3	848	858	PF02747	0.468
LIG_PDZ_Class_1	1024	1029	PF00595	0.753
LIG_Pex14_2	469	473	PF04695	0.406
LIG_Pex14_2	483	487	PF04695	0.388
LIG_Pex14_2	880	884	PF04695	0.503
LIG_PTB_Apo_2	183	190	PF02174	0.495
LIG_SH2_CRK	143	147	PF00017	0.412
LIG_SH2_CRK	379	383	PF00017	0.641
LIG_SH2_CRK	520	524	PF00017	0.554
LIG_SH2_CRK	87	91	PF00017	0.475
LIG_SH2_SRC	479	482	PF00017	0.439
LIG_SH2_SRC	750	753	PF00017	0.541
LIG_SH2_STAP1	379	383	PF00017	0.641
LIG_SH2_STAP1	750	754	PF00017	0.507
LIG_SH2_STAP1	87	91	PF00017	0.479
LIG_SH2_STAT3	481	484	PF00017	0.524
LIG_SH2_STAT5	158	161	PF00017	0.518
LIG_SH2_STAT5	188	191	PF00017	0.494
LIG_SH2_STAT5	293	296	PF00017	0.533
LIG_SH2_STAT5	395	398	PF00017	0.608
LIG_SH2_STAT5	479	482	PF00017	0.405
LIG_SH2_STAT5	512	515	PF00017	0.547
LIG_SH2_STAT5	606	609	PF00017	0.631
LIG_SH2_STAT5	710	713	PF00017	0.507
LIG_SH2_STAT5	858	861	PF00017	0.420
LIG_SH3_1	395	401	PF00018	0.638
LIG_SH3_1	459	465	PF00018	0.640
LIG_SH3_2	462	467	PF14604	0.627
LIG_SH3_3	174	180	PF00018	0.676
LIG_SH3_3	395	401	PF00018	0.638
LIG_SH3_3	42	48	PF00018	0.549
LIG_SH3_3	459	465	PF00018	0.618
LIG_SH3_3	750	756	PF00018	0.457
LIG_SH3_3	968	974	PF00018	0.484
LIG_SUMO_SIM_anti_2	958	964	PF11976	0.519
LIG_SUMO_SIM_par_1	997	1003	PF11976	0.558
LIG_TRAF2_1	329	332	PF00917	0.660
LIG_TRAF2_1	635	638	PF00917	0.573
LIG_TRAF2_1	781	784	PF00917	0.514
LIG_TRFH_1	520	524	PF08558	0.545
LIG_TYR_ITIM	518	523	PF00017	0.526
LIG_WRC_WIRS_1	466	471	PF05994	0.503
LIG_WRC_WIRS_1	50	55	PF05994	0.652
LIG_WRC_WIRS_1	939	944	PF05994	0.586
MOD_CDC14_SPxK_1	162	165	PF00782	0.443
MOD_CDK_SPxK_1	159	165	PF00069	0.431
MOD_CDK_SPxxK_3	829	836	PF00069	0.650
MOD_CK1_1	128	134	PF00069	0.486
MOD_CK1_1	289	295	PF00069	0.603
MOD_CK1_1	433	439	PF00069	0.620
MOD_CK1_1	457	463	PF00069	0.666
MOD_CK1_1	580	586	PF00069	0.692
MOD_CK1_1	770	776	PF00069	0.578
MOD_CK1_1	8	14	PF00069	0.673
MOD_CK1_1	868	874	PF00069	0.637
MOD_CK1_1	875	881	PF00069	0.570
MOD_CK1_1	886	892	PF00069	0.297
MOD_CK2_1	145	151	PF00069	0.501
MOD_CK2_1	322	328	PF00069	0.645
MOD_CK2_1	38	44	PF00069	0.695
MOD_CK2_1	414	420	PF00069	0.744
MOD_CK2_1	471	477	PF00069	0.477
MOD_CK2_1	535	541	PF00069	0.449
MOD_CK2_1	555	561	PF00069	0.581
MOD_CK2_1	578	584	PF00069	0.633
MOD_CK2_1	61	67	PF00069	0.617
MOD_CK2_1	690	696	PF00069	0.578
MOD_CK2_1	716	722	PF00069	0.524
MOD_CK2_1	892	898	PF00069	0.522
MOD_Cter_Amidation	907	910	PF01082	0.629
MOD_DYRK1A_RPxSP_1	788	792	PF00069	0.470
MOD_GlcNHglycan	1	4	PF01048	0.717
MOD_GlcNHglycan	10	13	PF01048	0.727
MOD_GlcNHglycan	127	130	PF01048	0.533
MOD_GlcNHglycan	19	22	PF01048	0.695
MOD_GlcNHglycan	203	206	PF01048	0.580
MOD_GlcNHglycan	32	35	PF01048	0.565
MOD_GlcNHglycan	408	411	PF01048	0.774
MOD_GlcNHglycan	437	440	PF01048	0.651
MOD_GlcNHglycan	456	459	PF01048	0.436
MOD_GlcNHglycan	730	734	PF01048	0.500
MOD_GlcNHglycan	788	791	PF01048	0.474
MOD_GlcNHglycan	905	909	PF01048	0.681
MOD_GlcNHglycan	916	919	PF01048	0.515
MOD_GlcNHglycan	936	939	PF01048	0.482
MOD_GlcNHglycan	947	950	PF01048	0.489
MOD_GlcNHglycan	990	993	PF01048	0.516
MOD_GSK3_1	1	8	PF00069	0.685
MOD_GSK3_1	10	17	PF00069	0.744
MOD_GSK3_1	115	122	PF00069	0.387
MOD_GSK3_1	145	152	PF00069	0.518
MOD_GSK3_1	24	31	PF00069	0.651
MOD_GSK3_1	288	295	PF00069	0.623
MOD_GSK3_1	363	370	PF00069	0.565
MOD_GSK3_1	433	440	PF00069	0.663
MOD_GSK3_1	553	560	PF00069	0.647
MOD_GSK3_1	575	582	PF00069	0.559
MOD_GSK3_1	864	871	PF00069	0.618
MOD_GSK3_1	888	895	PF00069	0.508
MOD_GSK3_1	910	917	PF00069	0.662
MOD_GSK3_1	934	941	PF00069	0.572
MOD_GSK3_1	945	952	PF00069	0.585
MOD_GSK3_1	96	103	PF00069	0.604
MOD_N-GLC_1	115	120	PF02516	0.622
MOD_N-GLC_1	367	372	PF02516	0.597
MOD_N-GLC_1	767	772	PF02516	0.663
MOD_N-GLC_1	910	915	PF02516	0.665
MOD_N-GLC_1	995	1000	PF02516	0.578
MOD_NEK2_1	1	6	PF00069	0.738
MOD_NEK2_1	100	105	PF00069	0.563
MOD_NEK2_1	1000	1005	PF00069	0.553
MOD_NEK2_1	107	112	PF00069	0.442
MOD_NEK2_1	125	130	PF00069	0.493
MOD_NEK2_1	189	194	PF00069	0.498
MOD_NEK2_1	322	327	PF00069	0.699
MOD_NEK2_1	386	391	PF00069	0.612
MOD_NEK2_1	535	540	PF00069	0.480
MOD_NEK2_1	575	580	PF00069	0.721
MOD_NEK2_1	617	622	PF00069	0.645
MOD_NEK2_1	688	693	PF00069	0.469
MOD_NEK2_1	888	893	PF00069	0.452
MOD_NEK2_1	904	909	PF00069	0.613
MOD_NEK2_1	956	961	PF00069	0.401
MOD_NEK2_1	983	988	PF00069	0.468
MOD_PIKK_1	1015	1021	PF00454	0.564
MOD_PIKK_1	334	340	PF00454	0.682
MOD_PIKK_1	367	373	PF00454	0.683
MOD_PIKK_1	404	410	PF00454	0.753
MOD_PIKK_1	688	694	PF00454	0.551
MOD_PIKK_1	868	874	PF00454	0.603
MOD_PIKK_1	875	881	PF00454	0.548
MOD_PIKK_1	883	889	PF00454	0.317
MOD_PK_1	910	916	PF00069	0.726
MOD_PKA_1	909	915	PF00069	0.682
MOD_PKA_2	1021	1027	PF00069	0.750
MOD_PKA_2	14	20	PF00069	0.641
MOD_PKA_2	221	227	PF00069	0.570
MOD_PKA_2	289	295	PF00069	0.603
MOD_PKA_2	334	340	PF00069	0.674
MOD_PKA_2	404	410	PF00069	0.673
MOD_PKA_2	617	623	PF00069	0.532
MOD_PKA_2	70	76	PF00069	0.677
MOD_PKA_2	868	874	PF00069	0.572
MOD_PKA_2	909	915	PF00069	0.680
MOD_Plk_1	119	125	PF00069	0.582
MOD_Plk_1	268	274	PF00069	0.616
MOD_Plk_1	367	373	PF00069	0.636
MOD_Plk_1	430	436	PF00069	0.750
MOD_Plk_1	55	61	PF00069	0.691
MOD_Plk_1	770	776	PF00069	0.578
MOD_Plk_1	872	878	PF00069	0.605
MOD_Plk_1	910	916	PF00069	0.636
MOD_Plk_1	995	1001	PF00069	0.571
MOD_Plk_2-3	414	420	PF00069	0.733
MOD_Plk_4	107	113	PF00069	0.473
MOD_Plk_4	145	151	PF00069	0.564
MOD_Plk_4	189	195	PF00069	0.569
MOD_Plk_4	289	295	PF00069	0.603
MOD_Plk_4	490	496	PF00069	0.565
MOD_Plk_4	892	898	PF00069	0.415
MOD_Plk_4	995	1001	PF00069	0.521
MOD_ProDKin_1	159	165	PF00069	0.548
MOD_ProDKin_1	433	439	PF00069	0.629
MOD_ProDKin_1	646	652	PF00069	0.644
MOD_ProDKin_1	752	758	PF00069	0.455
MOD_ProDKin_1	788	794	PF00069	0.517
MOD_ProDKin_1	829	835	PF00069	0.571
MOD_SUMO_for_1	350	353	PF00179	0.623
MOD_SUMO_rev_2	567	573	PF00179	0.586
TRG_DiLeu_BaEn_2	897	903	PF01217	0.538
TRG_DiLeu_BaLyEn_6	398	403	PF01217	0.678
TRG_DiLeu_BaLyEn_6	816	821	PF01217	0.506
TRG_ENDOCYTIC_2	143	146	PF00928	0.412
TRG_ENDOCYTIC_2	379	382	PF00928	0.608
TRG_ENDOCYTIC_2	479	482	PF00928	0.415
TRG_ENDOCYTIC_2	520	523	PF00928	0.564
TRG_ENDOCYTIC_2	750	753	PF00928	0.508
TRG_ENDOCYTIC_2	782	785	PF00928	0.602
TRG_ENDOCYTIC_2	811	814	PF00928	0.444
TRG_ENDOCYTIC_2	87	90	PF00928	0.483
TRG_ER_diArg_1	177	179	PF00400	0.599
TRG_ER_diArg_1	272	275	PF00400	0.641
TRG_ER_diArg_1	45	47	PF00400	0.762
TRG_ER_diArg_1	505	508	PF00400	0.466
TRG_ER_diArg_1	818	820	PF00400	0.514
TRG_ER_diArg_1	976	978	PF00400	0.525
TRG_NES_CRM1_1	363	377	PF08389	0.581
TRG_NES_CRM1_1	852	866	PF08389	0.439
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	718	722	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	818	822	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	836	840	PF00026	0.617
TRG_Pf-PMV_PEXEL_1	901	905	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW77	Leptomonas seymouri	52%	97%
A0A0S4ITT6	Bodo saltans	25%	100%
A0A1X0NQF9	Trypanosomatidae	31%	100%
A4H7H1	Leishmania braziliensis	77%	100%
A4HVV2	Leishmania infantum	99%	100%
C9ZT75	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9APK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QFX5	Leishmania major	94%	100%
V5BM93	Trypanosoma cruzi	29%	100%