T-complex protein 10 C-terminus, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Spindle assembly abnormal 4

Species:

Leishmania donovani

UniProt:

A0A3Q8I9S9_LEIDO

TriTrypDb:

LdBPK_131330.1 , LdCL_130020600 , LDHU3_13.1840

Length:

750

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005813	centrosome	3	1
GO:0005814	centriole	5	1
GO:0005815	microtubule organizing center	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8I9S9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9S9

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0061511	centriole elongation	3	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.637
CLV_C14_Caspase3-7	309	313	PF00656	0.650
CLV_C14_Caspase3-7	320	324	PF00656	0.543
CLV_C14_Caspase3-7	449	453	PF00656	0.701
CLV_C14_Caspase3-7	54	58	PF00656	0.676
CLV_NRD_NRD_1	120	122	PF00675	0.715
CLV_NRD_NRD_1	22	24	PF00675	0.656
CLV_NRD_NRD_1	235	237	PF00675	0.691
CLV_NRD_NRD_1	316	318	PF00675	0.673
CLV_NRD_NRD_1	350	352	PF00675	0.587
CLV_NRD_NRD_1	385	387	PF00675	0.500
CLV_NRD_NRD_1	393	395	PF00675	0.478
CLV_NRD_NRD_1	459	461	PF00675	0.746
CLV_NRD_NRD_1	506	508	PF00675	0.620
CLV_NRD_NRD_1	515	517	PF00675	0.611
CLV_NRD_NRD_1	542	544	PF00675	0.545
CLV_NRD_NRD_1	548	550	PF00675	0.571
CLV_NRD_NRD_1	55	57	PF00675	0.677
CLV_NRD_NRD_1	561	563	PF00675	0.656
CLV_NRD_NRD_1	583	585	PF00675	0.794
CLV_NRD_NRD_1	86	88	PF00675	0.742
CLV_PCSK_FUR_1	383	387	PF00082	0.524
CLV_PCSK_FUR_1	457	461	PF00082	0.604
CLV_PCSK_FUR_1	484	488	PF00082	0.634
CLV_PCSK_FUR_1	53	57	PF00082	0.698
CLV_PCSK_FUR_1	540	544	PF00082	0.473
CLV_PCSK_KEX2_1	120	122	PF00082	0.766
CLV_PCSK_KEX2_1	22	24	PF00082	0.669
CLV_PCSK_KEX2_1	235	237	PF00082	0.691
CLV_PCSK_KEX2_1	316	318	PF00082	0.673
CLV_PCSK_KEX2_1	350	352	PF00082	0.587
CLV_PCSK_KEX2_1	385	387	PF00082	0.500
CLV_PCSK_KEX2_1	393	395	PF00082	0.478
CLV_PCSK_KEX2_1	459	461	PF00082	0.746
CLV_PCSK_KEX2_1	486	488	PF00082	0.600
CLV_PCSK_KEX2_1	505	507	PF00082	0.584
CLV_PCSK_KEX2_1	517	519	PF00082	0.522
CLV_PCSK_KEX2_1	540	542	PF00082	0.643
CLV_PCSK_KEX2_1	55	57	PF00082	0.677
CLV_PCSK_KEX2_1	582	584	PF00082	0.753
CLV_PCSK_KEX2_1	597	599	PF00082	0.611
CLV_PCSK_KEX2_1	645	647	PF00082	0.317
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.623
CLV_PCSK_PC1ET2_1	517	519	PF00082	0.511
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.733
CLV_PCSK_PC1ET2_1	597	599	PF00082	0.683
CLV_PCSK_PC1ET2_1	645	647	PF00082	0.314
CLV_PCSK_PC7_1	231	237	PF00082	0.687
CLV_PCSK_PC7_1	346	352	PF00082	0.579
CLV_PCSK_PC7_1	593	599	PF00082	0.624
CLV_PCSK_SKI1_1	637	641	PF00082	0.548
CLV_PCSK_SKI1_1	656	660	PF00082	0.317
CLV_PCSK_SKI1_1	70	74	PF00082	0.677
CLV_PCSK_SKI1_1	720	724	PF00082	0.433
DEG_APCC_DBOX_1	359	367	PF00400	0.536
DOC_CKS1_1	569	574	PF01111	0.714
DOC_MAPK_gen_1	334	343	PF00069	0.510
DOC_MAPK_gen_1	459	469	PF00069	0.722
DOC_MAPK_gen_1	523	531	PF00069	0.612
DOC_PP2B_LxvP_1	145	148	PF13499	0.742
DOC_PP4_FxxP_1	234	237	PF00568	0.673
DOC_USP7_MATH_1	14	18	PF00917	0.766
DOC_USP7_MATH_1	148	152	PF00917	0.641
DOC_USP7_MATH_1	174	178	PF00917	0.717
DOC_USP7_MATH_1	223	227	PF00917	0.704
DOC_USP7_MATH_1	244	248	PF00917	0.759
DOC_USP7_MATH_1	252	256	PF00917	0.671
DOC_USP7_MATH_1	476	480	PF00917	0.665
DOC_USP7_MATH_1	585	589	PF00917	0.768
DOC_USP7_MATH_1	716	720	PF00917	0.547
DOC_USP7_MATH_1	734	738	PF00917	0.627
DOC_USP7_UBL2_3	11	15	PF12436	0.664
DOC_USP7_UBL2_3	272	276	PF12436	0.574
DOC_WW_Pin1_4	114	119	PF00397	0.833
DOC_WW_Pin1_4	139	144	PF00397	0.730
DOC_WW_Pin1_4	199	204	PF00397	0.733
DOC_WW_Pin1_4	248	253	PF00397	0.789
DOC_WW_Pin1_4	34	39	PF00397	0.701
DOC_WW_Pin1_4	413	418	PF00397	0.685
DOC_WW_Pin1_4	422	427	PF00397	0.711
DOC_WW_Pin1_4	470	475	PF00397	0.709
DOC_WW_Pin1_4	568	573	PF00397	0.682
LIG_14-3-3_CanoR_1	212	217	PF00244	0.728
LIG_14-3-3_CanoR_1	27	31	PF00244	0.672
LIG_14-3-3_CanoR_1	3	7	PF00244	0.672
LIG_14-3-3_CanoR_1	329	335	PF00244	0.482
LIG_14-3-3_CanoR_1	350	359	PF00244	0.621
LIG_14-3-3_CanoR_1	420	426	PF00244	0.800
LIG_14-3-3_CanoR_1	437	443	PF00244	0.667
LIG_14-3-3_CanoR_1	584	594	PF00244	0.685
LIG_14-3-3_CanoR_1	70	78	PF00244	0.663
LIG_14-3-3_CanoR_1	94	99	PF00244	0.755
LIG_APCC_ABBAyCdc20_2	720	726	PF00400	0.480
LIG_APCC_Cbox_1	510	516	PF00515	0.519
LIG_BIR_II_1	1	5	PF00653	0.790
LIG_BRCT_BRCA1_1	16	20	PF00533	0.737
LIG_FHA_1	614	620	PF00498	0.635
LIG_FHA_1	652	658	PF00498	0.556
LIG_FHA_1	91	97	PF00498	0.778
LIG_FHA_2	147	153	PF00498	0.767
LIG_FHA_2	359	365	PF00498	0.661
LIG_FHA_2	367	373	PF00498	0.562
LIG_FHA_2	601	607	PF00498	0.544
LIG_FHA_2	667	673	PF00498	0.517
LIG_LIR_Apic_2	133	137	PF02991	0.744
LIG_LIR_Nem_3	16	21	PF02991	0.686
LIG_LIR_Nem_3	332	338	PF02991	0.490
LIG_LIR_Nem_3	726	732	PF02991	0.453
LIG_Rb_LxCxE_1	404	424	PF01857	0.684
LIG_SH2_CRK	198	202	PF00017	0.812
LIG_SH2_CRK	213	217	PF00017	0.769
LIG_SH2_CRK	729	733	PF00017	0.471
LIG_SH2_GRB2like	650	653	PF00017	0.517
LIG_SH2_NCK_1	30	34	PF00017	0.754
LIG_SH2_NCK_1	686	690	PF00017	0.500
LIG_SH2_SRC	218	221	PF00017	0.695
LIG_SH2_SRC	281	284	PF00017	0.586
LIG_SH2_SRC	443	446	PF00017	0.733
LIG_SH2_SRC	650	653	PF00017	0.501
LIG_SH2_STAP1	165	169	PF00017	0.581
LIG_SH2_STAT5	160	163	PF00017	0.735
LIG_SH2_STAT5	233	236	PF00017	0.700
LIG_SH2_STAT5	239	242	PF00017	0.706
LIG_SH2_STAT5	512	515	PF00017	0.615
LIG_SH3_2	592	597	PF14604	0.663
LIG_SH3_3	126	132	PF00018	0.778
LIG_SH3_3	134	140	PF00018	0.694
LIG_SH3_3	150	156	PF00018	0.748
LIG_SH3_3	246	252	PF00018	0.655
LIG_SH3_3	566	572	PF00018	0.698
LIG_SH3_3	589	595	PF00018	0.670
LIG_SH3_3	654	660	PF00018	0.556
LIG_SH3_3	80	86	PF00018	0.710
LIG_SH3_3	93	99	PF00018	0.671
LIG_SH3_4	11	18	PF00018	0.725
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.685
LIG_SUMO_SIM_par_1	422	430	PF11976	0.596
LIG_SUMO_SIM_par_1	465	471	PF11976	0.716
LIG_TRAF2_1	257	260	PF00917	0.588
LIG_TRAF2_1	330	333	PF00917	0.547
LIG_TRAF2_1	501	504	PF00917	0.656
LIG_TRAF2_1	603	606	PF00917	0.530
LIG_TRAF2_1	747	750	PF00917	0.710
LIG_UBA3_1	263	272	PF00899	0.657
LIG_UBA3_1	398	403	PF00899	0.583
MOD_CDC14_SPxK_1	37	40	PF00782	0.746
MOD_CDK_SPK_2	199	204	PF00069	0.733
MOD_CDK_SPK_2	470	475	PF00069	0.716
MOD_CDK_SPK_2	568	573	PF00069	0.682
MOD_CDK_SPxK_1	114	120	PF00069	0.618
MOD_CDK_SPxK_1	34	40	PF00069	0.752
MOD_CDK_SPxxK_3	114	121	PF00069	0.619
MOD_CDK_SPxxK_3	413	420	PF00069	0.680
MOD_CK1_1	106	112	PF00069	0.776
MOD_CK1_1	185	191	PF00069	0.803
MOD_CK1_1	2	8	PF00069	0.711
MOD_CK1_1	31	37	PF00069	0.757
MOD_CK1_1	358	364	PF00069	0.570
MOD_CK1_1	416	422	PF00069	0.807
MOD_CK1_1	425	431	PF00069	0.698
MOD_CK1_1	439	445	PF00069	0.515
MOD_CK1_1	576	582	PF00069	0.530
MOD_CK1_1	661	667	PF00069	0.556
MOD_CK1_1	679	685	PF00069	0.440
MOD_CK1_1	737	743	PF00069	0.580
MOD_CK2_1	104	110	PF00069	0.759
MOD_CK2_1	146	152	PF00069	0.807
MOD_CK2_1	254	260	PF00069	0.630
MOD_CK2_1	358	364	PF00069	0.658
MOD_CK2_1	366	372	PF00069	0.563
MOD_CK2_1	600	606	PF00069	0.495
MOD_Cter_Amidation	643	646	PF01082	0.317
MOD_GlcNHglycan	106	109	PF01048	0.730
MOD_GlcNHglycan	169	172	PF01048	0.747
MOD_GlcNHglycan	177	180	PF01048	0.777
MOD_GlcNHglycan	204	207	PF01048	0.739
MOD_GlcNHglycan	219	224	PF01048	0.703
MOD_GlcNHglycan	226	229	PF01048	0.661
MOD_GlcNHglycan	30	33	PF01048	0.695
MOD_GlcNHglycan	338	341	PF01048	0.633
MOD_GlcNHglycan	413	416	PF01048	0.791
MOD_GlcNHglycan	432	436	PF01048	0.711
MOD_GlcNHglycan	439	442	PF01048	0.696
MOD_GlcNHglycan	564	567	PF01048	0.621
MOD_GlcNHglycan	575	578	PF01048	0.657
MOD_GlcNHglycan	585	588	PF01048	0.754
MOD_GlcNHglycan	642	645	PF01048	0.359
MOD_GlcNHglycan	660	663	PF01048	0.313
MOD_GlcNHglycan	678	681	PF01048	0.463
MOD_GlcNHglycan	96	99	PF01048	0.830
MOD_GSK3_1	100	107	PF00069	0.629
MOD_GSK3_1	161	168	PF00069	0.782
MOD_GSK3_1	219	226	PF00069	0.708
MOD_GSK3_1	244	251	PF00069	0.743
MOD_GSK3_1	416	423	PF00069	0.689
MOD_GSK3_1	427	434	PF00069	0.682
MOD_GSK3_1	573	580	PF00069	0.791
MOD_GSK3_1	658	665	PF00069	0.556
MOD_GSK3_1	676	683	PF00069	0.448
MOD_GSK3_1	704	711	PF00069	0.551
MOD_GSK3_1	90	97	PF00069	0.773
MOD_N-GLC_1	103	108	PF02516	0.715
MOD_N-GLC_1	336	341	PF02516	0.647
MOD_N-GLC_1	355	360	PF02516	0.372
MOD_N-GLC_1	651	656	PF02516	0.317
MOD_NEK2_1	161	166	PF00069	0.724
MOD_NEK2_1	28	33	PF00069	0.689
MOD_NEK2_1	366	371	PF00069	0.536
MOD_NEK2_1	640	645	PF00069	0.507
MOD_NEK2_1	666	671	PF00069	0.517
MOD_NEK2_1	705	710	PF00069	0.509
MOD_NEK2_2	14	19	PF00069	0.710
MOD_NEK2_2	577	582	PF00069	0.781
MOD_NEK2_2	651	656	PF00069	0.549
MOD_NEK2_2	662	667	PF00069	0.567
MOD_NEK2_2	688	693	PF00069	0.518
MOD_PIKK_1	350	356	PF00454	0.535
MOD_PIKK_1	358	364	PF00454	0.536
MOD_PIKK_1	623	629	PF00454	0.550
MOD_PIKK_1	691	697	PF00454	0.451
MOD_PKA_1	350	356	PF00069	0.535
MOD_PKA_1	459	465	PF00069	0.737
MOD_PKA_1	55	61	PF00069	0.614
MOD_PKA_1	562	568	PF00069	0.655
MOD_PKA_1	583	589	PF00069	0.808
MOD_PKA_2	185	191	PF00069	0.803
MOD_PKA_2	2	8	PF00069	0.692
MOD_PKA_2	26	32	PF00069	0.728
MOD_PKA_2	315	321	PF00069	0.610
MOD_PKA_2	328	334	PF00069	0.564
MOD_PKA_2	345	351	PF00069	0.402
MOD_PKA_2	419	425	PF00069	0.806
MOD_PKA_2	436	442	PF00069	0.732
MOD_PKA_2	459	465	PF00069	0.691
MOD_PKA_2	55	61	PF00069	0.614
MOD_PKA_2	583	589	PF00069	0.788
MOD_PKA_2	705	711	PF00069	0.555
MOD_PKB_1	457	465	PF00069	0.594
MOD_PKB_1	53	61	PF00069	0.677
MOD_Plk_1	161	167	PF00069	0.761
MOD_Plk_1	276	282	PF00069	0.534
MOD_Plk_1	336	342	PF00069	0.646
MOD_Plk_1	355	361	PF00069	0.438
MOD_Plk_1	737	743	PF00069	0.527
MOD_Plk_4	2	8	PF00069	0.802
MOD_Plk_4	680	686	PF00069	0.459
MOD_Plk_4	737	743	PF00069	0.527
MOD_ProDKin_1	114	120	PF00069	0.835
MOD_ProDKin_1	139	145	PF00069	0.734
MOD_ProDKin_1	199	205	PF00069	0.732
MOD_ProDKin_1	248	254	PF00069	0.790
MOD_ProDKin_1	34	40	PF00069	0.703
MOD_ProDKin_1	413	419	PF00069	0.689
MOD_ProDKin_1	422	428	PF00069	0.710
MOD_ProDKin_1	470	476	PF00069	0.706
MOD_ProDKin_1	568	574	PF00069	0.683
MOD_SUMO_for_1	216	219	PF00179	0.730
MOD_SUMO_rev_2	266	274	PF00179	0.653
MOD_SUMO_rev_2	519	525	PF00179	0.577
MOD_SUMO_rev_2	54	61	PF00179	0.668
MOD_SUMO_rev_2	556	565	PF00179	0.646
TRG_DiLeu_BaEn_1	259	264	PF01217	0.552
TRG_DiLeu_BaEn_2	15	21	PF01217	0.738
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.746
TRG_ENDOCYTIC_2	198	201	PF00928	0.800
TRG_ENDOCYTIC_2	213	216	PF00928	0.692
TRG_ENDOCYTIC_2	729	732	PF00928	0.464
TRG_ER_diArg_1	21	23	PF00400	0.682
TRG_ER_diArg_1	234	236	PF00400	0.697
TRG_ER_diArg_1	316	319	PF00400	0.675
TRG_ER_diArg_1	350	352	PF00400	0.587
TRG_ER_diArg_1	383	386	PF00400	0.505
TRG_ER_diArg_1	505	507	PF00400	0.584
TRG_ER_diArg_1	526	529	PF00400	0.631
TRG_ER_diArg_1	540	543	PF00400	0.621
TRG_ER_diArg_1	583	585	PF00400	0.726
TRG_Pf-PMV_PEXEL_1	350	354	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	511	515	PF00026	0.641
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW13	Leptomonas seymouri	57%	98%
A4H7E9	Leishmania braziliensis	79%	99%
A4HVT7	Leishmania infantum	100%	100%
E9API3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QFZ5	Leishmania major	94%	100%
V5B213	Trypanosoma cruzi	45%	98%