Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I9R2_LEIDO

TriTrypDb:

LdBPK_140120.1 , LdCL_140006100 , LDHU3_14.0150

Length:

357

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0035869	ciliary transition zone	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8I9R2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9R2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	227	229	PF00675	0.504
CLV_NRD_NRD_1	277	279	PF00675	0.615
CLV_NRD_NRD_1	293	295	PF00675	0.477
CLV_NRD_NRD_1	301	303	PF00675	0.596
CLV_NRD_NRD_1	333	335	PF00675	0.660
CLV_PCSK_FUR_1	309	313	PF00082	0.659
CLV_PCSK_KEX2_1	227	229	PF00082	0.509
CLV_PCSK_KEX2_1	293	295	PF00082	0.598
CLV_PCSK_KEX2_1	301	303	PF00082	0.593
CLV_PCSK_KEX2_1	311	313	PF00082	0.518
CLV_PCSK_KEX2_1	333	335	PF00082	0.660
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.714
DEG_SIAH_1	65	73	PF03145	0.613
DEG_SPOP_SBC_1	106	110	PF00917	0.586
DOC_CDC14_PxL_1	93	101	PF14671	0.571
DOC_CYCLIN_yCln2_LP_2	62	65	PF00134	0.626
DOC_PP2B_LxvP_1	62	65	PF13499	0.596
DOC_USP7_MATH_1	12	16	PF00917	0.641
DOC_USP7_MATH_1	32	36	PF00917	0.527
DOC_USP7_MATH_1	81	85	PF00917	0.665
DOC_WW_Pin1_4	100	105	PF00397	0.569
DOC_WW_Pin1_4	294	299	PF00397	0.678
DOC_WW_Pin1_4	302	307	PF00397	0.805
DOC_WW_Pin1_4	51	56	PF00397	0.616
LIG_14-3-3_CanoR_1	255	261	PF00244	0.537
LIG_14-3-3_CanoR_1	278	286	PF00244	0.571
LIG_14-3-3_CanoR_1	343	351	PF00244	0.606
LIG_BIR_II_1	1	5	PF00653	0.558
LIG_BRCT_BRCA1_1	204	208	PF00533	0.416
LIG_EH1_1	175	183	PF00400	0.404
LIG_eIF4E_1	176	182	PF01652	0.492
LIG_eIF4E_1	326	332	PF01652	0.641
LIG_EVH1_1	73	77	PF00568	0.636
LIG_FHA_1	106	112	PF00498	0.803
LIG_FHA_1	152	158	PF00498	0.574
LIG_FHA_1	178	184	PF00498	0.494
LIG_FHA_1	43	49	PF00498	0.579
LIG_FHA_2	220	226	PF00498	0.639
LIG_LIR_Gen_1	154	163	PF02991	0.454
LIG_LIR_Gen_1	246	257	PF02991	0.573
LIG_LIR_Gen_1	280	290	PF02991	0.471
LIG_LIR_Nem_3	135	140	PF02991	0.690
LIG_LIR_Nem_3	154	159	PF02991	0.341
LIG_LIR_Nem_3	246	252	PF02991	0.564
LIG_LIR_Nem_3	280	285	PF02991	0.468
LIG_LIR_Nem_3	346	351	PF02991	0.554
LIG_PTAP_UEV_1	57	62	PF05743	0.630
LIG_RPA_C_Fungi	223	235	PF08784	0.586
LIG_SH2_CRK	351	355	PF00017	0.627
LIG_SH2_STAP1	282	286	PF00017	0.559
LIG_SH2_STAT3	339	342	PF00017	0.574
LIG_SH2_STAT5	156	159	PF00017	0.477
LIG_SH2_STAT5	330	333	PF00017	0.542
LIG_SH3_2	262	267	PF14604	0.630
LIG_SH3_3	1	7	PF00018	0.707
LIG_SH3_3	101	107	PF00018	0.636
LIG_SH3_3	108	114	PF00018	0.724
LIG_SH3_3	125	131	PF00018	0.643
LIG_SH3_3	17	23	PF00018	0.599
LIG_SH3_3	24	30	PF00018	0.681
LIG_SH3_3	259	265	PF00018	0.701
LIG_SH3_3	317	323	PF00018	0.574
LIG_SH3_3	35	41	PF00018	0.666
LIG_SH3_3	43	49	PF00018	0.650
LIG_SH3_3	52	58	PF00018	0.598
LIG_SH3_3	61	67	PF00018	0.611
LIG_SH3_3	71	77	PF00018	0.464
LIG_SH3_3	84	90	PF00018	0.737
LIG_SH3_3	94	100	PF00018	0.713
LIG_SUMO_SIM_par_1	130	135	PF11976	0.623
LIG_TRAF2_1	158	161	PF00917	0.547
LIG_TRAF2_1	305	308	PF00917	0.605
LIG_TYR_ITSM	152	159	PF00017	0.574
MOD_CDK_SPxxK_3	294	301	PF00069	0.689
MOD_CDK_SPxxK_3	302	309	PF00069	0.636
MOD_CK1_1	15	21	PF00069	0.558
MOD_CK2_1	219	225	PF00069	0.646
MOD_CK2_1	240	246	PF00069	0.531
MOD_CK2_1	277	283	PF00069	0.492
MOD_CK2_1	302	308	PF00069	0.660
MOD_GlcNHglycan	279	282	PF01048	0.623
MOD_GlcNHglycan	32	35	PF01048	0.626
MOD_GlcNHglycan	58	61	PF01048	0.646
MOD_GlcNHglycan	83	86	PF01048	0.664
MOD_GlcNHglycan	90	93	PF01048	0.529
MOD_GSK3_1	202	209	PF00069	0.467
MOD_GSK3_1	322	329	PF00069	0.585
MOD_N-GLC_1	203	208	PF02516	0.518
MOD_N-GLC_1	326	331	PF02516	0.574
MOD_NEK2_1	151	156	PF00069	0.563
MOD_NEK2_1	208	213	PF00069	0.577
MOD_NEK2_1	277	282	PF00069	0.594
MOD_PIKK_1	208	214	PF00454	0.591
MOD_PKA_2	277	283	PF00069	0.589
MOD_Plk_1	203	209	PF00069	0.457
MOD_Plk_4	177	183	PF00069	0.416
MOD_Plk_4	219	225	PF00069	0.590
MOD_Plk_4	326	332	PF00069	0.571
MOD_Plk_4	66	72	PF00069	0.643
MOD_ProDKin_1	100	106	PF00069	0.567
MOD_ProDKin_1	294	300	PF00069	0.684
MOD_ProDKin_1	302	308	PF00069	0.807
MOD_ProDKin_1	51	57	PF00069	0.613
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.560
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.572
TRG_ENDOCYTIC_2	156	159	PF00928	0.460
TRG_ENDOCYTIC_2	282	285	PF00928	0.464
TRG_ENDOCYTIC_2	350	353	PF00928	0.607
TRG_ER_diArg_1	293	296	PF00400	0.573
TRG_ER_diArg_1	301	303	PF00400	0.681
TRG_ER_diArg_1	332	334	PF00400	0.647
TRG_Pf-PMV_PEXEL_1	155	160	PF00026	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NPB8	Trypanosomatidae	35%	74%
A4H7H3	Leishmania braziliensis	75%	100%
A4HVV4	Leishmania infantum	99%	100%
E9APK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QFX3	Leishmania major	88%	100%