DNA/RNA non-specific endonuclease-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA/RNA non-specific endonuclease-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8I9Q8_LEIDO

TriTrypDb:

LdBPK_131170.1 , LdCL_130017200 , LDHU3_13.1440

Length:

813

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005743	mitochondrial inner membrane	5	1
GO:0016020	membrane	2	2
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3Q8I9Q8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9Q8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004518	nuclease activity	4	6
GO:0004519	endonuclease activity	5	6
GO:0005488	binding	1	6
GO:0016787	hydrolase activity	2	6
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	6	1
GO:0004520	DNA endonuclease activity	5	1
GO:0004521	RNA endonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0004540	RNA nuclease activity	4	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	770	774	PF00656	0.578
CLV_NRD_NRD_1	110	112	PF00675	0.819
CLV_NRD_NRD_1	145	147	PF00675	0.764
CLV_NRD_NRD_1	160	162	PF00675	0.827
CLV_NRD_NRD_1	331	333	PF00675	0.636
CLV_NRD_NRD_1	350	352	PF00675	0.411
CLV_NRD_NRD_1	430	432	PF00675	0.773
CLV_NRD_NRD_1	45	47	PF00675	0.537
CLV_NRD_NRD_1	471	473	PF00675	0.776
CLV_NRD_NRD_1	633	635	PF00675	0.824
CLV_NRD_NRD_1	698	700	PF00675	0.759
CLV_NRD_NRD_1	717	719	PF00675	0.618
CLV_PCSK_FUR_1	329	333	PF00082	0.636
CLV_PCSK_FUR_1	714	718	PF00082	0.729
CLV_PCSK_KEX2_1	110	112	PF00082	0.819
CLV_PCSK_KEX2_1	145	147	PF00082	0.764
CLV_PCSK_KEX2_1	160	162	PF00082	0.827
CLV_PCSK_KEX2_1	228	230	PF00082	0.767
CLV_PCSK_KEX2_1	331	333	PF00082	0.636
CLV_PCSK_KEX2_1	350	352	PF00082	0.411
CLV_PCSK_KEX2_1	45	47	PF00082	0.537
CLV_PCSK_KEX2_1	471	473	PF00082	0.768
CLV_PCSK_KEX2_1	498	500	PF00082	0.846
CLV_PCSK_KEX2_1	585	587	PF00082	0.601
CLV_PCSK_KEX2_1	632	634	PF00082	0.855
CLV_PCSK_KEX2_1	698	700	PF00082	0.759
CLV_PCSK_KEX2_1	714	716	PF00082	0.653
CLV_PCSK_KEX2_1	717	719	PF00082	0.618
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.767
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.846
CLV_PCSK_PC1ET2_1	585	587	PF00082	0.601
CLV_PCSK_PC7_1	224	230	PF00082	0.693
CLV_PCSK_SKI1_1	119	123	PF00082	0.805
CLV_PCSK_SKI1_1	286	290	PF00082	0.703
CLV_PCSK_SKI1_1	335	339	PF00082	0.608
CLV_PCSK_SKI1_1	45	49	PF00082	0.537
CLV_PCSK_SKI1_1	689	693	PF00082	0.671
DEG_APCC_DBOX_1	123	131	PF00400	0.633
DEG_APCC_DBOX_1	185	193	PF00400	0.578
DEG_Nend_UBRbox_2	1	3	PF02207	0.718
DEG_SCF_FBW7_1	66	71	PF00400	0.774
DEG_SPOP_SBC_1	449	453	PF00917	0.574
DOC_ANK_TNKS_1	533	540	PF00023	0.577
DOC_ANK_TNKS_1	803	810	PF00023	0.467
DOC_CKS1_1	65	70	PF01111	0.778
DOC_CYCLIN_RxL_1	408	418	PF00134	0.380
DOC_CYCLIN_RxL_1	42	50	PF00134	0.733
DOC_CYCLIN_yCln2_LP_2	130	136	PF00134	0.622
DOC_CYCLIN_yCln2_LP_2	192	198	PF00134	0.589
DOC_MAPK_gen_1	119	129	PF00069	0.632
DOC_MAPK_gen_1	183	192	PF00069	0.572
DOC_MAPK_gen_1	329	339	PF00069	0.408
DOC_MAPK_gen_1	474	484	PF00069	0.486
DOC_MAPK_gen_1	569	577	PF00069	0.474
DOC_MAPK_gen_1	585	592	PF00069	0.400
DOC_MAPK_JIP1_4	186	192	PF00069	0.578
DOC_MAPK_MEF2A_6	290	299	PF00069	0.389
DOC_MAPK_MEF2A_6	571	579	PF00069	0.444
DOC_MAPK_MEF2A_6	780	787	PF00069	0.449
DOC_PP1_RVXF_1	208	215	PF00149	0.583
DOC_PP1_RVXF_1	333	340	PF00149	0.408
DOC_PP2B_LxvP_1	297	300	PF13499	0.482
DOC_PP2B_LxvP_1	35	38	PF13499	0.672
DOC_PP2B_LxvP_1	520	523	PF13499	0.548
DOC_PP2B_LxvP_1	656	659	PF13499	0.492
DOC_PP2B_LxvP_1	677	680	PF13499	0.488
DOC_PP4_FxxP_1	483	486	PF00568	0.570
DOC_USP7_MATH_1	152	156	PF00917	0.499
DOC_USP7_MATH_1	196	200	PF00917	0.591
DOC_USP7_MATH_1	227	231	PF00917	0.578
DOC_USP7_MATH_1	234	238	PF00917	0.516
DOC_USP7_MATH_1	25	29	PF00917	0.781
DOC_USP7_MATH_1	368	372	PF00917	0.435
DOC_USP7_MATH_1	449	453	PF00917	0.635
DOC_USP7_MATH_1	497	501	PF00917	0.571
DOC_USP7_MATH_1	510	514	PF00917	0.368
DOC_USP7_MATH_1	560	564	PF00917	0.504
DOC_USP7_MATH_1	609	613	PF00917	0.576
DOC_USP7_MATH_1	652	656	PF00917	0.507
DOC_USP7_MATH_1	68	72	PF00917	0.789
DOC_USP7_MATH_1	697	701	PF00917	0.555
DOC_USP7_MATH_1	705	709	PF00917	0.508
DOC_USP7_MATH_1	735	739	PF00917	0.426
DOC_USP7_MATH_1	75	79	PF00917	0.699
DOC_USP7_MATH_1	781	785	PF00917	0.603
DOC_WW_Pin1_4	102	107	PF00397	0.733
DOC_WW_Pin1_4	129	134	PF00397	0.627
DOC_WW_Pin1_4	191	196	PF00397	0.589
DOC_WW_Pin1_4	26	31	PF00397	0.650
DOC_WW_Pin1_4	291	296	PF00397	0.506
DOC_WW_Pin1_4	372	377	PF00397	0.380
DOC_WW_Pin1_4	4	9	PF00397	0.681
DOC_WW_Pin1_4	482	487	PF00397	0.491
DOC_WW_Pin1_4	602	607	PF00397	0.648
DOC_WW_Pin1_4	637	642	PF00397	0.662
DOC_WW_Pin1_4	64	69	PF00397	0.793
DOC_WW_Pin1_4	643	648	PF00397	0.589
DOC_WW_Pin1_4	71	76	PF00397	0.770
LIG_14-3-3_CanoR_1	114	123	PF00244	0.617
LIG_14-3-3_CanoR_1	146	156	PF00244	0.566
LIG_14-3-3_CanoR_1	301	307	PF00244	0.333
LIG_14-3-3_CanoR_1	313	317	PF00244	0.299
LIG_14-3-3_CanoR_1	335	340	PF00244	0.435
LIG_14-3-3_CanoR_1	474	484	PF00244	0.639
LIG_14-3-3_CanoR_1	596	606	PF00244	0.494
LIG_14-3-3_CanoR_1	717	727	PF00244	0.528
LIG_14-3-3_CanoR_1	788	794	PF00244	0.479
LIG_BRCT_BRCA1_1	246	250	PF00533	0.553
LIG_BRCT_BRCA1_1	479	483	PF00533	0.583
LIG_BRCT_BRCA1_1	707	711	PF00533	0.504
LIG_CSL_BTD_1	557	560	PF09270	0.513
LIG_deltaCOP1_diTrp_1	553	559	PF00928	0.541
LIG_FHA_1	157	163	PF00498	0.568
LIG_FHA_1	214	220	PF00498	0.651
LIG_FHA_1	221	227	PF00498	0.560
LIG_FHA_1	239	245	PF00498	0.450
LIG_FHA_1	434	440	PF00498	0.583
LIG_FHA_1	441	447	PF00498	0.535
LIG_FHA_1	585	591	PF00498	0.532
LIG_FHA_1	603	609	PF00498	0.498
LIG_FHA_1	690	696	PF00498	0.521
LIG_FHA_1	741	747	PF00498	0.497
LIG_FHA_1	87	93	PF00498	0.530
LIG_FHA_2	115	121	PF00498	0.575
LIG_FHA_2	206	212	PF00498	0.644
LIG_FHA_2	768	774	PF00498	0.578
LIG_HCF-1_HBM_1	50	53	PF13415	0.734
LIG_LIR_Apic_2	120	126	PF02991	0.601
LIG_LIR_Apic_2	480	486	PF02991	0.576
LIG_LIR_Apic_2	643	647	PF02991	0.542
LIG_LIR_Gen_1	31	41	PF02991	0.642
LIG_LIR_Gen_1	789	797	PF02991	0.550
LIG_LIR_LC3C_4	738	741	PF02991	0.487
LIG_LIR_Nem_3	141	147	PF02991	0.615
LIG_LIR_Nem_3	305	311	PF02991	0.338
LIG_LIR_Nem_3	31	36	PF02991	0.723
LIG_LIR_Nem_3	315	320	PF02991	0.311
LIG_LIR_Nem_3	660	666	PF02991	0.455
LIG_LIR_Nem_3	789	794	PF02991	0.554
LIG_PAM2_1	129	141	PF00658	0.564
LIG_PCNA_yPIPBox_3	393	403	PF02747	0.427
LIG_Pex14_1	317	321	PF04695	0.435
LIG_Pex14_2	663	667	PF04695	0.454
LIG_REV1ctd_RIR_1	337	347	PF16727	0.435
LIG_RPA_C_Fungi	694	706	PF08784	0.532
LIG_SH2_CRK	123	127	PF00017	0.763
LIG_SH2_CRK	308	312	PF00017	0.530
LIG_SH2_NCK_1	308	312	PF00017	0.530
LIG_SH2_SRC	308	311	PF00017	0.530
LIG_SH2_STAT3	410	413	PF00017	0.433
LIG_SH2_STAT5	116	119	PF00017	0.726
LIG_SH2_STAT5	321	324	PF00017	0.530
LIG_SH2_STAT5	410	413	PF00017	0.530
LIG_SH2_STAT5	53	56	PF00017	0.713
LIG_SH3_2	77	82	PF14604	0.770
LIG_SH3_3	2	8	PF00018	0.804
LIG_SH3_3	24	30	PF00018	0.660
LIG_SH3_3	613	619	PF00018	0.674
LIG_SH3_3	644	650	PF00018	0.766
LIG_SH3_3	677	683	PF00018	0.614
LIG_SH3_3	74	80	PF00018	0.746
LIG_SUMO_SIM_par_1	742	747	PF11976	0.582
LIG_SUMO_SIM_par_1	752	759	PF11976	0.479
LIG_TRFH_1	33	37	PF08558	0.645
LIG_TRFH_1	791	795	PF08558	0.671
LIG_TYR_ITIM	306	311	PF00017	0.530
LIG_WW_3	460	464	PF00397	0.747
MOD_CDC14_SPxK_1	194	197	PF00782	0.704
MOD_CDC14_SPxK_1	485	488	PF00782	0.712
MOD_CDK_SPxK_1	191	197	PF00069	0.706
MOD_CDK_SPxK_1	482	488	PF00069	0.779
MOD_CK1_1	14	20	PF00069	0.699
MOD_CK1_1	185	191	PF00069	0.801
MOD_CK1_1	199	205	PF00069	0.602
MOD_CK1_1	237	243	PF00069	0.600
MOD_CK1_1	28	34	PF00069	0.639
MOD_CK1_1	478	484	PF00069	0.631
MOD_CK1_1	500	506	PF00069	0.670
MOD_CK1_1	599	605	PF00069	0.612
MOD_CK1_1	640	646	PF00069	0.850
MOD_CK1_1	70	76	PF00069	0.819
MOD_CK1_1	710	716	PF00069	0.654
MOD_CK1_1	725	731	PF00069	0.466
MOD_CK1_1	771	777	PF00069	0.797
MOD_CK2_1	114	120	PF00069	0.802
MOD_CK2_1	152	158	PF00069	0.676
MOD_CK2_1	205	211	PF00069	0.835
MOD_CK2_1	442	448	PF00069	0.810
MOD_CK2_1	739	745	PF00069	0.570
MOD_CK2_1	750	756	PF00069	0.463
MOD_CMANNOS	554	557	PF00535	0.753
MOD_Cter_Amidation	469	472	PF01082	0.638
MOD_GlcNHglycan	150	153	PF01048	0.611
MOD_GlcNHglycan	202	205	PF01048	0.758
MOD_GlcNHglycan	229	232	PF01048	0.715
MOD_GlcNHglycan	246	249	PF01048	0.511
MOD_GlcNHglycan	275	278	PF01048	0.778
MOD_GlcNHglycan	286	289	PF01048	0.631
MOD_GlcNHglycan	477	480	PF01048	0.750
MOD_GlcNHglycan	502	505	PF01048	0.656
MOD_GlcNHglycan	526	529	PF01048	0.775
MOD_GlcNHglycan	562	565	PF01048	0.741
MOD_GlcNHglycan	762	765	PF01048	0.660
MOD_GSK3_1	102	109	PF00069	0.772
MOD_GSK3_1	11	18	PF00069	0.713
MOD_GSK3_1	148	155	PF00069	0.711
MOD_GSK3_1	196	203	PF00069	0.810
MOD_GSK3_1	234	241	PF00069	0.698
MOD_GSK3_1	244	251	PF00069	0.576
MOD_GSK3_1	275	282	PF00069	0.793
MOD_GSK3_1	341	348	PF00069	0.471
MOD_GSK3_1	368	375	PF00069	0.530
MOD_GSK3_1	440	447	PF00069	0.776
MOD_GSK3_1	478	485	PF00069	0.675
MOD_GSK3_1	524	531	PF00069	0.698
MOD_GSK3_1	591	598	PF00069	0.788
MOD_GSK3_1	64	71	PF00069	0.823
MOD_GSK3_1	718	725	PF00069	0.763
MOD_GSK3_1	731	738	PF00069	0.486
MOD_GSK3_1	756	763	PF00069	0.626
MOD_GSK3_1	764	771	PF00069	0.645
MOD_LATS_1	198	204	PF00433	0.833
MOD_N-GLC_2	334	336	PF02516	0.413
MOD_NEK2_1	147	152	PF00069	0.707
MOD_NEK2_1	244	249	PF00069	0.697
MOD_NEK2_1	345	350	PF00069	0.530
MOD_NEK2_1	662	667	PF00069	0.555
MOD_NEK2_1	739	744	PF00069	0.583
MOD_NEK2_1	750	755	PF00069	0.395
MOD_NEK2_1	83	88	PF00069	0.456
MOD_NEK2_2	652	657	PF00069	0.508
MOD_PIKK_1	114	120	PF00454	0.802
MOD_PIKK_1	450	456	PF00454	0.844
MOD_PIKK_1	75	81	PF00454	0.706
MOD_PKA_1	431	437	PF00069	0.631
MOD_PKA_1	498	504	PF00069	0.750
MOD_PKA_1	698	704	PF00069	0.647
MOD_PKA_2	182	188	PF00069	0.789
MOD_PKA_2	196	202	PF00069	0.598
MOD_PKA_2	205	211	PF00069	0.692
MOD_PKA_2	237	243	PF00069	0.572
MOD_PKA_2	253	259	PF00069	0.472
MOD_PKA_2	312	318	PF00069	0.502
MOD_PKA_2	323	329	PF00069	0.307
MOD_PKA_2	498	504	PF00069	0.706
MOD_PKA_2	510	516	PF00069	0.505
MOD_PKA_2	595	601	PF00069	0.708
MOD_PKA_2	697	703	PF00069	0.710
MOD_PKA_2	719	725	PF00069	0.663
MOD_PKA_2	771	777	PF00069	0.797
MOD_PKB_1	429	437	PF00069	0.628
MOD_PKB_1	716	724	PF00069	0.666
MOD_PKB_1	758	766	PF00069	0.672
MOD_Plk_1	341	347	PF00069	0.530
MOD_Plk_4	138	144	PF00069	0.697
MOD_Plk_4	185	191	PF00069	0.801
MOD_Plk_4	28	34	PF00069	0.690
MOD_Plk_4	312	318	PF00069	0.394
MOD_Plk_4	478	484	PF00069	0.600
MOD_Plk_4	652	658	PF00069	0.680
MOD_Plk_4	750	756	PF00069	0.602
MOD_ProDKin_1	102	108	PF00069	0.733
MOD_ProDKin_1	129	135	PF00069	0.796
MOD_ProDKin_1	191	197	PF00069	0.744
MOD_ProDKin_1	26	32	PF00069	0.549
MOD_ProDKin_1	291	297	PF00069	0.613
MOD_ProDKin_1	372	378	PF00069	0.452
MOD_ProDKin_1	4	10	PF00069	0.595
MOD_ProDKin_1	482	488	PF00069	0.608
MOD_ProDKin_1	602	608	PF00069	0.828
MOD_ProDKin_1	637	643	PF00069	0.850
MOD_ProDKin_1	64	70	PF00069	0.753
MOD_ProDKin_1	71	77	PF00069	0.711
TRG_DiLeu_BaEn_1	673	678	PF01217	0.607
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.672
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.742
TRG_DiLeu_BaLyEn_6	515	520	PF01217	0.621
TRG_DiLeu_BaLyEn_6	616	621	PF01217	0.660
TRG_ENDOCYTIC_2	308	311	PF00928	0.530
TRG_ER_diArg_1	144	146	PF00400	0.707
TRG_ER_diArg_1	160	162	PF00400	0.797
TRG_ER_diArg_1	329	332	PF00400	0.530
TRG_ER_diArg_1	350	352	PF00400	0.526
TRG_ER_diArg_1	45	47	PF00400	0.672
TRG_ER_diArg_1	471	474	PF00400	0.756
TRG_ER_diArg_1	624	627	PF00400	0.648
TRG_ER_diArg_1	632	634	PF00400	0.694
TRG_ER_diArg_1	714	717	PF00400	0.682
TRG_ER_diArg_1	757	760	PF00400	0.607
TRG_ER_diArg_1	797	800	PF00400	0.730
TRG_NES_CRM1_1	730	745	PF08389	0.548
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.700
TRG_Pf-PMV_PEXEL_1	45	50	PF00026	0.748
TRG_Pf-PMV_PEXEL_1	507	512	PF00026	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H7B0	Leishmania braziliensis	65%	100%
A4HVQ5	Leishmania infantum	100%	100%
E9APF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QG27	Leishmania major	87%	100%