Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I9Q1_LEIDO

TriTrypDb:

LdBPK_131340.1 , LdCL_130020700 , LDHU3_13.1850

Length:

1204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8I9Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9Q1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.516
CLV_C14_Caspase3-7	538	542	PF00656	0.444
CLV_C14_Caspase3-7	761	765	PF00656	0.424
CLV_C14_Caspase3-7	809	813	PF00656	0.411
CLV_C14_Caspase3-7	992	996	PF00656	0.466
CLV_NRD_NRD_1	1193	1195	PF00675	0.476
CLV_NRD_NRD_1	180	182	PF00675	0.678
CLV_NRD_NRD_1	269	271	PF00675	0.720
CLV_NRD_NRD_1	391	393	PF00675	0.708
CLV_NRD_NRD_1	698	700	PF00675	0.723
CLV_NRD_NRD_1	874	876	PF00675	0.587
CLV_PCSK_FUR_1	872	876	PF00082	0.593
CLV_PCSK_KEX2_1	1044	1046	PF00082	0.727
CLV_PCSK_KEX2_1	180	182	PF00082	0.694
CLV_PCSK_KEX2_1	269	271	PF00082	0.720
CLV_PCSK_KEX2_1	391	393	PF00082	0.708
CLV_PCSK_KEX2_1	698	700	PF00082	0.723
CLV_PCSK_KEX2_1	874	876	PF00082	0.587
CLV_PCSK_PC1ET2_1	1044	1046	PF00082	0.684
CLV_PCSK_PC7_1	870	876	PF00082	0.652
CLV_PCSK_SKI1_1	180	184	PF00082	0.731
CLV_PCSK_SKI1_1	270	274	PF00082	0.716
CLV_PCSK_SKI1_1	278	282	PF00082	0.661
CLV_PCSK_SKI1_1	335	339	PF00082	0.629
CLV_PCSK_SKI1_1	656	660	PF00082	0.677
CLV_PCSK_SKI1_1	866	870	PF00082	0.694
CLV_PCSK_SKI1_1	874	878	PF00082	0.626
DEG_APCC_DBOX_1	334	342	PF00400	0.425
DEG_APCC_DBOX_1	741	749	PF00400	0.516
DEG_APCC_DBOX_1	780	788	PF00400	0.497
DEG_APCC_DBOX_1	869	877	PF00400	0.499
DEG_SPOP_SBC_1	1077	1081	PF00917	0.441
DEG_SPOP_SBC_1	147	151	PF00917	0.625
DEG_SPOP_SBC_1	33	37	PF00917	0.458
DOC_CKS1_1	558	563	PF01111	0.457
DOC_CYCLIN_yClb5_NLxxxL_5	219	227	PF00134	0.466
DOC_MAPK_gen_1	79	88	PF00069	0.515
DOC_MAPK_MEF2A_6	491	499	PF00069	0.538
DOC_USP7_MATH_1	1018	1022	PF00917	0.520
DOC_USP7_MATH_1	115	119	PF00917	0.538
DOC_USP7_MATH_1	1158	1162	PF00917	0.644
DOC_USP7_MATH_1	1180	1184	PF00917	0.726
DOC_USP7_MATH_1	17	21	PF00917	0.596
DOC_USP7_MATH_1	193	197	PF00917	0.502
DOC_USP7_MATH_1	235	239	PF00917	0.475
DOC_USP7_MATH_1	244	248	PF00917	0.470
DOC_USP7_MATH_1	260	264	PF00917	0.468
DOC_USP7_MATH_1	309	313	PF00917	0.456
DOC_USP7_MATH_1	396	400	PF00917	0.470
DOC_USP7_MATH_1	434	438	PF00917	0.486
DOC_USP7_MATH_1	458	462	PF00917	0.488
DOC_USP7_MATH_1	711	715	PF00917	0.576
DOC_USP7_MATH_1	737	741	PF00917	0.440
DOC_USP7_MATH_1	966	970	PF00917	0.503
DOC_USP7_MATH_2	1160	1166	PF00917	0.706
DOC_USP7_UBL2_3	1191	1195	PF12436	0.672
DOC_USP7_UBL2_3	277	281	PF12436	0.450
DOC_WW_Pin1_4	109	114	PF00397	0.570
DOC_WW_Pin1_4	117	122	PF00397	0.549
DOC_WW_Pin1_4	150	155	PF00397	0.491
DOC_WW_Pin1_4	361	366	PF00397	0.506
DOC_WW_Pin1_4	367	372	PF00397	0.556
DOC_WW_Pin1_4	486	491	PF00397	0.457
DOC_WW_Pin1_4	557	562	PF00397	0.580
DOC_WW_Pin1_4	591	596	PF00397	0.498
DOC_WW_Pin1_4	597	602	PF00397	0.426
DOC_WW_Pin1_4	681	686	PF00397	0.495
DOC_WW_Pin1_4	7	12	PF00397	0.485
DOC_WW_Pin1_4	845	850	PF00397	0.471
LIG_14-3-3_CanoR_1	1113	1121	PF00244	0.458
LIG_14-3-3_CanoR_1	25	31	PF00244	0.491
LIG_14-3-3_CanoR_1	269	279	PF00244	0.443
LIG_14-3-3_CanoR_1	353	357	PF00244	0.496
LIG_14-3-3_CanoR_1	537	544	PF00244	0.513
LIG_14-3-3_CanoR_1	752	757	PF00244	0.482
LIG_14-3-3_CanoR_1	772	780	PF00244	0.368
LIG_14-3-3_CanoR_1	781	791	PF00244	0.420
LIG_14-3-3_CanoR_1	864	873	PF00244	0.421
LIG_14-3-3_CanoR_1	874	883	PF00244	0.419
LIG_Actin_WH2_2	254	271	PF00022	0.435
LIG_Actin_WH2_2	337	355	PF00022	0.520
LIG_Actin_WH2_2	435	452	PF00022	0.554
LIG_Actin_WH2_2	84	101	PF00022	0.431
LIG_AP2alpha_1	749	753	PF02296	0.477
LIG_APCC_ABBA_1	401	406	PF00400	0.489
LIG_BRCT_BRCA1_1	723	727	PF00533	0.487
LIG_DLG_GKlike_1	752	760	PF00625	0.413
LIG_eIF4E_1	1147	1153	PF01652	0.335
LIG_FHA_1	1097	1103	PF00498	0.447
LIG_FHA_1	1109	1115	PF00498	0.475
LIG_FHA_1	1120	1126	PF00498	0.480
LIG_FHA_1	181	187	PF00498	0.501
LIG_FHA_1	201	207	PF00498	0.476
LIG_FHA_1	263	269	PF00498	0.437
LIG_FHA_1	271	277	PF00498	0.436
LIG_FHA_1	382	388	PF00498	0.468
LIG_FHA_1	422	428	PF00498	0.569
LIG_FHA_1	479	485	PF00498	0.496
LIG_FHA_1	563	569	PF00498	0.504
LIG_FHA_1	571	577	PF00498	0.423
LIG_FHA_1	592	598	PF00498	0.586
LIG_FHA_1	634	640	PF00498	0.488
LIG_FHA_1	708	714	PF00498	0.549
LIG_FHA_1	755	761	PF00498	0.471
LIG_FHA_1	8	14	PF00498	0.564
LIG_FHA_1	819	825	PF00498	0.501
LIG_FHA_1	875	881	PF00498	0.426
LIG_FHA_2	1105	1111	PF00498	0.559
LIG_FHA_2	1179	1185	PF00498	0.765
LIG_FHA_2	283	289	PF00498	0.574
LIG_FHA_2	293	299	PF00498	0.441
LIG_FHA_2	35	41	PF00498	0.455
LIG_FHA_2	439	445	PF00498	0.549
LIG_FHA_2	536	542	PF00498	0.508
LIG_FHA_2	570	576	PF00498	0.475
LIG_FHA_2	686	692	PF00498	0.475
LIG_FHA_2	73	79	PF00498	0.441
LIG_FHA_2	774	780	PF00498	0.453
LIG_GBD_Chelix_1	525	533	PF00786	0.738
LIG_LIR_Gen_1	29	34	PF02991	0.527
LIG_LIR_Gen_1	489	499	PF02991	0.452
LIG_LIR_Gen_1	751	760	PF02991	0.470
LIG_LIR_Gen_1	82	91	PF02991	0.487
LIG_LIR_Nem_3	1144	1149	PF02991	0.336
LIG_LIR_Nem_3	29	33	PF02991	0.532
LIG_LIR_Nem_3	304	310	PF02991	0.533
LIG_LIR_Nem_3	489	495	PF02991	0.451
LIG_LIR_Nem_3	600	606	PF02991	0.441
LIG_LIR_Nem_3	751	756	PF02991	0.474
LIG_LIR_Nem_3	82	86	PF02991	0.492
LIG_PCNA_yPIPBox_3	179	189	PF02747	0.495
LIG_Pex14_2	749	753	PF04695	0.477
LIG_SH2_PTP2	30	33	PF00017	0.531
LIG_SH2_SRC	30	33	PF00017	0.531
LIG_SH2_SRC	605	608	PF00017	0.437
LIG_SH2_STAP1	18	22	PF00017	0.582
LIG_SH2_STAP1	76	80	PF00017	0.529
LIG_SH2_STAT5	1147	1150	PF00017	0.336
LIG_SH2_STAT5	1199	1202	PF00017	0.694
LIG_SH2_STAT5	30	33	PF00017	0.531
LIG_SH2_STAT5	605	608	PF00017	0.437
LIG_SH3_1	8	14	PF00018	0.564
LIG_SH3_3	1154	1160	PF00018	0.547
LIG_SH3_3	468	474	PF00018	0.577
LIG_SH3_3	484	490	PF00018	0.454
LIG_SH3_3	663	669	PF00018	0.617
LIG_SH3_3	8	14	PF00018	0.480
LIG_SUMO_SIM_anti_2	29	38	PF11976	0.511
LIG_SUMO_SIM_anti_2	48	54	PF11976	0.523
LIG_SUMO_SIM_par_1	1139	1144	PF11976	0.305
LIG_TRAF2_1	1101	1104	PF00917	0.543
LIG_TRAF2_1	1160	1163	PF00917	0.651
LIG_TRAF2_1	252	255	PF00917	0.521
LIG_TRAF2_1	340	343	PF00917	0.464
LIG_TRAF2_1	378	381	PF00917	0.422
LIG_TRAF2_1	441	444	PF00917	0.528
LIG_TRAF2_1	549	552	PF00917	0.474
LIG_TRAF2_1	618	621	PF00917	0.452
LIG_TRAF2_1	830	833	PF00917	0.524
LIG_TRAF2_1	834	837	PF00917	0.490
LIG_UBA3_1	400	405	PF00899	0.532
LIG_WRC_WIRS_1	1047	1052	PF05994	0.475
LIG_WRC_WIRS_1	609	614	PF05994	0.502
LIG_WRC_WIRS_1	80	85	PF05994	0.618
MOD_CDK_SPK_2	486	491	PF00069	0.556
MOD_CDK_SPxxK_3	597	604	PF00069	0.551
MOD_CK1_1	1096	1102	PF00069	0.671
MOD_CK1_1	1108	1114	PF00069	0.564
MOD_CK1_1	148	154	PF00069	0.725
MOD_CK1_1	256	262	PF00069	0.686
MOD_CK1_1	282	288	PF00069	0.611
MOD_CK1_1	312	318	PF00069	0.691
MOD_CK1_1	354	360	PF00069	0.671
MOD_CK1_1	363	369	PF00069	0.648
MOD_CK1_1	395	401	PF00069	0.545
MOD_CK1_1	437	443	PF00069	0.705
MOD_CK1_1	520	526	PF00069	0.668
MOD_CK1_1	539	545	PF00069	0.455
MOD_CK1_1	557	563	PF00069	0.655
MOD_CK1_1	608	614	PF00069	0.512
MOD_CK1_1	715	721	PF00069	0.580
MOD_CK1_1	790	796	PF00069	0.647
MOD_CK1_1	885	891	PF00069	0.579
MOD_CK2_1	1020	1026	PF00069	0.632
MOD_CK2_1	1037	1043	PF00069	0.488
MOD_CK2_1	1178	1184	PF00069	0.670
MOD_CK2_1	162	168	PF00069	0.636
MOD_CK2_1	282	288	PF00069	0.630
MOD_CK2_1	32	38	PF00069	0.574
MOD_CK2_1	438	444	PF00069	0.636
MOD_CK2_1	569	575	PF00069	0.591
MOD_CK2_1	615	621	PF00069	0.555
MOD_CK2_1	627	633	PF00069	0.592
MOD_CK2_1	685	691	PF00069	0.559
MOD_CK2_1	773	779	PF00069	0.586
MOD_CK2_1	79	85	PF00069	0.621
MOD_CK2_1	808	814	PF00069	0.671
MOD_GlcNHglycan	1022	1025	PF01048	0.646
MOD_GlcNHglycan	1039	1042	PF01048	0.493
MOD_GlcNHglycan	1065	1068	PF01048	0.443
MOD_GlcNHglycan	1080	1083	PF01048	0.577
MOD_GlcNHglycan	1099	1102	PF01048	0.673
MOD_GlcNHglycan	113	116	PF01048	0.746
MOD_GlcNHglycan	1162	1167	PF01048	0.639
MOD_GlcNHglycan	1172	1175	PF01048	0.577
MOD_GlcNHglycan	133	136	PF01048	0.446
MOD_GlcNHglycan	195	198	PF01048	0.691
MOD_GlcNHglycan	237	240	PF01048	0.595
MOD_GlcNHglycan	258	261	PF01048	0.647
MOD_GlcNHglycan	262	265	PF01048	0.537
MOD_GlcNHglycan	284	288	PF01048	0.597
MOD_GlcNHglycan	372	375	PF01048	0.597
MOD_GlcNHglycan	393	397	PF01048	0.648
MOD_GlcNHglycan	436	439	PF01048	0.595
MOD_GlcNHglycan	456	459	PF01048	0.448
MOD_GlcNHglycan	460	463	PF01048	0.606
MOD_GlcNHglycan	538	541	PF01048	0.582
MOD_GlcNHglycan	728	731	PF01048	0.646
MOD_GlcNHglycan	776	779	PF01048	0.532
MOD_GlcNHglycan	890	893	PF01048	0.569
MOD_GlcNHglycan	919	923	PF01048	0.552
MOD_GlcNHglycan	981	984	PF01048	0.575
MOD_GSK3_1	1026	1033	PF00069	0.559
MOD_GSK3_1	1057	1064	PF00069	0.522
MOD_GSK3_1	1068	1075	PF00069	0.493
MOD_GSK3_1	109	116	PF00069	0.692
MOD_GSK3_1	1093	1100	PF00069	0.671
MOD_GSK3_1	1104	1111	PF00069	0.582
MOD_GSK3_1	1115	1122	PF00069	0.609
MOD_GSK3_1	1158	1165	PF00069	0.626
MOD_GSK3_1	142	149	PF00069	0.818
MOD_GSK3_1	150	157	PF00069	0.723
MOD_GSK3_1	256	263	PF00069	0.533
MOD_GSK3_1	279	286	PF00069	0.541
MOD_GSK3_1	351	358	PF00069	0.619
MOD_GSK3_1	363	370	PF00069	0.558
MOD_GSK3_1	392	399	PF00069	0.591
MOD_GSK3_1	417	424	PF00069	0.572
MOD_GSK3_1	434	441	PF00069	0.584
MOD_GSK3_1	454	461	PF00069	0.489
MOD_GSK3_1	517	524	PF00069	0.548
MOD_GSK3_1	535	542	PF00069	0.580
MOD_GSK3_1	615	622	PF00069	0.557
MOD_GSK3_1	627	634	PF00069	0.599
MOD_GSK3_1	681	688	PF00069	0.643
MOD_GSK3_1	707	714	PF00069	0.575
MOD_GSK3_1	737	744	PF00069	0.506
MOD_GSK3_1	752	759	PF00069	0.679
MOD_GSK3_1	783	790	PF00069	0.567
MOD_GSK3_1	874	881	PF00069	0.642
MOD_GSK3_1	979	986	PF00069	0.564
MOD_N-GLC_1	1037	1042	PF02516	0.583
MOD_N-GLC_1	597	602	PF02516	0.670
MOD_N-GLC_1	622	627	PF02516	0.681
MOD_N-GLC_1	979	984	PF02516	0.553
MOD_NEK2_1	1114	1119	PF00069	0.588
MOD_NEK2_1	167	172	PF00069	0.677
MOD_NEK2_1	268	273	PF00069	0.607
MOD_NEK2_1	352	357	PF00069	0.669
MOD_NEK2_1	619	624	PF00069	0.640
MOD_NEK2_1	631	636	PF00069	0.502
MOD_NEK2_1	72	77	PF00069	0.587
MOD_NEK2_1	806	811	PF00069	0.731
MOD_NEK2_1	994	999	PF00069	0.529
MOD_PIKK_1	1000	1006	PF00454	0.602
MOD_PIKK_1	1010	1016	PF00454	0.544
MOD_PIKK_1	1105	1111	PF00454	0.670
MOD_PIKK_1	310	316	PF00454	0.552
MOD_PIKK_1	473	479	PF00454	0.731
MOD_PIKK_1	539	545	PF00454	0.681
MOD_PIKK_1	586	592	PF00454	0.646
MOD_PIKK_1	754	760	PF00454	0.607
MOD_PIKK_1	874	880	PF00454	0.507
MOD_PIKK_1	951	957	PF00454	0.647
MOD_PK_1	1086	1092	PF00069	0.582
MOD_PKA_1	180	186	PF00069	0.674
MOD_PKA_1	874	880	PF00069	0.484
MOD_PKA_2	1010	1016	PF00069	0.666
MOD_PKA_2	1096	1102	PF00069	0.671
MOD_PKA_2	180	186	PF00069	0.634
MOD_PKA_2	235	241	PF00069	0.709
MOD_PKA_2	268	274	PF00069	0.653
MOD_PKA_2	352	358	PF00069	0.675
MOD_PKA_2	536	542	PF00069	0.637
MOD_PKA_2	649	655	PF00069	0.689
MOD_PKA_2	741	747	PF00069	0.646
MOD_PKA_2	751	757	PF00069	0.513
MOD_PKA_2	771	777	PF00069	0.442
MOD_PKA_2	806	812	PF00069	0.656
MOD_PKA_2	874	880	PF00069	0.484
MOD_PKB_1	864	872	PF00069	0.632
MOD_Plk_1	1054	1060	PF00069	0.497
MOD_Plk_1	253	259	PF00069	0.672
MOD_Plk_1	493	499	PF00069	0.677
MOD_Plk_1	615	621	PF00069	0.555
MOD_Plk_1	711	717	PF00069	0.556
MOD_Plk_1	994	1000	PF00069	0.532
MOD_Plk_2-3	575	581	PF00069	0.638
MOD_Plk_2-3	615	621	PF00069	0.555
MOD_Plk_2-3	808	814	PF00069	0.502
MOD_Plk_4	1068	1074	PF00069	0.664
MOD_Plk_4	1141	1147	PF00069	0.319
MOD_Plk_4	26	32	PF00069	0.676
MOD_Plk_4	396	402	PF00069	0.543
MOD_Plk_4	605	611	PF00069	0.534
MOD_Plk_4	712	718	PF00069	0.549
MOD_Plk_4	929	935	PF00069	0.579
MOD_Plk_4	966	972	PF00069	0.631
MOD_Plk_4	994	1000	PF00069	0.532
MOD_ProDKin_1	109	115	PF00069	0.726
MOD_ProDKin_1	117	123	PF00069	0.690
MOD_ProDKin_1	150	156	PF00069	0.609
MOD_ProDKin_1	361	367	PF00069	0.639
MOD_ProDKin_1	486	492	PF00069	0.568
MOD_ProDKin_1	557	563	PF00069	0.735
MOD_ProDKin_1	591	597	PF00069	0.622
MOD_ProDKin_1	681	687	PF00069	0.617
MOD_ProDKin_1	7	13	PF00069	0.606
MOD_ProDKin_1	845	851	PF00069	0.580
MOD_SUMO_for_1	1052	1055	PF00179	0.575
MOD_SUMO_for_1	544	547	PF00179	0.658
MOD_SUMO_for_1	613	616	PF00179	0.548
MOD_SUMO_rev_2	1021	1030	PF00179	0.612
MOD_SUMO_rev_2	1066	1072	PF00179	0.535
MOD_SUMO_rev_2	274	279	PF00179	0.531
TRG_DiLeu_BaEn_1	912	917	PF01217	0.570
TRG_DiLeu_BaLyEn_6	1042	1047	PF01217	0.667
TRG_ENDOCYTIC_2	1146	1149	PF00928	0.337
TRG_ENDOCYTIC_2	30	33	PF00928	0.670
TRG_ENDOCYTIC_2	603	606	PF00928	0.544
TRG_ER_diArg_1	180	182	PF00400	0.623
TRG_ER_diArg_1	268	270	PF00400	0.647
TRG_ER_diArg_1	390	392	PF00400	0.640
TRG_ER_diArg_1	697	699	PF00400	0.669
TRG_ER_diArg_1	872	875	PF00400	0.485
TRG_NES_CRM1_1	48	62	PF08389	0.547
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.661
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	698	702	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	907	911	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P568	Leptomonas seymouri	44%	88%
A4H7F0	Leishmania braziliensis	74%	100%
A4HVT8	Leishmania infantum	99%	100%
E9API4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QFZ4	Leishmania major	90%	100%