Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I9N0_LEIDO

TriTrypDb:

LdBPK_131190.1 , LdCL_130017400 , LDHU3_13.1470

Length:

928

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I9N0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9N0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.636
CLV_C14_Caspase3-7	621	625	PF00656	0.496
CLV_C14_Caspase3-7	784	788	PF00656	0.576
CLV_NRD_NRD_1	264	266	PF00675	0.728
CLV_NRD_NRD_1	298	300	PF00675	0.663
CLV_NRD_NRD_1	519	521	PF00675	0.561
CLV_NRD_NRD_1	576	578	PF00675	0.727
CLV_NRD_NRD_1	583	585	PF00675	0.706
CLV_PCSK_FUR_1	262	266	PF00082	0.831
CLV_PCSK_KEX2_1	261	263	PF00082	0.689
CLV_PCSK_KEX2_1	264	266	PF00082	0.661
CLV_PCSK_KEX2_1	298	300	PF00082	0.663
CLV_PCSK_KEX2_1	519	521	PF00082	0.561
CLV_PCSK_KEX2_1	583	585	PF00082	0.854
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.688
CLV_PCSK_SKI1_1	449	453	PF00082	0.564
CLV_PCSK_SKI1_1	620	624	PF00082	0.506
CLV_PCSK_SKI1_1	680	684	PF00082	0.478
CLV_PCSK_SKI1_1	69	73	PF00082	0.759
CLV_PCSK_SKI1_1	7	11	PF00082	0.747
CLV_PCSK_SKI1_1	856	860	PF00082	0.406
DEG_APCC_DBOX_1	448	456	PF00400	0.565
DEG_APCC_DBOX_1	619	627	PF00400	0.521
DEG_SPOP_SBC_1	100	104	PF00917	0.797
DEG_SPOP_SBC_1	303	307	PF00917	0.757
DEG_SPOP_SBC_1	415	419	PF00917	0.641
DEG_SPOP_SBC_1	58	62	PF00917	0.726
DEG_SPOP_SBC_1	719	723	PF00917	0.727
DEG_SPOP_SBC_1	760	764	PF00917	0.708
DOC_ANK_TNKS_1	149	156	PF00023	0.630
DOC_ANK_TNKS_1	768	775	PF00023	0.819
DOC_CKS1_1	765	770	PF01111	0.779
DOC_CYCLIN_RxL_1	156	166	PF00134	0.709
DOC_MAPK_gen_1	43	51	PF00069	0.748
DOC_MAPK_MEF2A_6	449	456	PF00069	0.565
DOC_MAPK_NFAT4_5	449	457	PF00069	0.564
DOC_PP2B_LxvP_1	161	164	PF13499	0.636
DOC_PP2B_LxvP_1	593	596	PF13499	0.629
DOC_PP4_FxxP_1	143	146	PF00568	0.752
DOC_PP4_FxxP_1	498	501	PF00568	0.587
DOC_USP7_MATH_1	100	104	PF00917	0.797
DOC_USP7_MATH_1	12	16	PF00917	0.833
DOC_USP7_MATH_1	120	124	PF00917	0.542
DOC_USP7_MATH_1	218	222	PF00917	0.819
DOC_USP7_MATH_1	301	305	PF00917	0.777
DOC_USP7_MATH_1	322	326	PF00917	0.652
DOC_USP7_MATH_1	354	358	PF00917	0.664
DOC_USP7_MATH_1	410	414	PF00917	0.741
DOC_USP7_MATH_1	415	419	PF00917	0.668
DOC_USP7_MATH_1	434	438	PF00917	0.689
DOC_USP7_MATH_1	439	443	PF00917	0.630
DOC_USP7_MATH_1	505	509	PF00917	0.642
DOC_USP7_MATH_1	58	62	PF00917	0.797
DOC_USP7_MATH_1	758	762	PF00917	0.728
DOC_USP7_MATH_1	776	780	PF00917	0.746
DOC_USP7_MATH_1	871	875	PF00917	0.475
DOC_WW_Pin1_4	167	172	PF00397	0.742
DOC_WW_Pin1_4	24	29	PF00397	0.745
DOC_WW_Pin1_4	299	304	PF00397	0.699
DOC_WW_Pin1_4	312	317	PF00397	0.735
DOC_WW_Pin1_4	339	344	PF00397	0.698
DOC_WW_Pin1_4	497	502	PF00397	0.671
DOC_WW_Pin1_4	568	573	PF00397	0.724
DOC_WW_Pin1_4	64	69	PF00397	0.794
DOC_WW_Pin1_4	685	690	PF00397	0.593
DOC_WW_Pin1_4	727	732	PF00397	0.779
DOC_WW_Pin1_4	764	769	PF00397	0.817
DOC_WW_Pin1_4	772	777	PF00397	0.645
DOC_WW_Pin1_4	843	848	PF00397	0.717
DOC_WW_Pin1_4	89	94	PF00397	0.741
LIG_14-3-3_CanoR_1	150	156	PF00244	0.668
LIG_14-3-3_CanoR_1	21	28	PF00244	0.615
LIG_14-3-3_CanoR_1	268	277	PF00244	0.756
LIG_14-3-3_CanoR_1	280	284	PF00244	0.586
LIG_14-3-3_CanoR_1	492	498	PF00244	0.691
LIG_14-3-3_CanoR_1	648	657	PF00244	0.665
LIG_14-3-3_CanoR_1	680	686	PF00244	0.454
LIG_14-3-3_CanoR_1	836	845	PF00244	0.702
LIG_14-3-3_CanoR_1	868	874	PF00244	0.441
LIG_14-3-3_CanoR_1	899	903	PF00244	0.490
LIG_Actin_WH2_2	888	906	PF00022	0.597
LIG_BIR_II_1	1	5	PF00653	0.663
LIG_BIR_III_3	1	5	PF00653	0.663
LIG_BRCT_BRCA1_1	341	345	PF00533	0.708
LIG_BRCT_BRCA1_1	478	482	PF00533	0.695
LIG_BRCT_BRCA1_1	493	497	PF00533	0.511
LIG_BRCT_BRCA1_1	507	511	PF00533	0.663
LIG_Clathr_ClatBox_1	453	457	PF01394	0.563
LIG_Clathr_ClatBox_1	699	703	PF01394	0.454
LIG_deltaCOP1_diTrp_1	543	551	PF00928	0.477
LIG_EVH1_1	498	502	PF00568	0.546
LIG_FHA_1	223	229	PF00498	0.707
LIG_FHA_1	319	325	PF00498	0.789
LIG_FHA_1	371	377	PF00498	0.738
LIG_FHA_1	417	423	PF00498	0.727
LIG_FHA_1	433	439	PF00498	0.743
LIG_FHA_1	550	556	PF00498	0.583
LIG_FHA_1	562	568	PF00498	0.608
LIG_FHA_1	639	645	PF00498	0.666
LIG_FHA_1	739	745	PF00498	0.819
LIG_FHA_2	619	625	PF00498	0.579
LIG_FHA_2	712	718	PF00498	0.726
LIG_FHA_2	721	727	PF00498	0.803
LIG_GBD_Chelix_1	514	522	PF00786	0.370
LIG_LIR_Apic_2	141	146	PF02991	0.719
LIG_LIR_Apic_2	496	501	PF02991	0.589
LIG_LIR_Apic_2	683	689	PF02991	0.508
LIG_LIR_Gen_1	342	352	PF02991	0.692
LIG_LIR_Gen_1	494	503	PF02991	0.589
LIG_LIR_Gen_1	508	518	PF02991	0.507
LIG_LIR_Gen_1	839	849	PF02991	0.725
LIG_LIR_Nem_3	342	348	PF02991	0.698
LIG_LIR_Nem_3	423	428	PF02991	0.755
LIG_LIR_Nem_3	480	486	PF02991	0.765
LIG_LIR_Nem_3	494	498	PF02991	0.550
LIG_LIR_Nem_3	508	514	PF02991	0.581
LIG_LIR_Nem_3	839	845	PF02991	0.736
LIG_MLH1_MIPbox_1	479	483	PF16413	0.663
LIG_NRBOX	677	683	PF00104	0.521
LIG_PCNA_yPIPBox_3	608	620	PF02747	0.419
LIG_SH2_CRK	112	116	PF00017	0.615
LIG_SH2_CRK	800	804	PF00017	0.451
LIG_SH2_PTP2	686	689	PF00017	0.550
LIG_SH2_STAP1	913	917	PF00017	0.485
LIG_SH2_STAT5	283	286	PF00017	0.775
LIG_SH2_STAT5	541	544	PF00017	0.455
LIG_SH2_STAT5	686	689	PF00017	0.503
LIG_SH3_1	87	93	PF00018	0.777
LIG_SH3_3	143	149	PF00018	0.763
LIG_SH3_3	214	220	PF00018	0.712
LIG_SH3_3	313	319	PF00018	0.744
LIG_SH3_3	375	381	PF00018	0.683
LIG_SH3_3	48	54	PF00018	0.822
LIG_SH3_3	496	502	PF00018	0.749
LIG_SH3_3	592	598	PF00018	0.831
LIG_SH3_3	684	690	PF00018	0.610
LIG_SH3_3	728	734	PF00018	0.741
LIG_SH3_3	770	776	PF00018	0.746
LIG_SH3_3	87	93	PF00018	0.754
LIG_SH3_3	877	883	PF00018	0.552
LIG_Sin3_3	320	327	PF02671	0.603
LIG_SUMO_SIM_anti_2	450	457	PF11976	0.486
LIG_SUMO_SIM_anti_2	674	680	PF11976	0.500
LIG_SUMO_SIM_par_1	450	457	PF11976	0.560
LIG_SUMO_SIM_par_1	563	569	PF11976	0.574
LIG_TRAF2_1	176	179	PF00917	0.696
LIG_TYR_ITIM	798	803	PF00017	0.451
LIG_Vh1_VBS_1	862	880	PF01044	0.576
LIG_WRC_WIRS_1	422	427	PF05994	0.612
LIG_WW_3	147	151	PF00397	0.625
LIG_WW_3	688	692	PF00397	0.520
MOD_CDC14_SPxK_1	688	691	PF00782	0.523
MOD_CDK_SPK_2	64	69	PF00069	0.758
MOD_CDK_SPK_2	764	769	PF00069	0.780
MOD_CDK_SPK_2	843	848	PF00069	0.640
MOD_CDK_SPxK_1	685	691	PF00069	0.506
MOD_CDK_SPxxK_3	843	850	PF00069	0.710
MOD_CK1_1	123	129	PF00069	0.761
MOD_CK1_1	204	210	PF00069	0.693
MOD_CK1_1	222	228	PF00069	0.764
MOD_CK1_1	24	30	PF00069	0.620
MOD_CK1_1	282	288	PF00069	0.814
MOD_CK1_1	302	308	PF00069	0.700
MOD_CK1_1	315	321	PF00069	0.609
MOD_CK1_1	331	337	PF00069	0.668
MOD_CK1_1	414	420	PF00069	0.720
MOD_CK1_1	437	443	PF00069	0.660
MOD_CK1_1	566	572	PF00069	0.721
MOD_CK1_1	60	66	PF00069	0.762
MOD_CK1_1	651	657	PF00069	0.658
MOD_CK1_1	67	73	PF00069	0.787
MOD_CK1_1	730	736	PF00069	0.747
MOD_CK1_1	738	744	PF00069	0.744
MOD_CK1_1	761	767	PF00069	0.764
MOD_CK1_1	906	912	PF00069	0.536
MOD_CK1_1	92	98	PF00069	0.686
MOD_CK2_1	720	726	PF00069	0.777
MOD_CK2_1	906	912	PF00069	0.490
MOD_Cter_Amidation	581	584	PF01082	0.770
MOD_GlcNHglycan	115	118	PF01048	0.607
MOD_GlcNHglycan	126	129	PF01048	0.641
MOD_GlcNHglycan	130	133	PF01048	0.608
MOD_GlcNHglycan	151	154	PF01048	0.799
MOD_GlcNHglycan	171	174	PF01048	0.629
MOD_GlcNHglycan	208	211	PF01048	0.756
MOD_GlcNHglycan	238	241	PF01048	0.735
MOD_GlcNHglycan	24	27	PF01048	0.717
MOD_GlcNHglycan	271	274	PF01048	0.755
MOD_GlcNHglycan	324	327	PF01048	0.822
MOD_GlcNHglycan	330	333	PF01048	0.757
MOD_GlcNHglycan	356	359	PF01048	0.728
MOD_GlcNHglycan	413	416	PF01048	0.688
MOD_GlcNHglycan	439	442	PF01048	0.668
MOD_GlcNHglycan	449	452	PF01048	0.485
MOD_GlcNHglycan	507	510	PF01048	0.662
MOD_GlcNHglycan	568	571	PF01048	0.744
MOD_GlcNHglycan	69	72	PF01048	0.723
MOD_GlcNHglycan	776	779	PF01048	0.753
MOD_GlcNHglycan	783	786	PF01048	0.694
MOD_GlcNHglycan	838	841	PF01048	0.695
MOD_GlcNHglycan	873	876	PF01048	0.579
MOD_GSK3_1	120	127	PF00069	0.769
MOD_GSK3_1	202	209	PF00069	0.790
MOD_GSK3_1	218	225	PF00069	0.596
MOD_GSK3_1	232	239	PF00069	0.663
MOD_GSK3_1	246	253	PF00069	0.587
MOD_GSK3_1	279	286	PF00069	0.741
MOD_GSK3_1	299	306	PF00069	0.772
MOD_GSK3_1	318	325	PF00069	0.754
MOD_GSK3_1	372	379	PF00069	0.784
MOD_GSK3_1	387	394	PF00069	0.413
MOD_GSK3_1	406	413	PF00069	0.495
MOD_GSK3_1	430	437	PF00069	0.595
MOD_GSK3_1	473	480	PF00069	0.563
MOD_GSK3_1	493	500	PF00069	0.474
MOD_GSK3_1	56	63	PF00069	0.739
MOD_GSK3_1	561	568	PF00069	0.667
MOD_GSK3_1	578	585	PF00069	0.584
MOD_GSK3_1	648	655	PF00069	0.786
MOD_GSK3_1	681	688	PF00069	0.473
MOD_GSK3_1	759	766	PF00069	0.748
MOD_GSK3_1	772	779	PF00069	0.644
MOD_GSK3_1	786	793	PF00069	0.473
MOD_GSK3_1	858	865	PF00069	0.579
MOD_GSK3_1	898	905	PF00069	0.517
MOD_GSK3_1	95	102	PF00069	0.696
MOD_N-GLC_1	167	172	PF02516	0.572
MOD_N-GLC_1	648	653	PF02516	0.476
MOD_NEK2_1	124	129	PF00069	0.645
MOD_NEK2_1	187	192	PF00069	0.703
MOD_NEK2_1	269	274	PF00069	0.763
MOD_NEK2_1	281	286	PF00069	0.740
MOD_NEK2_1	565	570	PF00069	0.738
MOD_NEK2_1	637	642	PF00069	0.555
MOD_NEK2_1	681	686	PF00069	0.475
MOD_NEK2_1	73	78	PF00069	0.770
MOD_NEK2_1	786	791	PF00069	0.669
MOD_NEK2_1	862	867	PF00069	0.532
MOD_NEK2_1	869	874	PF00069	0.445
MOD_NEK2_1	902	907	PF00069	0.565
MOD_NEK2_2	421	426	PF00069	0.600
MOD_NEK2_2	493	498	PF00069	0.562
MOD_NEK2_2	858	863	PF00069	0.487
MOD_PIKK_1	212	218	PF00454	0.666
MOD_PIKK_1	333	339	PF00454	0.538
MOD_PIKK_1	416	422	PF00454	0.723
MOD_PIKK_1	527	533	PF00454	0.602
MOD_PIKK_1	648	654	PF00454	0.711
MOD_PIKK_1	786	792	PF00454	0.662
MOD_PKA_1	577	583	PF00069	0.726
MOD_PKA_2	149	155	PF00069	0.671
MOD_PKA_2	22	28	PF00069	0.689
MOD_PKA_2	232	238	PF00069	0.824
MOD_PKA_2	279	285	PF00069	0.789
MOD_PKA_2	491	497	PF00069	0.711
MOD_PKA_2	582	588	PF00069	0.723
MOD_PKA_2	835	841	PF00069	0.786
MOD_PKA_2	898	904	PF00069	0.573
MOD_Plk_1	786	792	PF00069	0.553
MOD_Plk_4	196	202	PF00069	0.758
MOD_Plk_4	219	225	PF00069	0.702
MOD_Plk_4	421	427	PF00069	0.609
MOD_Plk_4	681	687	PF00069	0.461
MOD_Plk_4	858	864	PF00069	0.573
MOD_Plk_4	898	904	PF00069	0.486
MOD_ProDKin_1	167	173	PF00069	0.733
MOD_ProDKin_1	24	30	PF00069	0.745
MOD_ProDKin_1	299	305	PF00069	0.699
MOD_ProDKin_1	312	318	PF00069	0.731
MOD_ProDKin_1	339	345	PF00069	0.695
MOD_ProDKin_1	497	503	PF00069	0.666
MOD_ProDKin_1	568	574	PF00069	0.726
MOD_ProDKin_1	64	70	PF00069	0.794
MOD_ProDKin_1	685	691	PF00069	0.600
MOD_ProDKin_1	727	733	PF00069	0.778
MOD_ProDKin_1	764	770	PF00069	0.816
MOD_ProDKin_1	772	778	PF00069	0.644
MOD_ProDKin_1	843	849	PF00069	0.713
MOD_ProDKin_1	89	95	PF00069	0.742
MOD_SUMO_for_1	71	74	PF00179	0.757
MOD_SUMO_rev_2	717	722	PF00179	0.759
MOD_SUMO_rev_2	852	858	PF00179	0.448
TRG_DiLeu_BaLyEn_6	677	682	PF01217	0.403
TRG_ENDOCYTIC_2	800	803	PF00928	0.449
TRG_ENDOCYTIC_2	842	845	PF00928	0.768
TRG_ER_diArg_1	262	265	PF00400	0.736
TRG_ER_diArg_1	297	299	PF00400	0.633
TRG_ER_diArg_1	518	520	PF00400	0.562
TRG_ER_diArg_1	791	794	PF00400	0.520
TRG_ER_diArg_1	847	850	PF00400	0.621
TRG_NLS_MonoCore_2	260	265	PF00514	0.704
TRG_NLS_MonoExtC_3	260	265	PF00514	0.801
TRG_NLS_MonoExtN_4	258	265	PF00514	0.800
TRG_Pf-PMV_PEXEL_1	519	524	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	620	624	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	691	695	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	697	701	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEW5	Leptomonas seymouri	30%	97%
A4H7B2	Leishmania braziliensis	63%	100%
A4HVQ7	Leishmania infantum	99%	100%
E9APF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4QG25	Leishmania major	87%	100%