Protein kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I9M4_LEIDO

TriTrypDb:

LdBPK_130670.1 , LdCL_130012100 , LDHU3_13.0860

Length:

613

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8I9M4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9M4

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016310	phosphorylation	5	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9
GO:0007165	signal transduction	2	1
GO:0035556	intracellular signal transduction	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0004672	protein kinase activity	3	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016301	kinase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004707	MAP kinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.465
CLV_C14_Caspase3-7	290	294	PF00656	0.602
CLV_C14_Caspase3-7	385	389	PF00656	0.392
CLV_C14_Caspase3-7	57	61	PF00656	0.414
CLV_NRD_NRD_1	195	197	PF00675	0.582
CLV_NRD_NRD_1	325	327	PF00675	0.364
CLV_PCSK_KEX2_1	18	20	PF00082	0.471
CLV_PCSK_KEX2_1	195	197	PF00082	0.579
CLV_PCSK_KEX2_1	558	560	PF00082	0.565
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.471
CLV_PCSK_PC1ET2_1	558	560	PF00082	0.565
CLV_PCSK_SKI1_1	101	105	PF00082	0.445
CLV_PCSK_SKI1_1	173	177	PF00082	0.450
CLV_PCSK_SKI1_1	327	331	PF00082	0.364
CLV_PCSK_SKI1_1	348	352	PF00082	0.364
CLV_PCSK_SKI1_1	435	439	PF00082	0.382
CLV_PCSK_SKI1_1	476	480	PF00082	0.364
CLV_PCSK_SKI1_1	485	489	PF00082	0.364
CLV_PCSK_SKI1_1	575	579	PF00082	0.437
CLV_Separin_Metazoa	502	506	PF03568	0.334
DEG_APCC_DBOX_1	574	582	PF00400	0.426
DEG_COP1_1	554	563	PF00400	0.531
DEG_ODPH_VHL_1	186	199	PF01847	0.529
DEG_SPOP_SBC_1	239	243	PF00917	0.568
DEG_SPOP_SBC_1	288	292	PF00917	0.602
DOC_CYCLIN_RxL_1	432	442	PF00134	0.364
DOC_CYCLIN_RxL_1	98	105	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	266	272	PF00134	0.538
DOC_MAPK_gen_1	18	24	PF00069	0.462
DOC_MAPK_gen_1	348	357	PF00069	0.356
DOC_MAPK_RevD_3	5	19	PF00069	0.490
DOC_PP4_FxxP_1	136	139	PF00568	0.399
DOC_USP7_MATH_1	14	18	PF00917	0.516
DOC_USP7_MATH_1	209	213	PF00917	0.599
DOC_USP7_MATH_1	239	243	PF00917	0.568
DOC_USP7_MATH_1	288	292	PF00917	0.649
DOC_USP7_MATH_1	317	321	PF00917	0.531
DOC_USP7_MATH_1	459	463	PF00917	0.384
DOC_USP7_UBL2_3	484	488	PF12436	0.364
DOC_WW_Pin1_4	211	216	PF00397	0.645
DOC_WW_Pin1_4	403	408	PF00397	0.325
DOC_WW_Pin1_4	494	499	PF00397	0.415
DOC_WW_Pin1_4	503	508	PF00397	0.313
LIG_Actin_WH2_2	157	175	PF00022	0.368
LIG_EH_1	538	542	PF12763	0.325
LIG_eIF4E_1	89	95	PF01652	0.432
LIG_FHA_1	114	120	PF00498	0.434
LIG_FHA_1	29	35	PF00498	0.461
LIG_FHA_1	313	319	PF00498	0.533
LIG_FHA_1	378	384	PF00498	0.526
LIG_FHA_1	397	403	PF00498	0.281
LIG_FHA_1	473	479	PF00498	0.389
LIG_FHA_1	495	501	PF00498	0.479
LIG_FHA_1	89	95	PF00498	0.459
LIG_FHA_2	169	175	PF00498	0.435
LIG_FHA_2	180	186	PF00498	0.583
LIG_FHA_2	288	294	PF00498	0.665
LIG_FHA_2	383	389	PF00498	0.402
LIG_FHA_2	497	503	PF00498	0.334
LIG_FHA_2	79	85	PF00498	0.567
LIG_LIR_Apic_2	134	139	PF02991	0.410
LIG_LIR_Apic_2	391	397	PF02991	0.364
LIG_LIR_Gen_1	147	154	PF02991	0.460
LIG_LIR_Gen_1	159	170	PF02991	0.416
LIG_LIR_Gen_1	33	43	PF02991	0.437
LIG_LIR_Gen_1	591	598	PF02991	0.487
LIG_LIR_Nem_3	134	140	PF02991	0.458
LIG_LIR_Nem_3	147	151	PF02991	0.507
LIG_LIR_Nem_3	157	161	PF02991	0.421
LIG_LIR_Nem_3	322	328	PF02991	0.364
LIG_LIR_Nem_3	33	38	PF02991	0.445
LIG_LIR_Nem_3	39	44	PF02991	0.487
LIG_LIR_Nem_3	414	419	PF02991	0.364
LIG_LIR_Nem_3	451	456	PF02991	0.336
LIG_LIR_Nem_3	51	55	PF02991	0.625
LIG_LIR_Nem_3	545	550	PF02991	0.629
LIG_LIR_Nem_3	591	596	PF02991	0.500
LIG_NRBOX	33	39	PF00104	0.430
LIG_NRBOX	499	505	PF00104	0.334
LIG_PTB_Apo_2	536	543	PF02174	0.364
LIG_REV1ctd_RIR_1	539	548	PF16727	0.464
LIG_SH2_CRK	148	152	PF00017	0.442
LIG_SH2_CRK	52	56	PF00017	0.453
LIG_SH2_CRK	547	551	PF00017	0.488
LIG_SH2_NCK_1	394	398	PF00017	0.364
LIG_SH2_NCK_1	41	45	PF00017	0.437
LIG_SH2_NCK_1	75	79	PF00017	0.500
LIG_SH2_SRC	547	550	PF00017	0.491
LIG_SH2_SRC	75	78	PF00017	0.498
LIG_SH2_STAP1	148	152	PF00017	0.419
LIG_SH2_STAP1	190	194	PF00017	0.559
LIG_SH2_STAP1	439	443	PF00017	0.364
LIG_SH2_STAT5	162	165	PF00017	0.394
LIG_SH2_STAT5	170	173	PF00017	0.425
LIG_SH2_STAT5	339	342	PF00017	0.392
LIG_SH2_STAT5	382	385	PF00017	0.468
LIG_SH2_STAT5	439	442	PF00017	0.364
LIG_SH2_STAT5	54	57	PF00017	0.468
LIG_SH3_3	306	312	PF00018	0.627
LIG_SH3_3	547	553	PF00018	0.506
LIG_SUMO_SIM_par_1	314	320	PF11976	0.514
LIG_SUMO_SIM_par_1	398	406	PF11976	0.370
LIG_TRAF2_1	71	74	PF00917	0.501
LIG_TRAF2_1	81	84	PF00917	0.434
LIG_TYR_ITIM	337	342	PF00017	0.354
MOD_CDK_SPxK_1	213	219	PF00069	0.556
MOD_CK1_1	213	219	PF00069	0.691
MOD_CK1_1	360	366	PF00069	0.364
MOD_CK2_1	168	174	PF00069	0.389
MOD_CK2_1	179	185	PF00069	0.500
MOD_CK2_1	36	42	PF00069	0.431
MOD_CK2_1	459	465	PF00069	0.428
MOD_CK2_1	496	502	PF00069	0.334
MOD_CK2_1	78	84	PF00069	0.504
MOD_GlcNHglycan	131	134	PF01048	0.417
MOD_GlcNHglycan	247	250	PF01048	0.702
MOD_GlcNHglycan	458	462	PF01048	0.380
MOD_GlcNHglycan	56	59	PF01048	0.440
MOD_GlcNHglycan	572	575	PF01048	0.443
MOD_GSK3_1	175	182	PF00069	0.516
MOD_GSK3_1	209	216	PF00069	0.607
MOD_GSK3_1	239	246	PF00069	0.783
MOD_GSK3_1	258	265	PF00069	0.489
MOD_GSK3_1	444	451	PF00069	0.401
MOD_GSK3_1	459	466	PF00069	0.367
MOD_GSK3_1	486	493	PF00069	0.352
MOD_GSK3_1	566	573	PF00069	0.499
MOD_N-GLC_1	376	381	PF02516	0.473
MOD_N-GLC_1	388	393	PF02516	0.321
MOD_NEK2_1	168	173	PF00069	0.423
MOD_NEK2_1	176	181	PF00069	0.520
MOD_NEK2_1	357	362	PF00069	0.321
MOD_NEK2_1	437	442	PF00069	0.413
MOD_NEK2_1	479	484	PF00069	0.378
MOD_NEK2_1	486	491	PF00069	0.393
MOD_NEK2_1	592	597	PF00069	0.487
MOD_PIKK_1	388	394	PF00454	0.364
MOD_PIKK_1	444	450	PF00454	0.401
MOD_PK_1	559	565	PF00069	0.547
MOD_PKA_2	218	224	PF00069	0.602
MOD_PKA_2	363	369	PF00069	0.364
MOD_PKA_2	529	535	PF00069	0.413
MOD_Plk_1	168	174	PF00069	0.377
MOD_Plk_1	176	182	PF00069	0.465
MOD_Plk_1	28	34	PF00069	0.482
MOD_Plk_1	357	363	PF00069	0.408
MOD_Plk_1	388	394	PF00069	0.423
MOD_Plk_1	76	82	PF00069	0.527
MOD_Plk_2-3	144	150	PF00069	0.420
MOD_Plk_4	147	153	PF00069	0.439
MOD_Plk_4	176	182	PF00069	0.545
MOD_Plk_4	189	195	PF00069	0.467
MOD_Plk_4	382	388	PF00069	0.364
MOD_Plk_4	448	454	PF00069	0.397
MOD_Plk_4	592	598	PF00069	0.467
MOD_Plk_4	6	12	PF00069	0.581
MOD_Plk_4	90	96	PF00069	0.433
MOD_ProDKin_1	211	217	PF00069	0.646
MOD_ProDKin_1	403	409	PF00069	0.325
MOD_ProDKin_1	494	500	PF00069	0.415
MOD_ProDKin_1	503	509	PF00069	0.313
MOD_SUMO_for_1	225	228	PF00179	0.555
MOD_SUMO_for_1	350	353	PF00179	0.364
MOD_SUMO_for_1	598	601	PF00179	0.476
MOD_SUMO_rev_2	584	592	PF00179	0.412
MOD_SUMO_rev_2	601	606	PF00179	0.490
TRG_DiLeu_BaEn_1	33	38	PF01217	0.427
TRG_DiLeu_BaLyEn_6	195	200	PF01217	0.465
TRG_ENDOCYTIC_2	148	151	PF00928	0.441
TRG_ENDOCYTIC_2	162	165	PF00928	0.394
TRG_ENDOCYTIC_2	325	328	PF00928	0.403
TRG_ENDOCYTIC_2	331	334	PF00928	0.429
TRG_ENDOCYTIC_2	339	342	PF00928	0.443
TRG_ENDOCYTIC_2	41	44	PF00928	0.416
TRG_ENDOCYTIC_2	52	55	PF00928	0.469
TRG_ENDOCYTIC_2	547	550	PF00928	0.491
TRG_ER_diArg_1	194	196	PF00400	0.570
TRG_ER_FFAT_1	73	81	PF00635	0.459
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	348	353	PF00026	0.364
TRG_Pf-PMV_PEXEL_1	454	458	PF00026	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZJ0	Leptomonas seymouri	71%	100%
A0A3Q8IH39	Leishmania donovani	28%	100%
A4H767	Leishmania braziliensis	82%	100%
A4HUC8	Leishmania infantum	28%	100%
A4HVK6	Leishmania infantum	100%	100%
E9APA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	94%
Q4QG76	Leishmania major	88%	92%