RanBP1 domain family protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ran-binding protein 1, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I9L6_LEIDO

TriTrypDb:

LdBPK_131530.1 , LdCL_130019400 , LDHU3_13.1700

Length:

158

Annotations

Annotations by Jardim et al.

Nuclear proteins, Ran-binding 1

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8I9L6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9L6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0009987	cellular process	1	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	71	73	PF00675	0.204
CLV_NRD_NRD_1	84	86	PF00675	0.176
CLV_PCSK_KEX2_1	84	86	PF00082	0.193
CLV_PCSK_SKI1_1	119	123	PF00082	0.072
CLV_PCSK_SKI1_1	78	82	PF00082	0.208
CLV_PCSK_SKI1_1	99	103	PF00082	0.219
DOC_MAPK_gen_1	105	114	PF00069	0.258
DOC_PP1_RVXF_1	109	116	PF00149	0.193
DOC_SPAK_OSR1_1	38	42	PF12202	0.258
DOC_USP7_UBL2_3	107	111	PF12436	0.338
LIG_BIR_II_1	1	5	PF00653	0.445
LIG_Clathr_ClatBox_1	11	15	PF01394	0.440
LIG_Clathr_ClatBox_1	49	53	PF01394	0.208
LIG_FHA_1	64	70	PF00498	0.308
LIG_FHA_2	120	126	PF00498	0.240
LIG_LIR_Gen_1	36	45	PF02991	0.208
LIG_LIR_Gen_1	76	83	PF02991	0.347
LIG_LIR_Nem_3	116	121	PF02991	0.287
LIG_LIR_Nem_3	36	42	PF02991	0.193
LIG_LIR_Nem_3	76	82	PF02991	0.347
LIG_PDZ_Class_1	153	158	PF00595	0.334
LIG_Pex14_2	128	132	PF04695	0.193
LIG_Pex14_2	39	43	PF04695	0.258
LIG_RPA_C_Fungi	80	92	PF08784	0.320
LIG_SH2_CRK	79	83	PF00017	0.227
LIG_SH2_STAT5	96	99	PF00017	0.237
LIG_TRAF2_1	34	37	PF00917	0.193
LIG_UBA3_1	149	155	PF00899	0.404
MOD_CK2_1	119	125	PF00069	0.208
MOD_CK2_1	134	140	PF00069	0.346
MOD_CK2_1	31	37	PF00069	0.193
MOD_GlcNHglycan	115	118	PF01048	0.338
MOD_GlcNHglycan	33	36	PF01048	0.193
MOD_GlcNHglycan	45	48	PF01048	0.193
MOD_N-GLC_1	74	79	PF02516	0.258
MOD_NEK2_1	101	106	PF00069	0.260
MOD_NEK2_1	113	118	PF00069	0.188
MOD_NEK2_1	134	139	PF00069	0.221
MOD_PKA_2	134	140	PF00069	0.274
TRG_ENDOCYTIC_2	79	82	PF00928	0.227
TRG_ER_diArg_1	83	85	PF00400	0.198
TRG_NES_CRM1_1	10	21	PF08389	0.449
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.298

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I970	Leptomonas seymouri	80%	100%
A0A0S4IS61	Bodo saltans	61%	100%
A0A1X0NJS5	Trypanosomatidae	69%	100%
A0A422P498	Trypanosoma rangeli	73%	99%
A4H7C9	Leishmania braziliensis	96%	100%
A4HVS6	Leishmania infantum	100%	100%
D0A6G3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9APH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
P34022	Mus musculus	32%	78%
P41920	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	79%
P43487	Homo sapiens	32%	79%
P92985	Arabidopsis thaliana	37%	72%
Q4QG06	Leishmania major	99%	100%
Q54KD9	Dictyostelium discoideum	34%	81%
Q8RWG8	Arabidopsis thaliana	39%	73%
Q9LMK7	Arabidopsis thaliana	41%	69%
V5DIJ0	Trypanosoma cruzi	71%	100%