Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I9L5_LEIDO

TriTrypDb:

LdBPK_130480.1 , LdCL_130010200 , LDHU3_13.0650

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3Q8I9L5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9L5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	134	138	PF00082	0.604
CLV_PCSK_SKI1_1	70	74	PF00082	0.599
DEG_Nend_UBRbox_2	1	3	PF02207	0.468
DOC_CKS1_1	85	90	PF01111	0.405
DOC_MAPK_MEF2A_6	24	33	PF00069	0.549
DOC_MAPK_MEF2A_6	298	307	PF00069	0.468
DOC_MAPK_NFAT4_5	298	306	PF00069	0.472
DOC_PP1_RVXF_1	147	154	PF00149	0.504
DOC_PP1_RVXF_1	62	68	PF00149	0.499
DOC_PP2B_LxvP_1	180	183	PF13499	0.529
DOC_PP4_FxxP_1	247	250	PF00568	0.518
DOC_USP7_MATH_1	142	146	PF00917	0.610
DOC_USP7_MATH_1	234	238	PF00917	0.762
DOC_USP7_MATH_1	254	258	PF00917	0.317
DOC_USP7_MATH_1	68	72	PF00917	0.561
DOC_USP7_UBL2_3	137	141	PF12436	0.609
DOC_WW_Pin1_4	104	109	PF00397	0.543
DOC_WW_Pin1_4	228	233	PF00397	0.776
DOC_WW_Pin1_4	262	267	PF00397	0.473
DOC_WW_Pin1_4	84	89	PF00397	0.418
LIG_14-3-3_CanoR_1	221	225	PF00244	0.718
LIG_14-3-3_CanoR_1	24	31	PF00244	0.439
LIG_14-3-3_CanoR_1	43	47	PF00244	0.298
LIG_14-3-3_CanoR_1	62	68	PF00244	0.315
LIG_Actin_WH2_2	248	265	PF00022	0.445
LIG_FHA_1	177	183	PF00498	0.578
LIG_FHA_1	43	49	PF00498	0.485
LIG_FHA_2	214	220	PF00498	0.769
LIG_FHA_2	262	268	PF00498	0.536
LIG_FHA_2	314	320	PF00498	0.530
LIG_LIR_Apic_2	82	88	PF02991	0.434
LIG_LIR_Gen_1	174	183	PF02991	0.446
LIG_LIR_Gen_1	319	325	PF02991	0.618
LIG_LIR_Gen_1	35	44	PF02991	0.434
LIG_LIR_Nem_3	15	19	PF02991	0.413
LIG_LIR_Nem_3	174	180	PF02991	0.452
LIG_LIR_Nem_3	26	31	PF02991	0.411
LIG_LIR_Nem_3	319	325	PF02991	0.660
LIG_LIR_Nem_3	35	39	PF02991	0.209
LIG_LIR_Nem_3	53	59	PF02991	0.371
LIG_LYPXL_yS_3	28	31	PF13949	0.541
LIG_SH2_CRK	36	40	PF00017	0.490
LIG_SH2_CRK	44	48	PF00017	0.543
LIG_SH2_CRK	60	64	PF00017	0.327
LIG_SH2_CRK	85	89	PF00017	0.439
LIG_SH2_NCK_1	36	40	PF00017	0.497
LIG_SH2_SRC	58	61	PF00017	0.516
LIG_SH2_STAP1	19	23	PF00017	0.489
LIG_SH2_STAP1	50	54	PF00017	0.484
LIG_SH2_STAT5	186	189	PF00017	0.533
LIG_SH2_STAT5	246	249	PF00017	0.475
LIG_SH2_STAT5	44	47	PF00017	0.458
LIG_SH2_STAT5	56	59	PF00017	0.378
LIG_SH2_STAT5	78	81	PF00017	0.490
LIG_SH3_3	192	198	PF00018	0.536
LIG_WRC_WIRS_1	239	244	PF05994	0.508
MOD_CK1_1	145	151	PF00069	0.574
MOD_CK1_1	223	229	PF00069	0.755
MOD_CK1_1	311	317	PF00069	0.438
MOD_CK1_1	37	43	PF00069	0.446
MOD_CK2_1	214	220	PF00069	0.691
MOD_CK2_1	261	267	PF00069	0.452
MOD_GlcNHglycan	216	219	PF01048	0.716
MOD_GlcNHglycan	225	228	PF01048	0.718
MOD_GlcNHglycan	236	239	PF01048	0.470
MOD_GlcNHglycan	273	276	PF01048	0.516
MOD_GlcNHglycan	291	294	PF01048	0.391
MOD_GlcNHglycan	313	316	PF01048	0.475
MOD_GlcNHglycan	35	39	PF01048	0.457
MOD_GlcNHglycan	52	55	PF01048	0.565
MOD_GlcNHglycan	81	84	PF01048	0.447
MOD_GSK3_1	186	193	PF00069	0.504
MOD_GSK3_1	228	235	PF00069	0.787
MOD_GSK3_1	254	261	PF00069	0.517
MOD_GSK3_1	79	86	PF00069	0.430
MOD_NEK2_1	111	116	PF00069	0.568
MOD_NEK2_1	240	245	PF00069	0.621
MOD_NEK2_1	286	291	PF00069	0.555
MOD_NEK2_1	305	310	PF00069	0.319
MOD_NEK2_1	42	47	PF00069	0.447
MOD_PIKK_1	127	133	PF00454	0.588
MOD_PIKK_1	186	192	PF00454	0.568
MOD_PIKK_1	220	226	PF00454	0.718
MOD_PKA_2	220	226	PF00069	0.718
MOD_PKA_2	23	29	PF00069	0.451
MOD_PKA_2	42	48	PF00069	0.298
MOD_PKA_2	63	69	PF00069	0.476
MOD_Plk_1	142	148	PF00069	0.573
MOD_Plk_1	171	177	PF00069	0.560
MOD_Plk_1	34	40	PF00069	0.365
MOD_Plk_1	68	74	PF00069	0.556
MOD_Plk_4	176	182	PF00069	0.538
MOD_Plk_4	190	196	PF00069	0.389
MOD_ProDKin_1	104	110	PF00069	0.540
MOD_ProDKin_1	228	234	PF00069	0.772
MOD_ProDKin_1	262	268	PF00069	0.472
MOD_ProDKin_1	84	90	PF00069	0.409
MOD_SUMO_for_1	140	143	PF00179	0.610
TRG_ENDOCYTIC_2	28	31	PF00928	0.533
TRG_ENDOCYTIC_2	281	284	PF00928	0.475
TRG_ENDOCYTIC_2	36	39	PF00928	0.397
TRG_ENDOCYTIC_2	56	59	PF00928	0.456
TRG_ER_diArg_1	62	65	PF00400	0.466
TRG_NES_CRM1_1	2	15	PF08389	0.555
TRG_PTS1	322	325	PF00515	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I141	Leptomonas seymouri	59%	100%
A0A1X0NNS3	Trypanosomatidae	40%	100%
A4H748	Leishmania braziliensis	86%	100%
A4HVI8	Leishmania infantum	98%	100%
D0A6R7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AP83	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QG95	Leishmania major	95%	100%
V5BJY4	Trypanosoma cruzi	38%	100%