LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8I9K2_LEIDO
TriTrypDb:
LdBPK_130680.1 * , LdCL_130012200 , LDHU3_13.0870
Length:
695

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
TermNameLevelCount
GO:0005829 cytosol 2 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

A0A3Q8I9K2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9K2

Function

Biological processes
TermNameLevelCount
GO:0002097 tRNA wobble base modification 7 7
GO:0002098 tRNA wobble uridine modification 8 7
GO:0002143 tRNA wobble position uridine thiolation 8 1
GO:0006139 nucleobase-containing compound metabolic process 3 7
GO:0006396 RNA processing 6 7
GO:0006399 tRNA metabolic process 7 7
GO:0006400 tRNA modification 6 7
GO:0006725 cellular aromatic compound metabolic process 3 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0008033 tRNA processing 8 7
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Molecular functions
TermNameLevelCount
GO:0000049 tRNA binding 5 7
GO:0003676 nucleic acid binding 3 7
GO:0003723 RNA binding 4 7
GO:0003824 catalytic activity 1 1
GO:0005488 binding 1 7
GO:0016740 transferase activity 2 1
GO:0016782 transferase activity, transferring sulphur-containing groups 3 1
GO:0016783 sulfurtransferase activity 4 1
GO:0097159 organic cyclic compound binding 2 7
GO:1901363 heterocyclic compound binding 2 7
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 617 621 PF00656 0.710
CLV_NRD_NRD_1 172 174 PF00675 0.677
CLV_NRD_NRD_1 324 326 PF00675 0.473
CLV_NRD_NRD_1 525 527 PF00675 0.752
CLV_NRD_NRD_1 82 84 PF00675 0.618
CLV_PCSK_KEX2_1 194 196 PF00082 0.676
CLV_PCSK_KEX2_1 82 84 PF00082 0.618
CLV_PCSK_PC1ET2_1 194 196 PF00082 0.676
CLV_PCSK_PC7_1 78 84 PF00082 0.571
CLV_PCSK_SKI1_1 286 290 PF00082 0.590
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1PDC5 Leptomonas seymouri 42% 100%
A4H768 Leishmania braziliensis 68% 97%
A4HVK7 Leishmania infantum 99% 100%
E9APA3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 98%
Q4QG75 Leishmania major 88% 99%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS