Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I9K2_LEIDO

TriTrypDb:

LdBPK_130680.1 , LdCL_130012200 , LDHU3_13.0870

Length:

695

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3Q8I9K2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9K2

Function

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Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	7
GO:0002098	tRNA wobble uridine modification	8	7
GO:0002143	tRNA wobble position uridine thiolation	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006399	tRNA metabolic process	7	7
GO:0006400	tRNA modification	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008033	tRNA processing	8	7

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Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	7
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	7
GO:0016740	transferase activity	2	1
GO:0016782	transferase activity, transferring sulphur-containing groups	3	1
GO:0016783	sulfurtransferase activity	4	1
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	617	621	PF00656	0.710
CLV_NRD_NRD_1	172	174	PF00675	0.677
CLV_NRD_NRD_1	324	326	PF00675	0.473
CLV_NRD_NRD_1	525	527	PF00675	0.752
CLV_NRD_NRD_1	82	84	PF00675	0.618
CLV_PCSK_KEX2_1	194	196	PF00082	0.676
CLV_PCSK_KEX2_1	82	84	PF00082	0.618
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.676
CLV_PCSK_PC7_1	78	84	PF00082	0.571
CLV_PCSK_SKI1_1	286	290	PF00082	0.590

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDC5	Leptomonas seymouri	42%	100%
A4H768	Leishmania braziliensis	68%	97%
A4HVK7	Leishmania infantum	99%	100%
E9APA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	98%
Q4QG75	Leishmania major	88%	99%

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