Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I9K2_LEIDO

TriTrypDb:

LdBPK_130680.1 , LdCL_130012200 , LDHU3_13.0870

Length:

695

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8I9K2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9K2

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	7
GO:0002098	tRNA wobble uridine modification	8	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006399	tRNA metabolic process	7	7
GO:0006400	tRNA modification	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008033	tRNA processing	8	7
GO:0008152	metabolic process	1	7
GO:0009451	RNA modification	5	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0034227	tRNA thio-modification	7	7
GO:0034470	ncRNA processing	7	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034660	ncRNA metabolic process	6	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0002143	tRNA wobble position uridine thiolation	8	1

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	7
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016782	transferase activity, transferring sulphur-containing groups	3	1
GO:0016783	sulfurtransferase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	617	621	PF00656	0.710
CLV_NRD_NRD_1	172	174	PF00675	0.677
CLV_NRD_NRD_1	324	326	PF00675	0.473
CLV_NRD_NRD_1	525	527	PF00675	0.752
CLV_NRD_NRD_1	82	84	PF00675	0.618
CLV_PCSK_KEX2_1	194	196	PF00082	0.676
CLV_PCSK_KEX2_1	82	84	PF00082	0.618
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.676
CLV_PCSK_PC7_1	78	84	PF00082	0.571
CLV_PCSK_SKI1_1	286	290	PF00082	0.590
CLV_PCSK_SKI1_1	299	303	PF00082	0.426
CLV_PCSK_SKI1_1	408	412	PF00082	0.506
CLV_PCSK_SKI1_1	421	425	PF00082	0.445
CLV_PCSK_SKI1_1	526	530	PF00082	0.832
CLV_Separin_Metazoa	492	496	PF03568	0.664
DEG_SCF_FBW7_1	219	225	PF00400	0.839
DEG_SCF_FBW7_1	606	611	PF00400	0.743
DEG_SPOP_SBC_1	137	141	PF00917	0.819
DEG_SPOP_SBC_1	599	603	PF00917	0.606
DOC_CKS1_1	219	224	PF01111	0.837
DOC_CYCLIN_yCln2_LP_2	543	549	PF00134	0.775
DOC_MAPK_gen_1	370	377	PF00069	0.549
DOC_PP2B_LxvP_1	130	133	PF13499	0.539
DOC_PP2B_LxvP_1	543	546	PF13499	0.758
DOC_USP7_MATH_1	113	117	PF00917	0.633
DOC_USP7_MATH_1	137	141	PF00917	0.735
DOC_USP7_MATH_1	143	147	PF00917	0.752
DOC_USP7_MATH_1	222	226	PF00917	0.695
DOC_USP7_MATH_1	249	253	PF00917	0.796
DOC_USP7_MATH_1	349	353	PF00917	0.659
DOC_USP7_MATH_1	450	454	PF00917	0.656
DOC_USP7_MATH_1	608	612	PF00917	0.822
DOC_USP7_MATH_1	613	617	PF00917	0.737
DOC_USP7_MATH_1	622	626	PF00917	0.752
DOC_USP7_MATH_1	680	684	PF00917	0.707
DOC_USP7_UBL2_3	194	198	PF12436	0.819
DOC_USP7_UBL2_3	523	527	PF12436	0.836
DOC_WW_Pin1_4	103	108	PF00397	0.564
DOC_WW_Pin1_4	109	114	PF00397	0.623
DOC_WW_Pin1_4	139	144	PF00397	0.721
DOC_WW_Pin1_4	218	223	PF00397	0.842
DOC_WW_Pin1_4	237	242	PF00397	0.544
DOC_WW_Pin1_4	439	444	PF00397	0.537
DOC_WW_Pin1_4	48	53	PF00397	0.509
DOC_WW_Pin1_4	500	505	PF00397	0.609
DOC_WW_Pin1_4	604	609	PF00397	0.816
DOC_WW_Pin1_4	611	616	PF00397	0.705
DOC_WW_Pin1_4	625	630	PF00397	0.508
DOC_WW_Pin1_4	84	89	PF00397	0.702
LIG_14-3-3_CanoR_1	100	107	PF00244	0.671
LIG_14-3-3_CanoR_1	160	166	PF00244	0.574
LIG_14-3-3_CanoR_1	293	303	PF00244	0.516
LIG_14-3-3_CanoR_1	307	312	PF00244	0.521
LIG_14-3-3_CanoR_1	408	417	PF00244	0.544
LIG_14-3-3_CanoR_1	418	424	PF00244	0.397
LIG_14-3-3_CanoR_1	554	563	PF00244	0.589
LIG_APCC_ABBA_1	547	552	PF00400	0.687
LIG_BIR_III_2	645	649	PF00653	0.621
LIG_CSL_BTD_1	646	649	PF09270	0.616
LIG_deltaCOP1_diTrp_1	645	652	PF00928	0.708
LIG_EH1_1	459	467	PF00400	0.388
LIG_EVH1_1	132	136	PF00568	0.678
LIG_EVH1_2	648	652	PF00568	0.643
LIG_FHA_1	202	208	PF00498	0.687
LIG_FHA_1	257	263	PF00498	0.603
LIG_FHA_1	409	415	PF00498	0.592
LIG_FHA_1	440	446	PF00498	0.542
LIG_FHA_1	449	455	PF00498	0.551
LIG_FHA_1	682	688	PF00498	0.700
LIG_FHA_2	162	168	PF00498	0.575
LIG_FHA_2	249	255	PF00498	0.609
LIG_FHA_2	615	621	PF00498	0.704
LIG_FHA_2	656	662	PF00498	0.745
LIG_LIR_Gen_1	166	176	PF02991	0.572
LIG_LIR_Gen_1	300	311	PF02991	0.607
LIG_LIR_Gen_1	471	480	PF02991	0.480
LIG_LIR_Nem_3	166	172	PF02991	0.567
LIG_LIR_Nem_3	27	32	PF02991	0.466
LIG_LIR_Nem_3	300	306	PF02991	0.516
LIG_LIR_Nem_3	471	477	PF02991	0.471
LIG_SH2_CRK	303	307	PF00017	0.501
LIG_SH2_CRK	431	435	PF00017	0.580
LIG_SH2_STAP1	273	277	PF00017	0.605
LIG_SH2_STAP1	287	291	PF00017	0.408
LIG_SH2_STAT3	175	178	PF00017	0.552
LIG_SH2_STAT3	638	641	PF00017	0.608
LIG_SH2_STAT5	175	178	PF00017	0.676
LIG_SH2_STAT5	24	27	PF00017	0.461
LIG_SH2_STAT5	281	284	PF00017	0.512
LIG_SH2_STAT5	32	35	PF00017	0.449
LIG_SH2_STAT5	431	434	PF00017	0.529
LIG_SH2_STAT5	441	444	PF00017	0.484
LIG_SH3_3	128	134	PF00018	0.464
LIG_SUMO_SIM_anti_2	116	122	PF11976	0.599
LIG_SUMO_SIM_par_1	596	604	PF11976	0.703
LIG_TRAF2_1	164	167	PF00917	0.560
LIG_TRAF2_1	339	342	PF00917	0.733
LIG_TRAF2_1	489	492	PF00917	0.628
LIG_TYR_ITIM	429	434	PF00017	0.588
LIG_WW_3	179	183	PF00397	0.691
MOD_CDK_SPK_2	604	609	PF00069	0.816
MOD_CDK_SPxK_1	84	90	PF00069	0.660
MOD_CDK_SPxxK_3	103	110	PF00069	0.743
MOD_CK1_1	108	114	PF00069	0.665
MOD_CK1_1	139	145	PF00069	0.822
MOD_CK1_1	218	224	PF00069	0.681
MOD_CK1_1	233	239	PF00069	0.716
MOD_CK1_1	252	258	PF00069	0.505
MOD_CK1_1	292	298	PF00069	0.541
MOD_CK1_1	468	474	PF00069	0.596
MOD_CK1_1	517	523	PF00069	0.709
MOD_CK1_1	578	584	PF00069	0.656
MOD_CK1_1	601	607	PF00069	0.776
MOD_CK1_1	611	617	PF00069	0.682
MOD_CK1_1	625	631	PF00069	0.543
MOD_CK1_1	665	671	PF00069	0.683
MOD_CK1_1	99	105	PF00069	0.767
MOD_CK2_1	160	166	PF00069	0.565
MOD_CK2_1	248	254	PF00069	0.618
MOD_CK2_1	294	300	PF00069	0.501
MOD_CK2_1	554	560	PF00069	0.685
MOD_CK2_1	620	626	PF00069	0.696
MOD_CK2_1	653	659	PF00069	0.814
MOD_GlcNHglycan	107	110	PF01048	0.610
MOD_GlcNHglycan	151	154	PF01048	0.746
MOD_GlcNHglycan	232	235	PF01048	0.751
MOD_GlcNHglycan	236	239	PF01048	0.772
MOD_GlcNHglycan	251	254	PF01048	0.520
MOD_GlcNHglycan	277	280	PF01048	0.565
MOD_GlcNHglycan	500	503	PF01048	0.778
MOD_GlcNHglycan	519	522	PF01048	0.676
MOD_GlcNHglycan	57	60	PF01048	0.499
MOD_GlcNHglycan	603	606	PF01048	0.728
MOD_GlcNHglycan	610	613	PF01048	0.661
MOD_GlcNHglycan	622	625	PF01048	0.492
MOD_GlcNHglycan	655	658	PF01048	0.683
MOD_GSK3_1	105	112	PF00069	0.716
MOD_GSK3_1	137	144	PF00069	0.672
MOD_GSK3_1	218	225	PF00069	0.778
MOD_GSK3_1	230	237	PF00069	0.665
MOD_GSK3_1	248	255	PF00069	0.535
MOD_GSK3_1	271	278	PF00069	0.478
MOD_GSK3_1	364	371	PF00069	0.658
MOD_GSK3_1	444	451	PF00069	0.673
MOD_GSK3_1	517	524	PF00069	0.762
MOD_GSK3_1	600	607	PF00069	0.726
MOD_GSK3_1	662	669	PF00069	0.653
MOD_GSK3_1	96	103	PF00069	0.743
MOD_N-GLC_1	498	503	PF02516	0.562
MOD_N-GLC_1	586	591	PF02516	0.573
MOD_N-GLC_1	665	670	PF02516	0.746
MOD_NEK2_1	114	119	PF00069	0.553
MOD_NEK2_1	138	143	PF00069	0.772
MOD_NEK2_1	277	282	PF00069	0.574
MOD_NEK2_1	289	294	PF00069	0.510
MOD_NEK2_1	364	369	PF00069	0.774
MOD_NEK2_1	376	381	PF00069	0.387
MOD_NEK2_1	465	470	PF00069	0.515
MOD_NEK2_1	598	603	PF00069	0.689
MOD_NEK2_2	450	455	PF00069	0.651
MOD_OFUCOSY	575	582	PF10250	0.630
MOD_PIKK_1	515	521	PF00454	0.800
MOD_PKA_2	161	167	PF00069	0.546
MOD_PKA_2	271	277	PF00069	0.523
MOD_PKA_2	292	298	PF00069	0.519
MOD_PKA_2	608	614	PF00069	0.824
MOD_PKA_2	653	659	PF00069	0.689
MOD_PKA_2	99	105	PF00069	0.817
MOD_PKB_1	305	313	PF00069	0.601
MOD_Plk_2-3	655	661	PF00069	0.741
MOD_Plk_4	10	16	PF00069	0.483
MOD_Plk_4	114	120	PF00069	0.633
MOD_Plk_4	277	283	PF00069	0.511
MOD_Plk_4	562	568	PF00069	0.597
MOD_Plk_4	60	66	PF00069	0.486
MOD_Plk_4	614	620	PF00069	0.677
MOD_Plk_4	647	653	PF00069	0.717
MOD_ProDKin_1	103	109	PF00069	0.561
MOD_ProDKin_1	139	145	PF00069	0.720
MOD_ProDKin_1	218	224	PF00069	0.836
MOD_ProDKin_1	237	243	PF00069	0.544
MOD_ProDKin_1	439	445	PF00069	0.537
MOD_ProDKin_1	48	54	PF00069	0.503
MOD_ProDKin_1	500	506	PF00069	0.613
MOD_ProDKin_1	604	610	PF00069	0.817
MOD_ProDKin_1	611	617	PF00069	0.705
MOD_ProDKin_1	625	631	PF00069	0.508
MOD_ProDKin_1	84	90	PF00069	0.710
TRG_ENDOCYTIC_2	273	276	PF00928	0.608
TRG_ENDOCYTIC_2	303	306	PF00928	0.503
TRG_ENDOCYTIC_2	431	434	PF00928	0.583
TRG_ENDOCYTIC_2	469	472	PF00928	0.527
TRG_ER_diArg_1	81	83	PF00400	0.601
TRG_NLS_MonoExtC_3	193	198	PF00514	0.728
TRG_NLS_MonoExtN_4	194	201	PF00514	0.728
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDC5	Leptomonas seymouri	42%	100%
A4H768	Leishmania braziliensis	68%	97%
A4HVK7	Leishmania infantum	99%	100%
E9APA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	98%
Q4QG75	Leishmania major	88%	99%