EF-hand domain pair family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calmodulin, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I9J3_LEIDO

TriTrypDb:

LdBPK_131060.1 , LdCL_130015900 , LDHU3_13.1290

Length:

202

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8I9J3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9J3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005509	calcium ion binding	5	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.304
CLV_NRD_NRD_1	126	128	PF00675	0.526
CLV_NRD_NRD_1	32	34	PF00675	0.310
CLV_PCSK_KEX2_1	126	128	PF00082	0.482
CLV_PCSK_SKI1_1	10	14	PF00082	0.252
CLV_PCSK_SKI1_1	138	142	PF00082	0.416
DEG_Nend_UBRbox_3	1	3	PF02207	0.609
DOC_MAPK_gen_1	33	41	PF00069	0.241
DOC_PP2B_LxvP_1	74	77	PF13499	0.493
DOC_PP4_FxxP_1	144	147	PF00568	0.508
DOC_USP7_MATH_1	108	112	PF00917	0.560
DOC_USP7_MATH_1	69	73	PF00917	0.707
DOC_USP7_UBL2_3	169	173	PF12436	0.304
DOC_WW_Pin1_4	143	148	PF00397	0.471
DOC_WW_Pin1_4	65	70	PF00397	0.703
LIG_Actin_WH2_2	28	44	PF00022	0.259
LIG_EVH1_1	74	78	PF00568	0.535
LIG_FHA_1	154	160	PF00498	0.371
LIG_FHA_1	186	192	PF00498	0.259
LIG_FHA_1	53	59	PF00498	0.599
LIG_FHA_2	42	48	PF00498	0.457
LIG_LIR_Gen_1	14	22	PF02991	0.241
LIG_LIR_Nem_3	116	120	PF02991	0.350
LIG_LIR_Nem_3	14	19	PF02991	0.246
LIG_SH2_STAT5	132	135	PF00017	0.421
LIG_SH3_3	112	118	PF00018	0.432
LIG_SH3_3	144	150	PF00018	0.510
LIG_SH3_3	72	78	PF00018	0.623
LIG_SH3_4	42	49	PF00018	0.480
LIG_SUMO_SIM_par_1	24	31	PF11976	0.374
LIG_TRAF2_1	28	31	PF00917	0.349
LIG_TRAF2_1	44	47	PF00917	0.311
LIG_UBA3_1	35	42	PF00899	0.530
MOD_CK1_1	103	109	PF00069	0.628
MOD_CK1_1	130	136	PF00069	0.430
MOD_CK1_1	21	27	PF00069	0.316
MOD_CK1_1	57	63	PF00069	0.687
MOD_CK1_1	65	71	PF00069	0.676
MOD_CK2_1	2	8	PF00069	0.421
MOD_CK2_1	25	31	PF00069	0.241
MOD_CK2_1	41	47	PF00069	0.425
MOD_GlcNHglycan	110	113	PF01048	0.518
MOD_GlcNHglycan	22	26	PF01048	0.303
MOD_GlcNHglycan	64	67	PF01048	0.704
MOD_GlcNHglycan	69	72	PF01048	0.682
MOD_GSK3_1	21	28	PF00069	0.269
MOD_GSK3_1	65	72	PF00069	0.691
MOD_GSK3_1	99	106	PF00069	0.670
MOD_N-GLC_1	185	190	PF02516	0.304
MOD_N-GLC_1	92	97	PF02516	0.563
MOD_N-GLC_1	99	104	PF02516	0.620
MOD_NEK2_1	153	158	PF00069	0.503
MOD_NEK2_1	196	201	PF00069	0.304
MOD_NEK2_1	52	57	PF00069	0.562
MOD_Plk_4	119	125	PF00069	0.426
MOD_Plk_4	154	160	PF00069	0.396
MOD_Plk_4	76	82	PF00069	0.565
MOD_Plk_4	87	93	PF00069	0.462
MOD_ProDKin_1	143	149	PF00069	0.464
MOD_ProDKin_1	65	71	PF00069	0.703
MOD_SUMO_rev_2	5	15	PF00179	0.538
TRG_DiLeu_BaEn_1	14	19	PF01217	0.241
TRG_DiLeu_BaEn_1	175	180	PF01217	0.259
TRG_DiLeu_BaEn_1	31	36	PF01217	0.241
TRG_DiLeu_BaEn_4	53	59	PF01217	0.495
TRG_ENDOCYTIC_2	193	196	PF00928	0.241
TRG_ER_diArg_1	126	128	PF00400	0.526
TRG_NES_CRM1_1	30	45	PF08389	0.244
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.259

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P206	Leptomonas seymouri	27%	100%
A0A0N1PB14	Leptomonas seymouri	26%	96%
A0A0N1PDF8	Leptomonas seymouri	54%	100%
A0A0S4IS38	Bodo saltans	27%	100%
A0A0S4JFC8	Bodo saltans	27%	100%
A0A0S4JGV2	Bodo saltans	40%	100%
A0A1X0NMM5	Trypanosomatidae	27%	100%
A0A1X0NMZ8	Trypanosomatidae	44%	100%
A0A3S7WPW7	Leishmania donovani	26%	100%
A0A422MQ47	Trypanosoma rangeli	27%	100%
A0A422NL71	Trypanosoma rangeli	41%	100%
A2WN93	Oryza sativa subsp. indica	26%	100%
A2WNH1	Oryza sativa subsp. indica	26%	100%
A2Y609	Oryza sativa subsp. indica	25%	100%
A3E3H0	Pfiesteria piscicida	27%	100%
A3E4D8	Prorocentrum minimum	27%	100%
A3E4F9	Karlodinium veneficum	27%	100%
A4H522	Leishmania braziliensis	25%	98%
A4H5R9	Leishmania braziliensis	27%	100%
A4HT95	Leishmania infantum	27%	96%
A4HU13	Leishmania infantum	27%	100%
A4HVP4	Leishmania infantum	100%	100%
A4UHC0	Alexandrium fundyense	27%	100%
A8CEP3	Saccharina japonica	27%	100%
A8I1Q0	Heterocapsa triquetra	27%	100%
B1PSN3	Leishmania donovani	27%	100%
C9ZUM6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A6K2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
D0A9H8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0A9H9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AL84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	96%
E9AMU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9APE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O02367	Ciona intestinalis	28%	100%
O16305	Caenorhabditis elegans	28%	100%
O23320	Arabidopsis thaliana	26%	100%
O82018	Mougeotia scalaris	26%	100%
O94739	Pleurotus ostreatus	26%	100%
O96081	Halocynthia roretzi	28%	100%
O96102	Physarum polycephalum	28%	100%
O97341	Suberites domuncula	28%	100%
P02594	Electrophorus electricus	27%	100%
P02595	Patinopecten sp.	28%	100%
P02597	Gallus gallus	28%	100%
P02598	Tetrahymena pyriformis	26%	100%
P02599	Dictyostelium discoideum	28%	100%
P04352	Chlamydomonas reinhardtii	27%	100%
P04353	Spinacia oleracea	26%	100%
P04464	Triticum aestivum	26%	100%
P05932	Arbacia punctulata	28%	100%
P05933	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
P07463	Paramecium tetraurelia	25%	100%
P0DH95	Arabidopsis thaliana	25%	100%
P0DH96	Arabidopsis thaliana	25%	100%
P0DH97	Arabidopsis thaliana	26%	100%
P0DH98	Arabidopsis thaliana	26%	100%
P0DP23	Homo sapiens	27%	100%
P0DP24	Homo sapiens	27%	100%
P0DP25	Homo sapiens	27%	100%
P0DP26	Mus musculus	27%	100%
P0DP27	Mus musculus	27%	100%
P0DP28	Mus musculus	27%	100%
P0DP29	Rattus norvegicus	27%	100%
P0DP30	Rattus norvegicus	27%	100%
P0DP31	Rattus norvegicus	27%	100%
P0DP33	Xenopus laevis	27%	100%
P0DP34	Xenopus laevis	27%	100%
P0DP35	Xenopus laevis	27%	100%
P11118	Euglena gracilis	27%	100%
P11120	Pleurotus cornucopiae	26%	100%
P11121	Pyuridae sp.	28%	100%
P13868	Solanum tuberosum	27%	100%
P14533	Doryteuthis pealeii	25%	100%
P15094	Achlya klebsiana	26%	100%
P17928	Medicago sativa	26%	100%
P18061	Trypanosoma cruzi	27%	100%
P21251	Stichopus japonicus	27%	100%
P23286	Candida albicans	26%	100%
P24044	Plasmodium falciparum	27%	100%
P27161	Solanum lycopersicum	27%	100%
P27163	Petunia hybrida	26%	100%
P27164	Petunia hybrida	26%	100%
P27165	Phytophthora infestans	27%	100%
P27166	Stylonychia lemnae	26%	100%
P27482	Homo sapiens	29%	100%
P41040	Zea mays	25%	100%
P41041	Pneumocystis carinii	27%	100%
P48976	Malus domestica	25%	100%
P49258	Drosophila melanogaster	26%	100%
P53440	Naegleria gruberi	26%	100%
P59220	Arabidopsis thaliana	26%	100%
P60204	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	26%	100%
P60205	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	26%	100%
P60206	Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)	26%	100%
P61859	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	26%	100%
P61860	Colletotrichum trifolii	26%	100%
P61861	Colletotrichum gloeosporioides	26%	100%
P62144	Anas platyrhynchos	27%	100%
P62145	Aplysia californica	28%	100%
P62146	Arbacia punctulata	27%	100%
P62147	Branchiostoma floridae	28%	100%
P62148	Branchiostoma lanceolatum	28%	100%
P62149	Gallus gallus	27%	100%
P62150	Oryzias latipes	27%	100%
P62151	Tetronarce californica	27%	100%
P62152	Drosophila melanogaster	28%	100%
P62153	Halocynthia roretzi	28%	100%
P62154	Locusta migratoria	28%	100%
P62156	Oncorhynchus sp.	27%	100%
P62157	Bos taurus	27%	100%
P62160	Oryctolagus cuniculus	27%	100%
P62162	Hordeum vulgare	26%	100%
P62163	Glycine max	26%	100%
P62184	Renilla reniformis	28%	100%
P62199	Petunia hybrida	26%	100%
P62200	Daucus carota	26%	100%
P62201	Lilium longiflorum	26%	100%
P62202	Bryonia dioica	26%	100%
P62203	Plasmodium falciparum (isolate 3D7)	27%	100%
P69097	Trypanosoma brucei brucei	27%	100%
P69098	Trypanosoma brucei gambiense	27%	100%
P84339	Agaricus bisporus	26%	100%
P93087	Capsicum annuum	26%	100%
P93171	Helianthus annuus	26%	100%
Q03509	Arabidopsis thaliana	26%	100%
Q0JNL7	Oryza sativa subsp. japonica	25%	100%
Q0JNS6	Oryza sativa subsp. japonica	26%	100%
Q2R1Z5	Oryza sativa subsp. japonica	22%	100%
Q39752	Fagus sylvatica	25%	100%
Q40302	Macrocystis pyrifera	27%	100%
Q40642	Oryza sativa subsp. indica	25%	100%
Q4QG38	Leishmania major	96%	100%
Q4QHT2	Leishmania major	27%	100%
Q4QIM0	Leishmania major	27%	96%
Q5RAD2	Pongo abelii	27%	100%
Q5U206	Rattus norvegicus	30%	100%
Q682T9	Arabidopsis thaliana	26%	100%
Q6F332	Oryza sativa subsp. japonica	25%	100%
Q6IT78	Ctenopharyngodon idella	27%	100%
Q6PI52	Danio rerio	27%	100%
Q6R520	Oreochromis mossambicus	26%	100%
Q6YNX6	Ovis aries	27%	100%
Q71UH5	Globisporangium splendens	27%	100%
Q71UH6	Perca flavescens	27%	100%
Q7DMN9	Solanum tuberosum	26%	100%
Q7T3T2	Epinephelus akaara	27%	100%
Q7Y052	Euphorbia characias	26%	100%
Q8S1Y9	Oryza sativa subsp. japonica	25%	100%
Q8STF0	Strongylocentrotus intermedius	28%	100%
Q8X187	Paxillus involutus	26%	100%
Q95NI4	Halichondria okadai	28%	100%
Q95NR9	Metridium senile	28%	100%
Q9D6P8	Mus musculus	30%	100%
Q9GRJ1	Lumbricus rubellus	28%	100%
Q9HFY6	Blastocladiella emersonii	26%	100%
Q9LIK5	Arabidopsis thaliana	26%	100%
Q9U6D3	Myxine glutinosa	28%	100%
Q9UB37	Branchiostoma lanceolatum	28%	100%
Q9UWF0	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	26%	100%
Q9XZP2	Branchiostoma floridae	28%	100%