Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I9J2_LEIDO

TriTrypDb:

LdBPK_130510.1 , LdCL_130010500 , LDHU3_13.0690

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8I9J2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9J2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	116	122	PF00089	0.587
CLV_NRD_NRD_1	118	120	PF00675	0.725
CLV_NRD_NRD_1	181	183	PF00675	0.788
CLV_NRD_NRD_1	275	277	PF00675	0.476
CLV_NRD_NRD_1	305	307	PF00675	0.443
CLV_NRD_NRD_1	312	314	PF00675	0.437
CLV_NRD_NRD_1	327	329	PF00675	0.452
CLV_NRD_NRD_1	381	383	PF00675	0.439
CLV_NRD_NRD_1	394	396	PF00675	0.417
CLV_NRD_NRD_1	73	75	PF00675	0.646
CLV_PCSK_KEX2_1	118	120	PF00082	0.725
CLV_PCSK_KEX2_1	275	277	PF00082	0.476
CLV_PCSK_KEX2_1	305	307	PF00082	0.443
CLV_PCSK_KEX2_1	312	314	PF00082	0.437
CLV_PCSK_SKI1_1	312	316	PF00082	0.436
CLV_PCSK_SKI1_1	342	346	PF00082	0.424
CLV_PCSK_SKI1_1	382	386	PF00082	0.521
CLV_PCSK_SKI1_1	409	413	PF00082	0.430
DEG_APCC_DBOX_1	408	416	PF00400	0.411
DEG_SCF_FBW7_1	211	216	PF00400	0.701
DEG_SCF_FBW7_1	35	42	PF00400	0.629
DEG_SPOP_SBC_1	131	135	PF00917	0.666
DEG_SPOP_SBC_1	152	156	PF00917	0.700
DEG_SPOP_SBC_1	251	255	PF00917	0.642
DEG_SPOP_SBC_1	59	63	PF00917	0.625
DEG_SPOP_SBC_1	86	90	PF00917	0.669
DEG_SPOP_SBC_1	92	96	PF00917	0.612
DOC_CKS1_1	210	215	PF01111	0.704
DOC_CKS1_1	36	41	PF01111	0.728
DOC_MAPK_DCC_7	413	421	PF00069	0.508
DOC_MAPK_MEF2A_6	413	421	PF00069	0.556
DOC_USP7_MATH_1	108	112	PF00917	0.492
DOC_USP7_MATH_1	131	135	PF00917	0.688
DOC_USP7_MATH_1	146	150	PF00917	0.560
DOC_USP7_MATH_1	153	157	PF00917	0.661
DOC_USP7_MATH_1	229	233	PF00917	0.723
DOC_USP7_MATH_1	251	255	PF00917	0.627
DOC_USP7_MATH_1	291	295	PF00917	0.456
DOC_USP7_MATH_1	403	407	PF00917	0.358
DOC_USP7_MATH_1	59	63	PF00917	0.625
DOC_USP7_MATH_1	86	90	PF00917	0.654
DOC_USP7_MATH_1	92	96	PF00917	0.627
DOC_USP7_UBL2_3	75	79	PF12436	0.557
DOC_WW_Pin1_4	127	132	PF00397	0.770
DOC_WW_Pin1_4	154	159	PF00397	0.676
DOC_WW_Pin1_4	171	176	PF00397	0.513
DOC_WW_Pin1_4	209	214	PF00397	0.707
DOC_WW_Pin1_4	28	33	PF00397	0.587
DOC_WW_Pin1_4	35	40	PF00397	0.664
LIG_14-3-3_CanoR_1	305	314	PF00244	0.437
LIG_14-3-3_CanoR_1	382	391	PF00244	0.512
LIG_APCC_ABBA_1	314	319	PF00400	0.438
LIG_APCC_ABBAyCdc20_2	313	319	PF00400	0.439
LIG_BRCT_BRCA1_1	23	27	PF00533	0.614
LIG_EH_1	47	51	PF12763	0.643
LIG_FHA_1	135	141	PF00498	0.619
LIG_FHA_1	217	223	PF00498	0.622
LIG_FHA_1	291	297	PF00498	0.491
LIG_FHA_1	40	46	PF00498	0.637
LIG_FHA_1	79	85	PF00498	0.685
LIG_FHA_1	94	100	PF00498	0.504
LIG_FHA_2	320	326	PF00498	0.464
LIG_LIR_Gen_1	9	19	PF02991	0.613
LIG_LIR_Nem_3	9	14	PF02991	0.656
LIG_LYPXL_yS_3	18	21	PF13949	0.613
LIG_PCNA_yPIPBox_3	353	363	PF02747	0.411
LIG_SH2_CRK	11	15	PF00017	0.663
LIG_SH2_CRK	189	193	PF00017	0.510
LIG_SH2_CRK	224	228	PF00017	0.703
LIG_SH3_3	212	218	PF00018	0.706
LIG_SH3_3	263	269	PF00018	0.556
LIG_SH3_3	46	52	PF00018	0.575
LIG_SUMO_SIM_anti_2	389	395	PF11976	0.427
LIG_SUMO_SIM_par_1	94	102	PF11976	0.584
LIG_TRAF2_1	323	326	PF00917	0.436
LIG_TRAF2_1	334	337	PF00917	0.430
LIG_TYR_ITIM	222	227	PF00017	0.662
MOD_CK1_1	104	110	PF00069	0.554
MOD_CK1_1	129	135	PF00069	0.620
MOD_CK1_1	154	160	PF00069	0.732
MOD_CK1_1	216	222	PF00069	0.688
MOD_CK1_1	254	260	PF00069	0.629
MOD_CK1_1	281	287	PF00069	0.529
MOD_CK1_1	58	64	PF00069	0.786
MOD_CK1_1	73	79	PF00069	0.574
MOD_CK1_1	82	88	PF00069	0.581
MOD_CK1_1	95	101	PF00069	0.683
MOD_CK2_1	319	325	PF00069	0.482
MOD_Cter_Amidation	310	313	PF01082	0.442
MOD_GlcNHglycan	106	109	PF01048	0.499
MOD_GlcNHglycan	110	113	PF01048	0.649
MOD_GlcNHglycan	204	207	PF01048	0.718
MOD_GlcNHglycan	229	232	PF01048	0.672
MOD_GlcNHglycan	241	244	PF01048	0.510
MOD_GlcNHglycan	259	262	PF01048	0.620
MOD_GlcNHglycan	288	291	PF01048	0.605
MOD_GlcNHglycan	292	296	PF01048	0.525
MOD_GlcNHglycan	404	408	PF01048	0.555
MOD_GlcNHglycan	57	60	PF01048	0.668
MOD_GlcNHglycan	81	84	PF01048	0.670
MOD_GlcNHglycan	89	92	PF01048	0.604
MOD_GSK3_1	104	111	PF00069	0.483
MOD_GSK3_1	125	132	PF00069	0.817
MOD_GSK3_1	154	161	PF00069	0.673
MOD_GSK3_1	209	216	PF00069	0.711
MOD_GSK3_1	235	242	PF00069	0.803
MOD_GSK3_1	246	253	PF00069	0.592
MOD_GSK3_1	278	285	PF00069	0.550
MOD_GSK3_1	286	293	PF00069	0.517
MOD_GSK3_1	340	347	PF00069	0.401
MOD_GSK3_1	35	42	PF00069	0.591
MOD_GSK3_1	55	62	PF00069	0.490
MOD_GSK3_1	75	82	PF00069	0.524
MOD_GSK3_1	87	94	PF00069	0.584
MOD_GSK3_1	95	102	PF00069	0.458
MOD_N-GLC_1	55	60	PF02516	0.596
MOD_NEK2_1	125	130	PF00069	0.649
MOD_NEK2_1	252	257	PF00069	0.655
MOD_NEK2_1	307	312	PF00069	0.439
MOD_NEK2_1	340	345	PF00069	0.425
MOD_NEK2_1	93	98	PF00069	0.594
MOD_NEK2_1	99	104	PF00069	0.543
MOD_PKA_1	118	124	PF00069	0.728
MOD_PKA_1	382	388	PF00069	0.492
MOD_PKA_2	118	124	PF00069	0.709
MOD_PKA_2	389	395	PF00069	0.447
MOD_PKA_2	73	79	PF00069	0.748
MOD_Plk_1	291	297	PF00069	0.431
MOD_Plk_4	389	395	PF00069	0.499
MOD_ProDKin_1	127	133	PF00069	0.769
MOD_ProDKin_1	154	160	PF00069	0.677
MOD_ProDKin_1	171	177	PF00069	0.515
MOD_ProDKin_1	209	215	PF00069	0.702
MOD_ProDKin_1	28	34	PF00069	0.585
MOD_ProDKin_1	35	41	PF00069	0.667
MOD_SUMO_rev_2	325	331	PF00179	0.415
TRG_DiLeu_BaEn_1	336	341	PF01217	0.423
TRG_DiLeu_BaEn_4	326	332	PF01217	0.524
TRG_DiLeu_BaLyEn_6	303	308	PF01217	0.437
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.580
TRG_ENDOCYTIC_2	11	14	PF00928	0.631
TRG_ENDOCYTIC_2	18	21	PF00928	0.565
TRG_ENDOCYTIC_2	189	192	PF00928	0.542
TRG_ENDOCYTIC_2	224	227	PF00928	0.709
TRG_ER_diArg_1	118	120	PF00400	0.648
TRG_ER_diArg_1	274	276	PF00400	0.466
TRG_ER_diArg_1	305	307	PF00400	0.443
TRG_ER_diArg_1	312	314	PF00400	0.437
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	382	386	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEE7	Leptomonas seymouri	44%	100%
A4H751	Leishmania braziliensis	70%	98%
A4HVJ1	Leishmania infantum	100%	100%
E9AP86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QG92	Leishmania major	90%	100%