OTU-like cysteine protease, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I9I8_LEIDO

TriTrypDb:

LdBPK_161460.1 , LdCL_160019600 , LDHU3_16.1740

Length:

935

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I9I8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9I8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0019538	protein metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008233	peptidase activity	3	2
GO:0016787	hydrolase activity	2	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	859	863	PF00656	0.823
CLV_NRD_NRD_1	131	133	PF00675	0.724
CLV_NRD_NRD_1	180	182	PF00675	0.801
CLV_NRD_NRD_1	235	237	PF00675	0.801
CLV_NRD_NRD_1	270	272	PF00675	0.769
CLV_NRD_NRD_1	368	370	PF00675	0.601
CLV_NRD_NRD_1	516	518	PF00675	0.645
CLV_NRD_NRD_1	520	522	PF00675	0.634
CLV_NRD_NRD_1	577	579	PF00675	0.674
CLV_NRD_NRD_1	697	699	PF00675	0.571
CLV_NRD_NRD_1	749	751	PF00675	0.819
CLV_PCSK_FUR_1	513	517	PF00082	0.643
CLV_PCSK_KEX2_1	131	133	PF00082	0.724
CLV_PCSK_KEX2_1	180	182	PF00082	0.801
CLV_PCSK_KEX2_1	235	237	PF00082	0.801
CLV_PCSK_KEX2_1	272	274	PF00082	0.758
CLV_PCSK_KEX2_1	368	370	PF00082	0.601
CLV_PCSK_KEX2_1	515	517	PF00082	0.650
CLV_PCSK_KEX2_1	520	522	PF00082	0.618
CLV_PCSK_KEX2_1	577	579	PF00082	0.674
CLV_PCSK_KEX2_1	749	751	PF00082	0.819
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.758
CLV_PCSK_PC7_1	516	522	PF00082	0.670
CLV_PCSK_SKI1_1	520	524	PF00082	0.707
CLV_PCSK_SKI1_1	841	845	PF00082	0.803
DEG_Nend_Nbox_1	1	3	PF02207	0.730
DEG_SCF_FBW7_1	341	347	PF00400	0.713
DEG_SPOP_SBC_1	166	170	PF00917	0.663
DEG_SPOP_SBC_1	344	348	PF00917	0.715
DEG_SPOP_SBC_1	617	621	PF00917	0.739
DEG_SPOP_SBC_1	842	846	PF00917	0.803
DOC_CKS1_1	341	346	PF01111	0.790
DOC_CKS1_1	627	632	PF01111	0.746
DOC_CKS1_1	920	925	PF01111	0.835
DOC_CYCLIN_yCln2_LP_2	627	633	PF00134	0.822
DOC_MAPK_gen_1	334	341	PF00069	0.782
DOC_MAPK_gen_1	368	378	PF00069	0.597
DOC_MAPK_MEF2A_6	252	261	PF00069	0.818
DOC_MAPK_MEF2A_6	372	380	PF00069	0.584
DOC_MAPK_MEF2A_6	386	394	PF00069	0.399
DOC_MAPK_MEF2A_6	879	887	PF00069	0.604
DOC_PP1_RVXF_1	308	315	PF00149	0.799
DOC_PP2B_PxIxI_1	93	99	PF00149	0.751
DOC_PP4_FxxP_1	442	445	PF00568	0.622
DOC_PP4_FxxP_1	677	680	PF00568	0.545
DOC_USP7_MATH_1	119	123	PF00917	0.709
DOC_USP7_MATH_1	126	130	PF00917	0.498
DOC_USP7_MATH_1	162	166	PF00917	0.796
DOC_USP7_MATH_1	208	212	PF00917	0.779
DOC_USP7_MATH_1	266	270	PF00917	0.777
DOC_USP7_MATH_1	288	292	PF00917	0.790
DOC_USP7_MATH_1	293	297	PF00917	0.660
DOC_USP7_MATH_1	303	307	PF00917	0.499
DOC_USP7_MATH_1	344	348	PF00917	0.793
DOC_USP7_MATH_1	592	596	PF00917	0.799
DOC_USP7_MATH_1	680	684	PF00917	0.608
DOC_USP7_MATH_1	814	818	PF00917	0.825
DOC_USP7_MATH_1	843	847	PF00917	0.810
DOC_USP7_MATH_1	858	862	PF00917	0.593
DOC_USP7_MATH_1	918	922	PF00917	0.805
DOC_USP7_MATH_1	926	930	PF00917	0.733
DOC_USP7_UBL2_3	334	338	PF12436	0.783
DOC_USP7_UBL2_3	351	355	PF12436	0.556
DOC_WW_Pin1_4	143	148	PF00397	0.706
DOC_WW_Pin1_4	191	196	PF00397	0.792
DOC_WW_Pin1_4	204	209	PF00397	0.514
DOC_WW_Pin1_4	253	258	PF00397	0.819
DOC_WW_Pin1_4	325	330	PF00397	0.812
DOC_WW_Pin1_4	33	38	PF00397	0.827
DOC_WW_Pin1_4	340	345	PF00397	0.553
DOC_WW_Pin1_4	357	362	PF00397	0.533
DOC_WW_Pin1_4	43	48	PF00397	0.677
DOC_WW_Pin1_4	441	446	PF00397	0.622
DOC_WW_Pin1_4	626	631	PF00397	0.745
DOC_WW_Pin1_4	719	724	PF00397	0.793
DOC_WW_Pin1_4	758	763	PF00397	0.750
DOC_WW_Pin1_4	83	88	PF00397	0.821
DOC_WW_Pin1_4	916	921	PF00397	0.841
LIG_14-3-3_CanoR_1	118	122	PF00244	0.712
LIG_14-3-3_CanoR_1	235	241	PF00244	0.804
LIG_14-3-3_CanoR_1	252	260	PF00244	0.555
LIG_14-3-3_CanoR_1	406	413	PF00244	0.622
LIG_14-3-3_CanoR_1	434	439	PF00244	0.622
LIG_14-3-3_CanoR_1	468	476	PF00244	0.622
LIG_14-3-3_CanoR_1	547	552	PF00244	0.739
LIG_14-3-3_CanoR_1	578	588	PF00244	0.756
LIG_14-3-3_CanoR_1	719	723	PF00244	0.757
LIG_14-3-3_CanoR_1	782	789	PF00244	0.723
LIG_14-3-3_CanoR_1	798	803	PF00244	0.554
LIG_14-3-3_CanoR_1	815	821	PF00244	0.627
LIG_14-3-3_CanoR_1	841	849	PF00244	0.766
LIG_Actin_WH2_2	376	393	PF00022	0.592
LIG_APCC_ABBA_1	96	101	PF00400	0.825
LIG_BIR_III_2	245	249	PF00653	0.752
LIG_BRCT_BRCA1_1	199	203	PF00533	0.796
LIG_BRCT_BRCA1_1	539	543	PF00533	0.824
LIG_FHA_1	139	145	PF00498	0.800
LIG_FHA_1	254	260	PF00498	0.815
LIG_FHA_1	307	313	PF00498	0.649
LIG_FHA_1	609	615	PF00498	0.820
LIG_FHA_1	669	675	PF00498	0.817
LIG_FHA_1	687	693	PF00498	0.526
LIG_FHA_1	710	716	PF00498	0.758
LIG_FHA_1	784	790	PF00498	0.728
LIG_FHA_1	878	884	PF00498	0.642
LIG_FHA_1	93	99	PF00498	0.774
LIG_FHA_2	24	30	PF00498	0.824
LIG_FHA_2	352	358	PF00498	0.817
LIG_FHA_2	362	368	PF00498	0.551
LIG_FHA_2	736	742	PF00498	0.839
LIG_Integrin_isoDGR_2	42	44	PF01839	0.763
LIG_IRF3_LxIS_1	248	254	PF10401	0.823
LIG_LIR_Apic_2	439	445	PF02991	0.622
LIG_LIR_Apic_2	550	555	PF02991	0.732
LIG_LIR_Apic_2	888	892	PF02991	0.562
LIG_LIR_Gen_1	416	426	PF02991	0.622
LIG_LIR_Gen_1	449	458	PF02991	0.622
LIG_LIR_Gen_1	472	481	PF02991	0.622
LIG_LIR_Gen_1	755	764	PF02991	0.750
LIG_LIR_Gen_1	792	799	PF02991	0.810
LIG_LIR_Gen_1	97	106	PF02991	0.665
LIG_LIR_LC3C_4	389	394	PF02991	0.596
LIG_LIR_Nem_3	200	206	PF02991	0.794
LIG_LIR_Nem_3	416	421	PF02991	0.622
LIG_LIR_Nem_3	437	441	PF02991	0.544
LIG_LIR_Nem_3	449	455	PF02991	0.622
LIG_LIR_Nem_3	472	478	PF02991	0.622
LIG_LIR_Nem_3	755	760	PF02991	0.752
LIG_LIR_Nem_3	807	812	PF02991	0.741
LIG_LIR_Nem_3	884	889	PF02991	0.559
LIG_LIR_Nem_3	97	102	PF02991	0.677
LIG_MYND_1	613	617	PF01753	0.812
LIG_Pex14_2	438	442	PF04695	0.622
LIG_PTB_Apo_2	412	419	PF02174	0.622
LIG_PTB_Phospho_1	412	418	PF10480	0.622
LIG_SH2_CRK	150	154	PF00017	0.787
LIG_SH2_CRK	384	388	PF00017	0.586
LIG_SH2_CRK	452	456	PF00017	0.622
LIG_SH2_CRK	552	556	PF00017	0.713
LIG_SH2_CRK	895	899	PF00017	0.575
LIG_SH2_GRB2like	452	455	PF00017	0.619
LIG_SH2_GRB2like	475	478	PF00017	0.622
LIG_SH2_PTP2	475	478	PF00017	0.622
LIG_SH2_SRC	475	478	PF00017	0.622
LIG_SH2_SRC	889	892	PF00017	0.566
LIG_SH2_STAP1	498	502	PF00017	0.585
LIG_SH2_STAT3	526	529	PF00017	0.773
LIG_SH2_STAT5	441	444	PF00017	0.622
LIG_SH2_STAT5	475	478	PF00017	0.517
LIG_SH2_STAT5	489	492	PF00017	0.444
LIG_SH2_STAT5	505	508	PF00017	0.411
LIG_SH2_STAT5	889	892	PF00017	0.566
LIG_SH3_3	202	208	PF00018	0.706
LIG_SH3_3	254	260	PF00018	0.815
LIG_SH3_3	262	268	PF00018	0.664
LIG_SH3_3	3	9	PF00018	0.793
LIG_SH3_3	630	636	PF00018	0.817
LIG_SH3_3	68	74	PF00018	0.641
LIG_SH3_3	691	697	PF00018	0.815
LIG_SH3_3	799	805	PF00018	0.718
LIG_SH3_3	84	90	PF00018	0.652
LIG_SH3_3	917	923	PF00018	0.841
LIG_SH3_5	494	498	PF00018	0.556
LIG_SUMO_SIM_anti_2	772	779	PF11976	0.830
LIG_TRAF2_1	482	485	PF00917	0.622
LIG_TRAF2_1	738	741	PF00917	0.840
LIG_TYR_ITIM	893	898	PF00017	0.567
LIG_WRC_WIRS_1	754	759	PF05994	0.749
LIG_WW_3	90	94	PF00397	0.810
MOD_CDC14_SPxK_1	194	197	PF00782	0.781
MOD_CDK_SPK_2	325	330	PF00069	0.812
MOD_CDK_SPK_2	33	38	PF00069	0.827
MOD_CDK_SPxK_1	191	197	PF00069	0.791
MOD_CDK_SPxxK_3	43	50	PF00069	0.752
MOD_CDK_SPxxK_3	758	765	PF00069	0.750
MOD_CK1_1	117	123	PF00069	0.778
MOD_CK1_1	165	171	PF00069	0.680
MOD_CK1_1	221	227	PF00069	0.713
MOD_CK1_1	24	30	PF00069	0.824
MOD_CK1_1	301	307	PF00069	0.691
MOD_CK1_1	313	319	PF00069	0.626
MOD_CK1_1	340	346	PF00069	0.667
MOD_CK1_1	347	353	PF00069	0.632
MOD_CK1_1	501	507	PF00069	0.661
MOD_CK1_1	595	601	PF00069	0.724
MOD_CK1_1	718	724	PF00069	0.832
MOD_CK1_1	735	741	PF00069	0.577
MOD_CK1_1	745	751	PF00069	0.670
MOD_CK1_1	783	789	PF00069	0.770
MOD_CK1_1	800	806	PF00069	0.566
MOD_CK1_1	828	834	PF00069	0.747
MOD_CK1_1	85	91	PF00069	0.785
MOD_CK1_1	856	862	PF00069	0.827
MOD_CK2_1	166	172	PF00069	0.796
MOD_CK2_1	293	299	PF00069	0.719
MOD_CK2_1	351	357	PF00069	0.817
MOD_CK2_1	479	485	PF00069	0.510
MOD_CK2_1	557	563	PF00069	0.796
MOD_CK2_1	637	643	PF00069	0.800
MOD_CK2_1	734	740	PF00069	0.842
MOD_DYRK1A_RPxSP_1	204	208	PF00069	0.702
MOD_DYRK1A_RPxSP_1	719	723	PF00069	0.757
MOD_GlcNHglycan	164	167	PF01048	0.805
MOD_GlcNHglycan	182	185	PF01048	0.522
MOD_GlcNHglycan	199	202	PF01048	0.795
MOD_GlcNHglycan	210	213	PF01048	0.621
MOD_GlcNHglycan	223	226	PF01048	0.634
MOD_GlcNHglycan	253	256	PF01048	0.819
MOD_GlcNHglycan	295	298	PF01048	0.761
MOD_GlcNHglycan	315	318	PF01048	0.537
MOD_GlcNHglycan	347	350	PF01048	0.720
MOD_GlcNHglycan	500	503	PF01048	0.648
MOD_GlcNHglycan	54	57	PF01048	0.638
MOD_GlcNHglycan	590	593	PF01048	0.805
MOD_GlcNHglycan	597	600	PF01048	0.694
MOD_GlcNHglycan	639	642	PF01048	0.840
MOD_GlcNHglycan	64	67	PF01048	0.658
MOD_GlcNHglycan	682	685	PF01048	0.804
MOD_GlcNHglycan	734	737	PF01048	0.844
MOD_GlcNHglycan	744	747	PF01048	0.676
MOD_GlcNHglycan	816	819	PF01048	0.806
MOD_GlcNHglycan	821	824	PF01048	0.770
MOD_GlcNHglycan	827	830	PF01048	0.680
MOD_GlcNHglycan	858	861	PF01048	0.827
MOD_GlcNHglycan	864	867	PF01048	0.695
MOD_GlcNHglycan	928	931	PF01048	0.834
MOD_GlcNHglycan	932	935	PF01048	0.779
MOD_GSK3_1	136	143	PF00069	0.734
MOD_GSK3_1	162	169	PF00069	0.689
MOD_GSK3_1	204	211	PF00069	0.781
MOD_GSK3_1	217	224	PF00069	0.661
MOD_GSK3_1	236	243	PF00069	0.707
MOD_GSK3_1	298	305	PF00069	0.738
MOD_GSK3_1	306	313	PF00069	0.682
MOD_GSK3_1	316	323	PF00069	0.545
MOD_GSK3_1	340	347	PF00069	0.652
MOD_GSK3_1	357	364	PF00069	0.590
MOD_GSK3_1	421	428	PF00069	0.510
MOD_GSK3_1	488	495	PF00069	0.471
MOD_GSK3_1	52	59	PF00069	0.729
MOD_GSK3_1	543	550	PF00069	0.767
MOD_GSK3_1	584	591	PF00069	0.687
MOD_GSK3_1	618	625	PF00069	0.746
MOD_GSK3_1	711	718	PF00069	0.818
MOD_GSK3_1	73	80	PF00069	0.784
MOD_GSK3_1	730	737	PF00069	0.615
MOD_GSK3_1	776	783	PF00069	0.781
MOD_GSK3_1	785	792	PF00069	0.700
MOD_GSK3_1	825	832	PF00069	0.792
MOD_GSK3_1	858	865	PF00069	0.818
MOD_GSK3_1	910	917	PF00069	0.836
MOD_GSK3_1	926	933	PF00069	0.587
MOD_LATS_1	234	240	PF00433	0.803
MOD_N-GLC_1	320	325	PF02516	0.811
MOD_N-GLC_1	930	935	PF02516	0.763
MOD_NEK2_1	1	6	PF00069	0.775
MOD_NEK2_1	138	143	PF00069	0.686
MOD_NEK2_1	251	256	PF00069	0.825
MOD_NEK2_1	345	350	PF00069	0.721
MOD_NEK2_1	49	54	PF00069	0.763
MOD_NEK2_1	543	548	PF00069	0.807
MOD_NEK2_1	590	595	PF00069	0.800
MOD_NEK2_1	709	714	PF00069	0.812
MOD_NEK2_1	715	720	PF00069	0.768
MOD_NEK2_1	732	737	PF00069	0.581
MOD_NEK2_1	775	780	PF00069	0.828
MOD_NEK2_1	78	83	PF00069	0.801
MOD_NEK2_1	789	794	PF00069	0.592
MOD_NEK2_1	834	839	PF00069	0.762
MOD_NEK2_2	126	131	PF00069	0.732
MOD_NEK2_2	199	204	PF00069	0.794
MOD_NEK2_2	843	848	PF00069	0.813
MOD_NEK2_2	94	99	PF00069	0.751
MOD_PIKK_1	138	144	PF00454	0.688
MOD_PIKK_1	298	304	PF00454	0.715
MOD_PIKK_1	323	329	PF00454	0.812
MOD_PIKK_1	421	427	PF00454	0.364
MOD_PIKK_1	622	628	PF00454	0.827
MOD_PIKK_1	668	674	PF00454	0.728
MOD_PIKK_1	675	681	PF00454	0.784
MOD_PIKK_1	783	789	PF00454	0.782
MOD_PIKK_1	829	835	PF00454	0.825
MOD_PK_1	798	804	PF00069	0.724
MOD_PKA_1	180	186	PF00069	0.813
MOD_PKA_1	235	241	PF00069	0.804
MOD_PKA_1	337	343	PF00069	0.784
MOD_PKA_1	351	357	PF00069	0.600
MOD_PKA_1	622	628	PF00069	0.749
MOD_PKA_2	117	123	PF00069	0.712
MOD_PKA_2	180	186	PF00069	0.813
MOD_PKA_2	234	240	PF00069	0.799
MOD_PKA_2	251	257	PF00069	0.563
MOD_PKA_2	49	55	PF00069	0.793
MOD_PKA_2	492	498	PF00069	0.621
MOD_PKA_2	56	62	PF00069	0.728
MOD_PKA_2	584	590	PF00069	0.787
MOD_PKA_2	636	642	PF00069	0.838
MOD_PKA_2	718	724	PF00069	0.755
MOD_PKA_2	783	789	PF00069	0.727
MOD_PKA_2	797	803	PF00069	0.576
MOD_PKA_2	814	820	PF00069	0.629
MOD_PKA_2	92	98	PF00069	0.825
MOD_Plk_1	218	224	PF00069	0.781
MOD_Plk_1	228	234	PF00069	0.609
MOD_Plk_1	310	316	PF00069	0.804
MOD_Plk_1	463	469	PF00069	0.510
MOD_Plk_2-3	643	649	PF00069	0.750
MOD_Plk_2-3	663	669	PF00069	0.800
MOD_Plk_4	1	7	PF00069	0.800
MOD_Plk_4	140	146	PF00069	0.800
MOD_Plk_4	182	188	PF00069	0.735
MOD_Plk_4	337	343	PF00069	0.663
MOD_Plk_4	425	431	PF00069	0.510
MOD_Plk_4	501	507	PF00069	0.636
MOD_Plk_4	547	553	PF00069	0.809
MOD_Plk_4	78	84	PF00069	0.677
MOD_Plk_4	834	840	PF00069	0.810
MOD_Plk_4	885	891	PF00069	0.559
MOD_ProDKin_1	143	149	PF00069	0.703
MOD_ProDKin_1	191	197	PF00069	0.791
MOD_ProDKin_1	204	210	PF00069	0.516
MOD_ProDKin_1	253	259	PF00069	0.818
MOD_ProDKin_1	325	331	PF00069	0.812
MOD_ProDKin_1	33	39	PF00069	0.828
MOD_ProDKin_1	340	346	PF00069	0.555
MOD_ProDKin_1	357	363	PF00069	0.525
MOD_ProDKin_1	43	49	PF00069	0.675
MOD_ProDKin_1	441	447	PF00069	0.510
MOD_ProDKin_1	626	632	PF00069	0.746
MOD_ProDKin_1	719	725	PF00069	0.788
MOD_ProDKin_1	758	764	PF00069	0.751
MOD_ProDKin_1	83	89	PF00069	0.817
MOD_ProDKin_1	916	922	PF00069	0.841
MOD_SUMO_for_1	157	160	PF00179	0.769
MOD_SUMO_for_1	900	903	PF00179	0.628
TRG_DiLeu_BaLyEn_6	518	523	PF01217	0.691
TRG_DiLeu_BaLyEn_6	610	615	PF01217	0.817
TRG_ENDOCYTIC_2	150	153	PF00928	0.790
TRG_ENDOCYTIC_2	384	387	PF00928	0.576
TRG_ENDOCYTIC_2	418	421	PF00928	0.510
TRG_ENDOCYTIC_2	452	455	PF00928	0.510
TRG_ENDOCYTIC_2	475	478	PF00928	0.364
TRG_ENDOCYTIC_2	895	898	PF00928	0.566
TRG_ER_diArg_1	131	133	PF00400	0.724
TRG_ER_diArg_1	179	181	PF00400	0.795
TRG_ER_diArg_1	271	274	PF00400	0.759
TRG_ER_diArg_1	395	398	PF00400	0.591
TRG_ER_diArg_1	515	517	PF00400	0.650
TRG_ER_diArg_1	520	522	PF00400	0.618
TRG_ER_diArg_1	577	579	PF00400	0.674
TRG_NLS_MonoExtC_3	270	276	PF00514	0.759
TRG_NLS_MonoExtN_4	268	275	PF00514	0.769
TRG_Pf-PMV_PEXEL_1	577	581	PF00026	0.686

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HX35	Leishmania infantum	99%	100%
E9AQV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%