Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8I9I2_LEIDO

TriTrypDb:

LdBPK_120800.1 , LdCL_120019900 , LDHU3_12.1560

Length:

562

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I9I2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9I2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	365	369	PF00656	0.490
CLV_C14_Caspase3-7	376	380	PF00656	0.621
CLV_C14_Caspase3-7	48	52	PF00656	0.560
CLV_C14_Caspase3-7	513	517	PF00656	0.631
CLV_NRD_NRD_1	127	129	PF00675	0.708
CLV_NRD_NRD_1	210	212	PF00675	0.643
CLV_NRD_NRD_1	30	32	PF00675	0.575
CLV_NRD_NRD_1	422	424	PF00675	0.570
CLV_NRD_NRD_1	428	430	PF00675	0.574
CLV_NRD_NRD_1	449	451	PF00675	0.591
CLV_NRD_NRD_1	494	496	PF00675	0.618
CLV_NRD_NRD_1	96	98	PF00675	0.564
CLV_PCSK_FUR_1	28	32	PF00082	0.545
CLV_PCSK_KEX2_1	250	252	PF00082	0.435
CLV_PCSK_KEX2_1	30	32	PF00082	0.575
CLV_PCSK_KEX2_1	405	407	PF00082	0.744
CLV_PCSK_KEX2_1	422	424	PF00082	0.526
CLV_PCSK_KEX2_1	428	430	PF00082	0.574
CLV_PCSK_KEX2_1	449	451	PF00082	0.588
CLV_PCSK_KEX2_1	494	496	PF00082	0.618
CLV_PCSK_KEX2_1	96	98	PF00082	0.564
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.403
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.577
CLV_PCSK_SKI1_1	191	195	PF00082	0.475
CLV_PCSK_SKI1_1	266	270	PF00082	0.472
CLV_PCSK_SKI1_1	417	421	PF00082	0.596
CLV_PCSK_SKI1_1	422	426	PF00082	0.558
CLV_PCSK_SKI1_1	454	458	PF00082	0.582
CLV_PCSK_SKI1_1	97	101	PF00082	0.496
DEG_APCC_DBOX_1	95	103	PF00400	0.552
DEG_SCF_FBW7_2	504	511	PF00400	0.569
DOC_CKS1_1	194	199	PF01111	0.586
DOC_CKS1_1	312	317	PF01111	0.496
DOC_CKS1_1	552	557	PF01111	0.560
DOC_CYCLIN_RxL_1	188	196	PF00134	0.453
DOC_CYCLIN_RxL_1	76	87	PF00134	0.682
DOC_CYCLIN_RxL_1	93	104	PF00134	0.410
DOC_CYCLIN_yCln2_LP_2	194	200	PF00134	0.585
DOC_MAPK_gen_1	112	121	PF00069	0.505
DOC_MAPK_gen_1	179	188	PF00069	0.420
DOC_MAPK_gen_1	226	234	PF00069	0.459
DOC_MAPK_gen_1	494	501	PF00069	0.609
DOC_MAPK_gen_1	93	102	PF00069	0.557
DOC_PP2B_LxvP_1	198	201	PF13499	0.634
DOC_PP2B_LxvP_1	410	413	PF13499	0.607
DOC_USP7_MATH_1	172	176	PF00917	0.461
DOC_USP7_MATH_1	427	431	PF00917	0.701
DOC_USP7_MATH_1	481	485	PF00917	0.644
DOC_USP7_MATH_1	533	537	PF00917	0.560
DOC_USP7_UBL2_3	212	216	PF12436	0.625
DOC_USP7_UBL2_3	443	447	PF12436	0.624
DOC_WW_Pin1_4	17	22	PF00397	0.648
DOC_WW_Pin1_4	193	198	PF00397	0.568
DOC_WW_Pin1_4	311	316	PF00397	0.524
DOC_WW_Pin1_4	319	324	PF00397	0.463
DOC_WW_Pin1_4	504	509	PF00397	0.652
DOC_WW_Pin1_4	551	556	PF00397	0.588
DOC_WW_Pin1_4	85	90	PF00397	0.446
LIG_14-3-3_CanoR_1	406	411	PF00244	0.591
LIG_14-3-3_CanoR_1	422	427	PF00244	0.555
LIG_14-3-3_CanoR_1	494	501	PF00244	0.605
LIG_Actin_WH2_2	453	468	PF00022	0.506
LIG_BIR_II_1	1	5	PF00653	0.598
LIG_BRCT_BRCA1_1	146	150	PF00533	0.473
LIG_deltaCOP1_diTrp_1	246	256	PF00928	0.428
LIG_FHA_1	152	158	PF00498	0.611
LIG_FHA_1	302	308	PF00498	0.577
LIG_FHA_1	352	358	PF00498	0.480
LIG_FHA_1	359	365	PF00498	0.457
LIG_FHA_1	456	462	PF00498	0.559
LIG_FHA_1	520	526	PF00498	0.551
LIG_FHA_1	76	82	PF00498	0.476
LIG_FHA_2	234	240	PF00498	0.450
LIG_FHA_2	374	380	PF00498	0.578
LIG_FHA_2	552	558	PF00498	0.561
LIG_LIR_Apic_2	318	323	PF02991	0.479
LIG_LIR_Gen_1	233	242	PF02991	0.459
LIG_LIR_Gen_1	324	335	PF02991	0.458
LIG_LIR_Gen_1	39	50	PF02991	0.562
LIG_LIR_Nem_3	233	237	PF02991	0.526
LIG_LIR_Nem_3	257	263	PF02991	0.447
LIG_LIR_Nem_3	314	319	PF02991	0.604
LIG_LIR_Nem_3	324	330	PF02991	0.447
LIG_LIR_Nem_3	39	45	PF02991	0.601
LIG_LIR_Nem_3	78	83	PF02991	0.538
LIG_PDZ_Class_3	557	562	PF00595	0.561
LIG_Pex14_1	252	256	PF04695	0.418
LIG_REV1ctd_RIR_1	336	345	PF16727	0.545
LIG_SH2_GRB2like	41	44	PF00017	0.534
LIG_SH2_SRC	295	298	PF00017	0.608
LIG_SH2_STAP1	415	419	PF00017	0.548
LIG_SH2_STAT5	255	258	PF00017	0.457
LIG_SH2_STAT5	260	263	PF00017	0.429
LIG_SH2_STAT5	295	298	PF00017	0.608
LIG_SH2_STAT5	332	335	PF00017	0.571
LIG_SH2_STAT5	349	352	PF00017	0.376
LIG_SH2_STAT5	359	362	PF00017	0.426
LIG_SH3_3	194	200	PF00018	0.567
LIG_SH3_3	525	531	PF00018	0.555
LIG_SH3_3	64	70	PF00018	0.525
LIG_SH3_5	315	319	PF00018	0.542
LIG_SUMO_SIM_par_1	241	246	PF11976	0.424
LIG_SUMO_SIM_par_1	370	379	PF11976	0.561
LIG_SUMO_SIM_par_1	98	104	PF11976	0.494
LIG_TRAF2_1	171	174	PF00917	0.476
LIG_TRAF2_1	221	224	PF00917	0.628
LIG_TRAF2_1	380	383	PF00917	0.659
LIG_TRAF2_1	397	400	PF00917	0.672
LIG_WRC_WIRS_1	4	9	PF05994	0.498
MOD_CDK_SPK_2	551	556	PF00069	0.564
MOD_CDK_SPxK_1	193	199	PF00069	0.611
MOD_CDK_SPxK_1	504	510	PF00069	0.652
MOD_CK1_1	3	9	PF00069	0.510
MOD_CK1_1	322	328	PF00069	0.426
MOD_CK1_1	33	39	PF00069	0.645
MOD_CK1_1	384	390	PF00069	0.747
MOD_CK1_1	521	527	PF00069	0.640
MOD_CK1_1	75	81	PF00069	0.591
MOD_CK1_1	84	90	PF00069	0.551
MOD_CK2_1	168	174	PF00069	0.436
MOD_CK2_1	375	381	PF00069	0.598
MOD_CK2_1	384	390	PF00069	0.601
MOD_CK2_1	551	557	PF00069	0.563
MOD_CMANNOS	249	252	PF00535	0.427
MOD_GlcNHglycan	170	173	PF01048	0.514
MOD_GlcNHglycan	174	177	PF01048	0.511
MOD_GlcNHglycan	32	35	PF01048	0.559
MOD_GlcNHglycan	324	327	PF01048	0.445
MOD_GlcNHglycan	381	386	PF01048	0.836
MOD_GlcNHglycan	429	432	PF01048	0.607
MOD_GlcNHglycan	45	48	PF01048	0.549
MOD_GSK3_1	144	151	PF00069	0.486
MOD_GSK3_1	168	175	PF00069	0.464
MOD_GSK3_1	299	306	PF00069	0.745
MOD_GSK3_1	3	10	PF00069	0.562
MOD_GSK3_1	33	40	PF00069	0.606
MOD_GSK3_1	339	346	PF00069	0.509
MOD_GSK3_1	481	488	PF00069	0.693
MOD_GSK3_1	533	540	PF00069	0.561
MOD_GSK3_1	81	88	PF00069	0.573
MOD_N-GLC_2	137	139	PF02516	0.497
MOD_NEK2_1	144	149	PF00069	0.676
MOD_NEK2_1	168	173	PF00069	0.438
MOD_NEK2_1	45	50	PF00069	0.668
MOD_NEK2_1	81	86	PF00069	0.523
MOD_PIKK_1	301	307	PF00454	0.572
MOD_PIKK_1	33	39	PF00454	0.544
MOD_PIKK_1	417	423	PF00454	0.633
MOD_PKA_1	30	36	PF00069	0.569
MOD_PKA_1	422	428	PF00069	0.588
MOD_PKA_2	30	36	PF00069	0.602
MOD_PKA_2	351	357	PF00069	0.471
MOD_PKA_2	422	428	PF00069	0.608
MOD_PKA_2	43	49	PF00069	0.588
MOD_PKA_2	465	471	PF00069	0.673
MOD_PKA_2	481	487	PF00069	0.500
MOD_PKA_2	493	499	PF00069	0.602
MOD_PKB_1	28	36	PF00069	0.535
MOD_Plk_1	343	349	PF00069	0.487
MOD_Plk_1	485	491	PF00069	0.585
MOD_Plk_2-3	233	239	PF00069	0.457
MOD_Plk_4	144	150	PF00069	0.483
MOD_Plk_4	161	167	PF00069	0.443
MOD_Plk_4	3	9	PF00069	0.501
MOD_Plk_4	37	43	PF00069	0.552
MOD_Plk_4	435	441	PF00069	0.628
MOD_Plk_4	45	51	PF00069	0.577
MOD_ProDKin_1	17	23	PF00069	0.650
MOD_ProDKin_1	193	199	PF00069	0.575
MOD_ProDKin_1	311	317	PF00069	0.522
MOD_ProDKin_1	319	325	PF00069	0.453
MOD_ProDKin_1	504	510	PF00069	0.652
MOD_ProDKin_1	551	557	PF00069	0.587
MOD_ProDKin_1	85	91	PF00069	0.445
MOD_SUMO_for_1	227	230	PF00179	0.536
MOD_SUMO_rev_2	171	181	PF00179	0.448
MOD_SUMO_rev_2	219	227	PF00179	0.586
TRG_DiLeu_BaEn_2	229	235	PF01217	0.473
TRG_DiLeu_BaEn_4	270	276	PF01217	0.497
TRG_DiLeu_BaEn_4	485	491	PF01217	0.609
TRG_ENDOCYTIC_2	327	330	PF00928	0.451
TRG_ENDOCYTIC_2	332	335	PF00928	0.439
TRG_ER_diArg_1	28	31	PF00400	0.566
TRG_ER_diArg_1	422	424	PF00400	0.604
TRG_ER_diArg_1	448	450	PF00400	0.590
TRG_ER_diArg_1	493	495	PF00400	0.614
TRG_ER_diArg_1	95	97	PF00400	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY24	Leptomonas seymouri	46%	98%
A4H700	Leishmania braziliensis	51%	95%
E9AGI4	Leishmania infantum	100%	100%
E9AP20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QGG9	Leishmania major	82%	100%