LeishMANIAdb
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Katanin p60 ATPase-containing subunit A-like 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Katanin p60 ATPase-containing subunit A-like 2
Gene product:
katanin-like protein
Species:
Leishmania donovani
UniProt:
A0A3Q8I9I1_LEIDO
TriTrypDb:
LdBPK_130850.1 * , LdCL_130013900 , LDHU3_13.1070
Length:
565

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0000922 spindle pole 2 11
GO:0005737 cytoplasm 2 11
GO:0005874 microtubule 6 11
GO:0099080 supramolecular complex 2 11
GO:0099081 supramolecular polymer 3 11
GO:0099512 supramolecular fiber 4 11
GO:0099513 polymeric cytoskeletal fiber 5 11
GO:0110165 cellular anatomical entity 1 11
GO:0005815 microtubule organizing center 2 1
GO:0036064 ciliary basal body 3 1

Expansion

Sequence features

A0A3Q8I9I1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9I1

Function

Biological processes
Term Name Level Count
GO:0000226 microtubule cytoskeleton organization 3 11
GO:0006996 organelle organization 4 11
GO:0007010 cytoskeleton organization 5 11
GO:0007017 microtubule-based process 2 11
GO:0009987 cellular process 1 11
GO:0016043 cellular component organization 3 11
GO:0051013 microtubule severing 4 11
GO:0071840 cellular component organization or biogenesis 2 11
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0005515 protein binding 2 11
GO:0005524 ATP binding 5 11
GO:0008017 microtubule binding 5 11
GO:0008092 cytoskeletal protein binding 3 11
GO:0008568 microtubule severing ATPase activity 2 11
GO:0015631 tubulin binding 4 11
GO:0016462 pyrophosphatase activity 5 11
GO:0016787 hydrolase activity 2 11
GO:0016817 hydrolase activity, acting on acid anhydrides 3 11
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 11
GO:0016853 isomerase activity 2 11
GO:0016887 ATP hydrolysis activity 7 11
GO:0017076 purine nucleotide binding 4 11
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:0140657 ATP-dependent activity 1 11
GO:0140776 protein-containing complex destabilizing activity 1 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 112 116 PF00656 0.661
CLV_C14_Caspase3-7 378 382 PF00656 0.235
CLV_C14_Caspase3-7 405 409 PF00656 0.368
CLV_C14_Caspase3-7 75 79 PF00656 0.470
CLV_NRD_NRD_1 132 134 PF00675 0.584
CLV_NRD_NRD_1 220 222 PF00675 0.650
CLV_NRD_NRD_1 244 246 PF00675 0.543
CLV_NRD_NRD_1 38 40 PF00675 0.462
CLV_NRD_NRD_1 397 399 PF00675 0.235
CLV_NRD_NRD_1 413 415 PF00675 0.235
CLV_NRD_NRD_1 437 439 PF00675 0.235
CLV_NRD_NRD_1 458 460 PF00675 0.460
CLV_NRD_NRD_1 498 500 PF00675 0.368
CLV_PCSK_FUR_1 36 40 PF00082 0.387
CLV_PCSK_KEX2_1 220 222 PF00082 0.650
CLV_PCSK_KEX2_1 244 246 PF00082 0.503
CLV_PCSK_KEX2_1 38 40 PF00082 0.383
CLV_PCSK_KEX2_1 397 399 PF00082 0.235
CLV_PCSK_KEX2_1 412 414 PF00082 0.235
CLV_PCSK_KEX2_1 437 439 PF00082 0.235
CLV_PCSK_KEX2_1 441 443 PF00082 0.235
CLV_PCSK_KEX2_1 458 460 PF00082 0.355
CLV_PCSK_PC1ET2_1 412 414 PF00082 0.254
CLV_PCSK_PC1ET2_1 441 443 PF00082 0.235
CLV_PCSK_PC7_1 437 443 PF00082 0.235
CLV_PCSK_SKI1_1 140 144 PF00082 0.729
CLV_PCSK_SKI1_1 244 248 PF00082 0.436
CLV_PCSK_SKI1_1 267 271 PF00082 0.326
CLV_PCSK_SKI1_1 288 292 PF00082 0.309
CLV_PCSK_SKI1_1 313 317 PF00082 0.246
CLV_PCSK_SKI1_1 325 329 PF00082 0.215
CLV_PCSK_SKI1_1 361 365 PF00082 0.235
CLV_PCSK_SKI1_1 38 42 PF00082 0.393
CLV_PCSK_SKI1_1 397 401 PF00082 0.235
CLV_PCSK_SKI1_1 441 445 PF00082 0.254
CLV_PCSK_SKI1_1 458 462 PF00082 0.394
DEG_APCC_DBOX_1 243 251 PF00400 0.465
DEG_Nend_UBRbox_1 1 4 PF02207 0.586
DEG_SPOP_SBC_1 141 145 PF00917 0.622
DEG_SPOP_SBC_1 6 10 PF00917 0.458
DOC_CYCLIN_RxL_1 358 365 PF00134 0.235
DOC_CYCLIN_RxL_1 453 464 PF00134 0.418
DOC_CYCLIN_yClb5_NLxxxL_5 161 170 PF00134 0.669
DOC_MAPK_gen_1 310 318 PF00069 0.299
DOC_MAPK_gen_1 358 368 PF00069 0.254
DOC_MAPK_gen_1 36 46 PF00069 0.355
DOC_MAPK_gen_1 412 421 PF00069 0.314
DOC_MAPK_gen_1 437 447 PF00069 0.235
DOC_MAPK_HePTP_8 35 47 PF00069 0.434
DOC_MAPK_MEF2A_6 38 47 PF00069 0.365
DOC_MAPK_MEF2A_6 438 447 PF00069 0.235
DOC_MAPK_RevD_3 443 459 PF00069 0.442
DOC_PP1_RVXF_1 451 458 PF00149 0.387
DOC_PP1_SILK_1 306 311 PF00149 0.436
DOC_PP2B_LxvP_1 523 526 PF13499 0.335
DOC_PP4_FxxP_1 318 321 PF00568 0.235
DOC_USP7_MATH_1 141 145 PF00917 0.728
DOC_USP7_MATH_1 15 19 PF00917 0.456
DOC_USP7_MATH_1 209 213 PF00917 0.700
DOC_USP7_MATH_1 227 231 PF00917 0.656
DOC_USP7_MATH_1 240 244 PF00917 0.599
DOC_USP7_MATH_1 344 348 PF00917 0.258
DOC_USP7_MATH_1 386 390 PF00917 0.303
DOC_USP7_MATH_1 6 10 PF00917 0.533
DOC_WW_Pin1_4 144 149 PF00397 0.697
LIG_14-3-3_CanoR_1 107 117 PF00244 0.543
LIG_14-3-3_CanoR_1 140 148 PF00244 0.708
LIG_14-3-3_CanoR_1 337 341 PF00244 0.254
LIG_14-3-3_CanoR_1 397 407 PF00244 0.235
LIG_14-3-3_CanoR_1 442 448 PF00244 0.295
LIG_14-3-3_CanoR_1 541 545 PF00244 0.300
LIG_14-3-3_CanoR_1 68 72 PF00244 0.488
LIG_Actin_WH2_2 147 164 PF00022 0.623
LIG_Actin_WH2_2 254 269 PF00022 0.491
LIG_BIR_III_4 113 117 PF00653 0.608
LIG_BIR_III_4 226 230 PF00653 0.467
LIG_BRCT_BRCA1_1 372 376 PF00533 0.235
LIG_CaM_IQ_9 60 75 PF13499 0.469
LIG_EVH1_1 250 254 PF00568 0.423
LIG_FHA_1 193 199 PF00498 0.667
LIG_FHA_1 253 259 PF00498 0.457
LIG_FHA_1 372 378 PF00498 0.235
LIG_FHA_1 399 405 PF00498 0.271
LIG_FHA_1 431 437 PF00498 0.278
LIG_FHA_2 403 409 PF00498 0.450
LIG_FHA_2 527 533 PF00498 0.262
LIG_Integrin_RGD_1 353 355 PF01839 0.235
LIG_LIR_Nem_3 275 281 PF02991 0.470
LIG_LIR_Nem_3 303 308 PF02991 0.348
LIG_LIR_Nem_3 338 343 PF02991 0.235
LIG_LIR_Nem_3 88 92 PF02991 0.372
LIG_LYPXL_yS_3 301 304 PF13949 0.359
LIG_MYND_1 159 163 PF01753 0.660
LIG_Rb_pABgroove_1 358 366 PF01858 0.278
LIG_SH2_SRC 370 373 PF00017 0.254
LIG_SH2_STAP1 471 475 PF00017 0.368
LIG_SH2_STAP1 89 93 PF00017 0.380
LIG_SH3_1 248 254 PF00018 0.426
LIG_SH3_2 519 524 PF14604 0.394
LIG_SH3_3 151 157 PF00018 0.599
LIG_SH3_3 234 240 PF00018 0.551
LIG_SH3_3 246 252 PF00018 0.401
LIG_SH3_3 292 298 PF00018 0.344
LIG_SH3_3 442 448 PF00018 0.235
LIG_SH3_3 513 519 PF00018 0.616
LIG_SUMO_SIM_anti_2 485 490 PF11976 0.235
LIG_SUMO_SIM_anti_2 78 84 PF11976 0.394
LIG_SUMO_SIM_par_1 42 48 PF11976 0.401
LIG_SUMO_SIM_par_1 443 449 PF11976 0.368
LIG_TRAF2_1 28 31 PF00917 0.442
LIG_TYR_ITIM 299 304 PF00017 0.355
LIG_UBA3_1 304 313 PF00899 0.347
LIG_UBA3_1 403 412 PF00899 0.254
LIG_UBA3_1 435 441 PF00899 0.270
MOD_CK1_1 144 150 PF00069 0.623
MOD_CK1_1 347 353 PF00069 0.246
MOD_CK1_1 382 388 PF00069 0.245
MOD_CK1_1 446 452 PF00069 0.522
MOD_CK1_1 464 470 PF00069 0.415
MOD_CK1_1 67 73 PF00069 0.403
MOD_CK2_1 209 215 PF00069 0.636
MOD_CK2_1 386 392 PF00069 0.334
MOD_CK2_1 500 506 PF00069 0.379
MOD_Cter_Amidation 218 221 PF01082 0.648
MOD_GlcNHglycan 123 126 PF01048 0.597
MOD_GlcNHglycan 180 183 PF01048 0.645
MOD_GlcNHglycan 195 198 PF01048 0.641
MOD_GlcNHglycan 205 208 PF01048 0.759
MOD_GlcNHglycan 211 214 PF01048 0.574
MOD_GlcNHglycan 285 288 PF01048 0.430
MOD_GlcNHglycan 384 387 PF01048 0.260
MOD_GlcNHglycan 481 484 PF01048 0.303
MOD_GlcNHglycan 560 563 PF01048 0.407
MOD_GlcNHglycan 74 77 PF01048 0.582
MOD_GSK3_1 140 147 PF00069 0.662
MOD_GSK3_1 331 338 PF00069 0.235
MOD_GSK3_1 343 350 PF00069 0.235
MOD_GSK3_1 382 389 PF00069 0.249
MOD_GSK3_1 398 405 PF00069 0.247
MOD_GSK3_1 475 482 PF00069 0.250
MOD_GSK3_1 533 540 PF00069 0.227
MOD_GSK3_1 558 565 PF00069 0.462
MOD_LATS_1 515 521 PF00433 0.383
MOD_NEK2_1 129 134 PF00069 0.501
MOD_NEK2_1 198 203 PF00069 0.761
MOD_NEK2_1 261 266 PF00069 0.330
MOD_NEK2_1 422 427 PF00069 0.236
MOD_NEK2_1 7 12 PF00069 0.644
MOD_NEK2_2 336 341 PF00069 0.235
MOD_PIKK_1 402 408 PF00454 0.368
MOD_PIKK_1 500 506 PF00454 0.258
MOD_PIKK_1 69 75 PF00454 0.554
MOD_PKA_2 161 167 PF00069 0.687
MOD_PKA_2 336 342 PF00069 0.254
MOD_PKA_2 386 392 PF00069 0.314
MOD_PKA_2 540 546 PF00069 0.334
MOD_PKA_2 67 73 PF00069 0.486
MOD_PKB_1 105 113 PF00069 0.517
MOD_Plk_4 261 267 PF00069 0.435
MOD_Plk_4 323 329 PF00069 0.245
MOD_Plk_4 336 342 PF00069 0.235
MOD_Plk_4 344 350 PF00069 0.235
MOD_Plk_4 371 377 PF00069 0.235
MOD_Plk_4 379 385 PF00069 0.235
MOD_Plk_4 81 87 PF00069 0.350
MOD_ProDKin_1 144 150 PF00069 0.698
MOD_SUMO_for_1 399 402 PF00179 0.235
MOD_SUMO_rev_2 30 35 PF00179 0.478
TRG_DiLeu_BaEn_1 379 384 PF01217 0.235
TRG_DiLeu_BaEn_1 440 445 PF01217 0.235
TRG_DiLeu_BaEn_4 30 36 PF01217 0.484
TRG_DiLeu_BaLyEn_6 456 461 PF01217 0.402
TRG_ENDOCYTIC_2 301 304 PF00928 0.359
TRG_ENDOCYTIC_2 92 95 PF00928 0.374
TRG_ER_diArg_1 104 107 PF00400 0.487
TRG_ER_diArg_1 244 246 PF00400 0.503
TRG_ER_diArg_1 35 38 PF00400 0.414
TRG_ER_diArg_1 397 399 PF00400 0.235
TRG_ER_diArg_1 436 438 PF00400 0.235
TRG_ER_diArg_1 457 459 PF00400 0.467
TRG_NLS_Bipartite_1 397 416 PF00514 0.254
TRG_NLS_MonoExtC_3 411 417 PF00514 0.254
TRG_Pf-PMV_PEXEL_1 267 271 PF00026 0.346
TRG_Pf-PMV_PEXEL_1 279 283 PF00026 0.334
TRG_Pf-PMV_PEXEL_1 361 365 PF00026 0.235
TRG_Pf-PMV_PEXEL_1 499 504 PF00026 0.319

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P897 Leptomonas seymouri 69% 98%
A0A0S4IR32 Bodo saltans 53% 100%
A0A1X0NPJ1 Trypanosomatidae 58% 98%
A0JMA9 Xenopus tropicalis 45% 100%
A2VDN5 Bos taurus 38% 92%
A4H784 Leishmania braziliensis 82% 100%
A4HVM4 Leishmania infantum 100% 100%
D0A6N0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 57% 100%
E9APC0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 99%
Q05AS3 Xenopus tropicalis 38% 94%
Q3B8D5 Xenopus laevis 39% 100%
Q4QG58 Leishmania major 95% 100%
Q8IYT4 Homo sapiens 42% 100%
Q9D3R6 Mus musculus 41% 100%
V5DBR1 Trypanosoma cruzi 58% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS