GP46-like surface antigen

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3Q8I9D9_LEIDO

TriTrypDb:

LdCL_120012900 , LDHU3_12.1200 , LDHU3_12.1260

Length:

630

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 40

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 14, no: 0
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	15
GO:0016020	membrane	2	10
GO:0042995	cell projection	2	15
GO:0043226	organelle	2	15
GO:0043227	membrane-bounded organelle	3	15
GO:0110165	cellular anatomical entity	1	15
GO:0120025	plasma membrane bounded cell projection	3	15
GO:0005886	plasma membrane	3	5

Expansion

Sequence features

A0A3Q8I9D9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9D9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004672	protein kinase activity	3	2
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	6	8	PF00675	0.691
CLV_PCSK_KEX2_1	6	8	PF00082	0.691
CLV_PCSK_SKI1_1	156	160	PF00082	0.494
CLV_PCSK_SKI1_1	167	171	PF00082	0.494
CLV_PCSK_SKI1_1	7	11	PF00082	0.669
DEG_SCF_FBW7_2	558	563	PF00400	0.448
DEG_SPOP_SBC_1	299	303	PF00917	0.436
DEG_SPOP_SBC_1	311	315	PF00917	0.473
DEG_SPOP_SBC_1	319	323	PF00917	0.451
DEG_SPOP_SBC_1	327	331	PF00917	0.441
DEG_SPOP_SBC_1	335	339	PF00917	0.440
DEG_SPOP_SBC_1	343	347	PF00917	0.435
DEG_SPOP_SBC_1	351	355	PF00917	0.442
DEG_SPOP_SBC_1	359	363	PF00917	0.460
DEG_SPOP_SBC_1	367	371	PF00917	0.435
DEG_SPOP_SBC_1	375	379	PF00917	0.435
DEG_SPOP_SBC_1	383	387	PF00917	0.449
DEG_SPOP_SBC_1	391	395	PF00917	0.459
DEG_SPOP_SBC_1	402	406	PF00917	0.449
DEG_SPOP_SBC_1	410	414	PF00917	0.430
DEG_SPOP_SBC_1	418	422	PF00917	0.436
DEG_SPOP_SBC_1	426	430	PF00917	0.431
DEG_SPOP_SBC_1	434	438	PF00917	0.445
DEG_SPOP_SBC_1	442	446	PF00917	0.461
DEG_SPOP_SBC_1	450	454	PF00917	0.449
DEG_SPOP_SBC_1	458	462	PF00917	0.438
DEG_SPOP_SBC_1	466	470	PF00917	0.437
DEG_SPOP_SBC_1	474	478	PF00917	0.442
DEG_SPOP_SBC_1	482	486	PF00917	0.466
DEG_SPOP_SBC_1	490	494	PF00917	0.466
DEG_SPOP_SBC_1	498	502	PF00917	0.448
DEG_SPOP_SBC_1	506	510	PF00917	0.445
DEG_SPOP_SBC_1	514	518	PF00917	0.447
DEG_SPOP_SBC_1	522	526	PF00917	0.449
DEG_SPOP_SBC_1	537	541	PF00917	0.445
DOC_AGCK_PIF_2	69	74	PF00069	0.272
DOC_CYCLIN_RxL_1	3	13	PF00134	0.547
DOC_MAPK_MEF2A_6	156	165	PF00069	0.223
DOC_MAPK_MEF2A_6	276	283	PF00069	0.429
DOC_PP1_RVXF_1	160	166	PF00149	0.222
DOC_USP7_MATH_1	154	158	PF00917	0.234
DOC_USP7_MATH_1	192	196	PF00917	0.252
DOC_USP7_MATH_1	606	610	PF00917	0.286
DOC_USP7_MATH_2	174	180	PF00917	0.236
DOC_USP7_MATH_2	198	204	PF00917	0.264
DOC_WW_Pin1_4	515	520	PF00397	0.437
DOC_WW_Pin1_4	550	555	PF00397	0.500
DOC_WW_Pin1_4	556	561	PF00397	0.495
DOC_WW_Pin1_4	75	80	PF00397	0.247
LIG_14-3-3_CanoR_1	194	198	PF00244	0.250
LIG_14-3-3_CanoR_1	318	328	PF00244	0.443
LIG_14-3-3_CanoR_1	334	344	PF00244	0.432
LIG_14-3-3_CanoR_1	350	360	PF00244	0.432
LIG_14-3-3_CanoR_1	366	376	PF00244	0.426
LIG_14-3-3_CanoR_1	382	392	PF00244	0.428
LIG_14-3-3_CanoR_1	401	411	PF00244	0.425
LIG_14-3-3_CanoR_1	417	427	PF00244	0.432
LIG_14-3-3_CanoR_1	43	48	PF00244	0.359
LIG_14-3-3_CanoR_1	433	443	PF00244	0.432
LIG_14-3-3_CanoR_1	449	459	PF00244	0.435
LIG_14-3-3_CanoR_1	465	475	PF00244	0.433
LIG_14-3-3_CanoR_1	481	491	PF00244	0.434
LIG_14-3-3_CanoR_1	497	507	PF00244	0.436
LIG_Actin_WH2_2	179	196	PF00022	0.252
LIG_BIR_II_1	1	5	PF00653	0.511
LIG_BRCT_BRCA1_1	135	139	PF00533	0.238
LIG_BRCT_BRCA1_1	70	74	PF00533	0.293
LIG_BRCT_BRCA1_2	70	76	PF00533	0.269
LIG_eIF4E_1	115	121	PF01652	0.270
LIG_FHA_1	168	174	PF00498	0.272
LIG_FHA_1	42	48	PF00498	0.411
LIG_FHA_1	594	600	PF00498	0.321
LIG_FHA_2	516	522	PF00498	0.457
LIG_FHA_2	538	544	PF00498	0.444
LIG_FHA_2	562	568	PF00498	0.411
LIG_FHA_2	92	98	PF00498	0.391
LIG_LIR_Gen_1	127	134	PF02991	0.296
LIG_LIR_Gen_1	151	158	PF02991	0.254
LIG_LIR_Gen_1	176	183	PF02991	0.243
LIG_LIR_Gen_1	200	209	PF02991	0.410
LIG_LIR_Gen_1	232	241	PF02991	0.323
LIG_LIR_Gen_1	248	257	PF02991	0.411
LIG_LIR_Gen_1	71	79	PF02991	0.386
LIG_LIR_Nem_3	127	131	PF02991	0.288
LIG_LIR_Nem_3	200	204	PF02991	0.391
LIG_LIR_Nem_3	215	221	PF02991	0.261
LIG_LIR_Nem_3	232	236	PF02991	0.306
LIG_LIR_Nem_3	71	75	PF02991	0.339
LIG_MYND_3	180	184	PF01753	0.241
LIG_PCNA_PIPBox_1	180	189	PF02747	0.269
LIG_PDZ_Class_2	625	630	PF00595	0.283
LIG_Pex14_2	86	90	PF04695	0.280
LIG_PTAP_UEV_1	533	538	PF05743	0.427
LIG_PTB_Apo_2	227	234	PF02174	0.240
LIG_SH2_STAT5	115	118	PF00017	0.291
LIG_SH2_STAT5	589	592	PF00017	0.321
LIG_SH3_3	516	522	PF00018	0.439
LIG_SH3_3	531	537	PF00018	0.453
LIG_SH3_3	542	548	PF00018	0.475
LIG_SH3_3	93	99	PF00018	0.414
LIG_SUMO_SIM_anti_2	205	211	PF11976	0.263
LIG_SUMO_SIM_anti_2	46	51	PF11976	0.374
LIG_SUMO_SIM_par_1	256	261	PF11976	0.260
LIG_SUMO_SIM_par_1	279	285	PF11976	0.368
LIG_TYR_ITIM	102	107	PF00017	0.334
MOD_CK1_1	157	163	PF00069	0.300
MOD_CK1_1	202	208	PF00069	0.306
MOD_CK1_1	226	232	PF00069	0.315
MOD_CK1_1	546	552	PF00069	0.440
MOD_CK1_1	593	599	PF00069	0.322
MOD_CK2_1	226	232	PF00069	0.276
MOD_CK2_1	515	521	PF00069	0.458
MOD_CK2_1	537	543	PF00069	0.441
MOD_CK2_1	561	567	PF00069	0.451
MOD_CK2_1	91	97	PF00069	0.385
MOD_GlcNHglycan	144	147	PF01048	0.480
MOD_GlcNHglycan	152	155	PF01048	0.576
MOD_GlcNHglycan	224	228	PF01048	0.507
MOD_GlcNHglycan	240	244	PF01048	0.591
MOD_GlcNHglycan	248	252	PF01048	0.520
MOD_GlcNHglycan	25	28	PF01048	0.690
MOD_GlcNHglycan	260	263	PF01048	0.558
MOD_GlcNHglycan	577	580	PF01048	0.580
MOD_GlcNHglycan	609	612	PF01048	0.302
MOD_GlcNHglycan	79	82	PF01048	0.509
MOD_GSK3_1	120	127	PF00069	0.340
MOD_GSK3_1	144	151	PF00069	0.311
MOD_GSK3_1	165	172	PF00069	0.290
MOD_GSK3_1	199	206	PF00069	0.325
MOD_GSK3_1	297	304	PF00069	0.531
MOD_GSK3_1	306	313	PF00069	0.518
MOD_GSK3_1	314	321	PF00069	0.472
MOD_GSK3_1	322	329	PF00069	0.448
MOD_GSK3_1	330	337	PF00069	0.455
MOD_GSK3_1	338	345	PF00069	0.441
MOD_GSK3_1	346	353	PF00069	0.448
MOD_GSK3_1	354	361	PF00069	0.460
MOD_GSK3_1	362	369	PF00069	0.453
MOD_GSK3_1	370	377	PF00069	0.438
MOD_GSK3_1	378	385	PF00069	0.444
MOD_GSK3_1	386	393	PF00069	0.456
MOD_GSK3_1	397	404	PF00069	0.460
MOD_GSK3_1	405	412	PF00069	0.438
MOD_GSK3_1	413	420	PF00069	0.443
MOD_GSK3_1	421	428	PF00069	0.435
MOD_GSK3_1	429	436	PF00069	0.450
MOD_GSK3_1	437	444	PF00069	0.449
MOD_GSK3_1	445	452	PF00069	0.455
MOD_GSK3_1	453	460	PF00069	0.458
MOD_GSK3_1	461	468	PF00069	0.449
MOD_GSK3_1	469	476	PF00069	0.441
MOD_GSK3_1	477	484	PF00069	0.461
MOD_GSK3_1	485	492	PF00069	0.469
MOD_GSK3_1	493	500	PF00069	0.459
MOD_GSK3_1	501	508	PF00069	0.446
MOD_GSK3_1	509	516	PF00069	0.440
MOD_GSK3_1	521	528	PF00069	0.436
MOD_GSK3_1	532	539	PF00069	0.436
MOD_GSK3_1	543	550	PF00069	0.483
MOD_GSK3_1	552	559	PF00069	0.506
MOD_GSK3_1	589	596	PF00069	0.362
MOD_GSK3_1	82	89	PF00069	0.361
MOD_N-GLC_1	62	67	PF02516	0.461
MOD_N-GLC_1	82	87	PF02516	0.559
MOD_N-GLC_2	290	292	PF02516	0.589
MOD_N-GLC_2	68	70	PF02516	0.430
MOD_NEK2_1	10	15	PF00069	0.494
MOD_NEK2_1	108	113	PF00069	0.284
MOD_NEK2_1	120	125	PF00069	0.364
MOD_NEK2_1	165	170	PF00069	0.378
MOD_NEK2_1	193	198	PF00069	0.302
MOD_NEK2_1	21	26	PF00069	0.476
MOD_NEK2_1	86	91	PF00069	0.381
MOD_PIKK_1	528	534	PF00454	0.433
MOD_PKA_2	193	199	PF00069	0.250
MOD_Plk_1	175	181	PF00069	0.244
MOD_Plk_1	199	205	PF00069	0.415
MOD_Plk_1	247	253	PF00069	0.457
MOD_Plk_1	82	88	PF00069	0.374
MOD_Plk_4	133	139	PF00069	0.399
MOD_Plk_4	205	211	PF00069	0.255
MOD_Plk_4	86	92	PF00069	0.410
MOD_ProDKin_1	515	521	PF00069	0.437
MOD_ProDKin_1	550	556	PF00069	0.501
MOD_ProDKin_1	75	81	PF00069	0.242
MOD_SUMO_rev_2	282	288	PF00179	0.333
TRG_ENDOCYTIC_2	104	107	PF00928	0.404
TRG_ER_diArg_1	6	8	PF00400	0.597
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4ISU4	Bodo saltans	25%	96%
E9AGG5	Leishmania infantum	59%	100%
E9AP08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
E9B1U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
Q4QGI0	Leishmania major	44%	100%
Q4QGI2	Leishmania major	43%	100%
Q4QGJ2	Leishmania major	43%	97%
Q4QGK2	Leishmania major	38%	100%
Q4QGK4	Leishmania major	43%	94%
Q4QGK8	Leishmania major	41%	100%
Q4QGL2	Leishmania major	41%	100%
Q4QGL8	Leishmania major	41%	100%
Q4QGM1	Leishmania major	37%	81%