Surface antigen protein 2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3Q8I9D0_LEIDO

TriTrypDb:

LdCL_120018200 , LDHU3_12.1160

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 80

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 35, no: 9
NetGPI	no	yes: 0, no: 44

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	45
GO:0042995	cell projection	2	45
GO:0043226	organelle	2	45
GO:0043227	membrane-bounded organelle	3	45
GO:0110165	cellular anatomical entity	1	45
GO:0120025	plasma membrane bounded cell projection	3	45
GO:0016020	membrane	2	9

Expansion

Sequence features

A0A3Q8I9D0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9D0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.338
CLV_MEL_PAP_1	245	251	PF00089	0.348
CLV_NRD_NRD_1	181	183	PF00675	0.241
CLV_NRD_NRD_1	189	191	PF00675	0.200
CLV_NRD_NRD_1	6	8	PF00675	0.681
CLV_NRD_NRD_1	61	63	PF00675	0.264
CLV_PCSK_KEX2_1	118	120	PF00082	0.227
CLV_PCSK_KEX2_1	181	183	PF00082	0.233
CLV_PCSK_KEX2_1	189	191	PF00082	0.197
CLV_PCSK_KEX2_1	6	8	PF00082	0.681
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.224
CLV_PCSK_SKI1_1	153	157	PF00082	0.217
CLV_PCSK_SKI1_1	7	11	PF00082	0.669
DEG_APCC_DBOX_1	129	137	PF00400	0.219
DEG_SPOP_SBC_1	22	26	PF00917	0.374
DOC_AGCK_PIF_2	69	74	PF00069	0.242
DOC_CYCLIN_RxL_1	186	196	PF00134	0.389
DOC_CYCLIN_RxL_1	3	13	PF00134	0.625
DOC_MAPK_gen_1	153	163	PF00069	0.260
DOC_MAPK_gen_1	181	188	PF00069	0.206
DOC_MAPK_MEF2A_6	79	86	PF00069	0.201
DOC_PP1_RVXF_1	108	115	PF00149	0.433
DOC_USP7_MATH_1	192	196	PF00917	0.415
DOC_USP7_MATH_1	22	26	PF00917	0.582
DOC_USP7_MATH_2	174	180	PF00917	0.450
LIG_14-3-3_CanoR_1	153	159	PF00244	0.288
LIG_14-3-3_CanoR_1	194	198	PF00244	0.404
LIG_14-3-3_CanoR_1	31	38	PF00244	0.388
LIG_14-3-3_CanoR_1	43	48	PF00244	0.385
LIG_Actin_WH2_2	179	196	PF00022	0.285
LIG_BIR_II_1	1	5	PF00653	0.623
LIG_Clathr_ClatBox_1	160	164	PF01394	0.191
LIG_FHA_1	168	174	PF00498	0.468
LIG_FHA_1	194	200	PF00498	0.362
LIG_FHA_1	42	48	PF00498	0.457
LIG_FHA_2	63	69	PF00498	0.435
LIG_FHA_2	92	98	PF00498	0.427
LIG_GBD_Chelix_1	183	191	PF00786	0.191
LIG_LIR_Gen_1	113	121	PF02991	0.262
LIG_LIR_Gen_1	127	136	PF02991	0.212
LIG_LIR_Gen_1	176	185	PF02991	0.345
LIG_LIR_Gen_1	80	91	PF02991	0.436
LIG_LIR_Nem_3	101	107	PF02991	0.399
LIG_LIR_Nem_3	113	117	PF02991	0.337
LIG_LIR_Nem_3	127	131	PF02991	0.306
LIG_LIR_Nem_3	215	221	PF02991	0.451
LIG_LIR_Nem_3	80	86	PF02991	0.335
LIG_NRBOX	182	188	PF00104	0.197
LIG_SH2_CRK	218	222	PF00017	0.557
LIG_SH2_STAT5	74	77	PF00017	0.488
LIG_SH3_3	134	140	PF00018	0.177
LIG_SH3_3	93	99	PF00018	0.502
LIG_SUMO_SIM_anti_2	129	135	PF11976	0.201
LIG_SUMO_SIM_anti_2	157	162	PF11976	0.192
LIG_SUMO_SIM_anti_2	46	51	PF11976	0.256
LIG_SUMO_SIM_par_1	132	138	PF11976	0.233
LIG_SUMO_SIM_par_1	208	213	PF11976	0.293
LIG_SUMO_SIM_par_1	97	103	PF11976	0.289
LIG_TYR_ITIM	102	107	PF00017	0.319
LIG_WW_3	245	249	PF00397	0.339
MOD_CK1_1	151	157	PF00069	0.401
MOD_CK1_1	203	209	PF00069	0.355
MOD_CK1_1	226	232	PF00069	0.417
MOD_CK2_1	126	132	PF00069	0.481
MOD_CK2_1	91	97	PF00069	0.500
MOD_Cter_Amidation	60	63	PF01082	0.245
MOD_GlcNHglycan	144	147	PF01048	0.259
MOD_GlcNHglycan	224	228	PF01048	0.452
MOD_GlcNHglycan	240	244	PF01048	0.468
MOD_GlcNHglycan	25	28	PF01048	0.646
MOD_GSK3_1	120	127	PF00069	0.402
MOD_GSK3_1	144	151	PF00069	0.364
MOD_GSK3_1	165	172	PF00069	0.406
MOD_GSK3_1	199	206	PF00069	0.380
MOD_GSK3_1	208	215	PF00069	0.359
MOD_GSK3_1	226	233	PF00069	0.440
MOD_GSK3_1	32	39	PF00069	0.534
MOD_GSK3_1	68	75	PF00069	0.412
MOD_N-GLC_1	77	82	PF02516	0.269
MOD_NEK2_1	10	15	PF00069	0.582
MOD_NEK2_1	120	125	PF00069	0.434
MOD_NEK2_1	193	198	PF00069	0.389
MOD_NEK2_1	212	217	PF00069	0.343
MOD_NEK2_1	241	246	PF00069	0.440
MOD_PIKK_1	212	218	PF00454	0.413
MOD_PKA_1	62	68	PF00069	0.264
MOD_PKA_2	193	199	PF00069	0.364
MOD_PKA_2	30	36	PF00069	0.393
MOD_Plk_1	175	181	PF00069	0.230
MOD_Plk_2-3	68	74	PF00069	0.271
MOD_Plk_4	132	138	PF00069	0.288
MOD_Plk_4	82	88	PF00069	0.350
MOD_SUMO_rev_2	97	107	PF00179	0.414
TRG_DiLeu_BaEn_1	132	137	PF01217	0.197
TRG_DiLeu_LyEn_5	261	266	PF01217	0.383
TRG_ENDOCYTIC_2	104	107	PF00928	0.412
TRG_ENDOCYTIC_2	218	221	PF00928	0.388
TRG_ER_diArg_1	180	182	PF00400	0.246
TRG_ER_diArg_1	188	190	PF00400	0.207
TRG_ER_diArg_1	5	7	PF00400	0.656
TRG_Pf-PMV_PEXEL_1	110	115	PF00026	0.176
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.264

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P276	Leptomonas seymouri	31%	92%
A0A0N0P2L4	Leptomonas seymouri	40%	96%
A0A0N0P4M2	Leptomonas seymouri	27%	100%
A0A0S4IIK7	Bodo saltans	28%	69%
A0A0S4IQ67	Bodo saltans	26%	100%
A0A0S4IR61	Bodo saltans	24%	71%
A0A0S4J1A6	Bodo saltans	30%	66%
A0A0S4J805	Bodo saltans	32%	100%
A0A0S4JHM1	Bodo saltans	27%	88%
A0A0S4JSH3	Bodo saltans	32%	80%
A0A0S4JU20	Bodo saltans	32%	98%
A0A0S4KHE4	Bodo saltans	29%	77%
A0A0S4KL26	Bodo saltans	25%	78%
A0A1X0NKN8	Trypanosomatidae	28%	99%
A0A3Q8I9A6	Leishmania donovani	60%	74%
A0A3Q8IIJ9	Leishmania donovani	35%	94%
A0A3S5H6D6	Leishmania donovani	34%	100%
A0A3S7WPB2	Leishmania donovani	30%	100%
A0A3S7X4J4	Leishmania donovani	35%	94%
A4H5P0	Leishmania braziliensis	31%	100%
A4HJC8	Leishmania braziliensis	34%	100%
A4HTX9	Leishmania infantum	34%	100%
A4HVB0	Leishmania infantum	62%	100%
A4I6S4	Leishmania infantum	36%	100%
A7PW81	Vitis vinifera	25%	86%
E8NHP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9ACQ0	Leishmania major	29%	100%
E9AG65	Leishmania infantum	28%	100%
E9AGG5	Leishmania infantum	60%	68%
E9AGH0	Leishmania infantum	60%	76%
E9AKM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AMQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AP02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
E9AP03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	73%
E9AP07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
E9AP08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	68%
E9B1U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	83%
E9B1U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	68%
E9B1U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
Q00874	Arabidopsis thaliana	27%	77%
Q05091	Pyrus communis	23%	86%
Q25331	Leishmania major	56%	74%
Q4Q6B6	Leishmania major	36%	100%
Q4Q6B7	Leishmania major	36%	100%
Q4QGJ4	Leishmania major	56%	74%
Q4QGJ7	Leishmania major	56%	76%
Q4QGK6	Leishmania major	56%	74%
Q4QGL4	Leishmania major	61%	72%
Q4QHW6	Leishmania major	30%	100%
Q4QJB2	Leishmania major	23%	100%