GP46-like surface antigen

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3Q8I9B4_LEIDO

TriTrypDb:

LdCL_120013300 , LdCL_120013800 , LdCL_120014300 , LdCL_120014800 , LdCL_120015300 , LdCL_120016300 , LdCL_120016800 , LdCL_120017300 , LDHU3_12.1200 , LDHU3_12.1260

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 55

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 16, no: 0
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	17
GO:0016020	membrane	2	12
GO:0042995	cell projection	2	17
GO:0043226	organelle	2	17
GO:0043227	membrane-bounded organelle	3	17
GO:0110165	cellular anatomical entity	1	17
GO:0120025	plasma membrane bounded cell projection	3	17
GO:0005886	plasma membrane	3	4

Expansion

Sequence features

A0A3Q8I9B4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9B4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004672	protein kinase activity	3	2
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	6	8	PF00675	0.632
CLV_PCSK_KEX2_1	6	8	PF00082	0.632
CLV_PCSK_SKI1_1	156	160	PF00082	0.474
CLV_PCSK_SKI1_1	167	171	PF00082	0.509
CLV_PCSK_SKI1_1	7	11	PF00082	0.613
DEG_SCF_FBW7_2	547	552	PF00400	0.438
DEG_SPOP_SBC_1	299	303	PF00917	0.443
DEG_SPOP_SBC_1	311	315	PF00917	0.472
DEG_SPOP_SBC_1	319	323	PF00917	0.456
DEG_SPOP_SBC_1	327	331	PF00917	0.463
DEG_SPOP_SBC_1	335	339	PF00917	0.446
DEG_SPOP_SBC_1	343	347	PF00917	0.462
DEG_SPOP_SBC_1	351	355	PF00917	0.442
DEG_SPOP_SBC_1	359	363	PF00917	0.454
DEG_SPOP_SBC_1	367	371	PF00917	0.443
DEG_SPOP_SBC_1	375	379	PF00917	0.457
DEG_SPOP_SBC_1	383	387	PF00917	0.460
DEG_SPOP_SBC_1	391	395	PF00917	0.457
DEG_SPOP_SBC_1	399	403	PF00917	0.434
DEG_SPOP_SBC_1	407	411	PF00917	0.454
DEG_SPOP_SBC_1	415	419	PF00917	0.465
DEG_SPOP_SBC_1	423	427	PF00917	0.471
DEG_SPOP_SBC_1	431	435	PF00917	0.460
DEG_SPOP_SBC_1	439	443	PF00917	0.439
DEG_SPOP_SBC_1	447	451	PF00917	0.446
DEG_SPOP_SBC_1	455	459	PF00917	0.442
DEG_SPOP_SBC_1	463	467	PF00917	0.440
DEG_SPOP_SBC_1	471	475	PF00917	0.451
DEG_SPOP_SBC_1	479	483	PF00917	0.471
DEG_SPOP_SBC_1	487	491	PF00917	0.466
DEG_SPOP_SBC_1	495	499	PF00917	0.444
DEG_SPOP_SBC_1	503	507	PF00917	0.452
DEG_SPOP_SBC_1	511	515	PF00917	0.459
DEG_SPOP_SBC_1	526	530	PF00917	0.450
DOC_AGCK_PIF_2	69	74	PF00069	0.270
DOC_CYCLIN_RxL_1	3	13	PF00134	0.480
DOC_MAPK_MEF2A_6	156	165	PF00069	0.222
DOC_MAPK_MEF2A_6	276	283	PF00069	0.397
DOC_PP1_RVXF_1	160	166	PF00149	0.221
DOC_USP7_MATH_1	154	158	PF00917	0.239
DOC_USP7_MATH_1	192	196	PF00917	0.272
DOC_USP7_MATH_1	595	599	PF00917	0.291
DOC_USP7_MATH_2	174	180	PF00917	0.279
DOC_USP7_MATH_2	198	204	PF00917	0.268
DOC_WW_Pin1_4	504	509	PF00397	0.434
DOC_WW_Pin1_4	539	544	PF00397	0.481
DOC_WW_Pin1_4	545	550	PF00397	0.454
DOC_WW_Pin1_4	75	80	PF00397	0.254
LIG_14-3-3_CanoR_1	194	198	PF00244	0.261
LIG_14-3-3_CanoR_1	318	328	PF00244	0.436
LIG_14-3-3_CanoR_1	334	344	PF00244	0.430
LIG_14-3-3_CanoR_1	350	360	PF00244	0.434
LIG_14-3-3_CanoR_1	366	376	PF00244	0.437
LIG_14-3-3_CanoR_1	382	392	PF00244	0.436
LIG_14-3-3_CanoR_1	398	408	PF00244	0.429
LIG_14-3-3_CanoR_1	414	424	PF00244	0.438
LIG_14-3-3_CanoR_1	43	48	PF00244	0.323
LIG_14-3-3_CanoR_1	430	440	PF00244	0.435
LIG_14-3-3_CanoR_1	446	456	PF00244	0.434
LIG_14-3-3_CanoR_1	462	472	PF00244	0.435
LIG_14-3-3_CanoR_1	478	488	PF00244	0.433
LIG_14-3-3_CanoR_1	494	504	PF00244	0.427
LIG_Actin_WH2_2	179	196	PF00022	0.270
LIG_BIR_II_1	1	5	PF00653	0.474
LIG_BRCT_BRCA1_1	135	139	PF00533	0.235
LIG_BRCT_BRCA1_1	70	74	PF00533	0.287
LIG_BRCT_BRCA1_2	70	76	PF00533	0.260
LIG_eIF4E_1	115	121	PF01652	0.266
LIG_FHA_1	168	174	PF00498	0.310
LIG_FHA_1	42	48	PF00498	0.367
LIG_FHA_1	583	589	PF00498	0.344
LIG_FHA_2	505	511	PF00498	0.456
LIG_FHA_2	527	533	PF00498	0.446
LIG_FHA_2	551	557	PF00498	0.420
LIG_FHA_2	92	98	PF00498	0.356
LIG_LIR_Gen_1	127	134	PF02991	0.286
LIG_LIR_Gen_1	151	158	PF02991	0.276
LIG_LIR_Gen_1	176	183	PF02991	0.296
LIG_LIR_Gen_1	200	209	PF02991	0.270
LIG_LIR_Gen_1	232	241	PF02991	0.312
LIG_LIR_Gen_1	248	257	PF02991	0.393
LIG_LIR_Gen_1	71	79	PF02991	0.346
LIG_LIR_Nem_3	127	131	PF02991	0.300
LIG_LIR_Nem_3	200	204	PF02991	0.254
LIG_LIR_Nem_3	215	221	PF02991	0.263
LIG_LIR_Nem_3	232	236	PF02991	0.300
LIG_LIR_Nem_3	71	75	PF02991	0.326
LIG_MYND_3	180	184	PF01753	0.242
LIG_PCNA_PIPBox_1	180	189	PF02747	0.236
LIG_PDZ_Class_2	614	619	PF00595	0.276
LIG_Pex14_2	86	90	PF04695	0.274
LIG_PTAP_UEV_1	522	527	PF05743	0.413
LIG_PTB_Apo_2	227	234	PF02174	0.240
LIG_SH2_STAT5	115	118	PF00017	0.305
LIG_SH2_STAT5	578	581	PF00017	0.335
LIG_SH3_3	505	511	PF00018	0.440
LIG_SH3_3	520	526	PF00018	0.443
LIG_SH3_3	531	537	PF00018	0.460
LIG_SH3_3	93	99	PF00018	0.399
LIG_SUMO_SIM_anti_2	205	211	PF11976	0.240
LIG_SUMO_SIM_anti_2	46	51	PF11976	0.339
LIG_SUMO_SIM_par_1	256	261	PF11976	0.256
LIG_SUMO_SIM_par_1	279	285	PF11976	0.350
LIG_TYR_ITIM	102	107	PF00017	0.317
MOD_CK1_1	157	163	PF00069	0.283
MOD_CK1_1	202	208	PF00069	0.305
MOD_CK1_1	226	232	PF00069	0.311
MOD_CK1_1	535	541	PF00069	0.436
MOD_CK1_1	582	588	PF00069	0.321
MOD_CK2_1	226	232	PF00069	0.275
MOD_CK2_1	504	510	PF00069	0.450
MOD_CK2_1	526	532	PF00069	0.443
MOD_CK2_1	550	556	PF00069	0.447
MOD_CK2_1	91	97	PF00069	0.354
MOD_GlcNHglycan	144	147	PF01048	0.565
MOD_GlcNHglycan	152	155	PF01048	0.492
MOD_GlcNHglycan	224	228	PF01048	0.506
MOD_GlcNHglycan	240	244	PF01048	0.572
MOD_GlcNHglycan	248	252	PF01048	0.509
MOD_GlcNHglycan	25	28	PF01048	0.643
MOD_GlcNHglycan	260	263	PF01048	0.536
MOD_GlcNHglycan	566	569	PF01048	0.591
MOD_GlcNHglycan	598	601	PF01048	0.302
MOD_GlcNHglycan	79	82	PF01048	0.481
MOD_GSK3_1	120	127	PF00069	0.319
MOD_GSK3_1	144	151	PF00069	0.311
MOD_GSK3_1	165	172	PF00069	0.456
MOD_GSK3_1	199	206	PF00069	0.361
MOD_GSK3_1	297	304	PF00069	0.497
MOD_GSK3_1	306	313	PF00069	0.499
MOD_GSK3_1	314	321	PF00069	0.458
MOD_GSK3_1	322	329	PF00069	0.447
MOD_GSK3_1	330	337	PF00069	0.455
MOD_GSK3_1	338	345	PF00069	0.442
MOD_GSK3_1	346	353	PF00069	0.456
MOD_GSK3_1	354	361	PF00069	0.441
MOD_GSK3_1	362	369	PF00069	0.451
MOD_GSK3_1	370	377	PF00069	0.440
MOD_GSK3_1	378	385	PF00069	0.454
MOD_GSK3_1	386	393	PF00069	0.458
MOD_GSK3_1	394	401	PF00069	0.448
MOD_GSK3_1	402	409	PF00069	0.437
MOD_GSK3_1	410	417	PF00069	0.465
MOD_GSK3_1	418	425	PF00069	0.474
MOD_GSK3_1	426	433	PF00069	0.462
MOD_GSK3_1	434	441	PF00069	0.453
MOD_GSK3_1	442	449	PF00069	0.442
MOD_GSK3_1	450	457	PF00069	0.449
MOD_GSK3_1	458	465	PF00069	0.449
MOD_GSK3_1	466	473	PF00069	0.446
MOD_GSK3_1	474	481	PF00069	0.464
MOD_GSK3_1	482	489	PF00069	0.472
MOD_GSK3_1	490	497	PF00069	0.455
MOD_GSK3_1	498	505	PF00069	0.438
MOD_GSK3_1	510	517	PF00069	0.446
MOD_GSK3_1	521	528	PF00069	0.435
MOD_GSK3_1	532	539	PF00069	0.471
MOD_GSK3_1	541	548	PF00069	0.467
MOD_GSK3_1	578	585	PF00069	0.362
MOD_GSK3_1	82	89	PF00069	0.331
MOD_N-GLC_1	62	67	PF02516	0.459
MOD_N-GLC_1	82	87	PF02516	0.525
MOD_N-GLC_2	290	292	PF02516	0.580
MOD_N-GLC_2	68	70	PF02516	0.428
MOD_NEK2_1	10	15	PF00069	0.459
MOD_NEK2_1	108	113	PF00069	0.270
MOD_NEK2_1	120	125	PF00069	0.334
MOD_NEK2_1	165	170	PF00069	0.296
MOD_NEK2_1	193	198	PF00069	0.346
MOD_NEK2_1	21	26	PF00069	0.452
MOD_NEK2_1	86	91	PF00069	0.332
MOD_PIKK_1	517	523	PF00454	0.422
MOD_PKA_2	193	199	PF00069	0.247
MOD_Plk_1	175	181	PF00069	0.306
MOD_Plk_1	199	205	PF00069	0.281
MOD_Plk_1	247	253	PF00069	0.448
MOD_Plk_1	82	88	PF00069	0.330
MOD_Plk_4	133	139	PF00069	0.280
MOD_Plk_4	205	211	PF00069	0.240
MOD_Plk_4	86	92	PF00069	0.282
MOD_ProDKin_1	504	510	PF00069	0.436
MOD_ProDKin_1	539	545	PF00069	0.482
MOD_ProDKin_1	75	81	PF00069	0.249
MOD_SUMO_rev_2	282	288	PF00179	0.322
TRG_ENDOCYTIC_2	104	107	PF00928	0.389
TRG_ER_diArg_1	6	8	PF00400	0.519
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4ISU4	Bodo saltans	25%	94%
A4H6Y8	Leishmania braziliensis	44%	68%
E9AGG5	Leishmania infantum	59%	100%
E9AP08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
E9B1U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
Q4QGI0	Leishmania major	43%	100%
Q4QGI8	Leishmania major	41%	81%
Q4QGJ2	Leishmania major	43%	96%
Q4QGK0	Leishmania major	48%	100%
Q4QGK2	Leishmania major	38%	100%
Q4QGK4	Leishmania major	43%	93%
Q4QGK8	Leishmania major	41%	100%
Q4QGL2	Leishmania major	41%	100%
Q4QGL8	Leishmania major	42%	100%
Q4QGM1	Leishmania major	37%	80%