Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8I9B3_LEIDO

TriTrypDb:

LdBPK_120420.1 , LdCL_120009800 , LDHU3_12.0600

Length:

784

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I9B3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9B3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	279	283	PF00656	0.749
CLV_C14_Caspase3-7	389	393	PF00656	0.703
CLV_C14_Caspase3-7	545	549	PF00656	0.708
CLV_C14_Caspase3-7	706	710	PF00656	0.856
CLV_NRD_NRD_1	106	108	PF00675	0.834
CLV_NRD_NRD_1	185	187	PF00675	0.707
CLV_NRD_NRD_1	252	254	PF00675	0.794
CLV_NRD_NRD_1	367	369	PF00675	0.813
CLV_NRD_NRD_1	595	597	PF00675	0.719
CLV_NRD_NRD_1	684	686	PF00675	0.635
CLV_NRD_NRD_1	738	740	PF00675	0.642
CLV_PCSK_KEX2_1	106	108	PF00082	0.828
CLV_PCSK_KEX2_1	185	187	PF00082	0.707
CLV_PCSK_KEX2_1	252	254	PF00082	0.794
CLV_PCSK_KEX2_1	366	368	PF00082	0.825
CLV_PCSK_KEX2_1	595	597	PF00082	0.719
CLV_PCSK_KEX2_1	684	686	PF00082	0.639
CLV_PCSK_KEX2_1	738	740	PF00082	0.683
CLV_PCSK_PC7_1	248	254	PF00082	0.783
CLV_PCSK_PC7_1	591	597	PF00082	0.756
CLV_PCSK_SKI1_1	110	114	PF00082	0.832
CLV_PCSK_SKI1_1	525	529	PF00082	0.728
CLV_PCSK_SKI1_1	60	64	PF00082	0.813
CLV_PCSK_SKI1_1	637	641	PF00082	0.702
DEG_Kelch_Keap1_1	501	506	PF01344	0.806
DEG_Nend_UBRbox_3	1	3	PF02207	0.779
DEG_SCF_FBW7_1	473	480	PF00400	0.808
DEG_SPOP_SBC_1	269	273	PF00917	0.653
DEG_SPOP_SBC_1	695	699	PF00917	0.741
DEG_SPOP_SBC_1	96	100	PF00917	0.779
DOC_ANK_TNKS_1	594	601	PF00023	0.680
DOC_CDC14_PxL_1	187	195	PF14671	0.778
DOC_CKS1_1	144	149	PF01111	0.732
DOC_CKS1_1	265	270	PF01111	0.751
DOC_CKS1_1	399	404	PF01111	0.635
DOC_CKS1_1	474	479	PF01111	0.851
DOC_CYCLIN_RxL_1	106	115	PF00134	0.770
DOC_CYCLIN_yClb3_PxF_3	259	265	PF00134	0.756
DOC_MAPK_gen_1	106	113	PF00069	0.828
DOC_MAPK_gen_1	757	764	PF00069	0.741
DOC_MAPK_JIP1_4	107	113	PF00069	0.770
DOC_PP2B_LxvP_1	119	122	PF13499	0.681
DOC_PP2B_LxvP_1	198	201	PF13499	0.852
DOC_PP2B_LxvP_1	527	530	PF13499	0.827
DOC_PP4_FxxP_1	265	268	PF00568	0.862
DOC_PP4_FxxP_1	4	7	PF00568	0.692
DOC_USP7_MATH_1	112	116	PF00917	0.824
DOC_USP7_MATH_1	122	126	PF00917	0.679
DOC_USP7_MATH_1	153	157	PF00917	0.737
DOC_USP7_MATH_1	169	173	PF00917	0.583
DOC_USP7_MATH_1	201	205	PF00917	0.782
DOC_USP7_MATH_1	209	213	PF00917	0.684
DOC_USP7_MATH_1	268	272	PF00917	0.711
DOC_USP7_MATH_1	491	495	PF00917	0.773
DOC_USP7_MATH_1	515	519	PF00917	0.765
DOC_USP7_MATH_1	695	699	PF00917	0.708
DOC_USP7_MATH_1	740	744	PF00917	0.821
DOC_USP7_MATH_1	75	79	PF00917	0.763
DOC_USP7_MATH_1	760	764	PF00917	0.522
DOC_USP7_MATH_1	84	88	PF00917	0.639
DOC_USP7_MATH_1	91	95	PF00917	0.542
DOC_WW_Pin1_4	140	145	PF00397	0.859
DOC_WW_Pin1_4	246	251	PF00397	0.835
DOC_WW_Pin1_4	26	31	PF00397	0.737
DOC_WW_Pin1_4	264	269	PF00397	0.579
DOC_WW_Pin1_4	270	275	PF00397	0.685
DOC_WW_Pin1_4	282	287	PF00397	0.580
DOC_WW_Pin1_4	293	298	PF00397	0.646
DOC_WW_Pin1_4	299	304	PF00397	0.617
DOC_WW_Pin1_4	310	315	PF00397	0.572
DOC_WW_Pin1_4	398	403	PF00397	0.844
DOC_WW_Pin1_4	426	431	PF00397	0.838
DOC_WW_Pin1_4	432	437	PF00397	0.735
DOC_WW_Pin1_4	44	49	PF00397	0.588
DOC_WW_Pin1_4	473	478	PF00397	0.851
DOC_WW_Pin1_4	712	717	PF00397	0.694
DOC_WW_Pin1_4	97	102	PF00397	0.782
LIG_14-3-3_CanoR_1	19	27	PF00244	0.719
LIG_14-3-3_CanoR_1	192	198	PF00244	0.780
LIG_14-3-3_CanoR_1	231	236	PF00244	0.823
LIG_14-3-3_CanoR_1	252	257	PF00244	0.743
LIG_14-3-3_CanoR_1	332	340	PF00244	0.853
LIG_14-3-3_CanoR_1	366	372	PF00244	0.819
LIG_14-3-3_CanoR_1	405	414	PF00244	0.769
LIG_14-3-3_CanoR_1	441	449	PF00244	0.816
LIG_14-3-3_CanoR_1	450	456	PF00244	0.657
LIG_14-3-3_CanoR_1	525	530	PF00244	0.749
LIG_14-3-3_CanoR_1	60	67	PF00244	0.806
LIG_14-3-3_CanoR_1	672	681	PF00244	0.720
LIG_14-3-3_CanoR_1	685	691	PF00244	0.520
LIG_14-3-3_CanoR_1	757	763	PF00244	0.714
LIG_Actin_WH2_2	671	686	PF00022	0.607
LIG_BIR_III_2	662	666	PF00653	0.684
LIG_BRCT_BRCA1_1	297	301	PF00533	0.692
LIG_BRCT_BRCA1_1	724	728	PF00533	0.746
LIG_BRCT_BRCA1_1	760	764	PF00533	0.738
LIG_BRCT_BRCA1_2	724	730	PF00533	0.743
LIG_CtBP_PxDLS_1	664	668	PF00389	0.594
LIG_deltaCOP1_diTrp_1	537	546	PF00928	0.623
LIG_FHA_1	23	29	PF00498	0.734
LIG_FHA_1	232	238	PF00498	0.705
LIG_FHA_1	265	271	PF00498	0.697
LIG_FHA_1	394	400	PF00498	0.644
LIG_FHA_1	521	527	PF00498	0.700
LIG_FHA_1	654	660	PF00498	0.750
LIG_FHA_2	455	461	PF00498	0.526
LIG_FHA_2	566	572	PF00498	0.544
LIG_FHA_2	687	693	PF00498	0.806
LIG_LIR_Apic_2	3	7	PF02991	0.685
LIG_LIR_Apic_2	429	434	PF02991	0.832
LIG_LIR_Apic_2	538	544	PF02991	0.784
LIG_LIR_Apic_2	618	623	PF02991	0.728
LIG_LIR_Nem_3	298	304	PF02991	0.701
LIG_LIR_Nem_3	522	527	PF02991	0.757
LIG_MYND_1	101	105	PF01753	0.778
LIG_PTAP_UEV_1	210	215	PF05743	0.662
LIG_SH2_CRK	431	435	PF00017	0.841
LIG_SH2_CRK	524	528	PF00017	0.712
LIG_SH2_GRB2like	606	609	PF00017	0.575
LIG_SH2_NCK_1	431	435	PF00017	0.841
LIG_SH2_STAP1	233	237	PF00017	0.583
LIG_SH2_STAP1	288	292	PF00017	0.790
LIG_SH2_STAP1	451	455	PF00017	0.690
LIG_SH2_STAP1	771	775	PF00017	0.760
LIG_SH2_STAT5	233	236	PF00017	0.583
LIG_SH2_STAT5	371	374	PF00017	0.807
LIG_SH2_STAT5	431	434	PF00017	0.799
LIG_SH3_2	101	106	PF14604	0.779
LIG_SH3_3	141	147	PF00018	0.776
LIG_SH3_3	208	214	PF00018	0.784
LIG_SH3_3	24	30	PF00018	0.720
LIG_SH3_3	253	259	PF00018	0.841
LIG_SH3_3	289	295	PF00018	0.631
LIG_SH3_3	305	311	PF00018	0.597
LIG_SH3_3	353	359	PF00018	0.694
LIG_SH3_3	396	402	PF00018	0.639
LIG_SH3_3	478	484	PF00018	0.750
LIG_SH3_3	710	716	PF00018	0.857
LIG_SH3_3	746	752	PF00018	0.776
LIG_SH3_3	8	14	PF00018	0.630
LIG_SH3_3	98	104	PF00018	0.751
LIG_SUMO_SIM_par_1	638	644	PF11976	0.769
LIG_TRAF2_1	778	781	PF00917	0.698
LIG_WRC_WIRS_1	1	6	PF05994	0.686
LIG_WRC_WIRS_1	378	383	PF05994	0.733
LIG_WRC_WIRS_1	543	548	PF05994	0.619
LIG_WW_3	103	107	PF00397	0.777
LIG_WW_3	338	342	PF00397	0.631
LIG_WW_3	480	484	PF00397	0.632
MOD_CDC14_SPxK_1	249	252	PF00782	0.818
MOD_CDC14_SPxK_1	480	483	PF00782	0.633
MOD_CDK_SPxK_1	246	252	PF00069	0.816
MOD_CDK_SPxK_1	477	483	PF00069	0.670
MOD_CDK_SPxxK_3	246	253	PF00069	0.737
MOD_CDK_SPxxK_3	398	405	PF00069	0.761
MOD_CK1_1	138	144	PF00069	0.827
MOD_CK1_1	18	24	PF00069	0.751
MOD_CK1_1	246	252	PF00069	0.857
MOD_CK1_1	293	299	PF00069	0.760
MOD_CK1_1	302	308	PF00069	0.636
MOD_CK1_1	37	43	PF00069	0.512
MOD_CK1_1	370	376	PF00069	0.807
MOD_CK1_1	406	412	PF00069	0.787
MOD_CK1_1	453	459	PF00069	0.695
MOD_CK1_1	475	481	PF00069	0.844
MOD_CK1_1	648	654	PF00069	0.677
MOD_CK1_1	696	702	PF00069	0.859
MOD_CK1_1	758	764	PF00069	0.823
MOD_CK1_1	767	773	PF00069	0.616
MOD_CK1_1	87	93	PF00069	0.739
MOD_CK2_1	220	226	PF00069	0.757
MOD_CK2_1	686	692	PF00069	0.801
MOD_CK2_1	712	718	PF00069	0.663
MOD_CK2_1	738	744	PF00069	0.854
MOD_GlcNHglycan	114	117	PF01048	0.827
MOD_GlcNHglycan	129	132	PF01048	0.629
MOD_GlcNHglycan	198	201	PF01048	0.798
MOD_GlcNHglycan	21	24	PF01048	0.532
MOD_GlcNHglycan	211	214	PF01048	0.705
MOD_GlcNHglycan	237	240	PF01048	0.723
MOD_GlcNHglycan	336	339	PF01048	0.834
MOD_GlcNHglycan	348	351	PF01048	0.635
MOD_GlcNHglycan	372	375	PF01048	0.704
MOD_GlcNHglycan	414	417	PF01048	0.818
MOD_GlcNHglycan	426	429	PF01048	0.615
MOD_GlcNHglycan	443	446	PF01048	0.610
MOD_GlcNHglycan	465	468	PF01048	0.740
MOD_GlcNHglycan	497	500	PF01048	0.764
MOD_GlcNHglycan	517	520	PF01048	0.610
MOD_GlcNHglycan	55	58	PF01048	0.696
MOD_GlcNHglycan	616	620	PF01048	0.721
MOD_GlcNHglycan	647	650	PF01048	0.644
MOD_GlcNHglycan	7	10	PF01048	0.774
MOD_GlcNHglycan	70	73	PF01048	0.560
MOD_GlcNHglycan	723	727	PF01048	0.785
MOD_GlcNHglycan	729	733	PF01048	0.732
MOD_GlcNHglycan	740	743	PF01048	0.571
MOD_GlcNHglycan	77	80	PF01048	0.680
MOD_GlcNHglycan	776	779	PF01048	0.559
MOD_GlcNHglycan	89	92	PF01048	0.614
MOD_GSK3_1	15	22	PF00069	0.658
MOD_GSK3_1	231	238	PF00069	0.803
MOD_GSK3_1	240	247	PF00069	0.719
MOD_GSK3_1	264	271	PF00069	0.741
MOD_GSK3_1	282	289	PF00069	0.640
MOD_GSK3_1	295	302	PF00069	0.604
MOD_GSK3_1	306	313	PF00069	0.616
MOD_GSK3_1	346	353	PF00069	0.755
MOD_GSK3_1	366	373	PF00069	0.735
MOD_GSK3_1	377	384	PF00069	0.631
MOD_GSK3_1	405	412	PF00069	0.795
MOD_GSK3_1	422	429	PF00069	0.549
MOD_GSK3_1	430	437	PF00069	0.682
MOD_GSK3_1	450	457	PF00069	0.537
MOD_GSK3_1	459	466	PF00069	0.695
MOD_GSK3_1	473	480	PF00069	0.640
MOD_GSK3_1	487	494	PF00069	0.651
MOD_GSK3_1	515	522	PF00069	0.754
MOD_GSK3_1	525	532	PF00069	0.722
MOD_GSK3_1	533	540	PF00069	0.562
MOD_GSK3_1	561	568	PF00069	0.538
MOD_GSK3_1	61	68	PF00069	0.700
MOD_GSK3_1	644	651	PF00069	0.774
MOD_GSK3_1	672	679	PF00069	0.596
MOD_GSK3_1	694	701	PF00069	0.759
MOD_GSK3_1	738	745	PF00069	0.546
MOD_GSK3_1	760	767	PF00069	0.808
MOD_GSK3_1	86	93	PF00069	0.738
MOD_GSK3_1	95	102	PF00069	0.698
MOD_N-GLC_1	127	132	PF02516	0.820
MOD_N-GLC_1	282	287	PF02516	0.811
MOD_N-GLC_1	406	411	PF02516	0.789
MOD_N-GLC_1	463	468	PF02516	0.663
MOD_N-GLC_1	607	612	PF02516	0.564
MOD_NEK2_1	235	240	PF00069	0.727
MOD_NEK2_1	244	249	PF00069	0.677
MOD_NEK2_1	377	382	PF00069	0.791
MOD_NEK2_1	403	408	PF00069	0.825
MOD_NEK2_1	58	63	PF00069	0.641
MOD_NEK2_1	673	678	PF00069	0.677
MOD_NEK2_1	722	727	PF00069	0.706
MOD_NEK2_1	728	733	PF00069	0.713
MOD_NEK2_1	764	769	PF00069	0.705
MOD_PIKK_1	332	338	PF00454	0.779
MOD_PIKK_1	475	481	PF00454	0.803
MOD_PIKK_1	686	692	PF00454	0.666
MOD_PIKK_1	733	739	PF00454	0.842
MOD_PK_1	252	258	PF00069	0.741
MOD_PKA_1	252	258	PF00069	0.780
MOD_PKA_1	366	372	PF00069	0.819
MOD_PKA_1	684	690	PF00069	0.756
MOD_PKA_1	738	744	PF00069	0.689
MOD_PKA_2	169	175	PF00069	0.658
MOD_PKA_2	18	24	PF00069	0.744
MOD_PKA_2	191	197	PF00069	0.728
MOD_PKA_2	252	258	PF00069	0.770
MOD_PKA_2	322	328	PF00069	0.725
MOD_PKA_2	366	372	PF00069	0.819
MOD_PKA_2	409	415	PF00069	0.785
MOD_PKA_2	645	651	PF00069	0.607
MOD_PKA_2	684	690	PF00069	0.838
MOD_PKA_2	738	744	PF00069	0.854
MOD_PKA_2	758	764	PF00069	0.494
MOD_PKB_1	441	449	PF00069	0.737
MOD_Plk_1	153	159	PF00069	0.674
MOD_Plk_1	458	464	PF00069	0.676
MOD_Plk_1	537	543	PF00069	0.719
MOD_Plk_1	615	621	PF00069	0.715
MOD_Plk_1	722	728	PF00069	0.827
MOD_Plk_2-3	160	166	PF00069	0.796
MOD_Plk_4	367	373	PF00069	0.815
MOD_Plk_4	537	543	PF00069	0.719
MOD_Plk_4	760	766	PF00069	0.730
MOD_ProDKin_1	140	146	PF00069	0.860
MOD_ProDKin_1	246	252	PF00069	0.839
MOD_ProDKin_1	26	32	PF00069	0.741
MOD_ProDKin_1	264	270	PF00069	0.581
MOD_ProDKin_1	282	288	PF00069	0.583
MOD_ProDKin_1	293	299	PF00069	0.645
MOD_ProDKin_1	310	316	PF00069	0.574
MOD_ProDKin_1	398	404	PF00069	0.843
MOD_ProDKin_1	426	432	PF00069	0.839
MOD_ProDKin_1	44	50	PF00069	0.589
MOD_ProDKin_1	473	479	PF00069	0.852
MOD_ProDKin_1	712	718	PF00069	0.692
MOD_ProDKin_1	97	103	PF00069	0.783
TRG_DiLeu_BaLyEn_6	522	527	PF01217	0.743
TRG_DiLeu_BaLyEn_6	669	674	PF01217	0.724
TRG_ENDOCYTIC_2	524	527	PF00928	0.713
TRG_ER_diArg_1	105	107	PF00400	0.835
TRG_ER_diArg_1	185	187	PF00400	0.707
TRG_ER_diArg_1	366	368	PF00400	0.701
TRG_ER_diArg_1	594	596	PF00400	0.755
TRG_ER_diArg_1	683	685	PF00400	0.719
TRG_ER_diArg_1	738	740	PF00400	0.699
TRG_ER_diArg_1	756	759	PF00400	0.679

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H707	Leishmania braziliensis	59%	100%
E9AGD4	Leishmania infantum	100%	100%
E9ANX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QGP6	Leishmania major	83%	100%