Surface antigen protein 2, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface antigen-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8I9A6_LEIDO

TriTrypDb:

LdBPK_090630.1 , LdCL_120012600 , LdCL_120013100 , LdCL_120013500 , LdCL_120014000 , LdCL_120014500 , LdCL_120015000 , LdCL_120015500 , LdCL_120016000 , LdCL_120016500 , LdCL_120017000 , LdCL_120017500 , LDHU3_12.1240

Length:

386

Annotations

LeishMANIAdb annotations

Publication identifier(s): 8702946
A surface coat protein involved in immune evasion in Leishmaniids. Extremely fast evolving, almost completely disordered mucin-like protein. . Localization: Cell surface (experimental)

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 140

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 56, no: 8
NetGPI	no	yes: 0, no: 64

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	65
GO:0042995	cell projection	2	65
GO:0043226	organelle	2	65
GO:0043227	membrane-bounded organelle	3	65
GO:0110165	cellular anatomical entity	1	65
GO:0120025	plasma membrane bounded cell projection	3	65
GO:0016020	membrane	2	23
GO:0005886	plasma membrane	3	5

Expansion

Sequence features

A0A3Q8I9A6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9A6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004672	protein kinase activity	3	3
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	6	8	PF00675	0.683
CLV_PCSK_KEX2_1	6	8	PF00082	0.683
CLV_PCSK_SKI1_1	227	231	PF00082	0.436
CLV_PCSK_SKI1_1	257	261	PF00082	0.420
CLV_PCSK_SKI1_1	31	35	PF00082	0.701
CLV_PCSK_SKI1_1	7	11	PF00082	0.668
DEG_SCF_FBW7_2	314	319	PF00400	0.417
DEG_SPOP_SBC_1	303	307	PF00917	0.400
DOC_ANK_TNKS_1	353	360	PF00023	0.297
DOC_CYCLIN_RxL_1	3	13	PF00134	0.464
DOC_MAPK_gen_1	227	237	PF00069	0.222
DOC_USP7_MATH_1	159	163	PF00917	0.302
DOC_USP7_MATH_1	216	220	PF00917	0.239
DOC_USP7_MATH_1	362	366	PF00917	0.218
DOC_USP7_UBL2_3	294	298	PF12436	0.299
DOC_WW_Pin1_4	306	311	PF00397	0.434
DOC_WW_Pin1_4	312	317	PF00397	0.422
LIG_Actin_WH2_2	177	192	PF00022	0.235
LIG_BIR_II_1	1	5	PF00653	0.541
LIG_FHA_1	103	109	PF00498	0.284
LIG_FHA_1	145	151	PF00498	0.363
LIG_FHA_1	184	190	PF00498	0.410
LIG_FHA_1	275	281	PF00498	0.291
LIG_FHA_1	44	50	PF00498	0.444
LIG_FHA_2	108	114	PF00498	0.272
LIG_FHA_2	207	213	PF00498	0.350
LIG_FHA_2	281	287	PF00498	0.377
LIG_FHA_2	318	324	PF00498	0.360
LIG_FHA_2	63	69	PF00498	0.403
LIG_FHA_2	92	98	PF00498	0.360
LIG_LIR_Gen_1	101	112	PF02991	0.276
LIG_LIR_Gen_1	128	136	PF02991	0.317
LIG_LIR_Gen_1	153	160	PF02991	0.315
LIG_LIR_Gen_1	186	194	PF02991	0.381
LIG_LIR_Gen_1	248	256	PF02991	0.419
LIG_LIR_Nem_3	101	107	PF02991	0.424
LIG_LIR_Nem_3	186	191	PF02991	0.384
LIG_LIR_Nem_3	71	75	PF02991	0.308
LIG_PCNA_PIPBox_1	132	141	PF02747	0.226
LIG_PCNA_PIPBox_1	181	190	PF02747	0.204
LIG_PDZ_Class_2	381	386	PF00595	0.260
LIG_Pex14_1	72	76	PF04695	0.199
LIG_SH2_CRK	104	108	PF00017	0.441
LIG_SH2_CRK	76	80	PF00017	0.220
LIG_SH2_GRB2like	104	107	PF00017	0.235
LIG_SH2_STAP1	104	108	PF00017	0.244
LIG_SH2_STAT5	104	107	PF00017	0.335
LIG_SH2_STAT5	188	191	PF00017	0.226
LIG_SH2_STAT5	345	348	PF00017	0.286
LIG_SH2_STAT5	74	77	PF00017	0.267
LIG_SH3_3	93	99	PF00018	0.391
LIG_SUMO_SIM_anti_2	207	212	PF11976	0.304
LIG_TYR_ITIM	102	107	PF00017	0.422
LIG_UBA3_1	210	217	PF00899	0.229
MOD_CK1_1	128	134	PF00069	0.353
MOD_CK1_1	153	159	PF00069	0.330
MOD_CK1_1	179	185	PF00069	0.244
MOD_CK1_1	204	210	PF00069	0.323
MOD_CK1_1	221	227	PF00069	0.401
MOD_CK1_1	245	251	PF00069	0.311
MOD_CK1_1	273	279	PF00069	0.309
MOD_CK1_1	349	355	PF00069	0.266
MOD_CK2_1	317	323	PF00069	0.393
MOD_CK2_1	91	97	PF00069	0.385
MOD_GlcNHglycan	113	117	PF01048	0.545
MOD_GlcNHglycan	121	124	PF01048	0.551
MOD_GlcNHglycan	170	173	PF01048	0.668
MOD_GlcNHglycan	194	197	PF01048	0.584
MOD_GlcNHglycan	218	221	PF01048	0.582
MOD_GlcNHglycan	230	233	PF01048	0.572
MOD_GlcNHglycan	241	245	PF01048	0.532
MOD_GlcNHglycan	25	28	PF01048	0.704
MOD_GlcNHglycan	250	253	PF01048	0.529
MOD_GlcNHglycan	261	264	PF01048	0.520
MOD_GlcNHglycan	333	336	PF01048	0.532
MOD_GlcNHglycan	365	368	PF01048	0.246
MOD_GlcNHglycan	79	82	PF01048	0.491
MOD_GSK3_1	121	128	PF00069	0.362
MOD_GSK3_1	130	137	PF00069	0.333
MOD_GSK3_1	146	153	PF00069	0.314
MOD_GSK3_1	176	183	PF00069	0.401
MOD_GSK3_1	200	207	PF00069	0.353
MOD_GSK3_1	242	249	PF00069	0.310
MOD_GSK3_1	270	277	PF00069	0.288
MOD_GSK3_1	302	309	PF00069	0.554
MOD_GSK3_1	345	352	PF00069	0.306
MOD_N-GLC_1	36	41	PF02516	0.581
MOD_N-GLC_2	297	299	PF02516	0.525
MOD_NEK2_1	10	15	PF00069	0.605
MOD_NEK2_1	112	117	PF00069	0.361
MOD_NEK2_1	121	126	PF00069	0.398
MOD_NEK2_1	165	170	PF00069	0.328
MOD_NEK2_1	189	194	PF00069	0.273
MOD_NEK2_1	21	26	PF00069	0.495
MOD_NEK2_1	242	247	PF00069	0.340
MOD_NEK2_1	38	43	PF00069	0.240
MOD_PIKK_1	107	113	PF00454	0.293
MOD_PIKK_1	165	171	PF00454	0.352
MOD_PIKK_1	274	280	PF00454	0.256
MOD_PIKK_1	38	44	PF00454	0.357
MOD_PKA_2	119	125	PF00069	0.298
MOD_PKA_2	144	150	PF00069	0.339
MOD_PKA_2	189	195	PF00069	0.414
MOD_Plk_4	131	137	PF00069	0.324
MOD_Plk_4	183	189	PF00069	0.260
MOD_Plk_4	206	212	PF00069	0.368
MOD_ProDKin_1	306	312	PF00069	0.435
MOD_SUMO_rev_2	224	232	PF00179	0.230
MOD_SUMO_rev_2	285	291	PF00179	0.267
TRG_ENDOCYTIC_2	104	107	PF00928	0.425
TRG_ENDOCYTIC_2	188	191	PF00928	0.226
TRG_ER_diArg_1	5	7	PF00400	0.608
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L4	Leptomonas seymouri	40%	100%
A0A0N0P4M2	Leptomonas seymouri	23%	100%
A0A0N1I121	Leptomonas seymouri	29%	77%
A0A0N1I661	Leptomonas seymouri	37%	68%
A0A0N1I7S5	Leptomonas seymouri	32%	76%
A0A0S4IZC7	Bodo saltans	25%	94%
A0A0S4JEP2	Bodo saltans	22%	66%
A0A0S4JS89	Bodo saltans	26%	87%
A0A0S4KMV2	Bodo saltans	27%	98%
A0A1X0NKN8	Trypanosomatidae	26%	100%
A0A3Q8I9D0	Leishmania donovani	60%	100%
A0A3Q8IIJ9	Leishmania donovani	33%	100%
A0A3Q8IK15	Leishmania donovani	36%	73%
A0A3S5H6D6	Leishmania donovani	31%	100%
A0A3S5H6L9	Leishmania donovani	57%	67%
A0A3S7WPB2	Leishmania donovani	23%	100%
A0A3S7X4J4	Leishmania donovani	33%	100%
A4H4D2	Leishmania braziliensis	24%	100%
A4H4G6	Leishmania braziliensis	23%	100%
A4H5P0	Leishmania braziliensis	29%	100%
A4HBX3	Leishmania braziliensis	36%	85%
A4HJC8	Leishmania braziliensis	32%	100%
A4HJX1	Leishmania braziliensis	37%	88%
A4HTX9	Leishmania infantum	30%	100%
A4HVB0	Leishmania infantum	53%	100%
A4I6S2	Leishmania infantum	35%	100%
A4I6S3	Leishmania infantum	40%	77%
A4I6S4	Leishmania infantum	33%	100%
D1GJ51	Leishmania infantum	51%	100%
E8NHG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	87%
E8NHP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9ACQ0	Leishmania major	29%	100%
E9AEF4	Leishmania major	43%	84%
E9AG65	Leishmania infantum	23%	100%
E9AGG5	Leishmania infantum	81%	100%
E9AGG9	Leishmania infantum	46%	71%
E9AGH0	Leishmania infantum	83%	98%
E9AKM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AMQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AP00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	99%
E9AP02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	93%
E9AP03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
E9AP05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	75%
E9AP07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	94%
E9AP08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
E9AVA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	84%
E9B1U3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	85%
E9B1U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B1U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B1U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
P21978	Leishmania amazonensis	50%	81%
Q25331	Leishmania major	55%	100%
Q4PSE6	Arabidopsis thaliana	23%	89%
Q4Q6B6	Leishmania major	34%	100%
Q4Q6B7	Leishmania major	34%	100%
Q4Q6B8	Leishmania major	35%	73%
Q4QGI0	Leishmania major	54%	76%
Q4QGI2	Leishmania major	46%	69%
Q4QGI4	Leishmania major	48%	72%
Q4QGI6	Leishmania major	47%	71%
Q4QGJ4	Leishmania major	54%	100%
Q4QGJ6	Leishmania major	50%	67%
Q4QGJ7	Leishmania major	55%	89%
Q4QGK0	Leishmania major	51%	68%
Q4QGK2	Leishmania major	52%	69%
Q4QGK6	Leishmania major	55%	100%
Q4QGK8	Leishmania major	52%	75%
Q4QGL2	Leishmania major	52%	75%
Q4QGL4	Leishmania major	59%	96%
Q4QGL5	Leishmania major	49%	71%
Q4QHW6	Leishmania major	30%	100%
Q4QJB2	Leishmania major	22%	100%
Q8W3M4	Arabidopsis thaliana	24%	96%
Q9LHF1	Arabidopsis thaliana	21%	78%