DUF4110 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Galactose oxidase, central domain/Domain of unknown function (DUF4110), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I9A1_LEIDO

TriTrypDb:

LdBPK_160090.1 , LdCL_160005800 , LDHU3_16.0090

Length:

735

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I9A1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I9A1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.334
CLV_C14_Caspase3-7	511	515	PF00656	0.565
CLV_NRD_NRD_1	372	374	PF00675	0.450
CLV_NRD_NRD_1	450	452	PF00675	0.369
CLV_NRD_NRD_1	551	553	PF00675	0.649
CLV_NRD_NRD_1	660	662	PF00675	0.258
CLV_NRD_NRD_1	7	9	PF00675	0.585
CLV_NRD_NRD_1	701	703	PF00675	0.280
CLV_NRD_NRD_1	717	719	PF00675	0.468
CLV_PCSK_FUR_1	5	9	PF00082	0.589
CLV_PCSK_FUR_1	699	703	PF00082	0.356
CLV_PCSK_KEX2_1	119	121	PF00082	0.298
CLV_PCSK_KEX2_1	19	21	PF00082	0.486
CLV_PCSK_KEX2_1	200	202	PF00082	0.335
CLV_PCSK_KEX2_1	330	332	PF00082	0.442
CLV_PCSK_KEX2_1	364	366	PF00082	0.350
CLV_PCSK_KEX2_1	372	374	PF00082	0.418
CLV_PCSK_KEX2_1	376	378	PF00082	0.501
CLV_PCSK_KEX2_1	450	452	PF00082	0.369
CLV_PCSK_KEX2_1	55	57	PF00082	0.525
CLV_PCSK_KEX2_1	551	553	PF00082	0.649
CLV_PCSK_KEX2_1	660	662	PF00082	0.246
CLV_PCSK_KEX2_1	7	9	PF00082	0.582
CLV_PCSK_KEX2_1	701	703	PF00082	0.280
CLV_PCSK_KEX2_1	717	719	PF00082	0.468
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.298
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.472
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.427
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.442
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.352
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.533
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.525
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.598
CLV_PCSK_PC7_1	372	378	PF00082	0.557
CLV_PCSK_SKI1_1	16	20	PF00082	0.511
CLV_PCSK_SKI1_1	182	186	PF00082	0.298
CLV_PCSK_SKI1_1	195	199	PF00082	0.456
CLV_PCSK_SKI1_1	23	27	PF00082	0.509
CLV_PCSK_SKI1_1	30	34	PF00082	0.545
CLV_PCSK_SKI1_1	373	377	PF00082	0.561
CLV_PCSK_SKI1_1	475	479	PF00082	0.345
CLV_PCSK_SKI1_1	606	610	PF00082	0.434
CLV_PCSK_SKI1_1	660	664	PF00082	0.358
CLV_PCSK_SKI1_1	678	682	PF00082	0.167
DEG_APCC_DBOX_1	677	685	PF00400	0.370
DEG_APCC_KENBOX_2	33	37	PF00400	0.616
DEG_SCF_FBW7_2	625	631	PF00400	0.400
DEG_SPOP_SBC_1	134	138	PF00917	0.279
DEG_SPOP_SBC_1	639	643	PF00917	0.370
DOC_ANK_TNKS_1	649	656	PF00023	0.370
DOC_CKS1_1	625	630	PF01111	0.263
DOC_CKS1_1	75	80	PF01111	0.453
DOC_MAPK_gen_1	19	28	PF00069	0.625
DOC_MAPK_gen_1	200	206	PF00069	0.315
DOC_MAPK_gen_1	364	371	PF00069	0.357
DOC_MAPK_gen_1	450	458	PF00069	0.366
DOC_MAPK_gen_1	602	610	PF00069	0.495
DOC_PP1_RVXF_1	550	557	PF00149	0.642
DOC_USP7_MATH_1	134	138	PF00917	0.263
DOC_USP7_MATH_1	428	432	PF00917	0.678
DOC_USP7_MATH_1	639	643	PF00917	0.338
DOC_USP7_MATH_1	649	653	PF00917	0.222
DOC_USP7_UBL2_3	3	7	PF12436	0.626
DOC_USP7_UBL2_3	30	34	PF12436	0.591
DOC_USP7_UBL2_3	55	59	PF12436	0.411
DOC_USP7_UBL2_3	605	609	PF12436	0.458
DOC_WW_Pin1_4	340	345	PF00397	0.415
DOC_WW_Pin1_4	584	589	PF00397	0.582
DOC_WW_Pin1_4	624	629	PF00397	0.263
DOC_WW_Pin1_4	74	79	PF00397	0.376
LIG_14-3-3_CanoR_1	125	134	PF00244	0.353
LIG_14-3-3_CanoR_1	135	143	PF00244	0.263
LIG_14-3-3_CanoR_1	174	181	PF00244	0.400
LIG_14-3-3_CanoR_1	249	255	PF00244	0.360
LIG_14-3-3_CanoR_1	274	282	PF00244	0.431
LIG_14-3-3_CanoR_1	640	645	PF00244	0.299
LIG_APCC_ABBA_1	254	259	PF00400	0.378
LIG_APCC_ABBA_1	608	613	PF00400	0.403
LIG_APCC_ABBA_1	84	89	PF00400	0.339
LIG_BRCT_BRCA1_1	323	327	PF00533	0.404
LIG_BRCT_BRCA1_1	479	483	PF00533	0.357
LIG_deltaCOP1_diTrp_1	167	171	PF00928	0.263
LIG_eIF4E_1	675	681	PF01652	0.370
LIG_FHA_1	460	466	PF00498	0.364
LIG_FHA_1	482	488	PF00498	0.421
LIG_FHA_1	585	591	PF00498	0.609
LIG_FHA_1	75	81	PF00498	0.359
LIG_FHA_2	411	417	PF00498	0.770
LIG_FHA_2	476	482	PF00498	0.341
LIG_FHA_2	64	70	PF00498	0.415
LIG_FHA_2	646	652	PF00498	0.381
LIG_LIR_Gen_1	160	168	PF02991	0.263
LIG_LIR_Gen_1	175	184	PF02991	0.263
LIG_LIR_Gen_1	269	280	PF02991	0.423
LIG_LIR_Gen_1	350	361	PF02991	0.416
LIG_LIR_Gen_1	631	639	PF02991	0.343
LIG_LIR_Nem_3	160	165	PF02991	0.277
LIG_LIR_Nem_3	175	181	PF02991	0.263
LIG_LIR_Nem_3	269	275	PF02991	0.430
LIG_LIR_Nem_3	350	356	PF02991	0.433
LIG_LIR_Nem_3	363	369	PF02991	0.318
LIG_LIR_Nem_3	491	496	PF02991	0.357
LIG_LIR_Nem_3	631	637	PF02991	0.376
LIG_LIR_Nem_3	706	712	PF02991	0.288
LIG_LYPXL_S_1	366	370	PF13949	0.333
LIG_LYPXL_yS_3	367	370	PF13949	0.340
LIG_MYND_1	563	567	PF01753	0.625
LIG_Pex14_2	150	154	PF04695	0.329
LIG_Pex14_2	165	169	PF04695	0.187
LIG_Pex14_2	219	223	PF04695	0.317
LIG_Pex14_2	634	638	PF04695	0.400
LIG_Pex14_2	97	101	PF04695	0.400
LIG_PTB_Apo_2	351	358	PF02174	0.349
LIG_PTB_Apo_2	458	465	PF02174	0.346
LIG_PTB_Phospho_1	351	357	PF10480	0.424
LIG_PTB_Phospho_1	458	464	PF10480	0.350
LIG_REV1ctd_RIR_1	113	124	PF16727	0.400
LIG_REV1ctd_RIR_1	635	644	PF16727	0.279
LIG_REV1ctd_RIR_1	695	706	PF16727	0.263
LIG_SH2_CRK	493	497	PF00017	0.393
LIG_SH2_GRB2like	210	213	PF00017	0.336
LIG_SH2_NCK_1	210	214	PF00017	0.350
LIG_SH2_NCK_1	712	716	PF00017	0.530
LIG_SH2_SRC	210	213	PF00017	0.336
LIG_SH2_SRC	464	467	PF00017	0.444
LIG_SH2_SRC	712	715	PF00017	0.528
LIG_SH2_STAP1	529	533	PF00017	0.569
LIG_SH2_STAT3	267	270	PF00017	0.444
LIG_SH2_STAT3	466	469	PF00017	0.452
LIG_SH2_STAT5	114	117	PF00017	0.279
LIG_SH2_STAT5	146	149	PF00017	0.356
LIG_SH2_STAT5	162	165	PF00017	0.356
LIG_SH2_STAT5	218	221	PF00017	0.323
LIG_SH2_STAT5	333	336	PF00017	0.304
LIG_SH2_STAT5	357	360	PF00017	0.391
LIG_SH2_STAT5	464	467	PF00017	0.329
LIG_SH3_3	561	567	PF00018	0.602
LIG_SH3_3	622	628	PF00018	0.263
LIG_SH3_3	70	76	PF00018	0.387
LIG_SH3_3	80	86	PF00018	0.260
LIG_SUMO_SIM_par_1	337	343	PF11976	0.348
LIG_TRAF2_1	405	408	PF00917	0.686
LIG_TRAF2_1	430	433	PF00917	0.701
LIG_TRAF2_1	66	69	PF00917	0.510
LIG_UBA3_1	288	295	PF00899	0.447
LIG_UBA3_1	482	489	PF00899	0.452
LIG_WRC_WIRS_1	349	354	PF05994	0.346
MOD_CDK_SPK_2	74	79	PF00069	0.370
MOD_CDK_SPxK_1	624	630	PF00069	0.280
MOD_CDK_SPxxK_3	340	347	PF00069	0.428
MOD_CK1_1	189	195	PF00069	0.325
MOD_CK1_1	250	256	PF00069	0.340
MOD_CK1_1	278	284	PF00069	0.366
MOD_CK1_1	410	416	PF00069	0.639
MOD_CK1_1	437	443	PF00069	0.559
MOD_CK1_1	517	523	PF00069	0.504
MOD_CK2_1	173	179	PF00069	0.400
MOD_CK2_1	401	407	PF00069	0.652
MOD_CK2_1	410	416	PF00069	0.625
MOD_CK2_1	470	476	PF00069	0.524
MOD_CK2_1	63	69	PF00069	0.404
MOD_CK2_1	645	651	PF00069	0.376
MOD_Cter_Amidation	549	552	PF01082	0.653
MOD_Cter_Amidation	603	606	PF01082	0.517
MOD_GlcNHglycan	127	130	PF01048	0.484
MOD_GlcNHglycan	191	194	PF01048	0.320
MOD_GlcNHglycan	249	252	PF01048	0.333
MOD_GlcNHglycan	394	397	PF01048	0.582
MOD_GlcNHglycan	453	456	PF01048	0.464
MOD_GlcNHglycan	500	504	PF01048	0.519
MOD_GlcNHglycan	519	522	PF01048	0.498
MOD_GlcNHglycan	525	528	PF01048	0.473
MOD_GlcNHglycan	622	625	PF01048	0.291
MOD_GSK3_1	153	160	PF00069	0.280
MOD_GSK3_1	232	239	PF00069	0.381
MOD_GSK3_1	403	410	PF00069	0.602
MOD_GSK3_1	424	431	PF00069	0.649
MOD_GSK3_1	477	484	PF00069	0.356
MOD_GSK3_1	495	502	PF00069	0.415
MOD_GSK3_1	510	517	PF00069	0.573
MOD_GSK3_1	519	526	PF00069	0.461
MOD_GSK3_1	620	627	PF00069	0.304
MOD_GSK3_1	645	652	PF00069	0.319
MOD_LATS_1	449	455	PF00433	0.479
MOD_N-GLC_1	110	115	PF02516	0.400
MOD_NEK2_1	348	353	PF00069	0.420
MOD_NEK2_1	470	475	PF00069	0.496
MOD_NEK2_1	619	624	PF00069	0.352
MOD_NEK2_1	638	643	PF00069	0.141
MOD_NEK2_2	287	292	PF00069	0.386
MOD_PIKK_1	135	141	PF00454	0.277
MOD_PIKK_1	153	159	PF00454	0.195
MOD_PIKK_1	232	238	PF00454	0.469
MOD_PIKK_1	266	272	PF00454	0.412
MOD_PIKK_1	428	434	PF00454	0.696
MOD_PIKK_1	495	501	PF00454	0.407
MOD_PKA_2	124	130	PF00069	0.317
MOD_PKA_2	134	140	PF00069	0.202
MOD_PKA_2	173	179	PF00069	0.400
MOD_PKA_2	639	645	PF00069	0.289
MOD_PKA_2	649	655	PF00069	0.265
MOD_PKA_2	89	95	PF00069	0.322
MOD_Plk_1	110	116	PF00069	0.329
MOD_Plk_1	278	284	PF00069	0.410
MOD_Plk_1	475	481	PF00069	0.354
MOD_Plk_1	50	56	PF00069	0.391
MOD_Plk_1	630	636	PF00069	0.398
MOD_Plk_2-3	514	520	PF00069	0.547
MOD_Plk_4	110	116	PF00069	0.372
MOD_Plk_4	252	258	PF00069	0.353
MOD_Plk_4	348	354	PF00069	0.529
MOD_Plk_4	459	465	PF00069	0.388
MOD_Plk_4	520	526	PF00069	0.456
MOD_Plk_4	586	592	PF00069	0.513
MOD_Plk_4	640	646	PF00069	0.376
MOD_ProDKin_1	340	346	PF00069	0.421
MOD_ProDKin_1	584	590	PF00069	0.580
MOD_ProDKin_1	624	630	PF00069	0.263
MOD_ProDKin_1	74	80	PF00069	0.373
MOD_SUMO_for_1	32	35	PF00179	0.510
MOD_SUMO_for_1	662	665	PF00179	0.378
MOD_SUMO_rev_2	175	184	PF00179	0.271
MOD_SUMO_rev_2	431	437	PF00179	0.544
MOD_SUMO_rev_2	651	658	PF00179	0.381
MOD_SUMO_rev_2	688	698	PF00179	0.400
TRG_DiLeu_BaEn_1	676	681	PF01217	0.263
TRG_DiLeu_BaEn_4	179	185	PF01217	0.298
TRG_DiLeu_BaLyEn_6	492	497	PF01217	0.494
TRG_ENDOCYTIC_2	146	149	PF00928	0.272
TRG_ENDOCYTIC_2	162	165	PF00928	0.323
TRG_ENDOCYTIC_2	353	356	PF00928	0.428
TRG_ENDOCYTIC_2	367	370	PF00928	0.249
TRG_ENDOCYTIC_2	493	496	PF00928	0.411
TRG_ER_diArg_1	371	373	PF00400	0.427
TRG_ER_diArg_1	450	452	PF00400	0.369
TRG_ER_diArg_1	660	662	PF00400	0.256
TRG_ER_diArg_1	701	703	PF00400	0.356
TRG_ER_diArg_1	717	719	PF00400	0.549
TRG_Pf-PMV_PEXEL_1	660	665	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	678	683	PF00026	0.218
TRG_Pf-PMV_PEXEL_1	701	706	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	717	721	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8R8	Leptomonas seymouri	75%	100%
A0A0S4JR73	Bodo saltans	50%	94%
A0A1X0NZQ9	Trypanosomatidae	60%	100%
A0A422NAE1	Trypanosoma rangeli	60%	100%
A4H8D5	Leishmania braziliensis	85%	100%
A4HWQ7	Leishmania infantum	100%	100%
C9ZPS3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	99%
E9AQG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q08979	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q4QF12	Leishmania major	95%	100%
Q5R8W1	Pongo abelii	32%	100%
Q8TBB5	Homo sapiens	30%	100%
Q921I2	Mus musculus	33%	100%
V5BBA4	Trypanosoma cruzi	60%	100%