Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8I993_LEIDO

TriTrypDb:

LdBPK_120430.1 , LdCL_120009900 , LDHU3_12.0610

Length:

709

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I993

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I993

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	258	262	PF00656	0.604
CLV_C14_Caspase3-7	91	95	PF00656	0.676
CLV_NRD_NRD_1	113	115	PF00675	0.659
CLV_NRD_NRD_1	145	147	PF00675	0.742
CLV_NRD_NRD_1	148	150	PF00675	0.746
CLV_NRD_NRD_1	159	161	PF00675	0.645
CLV_NRD_NRD_1	206	208	PF00675	0.679
CLV_NRD_NRD_1	222	224	PF00675	0.577
CLV_NRD_NRD_1	424	426	PF00675	0.685
CLV_PCSK_FUR_1	146	150	PF00082	0.661
CLV_PCSK_KEX2_1	145	147	PF00082	0.744
CLV_PCSK_KEX2_1	148	150	PF00082	0.743
CLV_PCSK_KEX2_1	159	161	PF00082	0.643
CLV_PCSK_KEX2_1	205	207	PF00082	0.684
CLV_PCSK_KEX2_1	222	224	PF00082	0.574
CLV_PCSK_KEX2_1	424	426	PF00082	0.685
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.680
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.680
CLV_PCSK_SKI1_1	206	210	PF00082	0.676
CLV_PCSK_SKI1_1	394	398	PF00082	0.659
CLV_PCSK_SKI1_1	408	412	PF00082	0.537
DEG_APCC_DBOX_1	503	511	PF00400	0.528
DEG_MDM2_SWIB_1	509	517	PF02201	0.534
DEG_SCF_FBW7_1	330	337	PF00400	0.575
DEG_SCF_TRCP1_1	230	235	PF00400	0.671
DEG_SPOP_SBC_1	284	288	PF00917	0.604
DOC_CKS1_1	467	472	PF01111	0.622
DOC_CKS1_1	659	664	PF01111	0.624
DOC_CYCLIN_RxL_1	200	212	PF00134	0.631
DOC_CYCLIN_yCln2_LP_2	361	367	PF00134	0.714
DOC_CYCLIN_yCln2_LP_2	434	440	PF00134	0.639
DOC_MAPK_gen_1	114	124	PF00069	0.645
DOC_MAPK_HePTP_8	318	330	PF00069	0.589
DOC_MAPK_MEF2A_6	321	330	PF00069	0.589
DOC_MAPK_MEF2A_6	536	545	PF00069	0.633
DOC_MIT_MIM_1	121	131	PF04212	0.548
DOC_PP2B_LxvP_1	208	211	PF13499	0.570
DOC_PP2B_LxvP_1	361	364	PF13499	0.759
DOC_PP2B_LxvP_1	543	546	PF13499	0.614
DOC_PP4_FxxP_1	54	57	PF00568	0.549
DOC_PP4_MxPP_1	544	547	PF00568	0.535
DOC_USP7_MATH_1	141	145	PF00917	0.706
DOC_USP7_MATH_1	155	159	PF00917	0.572
DOC_USP7_MATH_1	20	24	PF00917	0.633
DOC_USP7_MATH_1	216	220	PF00917	0.654
DOC_USP7_MATH_1	277	281	PF00917	0.763
DOC_USP7_MATH_1	283	287	PF00917	0.704
DOC_USP7_MATH_1	491	495	PF00917	0.722
DOC_USP7_MATH_1	515	519	PF00917	0.576
DOC_USP7_MATH_1	6	10	PF00917	0.721
DOC_USP7_MATH_1	634	638	PF00917	0.617
DOC_USP7_MATH_1	677	681	PF00917	0.645
DOC_USP7_MATH_1	74	78	PF00917	0.702
DOC_USP7_MATH_1	88	92	PF00917	0.540
DOC_USP7_UBL2_3	111	115	PF12436	0.660
DOC_WW_Pin1_4	241	246	PF00397	0.686
DOC_WW_Pin1_4	330	335	PF00397	0.727
DOC_WW_Pin1_4	433	438	PF00397	0.625
DOC_WW_Pin1_4	466	471	PF00397	0.645
DOC_WW_Pin1_4	658	663	PF00397	0.680
DOC_WW_Pin1_4	666	671	PF00397	0.641
DOC_WW_Pin1_4	96	101	PF00397	0.752
LIG_14-3-3_CanoR_1	109	114	PF00244	0.651
LIG_14-3-3_CanoR_1	127	132	PF00244	0.534
LIG_14-3-3_CanoR_1	149	155	PF00244	0.686
LIG_14-3-3_CanoR_1	217	222	PF00244	0.621
LIG_14-3-3_CanoR_1	246	251	PF00244	0.640
LIG_14-3-3_CanoR_1	424	431	PF00244	0.711
LIG_14-3-3_CanoR_1	504	510	PF00244	0.654
LIG_14-3-3_CanoR_1	536	541	PF00244	0.549
LIG_14-3-3_CanoR_1	610	616	PF00244	0.652
LIG_14-3-3_CanoR_1	80	84	PF00244	0.759
LIG_AP2alpha_1	54	58	PF02296	0.547
LIG_AP2alpha_2	56	58	PF02296	0.664
LIG_BIR_III_4	381	385	PF00653	0.565
LIG_BRCT_BRCA1_1	505	509	PF00533	0.615
LIG_BRCT_BRCA1_1	668	672	PF00533	0.582
LIG_FHA_1	173	179	PF00498	0.683
LIG_FHA_1	271	277	PF00498	0.622
LIG_FHA_1	321	327	PF00498	0.635
LIG_FHA_1	395	401	PF00498	0.662
LIG_FHA_1	437	443	PF00498	0.646
LIG_FHA_1	554	560	PF00498	0.570
LIG_FHA_1	652	658	PF00498	0.679
LIG_FHA_1	699	705	PF00498	0.657
LIG_FHA_1	74	80	PF00498	0.528
LIG_FHA_2	135	141	PF00498	0.661
LIG_FHA_2	189	195	PF00498	0.687
LIG_FHA_2	59	65	PF00498	0.638
LIG_Integrin_RGD_1	601	603	PF01839	0.589
LIG_LIR_Gen_1	167	176	PF02991	0.567
LIG_LIR_Gen_1	429	438	PF02991	0.567
LIG_LIR_Gen_1	498	507	PF02991	0.622
LIG_LIR_Gen_1	617	626	PF02991	0.607
LIG_LIR_Gen_1	675	685	PF02991	0.526
LIG_LIR_Nem_3	429	434	PF02991	0.580
LIG_LIR_Nem_3	498	502	PF02991	0.629
LIG_LIR_Nem_3	617	621	PF02991	0.599
LIG_LIR_Nem_3	675	681	PF02991	0.597
LIG_MYND_3	356	360	PF01753	0.663
LIG_PCNA_PIPBox_1	48	57	PF02747	0.558
LIG_Pex14_2	509	513	PF04695	0.616
LIG_Pex14_2	54	58	PF04695	0.547
LIG_Pex14_2	672	676	PF04695	0.553
LIG_SH2_NCK_1	551	555	PF00017	0.529
LIG_SH2_STAP1	295	299	PF00017	0.679
LIG_SH2_STAT5	267	270	PF00017	0.635
LIG_SH2_STAT5	561	564	PF00017	0.772
LIG_SH3_3	168	174	PF00018	0.691
LIG_SH3_3	521	527	PF00018	0.511
LIG_SH3_3	563	569	PF00018	0.658
LIG_SH3_3	656	662	PF00018	0.649
LIG_SH3_3	664	670	PF00018	0.670
LIG_SUMO_SIM_anti_2	320	327	PF11976	0.573
LIG_SUMO_SIM_anti_2	654	661	PF11976	0.624
LIG_SUMO_SIM_anti_2	701	706	PF11976	0.487
LIG_SUMO_SIM_par_1	322	327	PF11976	0.637
LIG_SUMO_SIM_par_1	395	403	PF11976	0.661
LIG_SUMO_SIM_par_1	700	706	PF11976	0.488
LIG_TRAF2_1	303	306	PF00917	0.637
LIG_TRAF2_1	370	373	PF00917	0.622
LIG_TRAF2_1	572	575	PF00917	0.622
LIG_WRC_WIRS_1	166	171	PF05994	0.568
LIG_WRC_WIRS_1	650	655	PF05994	0.652
MOD_CDK_SPK_2	241	246	PF00069	0.616
MOD_CDK_SPxK_1	330	336	PF00069	0.675
MOD_CK1_1	11	17	PF00069	0.606
MOD_CK1_1	134	140	PF00069	0.648
MOD_CK1_1	153	159	PF00069	0.632
MOD_CK1_1	201	207	PF00069	0.628
MOD_CK1_1	228	234	PF00069	0.621
MOD_CK1_1	23	29	PF00069	0.534
MOD_CK1_1	244	250	PF00069	0.680
MOD_CK1_1	253	259	PF00069	0.694
MOD_CK1_1	263	269	PF00069	0.658
MOD_CK1_1	286	292	PF00069	0.681
MOD_CK1_1	294	300	PF00069	0.606
MOD_CK1_1	320	326	PF00069	0.719
MOD_CK1_1	342	348	PF00069	0.687
MOD_CK1_1	420	426	PF00069	0.797
MOD_CK1_1	436	442	PF00069	0.529
MOD_CK1_1	451	457	PF00069	0.623
MOD_CK1_1	472	478	PF00069	0.755
MOD_CK1_1	553	559	PF00069	0.642
MOD_CK1_1	614	620	PF00069	0.669
MOD_CK1_1	666	672	PF00069	0.706
MOD_CK1_1	680	686	PF00069	0.584
MOD_CK2_1	115	121	PF00069	0.659
MOD_CK2_1	134	140	PF00069	0.505
MOD_CK2_1	164	170	PF00069	0.704
MOD_CK2_1	190	196	PF00069	0.620
MOD_CK2_1	341	347	PF00069	0.704
MOD_CK2_1	366	372	PF00069	0.647
MOD_CK2_1	495	501	PF00069	0.612
MOD_GlcNHglycan	117	120	PF01048	0.668
MOD_GlcNHglycan	13	16	PF01048	0.659
MOD_GlcNHglycan	22	25	PF01048	0.618
MOD_GlcNHglycan	230	233	PF01048	0.749
MOD_GlcNHglycan	341	344	PF01048	0.797
MOD_GlcNHglycan	381	385	PF01048	0.634
MOD_GlcNHglycan	445	448	PF01048	0.688
MOD_GlcNHglycan	474	477	PF01048	0.715
MOD_GlcNHglycan	493	496	PF01048	0.633
MOD_GlcNHglycan	513	516	PF01048	0.623
MOD_GlcNHglycan	517	520	PF01048	0.619
MOD_GlcNHglycan	521	524	PF01048	0.628
MOD_GlcNHglycan	552	555	PF01048	0.540
MOD_GlcNHglycan	607	610	PF01048	0.628
MOD_GlcNHglycan	695	698	PF01048	0.627
MOD_GlcNHglycan	76	79	PF01048	0.730
MOD_GlcNHglycan	83	86	PF01048	0.707
MOD_GlcNHglycan	90	93	PF01048	0.623
MOD_GSK3_1	109	116	PF00069	0.699
MOD_GSK3_1	11	18	PF00069	0.774
MOD_GSK3_1	127	134	PF00069	0.515
MOD_GSK3_1	149	156	PF00069	0.755
MOD_GSK3_1	184	191	PF00069	0.731
MOD_GSK3_1	19	26	PF00069	0.645
MOD_GSK3_1	2	9	PF00069	0.586
MOD_GSK3_1	212	219	PF00069	0.651
MOD_GSK3_1	228	235	PF00069	0.627
MOD_GSK3_1	244	251	PF00069	0.777
MOD_GSK3_1	271	278	PF00069	0.680
MOD_GSK3_1	283	290	PF00069	0.603
MOD_GSK3_1	305	312	PF00069	0.745
MOD_GSK3_1	313	320	PF00069	0.569
MOD_GSK3_1	330	337	PF00069	0.679
MOD_GSK3_1	339	346	PF00069	0.681
MOD_GSK3_1	413	420	PF00069	0.685
MOD_GSK3_1	429	436	PF00069	0.527
MOD_GSK3_1	491	498	PF00069	0.631
MOD_GSK3_1	505	512	PF00069	0.626
MOD_GSK3_1	515	522	PF00069	0.619
MOD_GSK3_1	526	533	PF00069	0.613
MOD_GSK3_1	546	553	PF00069	0.577
MOD_GSK3_1	560	567	PF00069	0.629
MOD_GSK3_1	610	617	PF00069	0.753
MOD_GSK3_1	666	673	PF00069	0.690
MOD_GSK3_1	676	683	PF00069	0.664
MOD_GSK3_1	70	77	PF00069	0.765
MOD_LATS_1	252	258	PF00433	0.674
MOD_N-GLC_1	70	75	PF02516	0.614
MOD_N-GLC_2	239	241	PF02516	0.658
MOD_NEK2_1	2	7	PF00069	0.643
MOD_NEK2_1	248	253	PF00069	0.705
MOD_NEK2_1	31	36	PF00069	0.709
MOD_NEK2_1	324	329	PF00069	0.667
MOD_NEK2_1	417	422	PF00069	0.666
MOD_NEK2_1	442	447	PF00069	0.659
MOD_NEK2_1	448	453	PF00069	0.603
MOD_NEK2_1	509	514	PF00069	0.531
MOD_NEK2_1	535	540	PF00069	0.727
MOD_NEK2_1	672	677	PF00069	0.631
MOD_NEK2_1	70	75	PF00069	0.664
MOD_NEK2_1	79	84	PF00069	0.649
MOD_NEK2_1	8	13	PF00069	0.571
MOD_NEK2_2	531	536	PF00069	0.593
MOD_PIKK_1	29	35	PF00454	0.701
MOD_PIKK_1	423	429	PF00454	0.682
MOD_PK_1	536	542	PF00069	0.521
MOD_PKA_1	159	165	PF00069	0.659
MOD_PKA_2	113	119	PF00069	0.690
MOD_PKA_2	126	132	PF00069	0.546
MOD_PKA_2	159	165	PF00069	0.777
MOD_PKA_2	216	222	PF00069	0.625
MOD_PKA_2	423	429	PF00069	0.708
MOD_PKA_2	491	497	PF00069	0.510
MOD_PKA_2	503	509	PF00069	0.654
MOD_PKA_2	535	541	PF00069	0.551
MOD_PKA_2	79	85	PF00069	0.645
MOD_Plk_1	271	277	PF00069	0.654
MOD_Plk_1	394	400	PF00069	0.697
MOD_Plk_1	634	640	PF00069	0.595
MOD_Plk_4	127	133	PF00069	0.552
MOD_Plk_4	209	215	PF00069	0.651
MOD_Plk_4	263	269	PF00069	0.669
MOD_Plk_4	271	277	PF00069	0.607
MOD_Plk_4	320	326	PF00069	0.668
MOD_Plk_4	505	511	PF00069	0.546
MOD_Plk_4	536	542	PF00069	0.682
MOD_Plk_4	546	552	PF00069	0.572
MOD_Plk_4	680	686	PF00069	0.601
MOD_ProDKin_1	241	247	PF00069	0.687
MOD_ProDKin_1	330	336	PF00069	0.730
MOD_ProDKin_1	433	439	PF00069	0.624
MOD_ProDKin_1	466	472	PF00069	0.645
MOD_ProDKin_1	658	664	PF00069	0.683
MOD_ProDKin_1	666	672	PF00069	0.640
MOD_ProDKin_1	96	102	PF00069	0.752
MOD_SUMO_rev_2	194	201	PF00179	0.618
TRG_DiLeu_BaLyEn_6	204	209	PF01217	0.577
TRG_ENDOCYTIC_2	591	594	PF00928	0.717
TRG_ER_diArg_1	146	149	PF00400	0.698
TRG_ER_diArg_1	206	208	PF00400	0.620
TRG_ER_diArg_1	221	223	PF00400	0.568
TRG_ER_diArg_1	461	464	PF00400	0.605
TRG_NLS_MonoCore_2	144	149	PF00514	0.653
TRG_NLS_MonoExtC_3	144	149	PF00514	0.678
TRG_NLS_MonoExtN_4	111	118	PF00514	0.657
TRG_NLS_MonoExtN_4	145	151	PF00514	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H6X0	Leishmania braziliensis	53%	100%
E9AGD5	Leishmania infantum	99%	100%
E9ANX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
Q4QGP5	Leishmania major	79%	100%