Serine/threonine-protein phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ser/thr protein phosphatase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I989_LEIDO

TriTrypDb:

LdBPK_120610.1 , LdCL_120011800 , LDHU3_12.0940

Length:

961

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3Q8I989

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I989

Function

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Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0004721	phosphoprotein phosphatase activity	3	14
GO:0004722	protein serine/threonine phosphatase activity	4	14
GO:0005488	binding	1	9
GO:0005509	calcium ion binding	5	9
GO:0016787	hydrolase activity	2	14
GO:0016788	hydrolase activity, acting on ester bonds	3	14
GO:0016791	phosphatase activity	5	14
GO:0017018	myosin phosphatase activity	5	14
GO:0042578	phosphoric ester hydrolase activity	4	14

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	614	618	PF00656	0.725
CLV_MEL_PAP_1	337	343	PF00089	0.559
CLV_NRD_NRD_1	123	125	PF00675	0.558
CLV_NRD_NRD_1	190	192	PF00675	0.642
CLV_NRD_NRD_1	33	35	PF00675	0.749
CLV_NRD_NRD_1	473	475	PF00675	0.357
CLV_NRD_NRD_1	656	658	PF00675	0.529
CLV_NRD_NRD_1	673	675	PF00675	0.350
CLV_NRD_NRD_1	78	80	PF00675	0.555
CLV_NRD_NRD_1	884	886	PF00675	0.542

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGT4	Leptomonas seymouri	81%	99%
A0A0S4JAH8	Bodo saltans	30%	76%
A0A0S4JE35	Bodo saltans	57%	100%
A0A1X0NNZ8	Trypanosomatidae	62%	100%
A0A422MRT7	Trypanosoma rangeli	59%	100%
A4H6X9	Leishmania braziliensis	90%	100%
C9ZHY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
C9ZUN2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	67%
E9AGF3	Leishmania infantum	100%	100%
E9ANZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%

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