Phosphodiesterase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Phosphodiesterase

Gene product:

cAMP specific phosphodiesterase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I987_LEIDO

TriTrypDb:

LdBPK_151540.1 , LdCL_150020800 , LDHU3_15.1870

Length:

940

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8I987

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I987

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	15
GO:0009987	cellular process	1	15
GO:0050789	regulation of biological process	2	15
GO:0050794	regulation of cellular process	3	15
GO:0065007	biological regulation	1	15

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	15
GO:0004112	cyclic-nucleotide phosphodiesterase activity	6	15
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	7	15
GO:0005488	binding	1	15
GO:0008081	phosphoric diester hydrolase activity	5	15
GO:0016787	hydrolase activity	2	15
GO:0016788	hydrolase activity, acting on ester bonds	3	15
GO:0042578	phosphoric ester hydrolase activity	4	15
GO:0043167	ion binding	2	15
GO:0043169	cation binding	3	15
GO:0046872	metal ion binding	4	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	612	616	PF00656	0.384
CLV_C14_Caspase3-7	926	930	PF00656	0.475
CLV_NRD_NRD_1	224	226	PF00675	0.442
CLV_NRD_NRD_1	36	38	PF00675	0.627
CLV_NRD_NRD_1	372	374	PF00675	0.394
CLV_NRD_NRD_1	673	675	PF00675	0.468
CLV_NRD_NRD_1	676	678	PF00675	0.497
CLV_NRD_NRD_1	823	825	PF00675	0.387
CLV_NRD_NRD_1	931	933	PF00675	0.583
CLV_PCSK_FUR_1	34	38	PF00082	0.506
CLV_PCSK_FUR_1	674	678	PF00082	0.453
CLV_PCSK_KEX2_1	36	38	PF00082	0.543
CLV_PCSK_KEX2_1	372	374	PF00082	0.262
CLV_PCSK_KEX2_1	672	674	PF00082	0.467
CLV_PCSK_KEX2_1	676	678	PF00082	0.494
CLV_PCSK_KEX2_1	823	825	PF00082	0.387
CLV_PCSK_KEX2_1	931	933	PF00082	0.583
CLV_PCSK_PC7_1	368	374	PF00082	0.262
CLV_PCSK_PC7_1	672	678	PF00082	0.474
CLV_PCSK_SKI1_1	210	214	PF00082	0.384
CLV_PCSK_SKI1_1	261	265	PF00082	0.284
CLV_PCSK_SKI1_1	333	337	PF00082	0.284
CLV_PCSK_SKI1_1	428	432	PF00082	0.284
CLV_PCSK_SKI1_1	435	439	PF00082	0.284
CLV_PCSK_SKI1_1	593	597	PF00082	0.562
DEG_APCC_KENBOX_2	816	820	PF00400	0.191
DEG_Nend_Nbox_1	1	3	PF02207	0.554
DOC_CYCLIN_yCln2_LP_2	176	182	PF00134	0.406
DOC_CYCLIN_yCln2_LP_2	336	342	PF00134	0.284
DOC_CYCLIN_yCln2_LP_2	512	518	PF00134	0.308
DOC_MAPK_gen_1	129	137	PF00069	0.331
DOC_MAPK_gen_1	402	411	PF00069	0.412
DOC_MAPK_gen_1	590	600	PF00069	0.564
DOC_MAPK_MEF2A_6	217	224	PF00069	0.389
DOC_MAPK_MEF2A_6	333	342	PF00069	0.412
DOC_MAPK_MEF2A_6	574	581	PF00069	0.599
DOC_MAPK_MEF2A_6	605	613	PF00069	0.500
DOC_MAPK_NFAT4_5	333	341	PF00069	0.412
DOC_MAPK_NFAT4_5	574	582	PF00069	0.602
DOC_MAPK_RevD_3	212	226	PF00069	0.379
DOC_PP2B_LxvP_1	176	179	PF13499	0.312
DOC_PP2B_LxvP_1	336	339	PF13499	0.284
DOC_PP4_FxxP_1	619	622	PF00568	0.471
DOC_USP7_MATH_1	16	20	PF00917	0.584
DOC_USP7_MATH_1	234	238	PF00917	0.391
DOC_USP7_MATH_1	276	280	PF00917	0.387
DOC_USP7_MATH_1	385	389	PF00917	0.292
DOC_USP7_MATH_1	440	444	PF00917	0.284
DOC_USP7_MATH_1	607	611	PF00917	0.517
DOC_USP7_MATH_1	65	69	PF00917	0.651
DOC_USP7_UBL2_3	400	404	PF12436	0.465
DOC_WW_Pin1_4	155	160	PF00397	0.399
DOC_WW_Pin1_4	4	9	PF00397	0.642
DOC_WW_Pin1_4	539	544	PF00397	0.327
DOC_WW_Pin1_4	598	603	PF00397	0.492
DOC_WW_Pin1_4	618	623	PF00397	0.327
DOC_WW_Pin1_4	68	73	PF00397	0.615
DOC_WW_Pin1_4	735	740	PF00397	0.289
LIG_14-3-3_CanoR_1	129	135	PF00244	0.382
LIG_14-3-3_CanoR_1	210	215	PF00244	0.317
LIG_14-3-3_CanoR_1	225	232	PF00244	0.412
LIG_14-3-3_CanoR_1	319	325	PF00244	0.387
LIG_14-3-3_CanoR_1	37	43	PF00244	0.523
LIG_14-3-3_CanoR_1	442	446	PF00244	0.329
LIG_14-3-3_CanoR_1	495	504	PF00244	0.455
LIG_14-3-3_CanoR_1	583	592	PF00244	0.552
LIG_BRCT_BRCA1_1	2	6	PF00533	0.494
LIG_BRCT_BRCA1_1	442	446	PF00533	0.284
LIG_BRCT_BRCA1_1	609	613	PF00533	0.517
LIG_BRCT_BRCA1_1	620	624	PF00533	0.362
LIG_eIF4E_1	783	789	PF01652	0.387
LIG_FHA_1	131	137	PF00498	0.377
LIG_FHA_1	173	179	PF00498	0.424
LIG_FHA_1	211	217	PF00498	0.409
LIG_FHA_1	330	336	PF00498	0.304
LIG_FHA_1	506	512	PF00498	0.284
LIG_FHA_1	546	552	PF00498	0.296
LIG_FHA_1	576	582	PF00498	0.579
LIG_FHA_1	715	721	PF00498	0.306
LIG_FHA_1	74	80	PF00498	0.594
LIG_FHA_2	244	250	PF00498	0.571
LIG_FHA_2	260	266	PF00498	0.404
LIG_FHA_2	475	481	PF00498	0.388
LIG_FHA_2	540	546	PF00498	0.299
LIG_FHA_2	599	605	PF00498	0.412
LIG_FHA_2	618	624	PF00498	0.371
LIG_FHA_2	705	711	PF00498	0.271
LIG_FHA_2	73	79	PF00498	0.464
LIG_GBD_Chelix_1	715	723	PF00786	0.305
LIG_GBD_Chelix_1	902	910	PF00786	0.327
LIG_LIR_Apic_2	618	622	PF02991	0.478
LIG_LIR_Apic_2	631	636	PF02991	0.517
LIG_LIR_Gen_1	112	122	PF02991	0.476
LIG_LIR_Gen_1	133	142	PF02991	0.391
LIG_LIR_Gen_1	203	212	PF02991	0.274
LIG_LIR_Gen_1	375	386	PF02991	0.284
LIG_LIR_Gen_1	454	463	PF02991	0.329
LIG_LIR_Gen_1	547	556	PF02991	0.326
LIG_LIR_Gen_1	621	629	PF02991	0.344
LIG_LIR_Gen_1	710	720	PF02991	0.336
LIG_LIR_Gen_1	805	815	PF02991	0.376
LIG_LIR_Nem_3	112	118	PF02991	0.490
LIG_LIR_Nem_3	133	137	PF02991	0.356
LIG_LIR_Nem_3	174	180	PF02991	0.385
LIG_LIR_Nem_3	203	207	PF02991	0.487
LIG_LIR_Nem_3	375	381	PF02991	0.301
LIG_LIR_Nem_3	547	552	PF02991	0.282
LIG_LIR_Nem_3	553	558	PF02991	0.281
LIG_LIR_Nem_3	621	627	PF02991	0.347
LIG_LIR_Nem_3	710	715	PF02991	0.336
LIG_LIR_Nem_3	771	776	PF02991	0.308
LIG_LIR_Nem_3	805	810	PF02991	0.346
LIG_PCNA_yPIPBox_3	519	531	PF02747	0.329
LIG_PDZ_Class_1	935	940	PF00595	0.575
LIG_PTB_Apo_2	727	734	PF02174	0.284
LIG_PTB_Phospho_1	727	733	PF10480	0.284
LIG_Rb_pABgroove_1	869	877	PF01858	0.304
LIG_REV1ctd_RIR_1	896	904	PF16727	0.304
LIG_SH2_CRK	12	16	PF00017	0.564
LIG_SH2_CRK	134	138	PF00017	0.405
LIG_SH2_CRK	2	6	PF00017	0.561
LIG_SH2_CRK	204	208	PF00017	0.275
LIG_SH2_CRK	675	679	PF00017	0.347
LIG_SH2_CRK	785	789	PF00017	0.387
LIG_SH2_GRB2like	680	683	PF00017	0.284
LIG_SH2_NCK_1	2	6	PF00017	0.452
LIG_SH2_PTP2	177	180	PF00017	0.332
LIG_SH2_PTP2	712	715	PF00017	0.412
LIG_SH2_SRC	491	494	PF00017	0.284
LIG_SH2_STAP1	2	6	PF00017	0.452
LIG_SH2_STAP1	204	208	PF00017	0.340
LIG_SH2_STAP1	456	460	PF00017	0.329
LIG_SH2_STAP1	783	787	PF00017	0.327
LIG_SH2_STAT3	506	509	PF00017	0.304
LIG_SH2_STAT5	12	15	PF00017	0.677
LIG_SH2_STAT5	177	180	PF00017	0.367
LIG_SH2_STAT5	696	699	PF00017	0.323
LIG_SH2_STAT5	712	715	PF00017	0.329
LIG_SH2_STAT5	733	736	PF00017	0.284
LIG_SH3_3	187	193	PF00018	0.339
LIG_SH3_3	2	8	PF00018	0.523
LIG_SH3_3	287	293	PF00018	0.304
LIG_SH3_3	306	312	PF00018	0.412
LIG_SH3_3	836	842	PF00018	0.312
LIG_SH3_3	87	93	PF00018	0.510
LIG_SUMO_SIM_anti_2	410	416	PF11976	0.428
LIG_SUMO_SIM_anti_2	521	527	PF11976	0.307
LIG_SUMO_SIM_par_1	168	175	PF11976	0.365
LIG_SUMO_SIM_par_1	410	416	PF11976	0.423
LIG_SUMO_SIM_par_1	596	601	PF11976	0.515
LIG_SUMO_SIM_par_1	712	717	PF11976	0.306
LIG_TRAF2_1	246	249	PF00917	0.620
LIG_TRAF2_1	601	604	PF00917	0.521
LIG_TYR_ITIM	643	648	PF00017	0.332
LIG_UBA3_1	445	450	PF00899	0.412
LIG_WRC_WIRS_1	378	383	PF05994	0.284
MOD_CDK_SPxxK_3	155	162	PF00069	0.384
MOD_CDK_SPxxK_3	598	605	PF00069	0.473
MOD_CK1_1	123	129	PF00069	0.384
MOD_CK1_1	237	243	PF00069	0.403
MOD_CK1_1	41	47	PF00069	0.504
MOD_CK1_1	68	74	PF00069	0.666
MOD_CK1_1	744	750	PF00069	0.292
MOD_CK1_1	805	811	PF00069	0.216
MOD_CK1_1	837	843	PF00069	0.304
MOD_CK1_1	934	940	PF00069	0.604
MOD_CK2_1	243	249	PF00069	0.560
MOD_CK2_1	259	265	PF00069	0.243
MOD_CK2_1	40	46	PF00069	0.550
MOD_CK2_1	459	465	PF00069	0.387
MOD_CK2_1	474	480	PF00069	0.177
MOD_CK2_1	598	604	PF00069	0.414
MOD_CK2_1	704	710	PF00069	0.290
MOD_CK2_1	748	754	PF00069	0.284
MOD_Cter_Amidation	370	373	PF01082	0.262
MOD_Cter_Amidation	929	932	PF01082	0.555
MOD_GlcNHglycan	122	125	PF01048	0.321
MOD_GlcNHglycan	193	196	PF01048	0.440
MOD_GlcNHglycan	2	5	PF01048	0.595
MOD_GlcNHglycan	304	307	PF01048	0.441
MOD_GlcNHglycan	361	364	PF01048	0.329
MOD_GlcNHglycan	461	464	PF01048	0.447
MOD_GlcNHglycan	480	483	PF01048	0.327
MOD_GlcNHglycan	497	500	PF01048	0.336
MOD_GlcNHglycan	650	653	PF01048	0.414
MOD_GlcNHglycan	67	70	PF01048	0.652
MOD_GlcNHglycan	744	747	PF01048	0.284
MOD_GlcNHglycan	776	779	PF01048	0.435
MOD_GlcNHglycan	812	815	PF01048	0.388
MOD_GSK3_1	105	112	PF00069	0.502
MOD_GSK3_1	168	175	PF00069	0.508
MOD_GSK3_1	216	223	PF00069	0.549
MOD_GSK3_1	243	250	PF00069	0.472
MOD_GSK3_1	252	259	PF00069	0.276
MOD_GSK3_1	263	270	PF00069	0.329
MOD_GSK3_1	325	332	PF00069	0.300
MOD_GSK3_1	37	44	PF00069	0.525
MOD_GSK3_1	474	481	PF00069	0.304
MOD_GSK3_1	491	498	PF00069	0.304
MOD_GSK3_1	556	563	PF00069	0.296
MOD_GSK3_1	68	75	PF00069	0.627
MOD_GSK3_1	692	699	PF00069	0.394
MOD_GSK3_1	700	707	PF00069	0.410
MOD_GSK3_1	744	751	PF00069	0.284
MOD_GSK3_1	805	812	PF00069	0.388
MOD_GSK3_1	931	938	PF00069	0.568
MOD_N-GLC_1	220	225	PF02516	0.444
MOD_N-GLC_1	320	325	PF02516	0.437
MOD_N-GLC_1	394	399	PF02516	0.494
MOD_N-GLC_1	560	565	PF02516	0.388
MOD_N-GLC_1	728	733	PF02516	0.300
MOD_N-GLC_1	748	753	PF02516	0.288
MOD_N-GLC_1	837	842	PF02516	0.320
MOD_NEK2_1	208	213	PF00069	0.346
MOD_NEK2_1	247	252	PF00069	0.420
MOD_NEK2_1	27	32	PF00069	0.502
MOD_NEK2_1	342	347	PF00069	0.387
MOD_NEK2_1	377	382	PF00069	0.308
MOD_NEK2_1	459	464	PF00069	0.304
MOD_NEK2_1	577	582	PF00069	0.624
MOD_NEK2_1	647	652	PF00069	0.380
MOD_NEK2_1	714	719	PF00069	0.302
MOD_NEK2_1	810	815	PF00069	0.242
MOD_NEK2_1	843	848	PF00069	0.304
MOD_NEK2_1	875	880	PF00069	0.327
MOD_NEK2_2	385	390	PF00069	0.297
MOD_NEK2_2	536	541	PF00069	0.304
MOD_PIKK_1	224	230	PF00454	0.447
MOD_PIKK_1	357	363	PF00454	0.434
MOD_PIKK_1	505	511	PF00454	0.304
MOD_PK_1	507	513	PF00069	0.412
MOD_PKA_1	402	408	PF00069	0.385
MOD_PKA_1	931	937	PF00069	0.596
MOD_PKA_2	120	126	PF00069	0.461
MOD_PKA_2	216	222	PF00069	0.370
MOD_PKA_2	224	230	PF00069	0.384
MOD_PKA_2	243	249	PF00069	0.490
MOD_PKA_2	267	273	PF00069	0.284
MOD_PKA_2	35	41	PF00069	0.608
MOD_PKA_2	441	447	PF00069	0.329
MOD_PKA_2	582	588	PF00069	0.568
MOD_PKA_2	805	811	PF00069	0.364
MOD_PKA_2	931	937	PF00069	0.568
MOD_Plk_1	220	226	PF00069	0.591
MOD_Plk_1	247	253	PF00069	0.452
MOD_Plk_1	320	326	PF00069	0.319
MOD_Plk_1	394	400	PF00069	0.516
MOD_Plk_1	440	446	PF00069	0.284
MOD_Plk_1	560	566	PF00069	0.391
MOD_Plk_1	660	666	PF00069	0.425
MOD_Plk_1	728	734	PF00069	0.284
MOD_Plk_1	748	754	PF00069	0.292
MOD_Plk_1	843	849	PF00069	0.363
MOD_Plk_2-3	704	710	PF00069	0.262
MOD_Plk_4	109	115	PF00069	0.512
MOD_Plk_4	172	178	PF00069	0.422
MOD_Plk_4	247	253	PF00069	0.412
MOD_Plk_4	267	273	PF00069	0.290
MOD_Plk_4	27	33	PF00069	0.525
MOD_Plk_4	342	348	PF00069	0.335
MOD_Plk_4	394	400	PF00069	0.487
MOD_Plk_4	422	428	PF00069	0.352
MOD_Plk_4	441	447	PF00069	0.166
MOD_Plk_4	507	513	PF00069	0.284
MOD_Plk_4	660	666	PF00069	0.376
MOD_Plk_4	692	698	PF00069	0.296
MOD_Plk_4	728	734	PF00069	0.286
MOD_Plk_4	748	754	PF00069	0.284
MOD_Plk_4	826	832	PF00069	0.387
MOD_ProDKin_1	155	161	PF00069	0.391
MOD_ProDKin_1	4	10	PF00069	0.642
MOD_ProDKin_1	539	545	PF00069	0.327
MOD_ProDKin_1	598	604	PF00069	0.482
MOD_ProDKin_1	618	624	PF00069	0.321
MOD_ProDKin_1	68	74	PF00069	0.612
MOD_ProDKin_1	735	741	PF00069	0.289
MOD_SUMO_rev_2	396	405	PF00179	0.419
MOD_SUMO_rev_2	41	50	PF00179	0.589
TRG_DiLeu_BaEn_1	248	253	PF01217	0.478
TRG_DiLeu_BaEn_1	710	715	PF01217	0.280
TRG_ENDOCYTIC_2	12	15	PF00928	0.601
TRG_ENDOCYTIC_2	134	137	PF00928	0.480
TRG_ENDOCYTIC_2	177	180	PF00928	0.341
TRG_ENDOCYTIC_2	2	5	PF00928	0.594
TRG_ENDOCYTIC_2	204	207	PF00928	0.282
TRG_ENDOCYTIC_2	456	459	PF00928	0.329
TRG_ENDOCYTIC_2	645	648	PF00928	0.338
TRG_ENDOCYTIC_2	675	678	PF00928	0.352
TRG_ENDOCYTIC_2	680	683	PF00928	0.284
TRG_ENDOCYTIC_2	684	687	PF00928	0.284
TRG_ENDOCYTIC_2	712	715	PF00928	0.352
TRG_ENDOCYTIC_2	785	788	PF00928	0.363
TRG_ER_diArg_1	35	37	PF00400	0.608
TRG_ER_diArg_1	672	674	PF00400	0.489
TRG_ER_diArg_1	675	677	PF00400	0.495
TRG_ER_diArg_1	823	825	PF00400	0.387
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.308
TRG_Pf-PMV_PEXEL_1	786	790	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P788	Leptomonas seymouri	69%	100%
A0A1X0NUP8	Trypanosomatidae	62%	100%
A0A3R7RI37	Trypanosoma rangeli	70%	100%
A0A3S7WTN0	Leishmania donovani	81%	100%
A4H893	Leishmania braziliensis	77%	100%
A4H8B6	Leishmania braziliensis	85%	100%
A4HWN6	Leishmania infantum	81%	99%
A4HWN7	Leishmania infantum	99%	100%
B3P3K2	Drosophila erecta	28%	83%
B4JXX2	Drosophila grimshawi	27%	87%
B4K9L4	Drosophila mojavensis	28%	84%
B4LVU6	Drosophila virilis	28%	100%
B4NAL6	Drosophila willistoni	28%	83%
B4PSS5	Drosophila yakuba	28%	82%
B4QZU1	Drosophila simulans	28%	82%
C9ZXQ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
C9ZXQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AQE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%
E9AQE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O00408	Homo sapiens	30%	100%
O54735	Rattus norvegicus	28%	100%
O76074	Homo sapiens	29%	100%
O77746	Canis lupus familiaris	29%	100%
P0C1Q2	Mus musculus	32%	100%
P11541	Bos taurus	25%	100%
P14099	Bos taurus	30%	100%
P16499	Homo sapiens	26%	100%
P16586	Bos taurus	27%	100%
P23439	Bos taurus	25%	100%
P23440	Mus musculus	25%	100%
P27664	Mus musculus	25%	100%
P33726	Canis lupus familiaris	25%	100%
P35913	Homo sapiens	24%	100%
P51160	Homo sapiens	26%	100%
P52731	Gallus gallus	25%	100%
Q01062	Rattus norvegicus	30%	100%
Q1KKS3	Takifugu rubripes	32%	100%
Q28156	Bos taurus	29%	100%
Q28263	Canis lupus familiaris	25%	100%
Q298P4	Drosophila pseudoobscura pseudoobscura	28%	85%
Q4QF31	Leishmania major	94%	100%
Q8CA95	Mus musculus	30%	100%
Q8CG03	Mus musculus	28%	100%
Q8VID6	Rattus norvegicus	32%	100%
Q91ZQ1	Mus musculus	27%	100%
Q922S4	Mus musculus	30%	100%
Q9HCR9	Homo sapiens	32%	100%
Q9QYJ6	Rattus norvegicus	31%	100%
Q9VFI9	Drosophila melanogaster	28%	84%
Q9Y233	Homo sapiens	29%	100%