Rab-GTPase-TBC domain family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I980_LEIDO

TriTrypDb:

LdBPK_151390.1 , LdCL_150019200 , LDHU3_15.1710

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I980

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I980

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.437
CLV_C14_Caspase3-7	338	342	PF00656	0.530
CLV_C14_Caspase3-7	448	452	PF00656	0.357
CLV_C14_Caspase3-7	492	496	PF00656	0.296
CLV_C14_Caspase3-7	607	611	PF00656	0.323
CLV_NRD_NRD_1	206	208	PF00675	0.482
CLV_NRD_NRD_1	366	368	PF00675	0.247
CLV_NRD_NRD_1	419	421	PF00675	0.554
CLV_NRD_NRD_1	631	633	PF00675	0.585
CLV_PCSK_KEX2_1	366	368	PF00082	0.247
CLV_PCSK_KEX2_1	418	420	PF00082	0.555
CLV_PCSK_KEX2_1	631	633	PF00082	0.585
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.635
CLV_PCSK_PC7_1	414	420	PF00082	0.579
CLV_PCSK_PC7_1	627	633	PF00082	0.578
CLV_PCSK_SKI1_1	219	223	PF00082	0.476
CLV_PCSK_SKI1_1	366	370	PF00082	0.242
CLV_PCSK_SKI1_1	384	388	PF00082	0.553
CLV_PCSK_SKI1_1	404	408	PF00082	0.406
CLV_PCSK_SKI1_1	439	443	PF00082	0.534
CLV_PCSK_SKI1_1	599	603	PF00082	0.500
CLV_PCSK_SKI1_1	695	699	PF00082	0.332
DEG_APCC_DBOX_1	234	242	PF00400	0.600
DEG_APCC_DBOX_1	438	446	PF00400	0.372
DEG_APCC_DBOX_1	694	702	PF00400	0.472
DOC_ANK_TNKS_1	245	252	PF00023	0.570
DOC_ANK_TNKS_1	50	57	PF00023	0.417
DOC_CKS1_1	3	8	PF01111	0.467
DOC_CYCLIN_yCln2_LP_2	374	380	PF00134	0.322
DOC_CYCLIN_yCln2_LP_2	577	583	PF00134	0.369
DOC_MAPK_DCC_7	235	243	PF00069	0.586
DOC_MAPK_gen_1	433	442	PF00069	0.384
DOC_MAPK_gen_1	631	637	PF00069	0.321
DOC_MAPK_MEF2A_6	235	243	PF00069	0.586
DOC_MAPK_MEF2A_6	372	380	PF00069	0.297
DOC_MAPK_MEF2A_6	587	596	PF00069	0.281
DOC_MAPK_MEF2A_6	677	686	PF00069	0.587
DOC_PP2B_LxvP_1	374	377	PF13499	0.322
DOC_PP2B_LxvP_1	577	580	PF13499	0.349
DOC_PP2B_LxvP_1	635	638	PF13499	0.331
DOC_PP2B_LxvP_1	84	87	PF13499	0.430
DOC_USP7_MATH_1	150	154	PF00917	0.552
DOC_USP7_MATH_1	160	164	PF00917	0.594
DOC_USP7_MATH_1	271	275	PF00917	0.652
DOC_USP7_MATH_1	328	332	PF00917	0.623
DOC_USP7_MATH_1	493	497	PF00917	0.409
DOC_USP7_MATH_1	58	62	PF00917	0.531
DOC_WW_Pin1_4	2	7	PF00397	0.561
DOC_WW_Pin1_4	214	219	PF00397	0.713
DOC_WW_Pin1_4	37	42	PF00397	0.556
DOC_WW_Pin1_4	557	562	PF00397	0.256
DOC_WW_Pin1_4	630	635	PF00397	0.355
DOC_WW_Pin1_4	648	653	PF00397	0.405
LIG_14-3-3_CanoR_1	195	203	PF00244	0.520
LIG_14-3-3_CanoR_1	51	57	PF00244	0.488
LIG_14-3-3_CanoR_1	632	638	PF00244	0.337
LIG_14-3-3_CanoR_1	693	698	PF00244	0.553
LIG_APCC_ABBAyCdc20_2	454	460	PF00400	0.291
LIG_BIR_II_1	1	5	PF00653	0.513
LIG_BRCT_BRCA1_1	197	201	PF00533	0.537
LIG_BRCT_BRCA1_1	241	245	PF00533	0.494
LIG_deltaCOP1_diTrp_1	66	71	PF00928	0.465
LIG_DLG_GKlike_1	693	701	PF00625	0.572
LIG_eIF4E_1	503	509	PF01652	0.397
LIG_FHA_1	220	226	PF00498	0.759
LIG_FHA_1	261	267	PF00498	0.550
LIG_FHA_1	330	336	PF00498	0.638
LIG_FHA_1	393	399	PF00498	0.520
LIG_FHA_1	457	463	PF00498	0.288
LIG_FHA_1	465	471	PF00498	0.269
LIG_FHA_1	523	529	PF00498	0.293
LIG_FHA_1	558	564	PF00498	0.253
LIG_FHA_1	584	590	PF00498	0.291
LIG_FHA_1	67	73	PF00498	0.415
LIG_FHA_1	692	698	PF00498	0.556
LIG_FHA_1	77	83	PF00498	0.448
LIG_FHA_2	142	148	PF00498	0.427
LIG_FHA_2	154	160	PF00498	0.536
LIG_FHA_2	284	290	PF00498	0.522
LIG_FHA_2	336	342	PF00498	0.572
LIG_FHA_2	676	682	PF00498	0.488
LIG_GBD_Chelix_1	115	123	PF00786	0.607
LIG_GBD_Chelix_1	544	552	PF00786	0.498
LIG_LIR_Gen_1	310	320	PF02991	0.567
LIG_LIR_Gen_1	341	349	PF02991	0.538
LIG_LIR_Gen_1	443	453	PF02991	0.372
LIG_LIR_Gen_1	522	531	PF02991	0.383
LIG_LIR_Gen_1	603	612	PF02991	0.272
LIG_LIR_Gen_1	616	626	PF02991	0.233
LIG_LIR_Gen_1	8	15	PF02991	0.533
LIG_LIR_Nem_3	242	248	PF02991	0.517
LIG_LIR_Nem_3	297	301	PF02991	0.614
LIG_LIR_Nem_3	310	315	PF02991	0.553
LIG_LIR_Nem_3	341	346	PF02991	0.537
LIG_LIR_Nem_3	443	449	PF02991	0.307
LIG_LIR_Nem_3	452	458	PF02991	0.269
LIG_LIR_Nem_3	495	500	PF02991	0.308
LIG_LIR_Nem_3	522	527	PF02991	0.297
LIG_LIR_Nem_3	588	594	PF02991	0.304
LIG_LIR_Nem_3	603	608	PF02991	0.241
LIG_LIR_Nem_3	610	615	PF02991	0.268
LIG_LIR_Nem_3	616	621	PF02991	0.249
LIG_LIR_Nem_3	66	71	PF02991	0.465
LIG_LIR_Nem_3	8	12	PF02991	0.553
LIG_LYPXL_yS_3	591	594	PF13949	0.278
LIG_MYND_3	302	306	PF01753	0.582
LIG_NRBOX	181	187	PF00104	0.299
LIG_NRBOX	697	703	PF00104	0.471
LIG_PCNA_yPIPBox_3	281	290	PF02747	0.621
LIG_SH2_CRK	9	13	PF00017	0.559
LIG_SH2_NCK_1	158	162	PF00017	0.412
LIG_SH2_NCK_1	542	546	PF00017	0.269
LIG_SH2_STAP1	158	162	PF00017	0.412
LIG_SH2_STAP1	370	374	PF00017	0.279
LIG_SH2_STAP1	458	462	PF00017	0.360
LIG_SH2_STAP1	542	546	PF00017	0.350
LIG_SH2_STAP1	661	665	PF00017	0.410
LIG_SH2_STAT5	311	314	PF00017	0.524
LIG_SH2_STAT5	405	408	PF00017	0.357
LIG_SH2_STAT5	455	458	PF00017	0.291
LIG_SH2_STAT5	497	500	PF00017	0.291
LIG_SH2_STAT5	52	55	PF00017	0.476
LIG_SH3_3	233	239	PF00018	0.626
LIG_SH3_3	89	95	PF00018	0.486
LIG_SUMO_SIM_anti_2	459	467	PF11976	0.354
LIG_SUMO_SIM_anti_2	681	686	PF11976	0.581
LIG_SUMO_SIM_par_1	283	289	PF11976	0.531
LIG_SUMO_SIM_par_1	330	338	PF11976	0.632
LIG_SUMO_SIM_par_1	376	382	PF11976	0.324
LIG_SUMO_SIM_par_1	633	639	PF11976	0.335
LIG_TRAF2_1	128	131	PF00917	0.393
LIG_TRAF2_1	428	431	PF00917	0.394
LIG_TYR_ITIM	589	594	PF00017	0.344
LIG_TYR_ITIM	7	12	PF00017	0.725
LIG_WRC_WIRS_1	614	619	PF05994	0.341
MOD_CDC14_SPxK_1	217	220	PF00782	0.658
MOD_CDK_SPK_2	214	219	PF00069	0.610
MOD_CDK_SPxK_1	214	220	PF00069	0.658
MOD_CK1_1	104	110	PF00069	0.422
MOD_CK1_1	13	19	PF00069	0.635
MOD_CK1_1	141	147	PF00069	0.592
MOD_CK1_1	153	159	PF00069	0.781
MOD_CK1_1	2	8	PF00069	0.784
MOD_CK1_1	496	502	PF00069	0.421
MOD_CK1_1	61	67	PF00069	0.630
MOD_CK1_1	633	639	PF00069	0.435
MOD_CK2_1	141	147	PF00069	0.580
MOD_CK2_1	153	159	PF00069	0.687
MOD_CK2_1	168	174	PF00069	0.497
MOD_CK2_1	283	289	PF00069	0.575
MOD_CK2_1	328	334	PF00069	0.526
MOD_CK2_1	424	430	PF00069	0.542
MOD_CK2_1	675	681	PF00069	0.352
MOD_GlcNHglycan	144	147	PF01048	0.708
MOD_GlcNHglycan	170	173	PF01048	0.499
MOD_GlcNHglycan	18	21	PF01048	0.724
MOD_GlcNHglycan	210	213	PF01048	0.517
MOD_GlcNHglycan	24	27	PF01048	0.644
MOD_GlcNHglycan	269	272	PF01048	0.506
MOD_GlcNHglycan	273	276	PF01048	0.567
MOD_GlcNHglycan	29	32	PF01048	0.596
MOD_GlcNHglycan	325	328	PF01048	0.591
MOD_GlcNHglycan	88	91	PF01048	0.611
MOD_GlcNHglycan	96	99	PF01048	0.534
MOD_GSK3_1	1	8	PF00069	0.677
MOD_GSK3_1	100	107	PF00069	0.455
MOD_GSK3_1	138	145	PF00069	0.692
MOD_GSK3_1	149	156	PF00069	0.656
MOD_GSK3_1	160	167	PF00069	0.555
MOD_GSK3_1	18	25	PF00069	0.700
MOD_GSK3_1	208	215	PF00069	0.659
MOD_GSK3_1	267	274	PF00069	0.481
MOD_GSK3_1	445	452	PF00069	0.437
MOD_GSK3_1	60	67	PF00069	0.556
MOD_N-GLC_1	212	217	PF02516	0.622
MOD_N-GLC_1	532	537	PF02516	0.428
MOD_NEK2_1	1	6	PF00069	0.704
MOD_NEK2_1	101	106	PF00069	0.493
MOD_NEK2_1	140	145	PF00069	0.654
MOD_NEK2_1	335	340	PF00069	0.291
MOD_NEK2_1	406	411	PF00069	0.441
MOD_NEK2_1	445	450	PF00069	0.531
MOD_NEK2_1	620	625	PF00069	0.289
MOD_NEK2_1	71	76	PF00069	0.530
MOD_NEK2_2	283	288	PF00069	0.375
MOD_NEK2_2	76	81	PF00069	0.596
MOD_PIKK_1	138	144	PF00454	0.609
MOD_PIKK_1	173	179	PF00454	0.466
MOD_PIKK_1	195	201	PF00454	0.471
MOD_PIKK_1	335	341	PF00454	0.374
MOD_PIKK_1	71	77	PF00454	0.587
MOD_PKA_1	207	213	PF00069	0.578
MOD_PKA_1	219	225	PF00069	0.600
MOD_PKA_2	13	19	PF00069	0.665
MOD_PKA_2	206	212	PF00069	0.577
MOD_PKA_2	27	33	PF00069	0.611
MOD_PKA_2	44	50	PF00069	0.676
MOD_Plk_1	164	170	PF00069	0.660
MOD_Plk_1	173	179	PF00069	0.474
MOD_Plk_1	329	335	PF00069	0.579
MOD_Plk_1	471	477	PF00069	0.384
MOD_Plk_2-3	613	619	PF00069	0.335
MOD_Plk_4	104	110	PF00069	0.375
MOD_Plk_4	283	289	PF00069	0.364
MOD_Plk_4	493	499	PF00069	0.358
MOD_Plk_4	569	575	PF00069	0.379
MOD_Plk_4	613	619	PF00069	0.335
MOD_ProDKin_1	2	8	PF00069	0.728
MOD_ProDKin_1	214	220	PF00069	0.658
MOD_ProDKin_1	37	43	PF00069	0.720
MOD_ProDKin_1	557	563	PF00069	0.297
MOD_ProDKin_1	630	636	PF00069	0.437
MOD_ProDKin_1	648	654	PF00069	0.496
MOD_SUMO_for_1	128	131	PF00179	0.466
MOD_SUMO_rev_2	472	481	PF00179	0.448
TRG_DiLeu_BaEn_1	522	527	PF01217	0.387
TRG_DiLeu_BaEn_2	186	192	PF01217	0.492
TRG_DiLeu_BaEn_4	233	239	PF01217	0.536
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.305
TRG_DiLeu_BaLyEn_6	432	437	PF01217	0.498
TRG_ENDOCYTIC_2	591	594	PF00928	0.329
TRG_ENDOCYTIC_2	9	12	PF00928	0.725
TRG_ER_diArg_1	365	367	PF00400	0.327
TRG_ER_diArg_1	419	421	PF00400	0.449
TRG_ER_diArg_1	433	436	PF00400	0.401
TRG_ER_diArg_1	692	695	PF00400	0.321
TRG_NLS_MonoExtN_4	416	422	PF00514	0.526
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	473	477	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	695	699	PF00026	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZA9	Leptomonas seymouri	65%	99%
A0A1X0NU07	Trypanosomatidae	41%	94%
A0A3R7NA24	Trypanosoma rangeli	41%	100%
A4H8A0	Leishmania braziliensis	78%	100%
A4HWM2	Leishmania infantum	100%	100%
C9ZXR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	95%
E9AQC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QF46	Leishmania major	93%	100%
V5B4P0	Trypanosoma cruzi	39%	100%