Polysaccharide biosynthesis protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I960_LEIDO

TriTrypDb:

LdBPK_111310.1 , LdCL_110019000 , LDHU3_11.1620

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3Q8I960

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I960

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	203	209	PF00089	0.289
CLV_PCSK_KEX2_1	283	285	PF00082	0.376
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.396
CLV_PCSK_SKI1_1	130	134	PF00082	0.451
DOC_CYCLIN_RxL_1	127	136	PF00134	0.480
DOC_MAPK_gen_1	287	295	PF00069	0.616
DOC_PP2B_LxvP_1	140	143	PF13499	0.519
DOC_PP4_FxxP_1	380	383	PF00568	0.590
DOC_PP4_FxxP_1	66	69	PF00568	0.447
DOC_USP7_MATH_1	205	209	PF00917	0.617
DOC_USP7_MATH_1	319	323	PF00917	0.368
DOC_USP7_MATH_1	49	53	PF00917	0.439
DOC_WW_Pin1_4	14	19	PF00397	0.748
LIG_14-3-3_CanoR_1	111	116	PF00244	0.396
LIG_14-3-3_CanoR_1	127	133	PF00244	0.272
LIG_14-3-3_CanoR_1	197	202	PF00244	0.619
LIG_14-3-3_CanoR_1	206	214	PF00244	0.577
LIG_14-3-3_CanoR_1	227	236	PF00244	0.457
LIG_14-3-3_CanoR_1	385	395	PF00244	0.588
LIG_BIR_II_1	1	5	PF00653	0.719
LIG_BRCT_BRCA1_1	113	117	PF00533	0.422
LIG_Clathr_ClatBox_1	334	338	PF01394	0.480
LIG_eIF4E_1	330	336	PF01652	0.352
LIG_eIF4E_1	401	407	PF01652	0.532
LIG_eIF4E_1	62	68	PF01652	0.402
LIG_FHA_1	127	133	PF00498	0.462
LIG_FHA_1	142	148	PF00498	0.588
LIG_FHA_1	186	192	PF00498	0.359
LIG_FHA_1	198	204	PF00498	0.663
LIG_FHA_1	372	378	PF00498	0.604
LIG_FHA_1	387	393	PF00498	0.535
LIG_FHA_1	406	412	PF00498	0.526
LIG_FHA_1	414	420	PF00498	0.579
LIG_FHA_1	426	432	PF00498	0.150
LIG_FHA_1	71	77	PF00498	0.476
LIG_FHA_1	79	85	PF00498	0.612
LIG_LIR_Gen_1	408	414	PF02991	0.588
LIG_LIR_Nem_3	322	327	PF02991	0.405
LIG_LYPXL_SIV_4	256	264	PF13949	0.330
LIG_MLH1_MIPbox_1	113	117	PF16413	0.422
LIG_NRBOX	190	196	PF00104	0.409
LIG_PTB_Apo_2	120	127	PF02174	0.313
LIG_RPA_C_Fungi	194	206	PF08784	0.624
LIG_SH2_CRK	226	230	PF00017	0.433
LIG_SH2_CRK	253	257	PF00017	0.486
LIG_SH2_CRK	395	399	PF00017	0.463
LIG_SH2_PTP2	401	404	PF00017	0.487
LIG_SH2_STAP1	211	215	PF00017	0.512
LIG_SH2_STAP1	409	413	PF00017	0.480
LIG_SH2_STAT5	401	404	PF00017	0.487
LIG_SH2_STAT5	50	53	PF00017	0.491
LIG_SH3_3	241	247	PF00018	0.450
LIG_SH3_3	270	276	PF00018	0.389
LIG_SH3_3	325	331	PF00018	0.435
LIG_SH3_3	334	340	PF00018	0.386
LIG_SH3_3	48	54	PF00018	0.562
LIG_SUMO_SIM_anti_2	300	307	PF11976	0.441
LIG_SUMO_SIM_anti_2	333	338	PF11976	0.475
LIG_SUMO_SIM_anti_2	428	436	PF11976	0.416
LIG_SUMO_SIM_par_1	102	107	PF11976	0.429
LIG_SUMO_SIM_par_1	198	204	PF11976	0.608
LIG_SUMO_SIM_par_1	33	39	PF11976	0.319
LIG_SUMO_SIM_par_1	333	338	PF11976	0.446
LIG_SUMO_SIM_par_1	428	436	PF11976	0.421
LIG_TRAF2_1	351	354	PF00917	0.530
LIG_TYR_ITIM	224	229	PF00017	0.266
LIG_TYR_ITIM	399	404	PF00017	0.412
LIG_UBA3_1	369	378	PF00899	0.487
LIG_WRC_WIRS_1	437	442	PF05994	0.679
MOD_CK1_1	435	441	PF00069	0.646
MOD_CK1_1	52	58	PF00069	0.414
MOD_CK1_1	97	103	PF00069	0.392
MOD_CK2_1	14	20	PF00069	0.501
MOD_CK2_1	435	441	PF00069	0.607
MOD_GlcNHglycan	146	150	PF01048	0.485
MOD_GlcNHglycan	161	164	PF01048	0.335
MOD_GlcNHglycan	229	232	PF01048	0.452
MOD_GlcNHglycan	297	300	PF01048	0.553
MOD_GlcNHglycan	349	352	PF01048	0.462
MOD_GlcNHglycan	359	362	PF01048	0.610
MOD_GlcNHglycan	38	41	PF01048	0.396
MOD_GlcNHglycan	54	57	PF01048	0.502
MOD_GlcNHglycan	84	87	PF01048	0.540
MOD_GlcNHglycan	99	102	PF01048	0.355
MOD_GSK3_1	141	148	PF00069	0.524
MOD_GSK3_1	197	204	PF00069	0.594
MOD_GSK3_1	343	350	PF00069	0.370
MOD_GSK3_1	413	420	PF00069	0.397
MOD_GSK3_1	421	428	PF00069	0.342
MOD_GSK3_1	431	438	PF00069	0.387
MOD_GSK3_1	78	85	PF00069	0.470
MOD_GSK3_1	90	97	PF00069	0.281
MOD_N-GLC_1	417	422	PF02516	0.305
MOD_NEK2_1	106	111	PF00069	0.347
MOD_NEK2_1	116	121	PF00069	0.377
MOD_NEK2_1	126	131	PF00069	0.150
MOD_NEK2_1	133	138	PF00069	0.239
MOD_NEK2_1	159	164	PF00069	0.401
MOD_NEK2_1	195	200	PF00069	0.544
MOD_NEK2_1	237	242	PF00069	0.345
MOD_NEK2_1	31	36	PF00069	0.349
MOD_NEK2_1	347	352	PF00069	0.512
MOD_NEK2_1	426	431	PF00069	0.413
MOD_NEK2_1	432	437	PF00069	0.413
MOD_NEK2_1	71	76	PF00069	0.376
MOD_NEK2_1	82	87	PF00069	0.410
MOD_NEK2_1	90	95	PF00069	0.226
MOD_PIKK_1	106	112	PF00454	0.539
MOD_PIKK_1	205	211	PF00454	0.518
MOD_PIKK_1	371	377	PF00454	0.503
MOD_PK_1	4	10	PF00069	0.712
MOD_PK_1	400	406	PF00069	0.508
MOD_PKA_2	126	132	PF00069	0.356
MOD_PKA_2	205	211	PF00069	0.493
MOD_Plk_1	417	423	PF00069	0.411
MOD_Plk_4	111	117	PF00069	0.466
MOD_Plk_4	128	134	PF00069	0.298
MOD_Plk_4	185	191	PF00069	0.344
MOD_Plk_4	274	280	PF00069	0.457
MOD_Plk_4	301	307	PF00069	0.414
MOD_Plk_4	31	37	PF00069	0.400
MOD_Plk_4	313	319	PF00069	0.317
MOD_Plk_4	330	336	PF00069	0.209
MOD_Plk_4	426	432	PF00069	0.456
MOD_Plk_4	71	77	PF00069	0.479
MOD_ProDKin_1	14	20	PF00069	0.699
MOD_SUMO_rev_2	298	304	PF00179	0.455
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.512
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.467
TRG_ENDOCYTIC_2	153	156	PF00928	0.436
TRG_ENDOCYTIC_2	226	229	PF00928	0.429
TRG_ENDOCYTIC_2	401	404	PF00928	0.487
TRG_ENDOCYTIC_2	409	412	PF00928	0.470
TRG_ENDOCYTIC_2	50	53	PF00928	0.470
TRG_ER_diArg_1	196	199	PF00400	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBZ5	Leptomonas seymouri	52%	100%
A0A1X0NUV1	Trypanosomatidae	25%	95%
A0A3R7NA95	Trypanosoma rangeli	24%	100%
A4H6Q3	Leishmania braziliensis	72%	100%
A4HV38	Leishmania infantum	99%	100%
D0A7B3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	96%
E9ANR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QGV0	Leishmania major	90%	100%
V5C1D7	Trypanosoma cruzi	25%	95%