SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I958_LEIDO

TriTrypDb:

LdBPK_120270.1 , LdCL_120007800 , LDHU3_12.0380

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3Q8I958

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I958

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016740	transferase activity	2	3

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.589
CLV_C14_Caspase3-7	24	28	PF00656	0.713
CLV_NRD_NRD_1	113	115	PF00675	0.539
CLV_NRD_NRD_1	18	20	PF00675	0.610
CLV_NRD_NRD_1	221	223	PF00675	0.568
CLV_NRD_NRD_1	303	305	PF00675	0.654
CLV_NRD_NRD_1	544	546	PF00675	0.472
CLV_PCSK_FUR_1	19	23	PF00082	0.617
CLV_PCSK_FUR_1	301	305	PF00082	0.602
CLV_PCSK_KEX2_1	112	114	PF00082	0.594

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7U7	Leptomonas seymouri	48%	99%
A0A1X0NNV4	Trypanosomatidae	38%	100%
A4H6U2	Leishmania braziliensis	71%	99%
A4HV71	Leishmania infantum	100%	100%
C9ZQA8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ANV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	95%
Q4QGR6	Leishmania major	87%	100%
V5BD95	Trypanosoma cruzi	33%	100%

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