SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I958_LEIDO

TriTrypDb:

LdBPK_120270.1 , LdCL_120007800 , LDHU3_12.0380

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8I958

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I958

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016740	transferase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.589
CLV_C14_Caspase3-7	24	28	PF00656	0.713
CLV_NRD_NRD_1	113	115	PF00675	0.539
CLV_NRD_NRD_1	18	20	PF00675	0.610
CLV_NRD_NRD_1	221	223	PF00675	0.568
CLV_NRD_NRD_1	303	305	PF00675	0.654
CLV_NRD_NRD_1	544	546	PF00675	0.472
CLV_PCSK_FUR_1	19	23	PF00082	0.617
CLV_PCSK_FUR_1	301	305	PF00082	0.602
CLV_PCSK_KEX2_1	112	114	PF00082	0.594
CLV_PCSK_KEX2_1	18	20	PF00082	0.610
CLV_PCSK_KEX2_1	21	23	PF00082	0.594
CLV_PCSK_KEX2_1	221	223	PF00082	0.568
CLV_PCSK_KEX2_1	303	305	PF00082	0.654
CLV_PCSK_KEX2_1	544	546	PF00082	0.476
CLV_PCSK_KEX2_1	548	550	PF00082	0.485
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.616
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.491
CLV_PCSK_PC7_1	544	550	PF00082	0.489
CLV_PCSK_SKI1_1	202	206	PF00082	0.428
CLV_PCSK_SKI1_1	222	226	PF00082	0.441
CLV_PCSK_SKI1_1	544	548	PF00082	0.478
CLV_PCSK_SKI1_1	549	553	PF00082	0.456
CLV_PCSK_SKI1_1	556	560	PF00082	0.396
CLV_PCSK_SKI1_1	6	10	PF00082	0.571
CLV_PCSK_SKI1_1	72	76	PF00082	0.582
DEG_SPOP_SBC_1	334	338	PF00917	0.746
DOC_CYCLIN_RxL_1	199	206	PF00134	0.454
DOC_CYCLIN_RxL_1	471	483	PF00134	0.455
DOC_CYCLIN_RxL_1	544	554	PF00134	0.516
DOC_MAPK_gen_1	112	121	PF00069	0.516
DOC_MAPK_HePTP_8	109	121	PF00069	0.536
DOC_MAPK_MEF2A_6	112	121	PF00069	0.555
DOC_MAPK_MEF2A_6	72	80	PF00069	0.607
DOC_PP2B_LxvP_1	225	228	PF13499	0.541
DOC_USP7_MATH_1	103	107	PF00917	0.299
DOC_USP7_MATH_1	12	16	PF00917	0.685
DOC_USP7_MATH_1	125	129	PF00917	0.760
DOC_USP7_MATH_1	148	152	PF00917	0.718
DOC_USP7_MATH_1	172	176	PF00917	0.763
DOC_USP7_MATH_1	334	338	PF00917	0.693
DOC_USP7_MATH_1	392	396	PF00917	0.633
DOC_USP7_MATH_1	398	402	PF00917	0.562
DOC_USP7_MATH_1	423	427	PF00917	0.471
DOC_USP7_MATH_1	491	495	PF00917	0.530
DOC_USP7_MATH_1	505	509	PF00917	0.505
DOC_WW_Pin1_4	160	165	PF00397	0.783
DOC_WW_Pin1_4	337	342	PF00397	0.626
DOC_WW_Pin1_4	44	49	PF00397	0.798
LIG_14-3-3_CanoR_1	149	155	PF00244	0.676
LIG_14-3-3_CanoR_1	171	177	PF00244	0.700
LIG_14-3-3_CanoR_1	202	211	PF00244	0.400
LIG_14-3-3_CanoR_1	22	26	PF00244	0.729
LIG_14-3-3_CanoR_1	221	225	PF00244	0.491
LIG_14-3-3_CanoR_1	430	436	PF00244	0.534
LIG_14-3-3_CanoR_1	549	559	PF00244	0.484
LIG_14-3-3_CanoR_1	61	66	PF00244	0.599
LIG_14-3-3_CanoR_1	72	77	PF00244	0.504
LIG_BIR_II_1	1	5	PF00653	0.640
LIG_BRCT_BRCA1_1	174	178	PF00533	0.734
LIG_BRCT_BRCA1_1	279	283	PF00533	0.414
LIG_EH1_1	470	478	PF00400	0.501
LIG_FHA_1	102	108	PF00498	0.382
LIG_FHA_1	212	218	PF00498	0.455
LIG_FHA_1	249	255	PF00498	0.471
LIG_FHA_1	368	374	PF00498	0.417
LIG_FHA_1	73	79	PF00498	0.556
LIG_FHA_1	88	94	PF00498	0.277
LIG_FHA_2	121	127	PF00498	0.580
LIG_FHA_2	280	286	PF00498	0.573
LIG_LIR_Apic_2	244	250	PF02991	0.506
LIG_LIR_Nem_3	356	361	PF02991	0.478
LIG_LIR_Nem_3	553	558	PF02991	0.511
LIG_LIR_Nem_3	97	102	PF02991	0.432
LIG_NRBOX	73	79	PF00104	0.568
LIG_REV1ctd_RIR_1	365	375	PF16727	0.415
LIG_RPA_C_Fungi	56	68	PF08784	0.482
LIG_SH2_CRK	247	251	PF00017	0.588
LIG_SH2_CRK	502	506	PF00017	0.575
LIG_SH2_CRK	555	559	PF00017	0.569
LIG_SH2_NCK_1	247	251	PF00017	0.489
LIG_SH2_NCK_1	25	29	PF00017	0.672
LIG_SH2_SRC	25	28	PF00017	0.670
LIG_SH2_SRC	500	503	PF00017	0.540
LIG_SH2_STAP1	383	387	PF00017	0.436
LIG_SH2_STAP1	99	103	PF00017	0.558
LIG_SH2_STAT5	193	196	PF00017	0.463
LIG_SH2_STAT5	247	250	PF00017	0.495
LIG_SH2_STAT5	417	420	PF00017	0.493
LIG_SH2_STAT5	500	503	PF00017	0.540
LIG_SH2_STAT5	557	560	PF00017	0.576
LIG_SH2_STAT5	85	88	PF00017	0.514
LIG_SH3_3	415	421	PF00018	0.568
LIG_SH3_3	440	446	PF00018	0.682
LIG_SH3_3	449	455	PF00018	0.687
LIG_SUMO_SIM_anti_2	482	489	PF11976	0.487
LIG_SUMO_SIM_par_1	117	124	PF11976	0.577
LIG_SUMO_SIM_par_1	253	259	PF11976	0.476
LIG_SUMO_SIM_par_1	482	489	PF11976	0.412
LIG_TRAF2_1	374	377	PF00917	0.496
MOD_CDK_SPK_2	160	165	PF00069	0.588
MOD_CDK_SPxxK_3	164	171	PF00069	0.694
MOD_CK1_1	11	17	PF00069	0.676
MOD_CK1_1	198	204	PF00069	0.458
MOD_CK1_1	2	8	PF00069	0.687
MOD_CK1_1	220	226	PF00069	0.518
MOD_CK1_1	277	283	PF00069	0.446
MOD_CK1_1	302	308	PF00069	0.727
MOD_CK1_1	313	319	PF00069	0.708
MOD_CK1_1	337	343	PF00069	0.684
MOD_CK1_1	461	467	PF00069	0.502
MOD_CK1_1	512	518	PF00069	0.642
MOD_CK1_1	52	58	PF00069	0.633
MOD_CK1_1	527	533	PF00069	0.756
MOD_CK2_1	124	130	PF00069	0.745
MOD_CK2_1	279	285	PF00069	0.572
MOD_GlcNHglycan	10	13	PF01048	0.755
MOD_GlcNHglycan	14	17	PF01048	0.752
MOD_GlcNHglycan	150	153	PF01048	0.780
MOD_GlcNHglycan	159	163	PF01048	0.719
MOD_GlcNHglycan	276	279	PF01048	0.416
MOD_GlcNHglycan	304	307	PF01048	0.706
MOD_GlcNHglycan	312	315	PF01048	0.690
MOD_GlcNHglycan	347	350	PF01048	0.595
MOD_GlcNHglycan	394	397	PF01048	0.611
MOD_GlcNHglycan	424	428	PF01048	0.531
MOD_GlcNHglycan	493	496	PF01048	0.595
MOD_GlcNHglycan	527	530	PF01048	0.770
MOD_GlcNHglycan	57	60	PF01048	0.618
MOD_GlcNHglycan	95	99	PF01048	0.507
MOD_GSK3_1	10	17	PF00069	0.774
MOD_GSK3_1	120	127	PF00069	0.609
MOD_GSK3_1	160	167	PF00069	0.656
MOD_GSK3_1	172	179	PF00069	0.721
MOD_GSK3_1	194	201	PF00069	0.450
MOD_GSK3_1	2	9	PF00069	0.770
MOD_GSK3_1	241	248	PF00069	0.538
MOD_GSK3_1	333	340	PF00069	0.740
MOD_GSK3_1	363	370	PF00069	0.378
MOD_GSK3_1	377	384	PF00069	0.399
MOD_GSK3_1	505	512	PF00069	0.541
MOD_GSK3_1	51	58	PF00069	0.623
MOD_N-GLC_1	267	272	PF02516	0.409
MOD_N-GLC_2	274	276	PF02516	0.389
MOD_NEK2_1	1	6	PF00069	0.772
MOD_NEK2_1	108	113	PF00069	0.427
MOD_NEK2_1	267	272	PF00069	0.497
MOD_NEK2_1	279	284	PF00069	0.487
MOD_NEK2_1	381	386	PF00069	0.428
MOD_NEK2_1	509	514	PF00069	0.611
MOD_NEK2_1	8	13	PF00069	0.613
MOD_NEK2_1	94	99	PF00069	0.440
MOD_NEK2_2	195	200	PF00069	0.394
MOD_NEK2_2	87	92	PF00069	0.525
MOD_PIKK_1	140	146	PF00454	0.720
MOD_PIKK_1	245	251	PF00454	0.532
MOD_PIKK_1	256	262	PF00454	0.376
MOD_PIKK_1	512	518	PF00454	0.727
MOD_PKA_1	21	27	PF00069	0.703
MOD_PKA_1	544	550	PF00069	0.564
MOD_PKA_2	148	154	PF00069	0.728
MOD_PKA_2	17	23	PF00069	0.582
MOD_PKA_2	170	176	PF00069	0.732
MOD_PKA_2	211	217	PF00069	0.424
MOD_PKA_2	220	226	PF00069	0.402
MOD_PKA_2	302	308	PF00069	0.711
MOD_PKA_2	353	359	PF00069	0.553
MOD_PKA_2	544	550	PF00069	0.478
MOD_Plk_1	377	383	PF00069	0.417
MOD_Plk_1	423	429	PF00069	0.525
MOD_Plk_1	94	100	PF00069	0.513
MOD_Plk_2-3	377	383	PF00069	0.516
MOD_Plk_4	103	109	PF00069	0.462
MOD_Plk_4	172	178	PF00069	0.669
MOD_Plk_4	229	235	PF00069	0.630
MOD_Plk_4	279	285	PF00069	0.529
MOD_Plk_4	363	369	PF00069	0.378
MOD_Plk_4	72	78	PF00069	0.564
MOD_ProDKin_1	160	166	PF00069	0.782
MOD_ProDKin_1	337	343	PF00069	0.627
MOD_ProDKin_1	44	50	PF00069	0.796
MOD_SUMO_for_1	421	424	PF00179	0.515
TRG_DiLeu_BaEn_2	423	429	PF01217	0.582
TRG_DiLeu_BaEn_4	376	382	PF01217	0.347
TRG_DiLeu_BaLyEn_6	557	562	PF01217	0.482
TRG_ENDOCYTIC_2	555	558	PF00928	0.432
TRG_ER_diArg_1	112	114	PF00400	0.589
TRG_ER_diArg_1	301	304	PF00400	0.670
TRG_ER_diArg_1	543	545	PF00400	0.538
TRG_ER_diArg_1	65	68	PF00400	0.634
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	549	554	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	560	564	PF00026	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7U7	Leptomonas seymouri	48%	99%
A0A1X0NNV4	Trypanosomatidae	38%	100%
A4H6U2	Leishmania braziliensis	71%	99%
A4HV71	Leishmania infantum	100%	100%
C9ZQA8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ANV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	95%
Q4QGR6	Leishmania major	87%	100%
V5BD95	Trypanosoma cruzi	33%	100%