LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8I949_LEIDO
TriTrypDb:
LdBPK_120075.1 , LdCL_120005800 , LDHU3_12.0110
Length:
90

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 4
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

A0A3Q8I949
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I949

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 54 58 PF00656 0.694
CLV_PCSK_SKI1_1 31 35 PF00082 0.537
CLV_PCSK_SKI1_1 73 77 PF00082 0.376
DEG_APCC_DBOX_1 72 80 PF00400 0.327
DEG_Nend_UBRbox_2 1 3 PF02207 0.792
DOC_CYCLIN_RxL_1 28 37 PF00134 0.735
DOC_MAPK_MEF2A_6 73 82 PF00069 0.520
DOC_MAPK_NFAT4_5 73 81 PF00069 0.426
DOC_PP4_FxxP_1 47 50 PF00568 0.723
DOC_WW_Pin1_4 16 21 PF00397 0.658
LIG_14-3-3_CanoR_1 35 42 PF00244 0.709
LIG_14-3-3_CanoR_1 73 79 PF00244 0.529
LIG_Actin_WH2_2 22 37 PF00022 0.744
LIG_FHA_1 4 10 PF00498 0.707
LIG_FHA_2 17 23 PF00498 0.747
LIG_FHA_2 25 31 PF00498 0.667
LIG_FHA_2 52 58 PF00498 0.697
LIG_LIR_Gen_1 62 72 PF02991 0.588
LIG_LIR_Nem_3 62 68 PF02991 0.598
LIG_PCNA_yPIPBox_3 56 68 PF02747 0.589
LIG_SH2_STAT5 25 28 PF00017 0.746
LIG_SH3_3 47 53 PF00018 0.773
LIG_WW_2 50 53 PF00397 0.630
MOD_CK2_1 16 22 PF00069 0.663
MOD_CK2_1 24 30 PF00069 0.622
MOD_CK2_1 34 40 PF00069 0.590
MOD_GlcNHglycan 36 39 PF01048 0.532
MOD_NEK2_1 24 29 PF00069 0.749
MOD_NEK2_1 34 39 PF00069 0.617
MOD_NEK2_1 68 73 PF00069 0.654
MOD_PKA_2 34 40 PF00069 0.632
MOD_Plk_1 59 65 PF00069 0.620
MOD_Plk_4 59 65 PF00069 0.609
MOD_Plk_4 74 80 PF00069 0.495
MOD_ProDKin_1 16 22 PF00069 0.657

Homologs

Protein Taxonomy Sequence identity Coverage
A4H6S3 Leishmania braziliensis 72% 100%
E9ACR2 Leishmania major 88% 100%
E9AGA4 Leishmania infantum 100% 100%
E9ANT4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS