Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I949_LEIDO

TriTrypDb:

LdBPK_120075.1 , LdCL_120005800 , LDHU3_12.0110

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

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Expansion

Sequence features

A0A3Q8I949

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I949

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	54	58	PF00656	0.694
CLV_PCSK_SKI1_1	31	35	PF00082	0.537
CLV_PCSK_SKI1_1	73	77	PF00082	0.376
DEG_APCC_DBOX_1	72	80	PF00400	0.327
DEG_Nend_UBRbox_2	1	3	PF02207	0.792
DOC_CYCLIN_RxL_1	28	37	PF00134	0.735
DOC_MAPK_MEF2A_6	73	82	PF00069	0.520
DOC_MAPK_NFAT4_5	73	81	PF00069	0.426
DOC_PP4_FxxP_1	47	50	PF00568	0.723
DOC_WW_Pin1_4	16	21	PF00397	0.658

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A4H6S3	Leishmania braziliensis	72%	100%
E9ACR2	Leishmania major	88%	100%
E9AGA4	Leishmania infantum	100%	100%
E9ANT4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%

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