HIT zinc finger containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HIT zinc finger, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I947_LEIDO

TriTrypDb:

LdBPK_110980.1 , LdCL_110015600 , LDHU3_11.1210

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5
GO:0000118	histone deacetylase complex	3	1
GO:0000812	Swr1 complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0070603	SWI/SNF superfamily-type complex	3	1
GO:0097346	INO80-type complex	4	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1904949	ATPase complex	3	1

Expansion

Sequence features

A0A3Q8I947

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I947

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0005488	binding	1	1
GO:0031491	nucleosome binding	3	1
GO:0044877	protein-containing complex binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.661
CLV_C14_Caspase3-7	230	234	PF00656	0.603
CLV_NRD_NRD_1	164	166	PF00675	0.723
CLV_NRD_NRD_1	172	174	PF00675	0.683
CLV_NRD_NRD_1	207	209	PF00675	0.825
CLV_NRD_NRD_1	217	219	PF00675	0.760
CLV_NRD_NRD_1	237	239	PF00675	0.683
CLV_NRD_NRD_1	300	302	PF00675	0.747
CLV_NRD_NRD_1	348	350	PF00675	0.739
CLV_NRD_NRD_1	368	370	PF00675	0.517
CLV_NRD_NRD_1	402	404	PF00675	0.779
CLV_NRD_NRD_1	405	407	PF00675	0.767
CLV_NRD_NRD_1	408	410	PF00675	0.734
CLV_NRD_NRD_1	87	89	PF00675	0.728
CLV_PCSK_FUR_1	403	407	PF00082	0.738
CLV_PCSK_KEX2_1	164	166	PF00082	0.723
CLV_PCSK_KEX2_1	172	174	PF00082	0.683
CLV_PCSK_KEX2_1	207	209	PF00082	0.825
CLV_PCSK_KEX2_1	219	221	PF00082	0.746
CLV_PCSK_KEX2_1	34	36	PF00082	0.641
CLV_PCSK_KEX2_1	348	350	PF00082	0.739
CLV_PCSK_KEX2_1	368	370	PF00082	0.517
CLV_PCSK_KEX2_1	404	406	PF00082	0.800
CLV_PCSK_KEX2_1	408	410	PF00082	0.759
CLV_PCSK_KEX2_1	83	85	PF00082	0.749
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.735
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.638
CLV_PCSK_PC1ET2_1	404	406	PF00082	0.741
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.690
CLV_PCSK_SKI1_1	271	275	PF00082	0.607
CLV_PCSK_SKI1_1	353	357	PF00082	0.740
CLV_PCSK_SKI1_1	369	373	PF00082	0.568
CLV_PCSK_SKI1_1	461	465	PF00082	0.384
CLV_PCSK_SKI1_1	478	482	PF00082	0.587
DEG_APCC_KENBOX_2	409	413	PF00400	0.606
DEG_SCF_TRCP1_1	413	418	PF00400	0.651
DEG_SPOP_SBC_1	296	300	PF00917	0.737
DOC_ANK_TNKS_1	207	214	PF00023	0.690
DOC_CYCLIN_RxL_1	363	375	PF00134	0.653
DOC_CYCLIN_RxL_1	474	483	PF00134	0.569
DOC_MAPK_gen_1	258	265	PF00069	0.584
DOC_PP1_RVXF_1	476	483	PF00149	0.588
DOC_PP2B_LxvP_1	371	374	PF13499	0.604
DOC_PP4_FxxP_1	393	396	PF00568	0.616
DOC_PP4_FxxP_1	428	431	PF00568	0.720
DOC_PP4_FxxP_1	52	55	PF00568	0.653
DOC_USP7_MATH_1	142	146	PF00917	0.706
DOC_USP7_MATH_1	243	247	PF00917	0.692
DOC_USP7_MATH_1	251	255	PF00917	0.579
DOC_USP7_MATH_1	294	298	PF00917	0.733
DOC_USP7_MATH_1	306	310	PF00917	0.656
DOC_USP7_MATH_1	367	371	PF00917	0.762
DOC_USP7_MATH_1	41	45	PF00917	0.654
DOC_USP7_MATH_1	55	59	PF00917	0.547
DOC_WW_Pin1_4	206	211	PF00397	0.617
DOC_WW_Pin1_4	283	288	PF00397	0.699
DOC_WW_Pin1_4	372	377	PF00397	0.682
LIG_14-3-3_CanoR_1	19	27	PF00244	0.712
LIG_14-3-3_CanoR_1	301	308	PF00244	0.684
LIG_14-3-3_CanoR_1	353	361	PF00244	0.694
LIG_14-3-3_CanoR_1	368	372	PF00244	0.625
LIG_14-3-3_CanoR_1	459	468	PF00244	0.577
LIG_14-3-3_CanoR_1	92	99	PF00244	0.691
LIG_Actin_WH2_2	465	483	PF00022	0.644
LIG_BIR_II_1	1	5	PF00653	0.647
LIG_FHA_1	105	111	PF00498	0.600
LIG_FHA_1	319	325	PF00498	0.641
LIG_FHA_1	381	387	PF00498	0.674
LIG_FHA_1	390	396	PF00498	0.577
LIG_FHA_1	475	481	PF00498	0.638
LIG_FHA_2	270	276	PF00498	0.607
LIG_FHA_2	354	360	PF00498	0.735
LIG_FHA_2	375	381	PF00498	0.673
LIG_GBD_Chelix_1	255	263	PF00786	0.531
LIG_LIR_Apic_2	192	197	PF02991	0.585
LIG_LIR_Apic_2	392	396	PF02991	0.585
LIG_LIR_Apic_2	427	431	PF02991	0.720
LIG_LIR_Apic_2	49	55	PF02991	0.655
LIG_LIR_Gen_1	127	132	PF02991	0.441
LIG_LIR_Gen_1	23	33	PF02991	0.648
LIG_LIR_Gen_1	337	346	PF02991	0.698
LIG_LIR_Gen_1	462	473	PF02991	0.626
LIG_LIR_Nem_3	127	131	PF02991	0.511
LIG_LIR_Nem_3	23	29	PF02991	0.664
LIG_LIR_Nem_3	337	341	PF02991	0.693
LIG_LIR_Nem_3	454	458	PF02991	0.610
LIG_LIR_Nem_3	462	468	PF02991	0.555
LIG_PDZ_Class_2	479	484	PF00595	0.612
LIG_SH2_CRK	455	459	PF00017	0.577
LIG_SH2_SRC	117	120	PF00017	0.574
LIG_SH2_SRC	314	317	PF00017	0.674
LIG_SH2_STAT5	117	120	PF00017	0.574
LIG_SH2_STAT5	314	317	PF00017	0.733
LIG_SH3_3	281	287	PF00018	0.697
LIG_SUMO_SIM_par_1	198	205	PF11976	0.726
LIG_TRAF2_1	356	359	PF00917	0.805
LIG_TRFH_1	332	336	PF08558	0.694
MOD_CDK_SPxxK_3	283	290	PF00069	0.707
MOD_CK1_1	182	188	PF00069	0.744
MOD_CK1_1	190	196	PF00069	0.663
MOD_CK1_1	286	292	PF00069	0.734
MOD_CK1_1	297	303	PF00069	0.610
MOD_CK1_1	70	76	PF00069	0.655
MOD_CK2_1	269	275	PF00069	0.631
MOD_CK2_1	353	359	PF00069	0.740
MOD_CK2_1	374	380	PF00069	0.713
MOD_Cter_Amidation	81	84	PF01082	0.592
MOD_GlcNHglycan	135	138	PF01048	0.747
MOD_GlcNHglycan	139	143	PF01048	0.718
MOD_GlcNHglycan	144	147	PF01048	0.660
MOD_GlcNHglycan	181	184	PF01048	0.745
MOD_GlcNHglycan	241	244	PF01048	0.703
MOD_GlcNHglycan	245	248	PF01048	0.633
MOD_GlcNHglycan	413	416	PF01048	0.717
MOD_GlcNHglycan	5	8	PF01048	0.731
MOD_GlcNHglycan	65	68	PF01048	0.722
MOD_GlcNHglycan	72	75	PF01048	0.649
MOD_GlcNHglycan	9	12	PF01048	0.638
MOD_GSK3_1	138	145	PF00069	0.637
MOD_GSK3_1	182	189	PF00069	0.687
MOD_GSK3_1	195	202	PF00069	0.640
MOD_GSK3_1	239	246	PF00069	0.648
MOD_GSK3_1	296	303	PF00069	0.734
MOD_GSK3_1	3	10	PF00069	0.605
MOD_GSK3_1	314	321	PF00069	0.523
MOD_GSK3_1	330	337	PF00069	0.540
MOD_GSK3_1	372	379	PF00069	0.669
MOD_GSK3_1	411	418	PF00069	0.741
MOD_GSK3_1	63	70	PF00069	0.716
MOD_N-GLC_1	411	416	PF02516	0.680
MOD_N-GLC_1	99	104	PF02516	0.517
MOD_NEK2_1	106	111	PF00069	0.594
MOD_NEK2_1	62	67	PF00069	0.692
MOD_NEK2_1	99	104	PF00069	0.640
MOD_NEK2_2	117	122	PF00069	0.572
MOD_NEK2_2	382	387	PF00069	0.579
MOD_PKA_1	404	410	PF00069	0.651
MOD_PKA_1	88	94	PF00069	0.723
MOD_PKA_2	18	24	PF00069	0.696
MOD_PKA_2	228	234	PF00069	0.730
MOD_PKA_2	300	306	PF00069	0.684
MOD_PKA_2	367	373	PF00069	0.835
MOD_PKA_2	404	410	PF00069	0.651
MOD_PKA_2	91	97	PF00069	0.698
MOD_Plk_1	269	275	PF00069	0.602
MOD_Plk_1	42	48	PF00069	0.649
MOD_Plk_2-3	430	436	PF00069	0.641
MOD_Plk_4	251	257	PF00069	0.630
MOD_Plk_4	55	61	PF00069	0.656
MOD_ProDKin_1	206	212	PF00069	0.619
MOD_ProDKin_1	283	289	PF00069	0.702
MOD_ProDKin_1	372	378	PF00069	0.680
MOD_SUMO_for_1	259	262	PF00179	0.581
MOD_SUMO_rev_2	144	153	PF00179	0.730
MOD_SUMO_rev_2	233	240	PF00179	0.670
MOD_SUMO_rev_2	309	315	PF00179	0.731
TRG_DiLeu_BaEn_2	21	27	PF01217	0.602
TRG_DiLeu_BaLyEn_6	324	329	PF01217	0.706
TRG_ENDOCYTIC_2	338	341	PF00928	0.699
TRG_ENDOCYTIC_2	455	458	PF00928	0.577
TRG_ER_diArg_1	206	208	PF00400	0.823
TRG_ER_diArg_1	218	221	PF00400	0.807
TRG_ER_diArg_1	367	369	PF00400	0.731
TRG_ER_diArg_1	403	406	PF00400	0.738
TRG_ER_diArg_1	458	461	PF00400	0.577
TRG_NLS_Bipartite_1	207	223	PF00514	0.748
TRG_NLS_MonoCore_2	218	223	PF00514	0.744
TRG_NLS_MonoCore_2	402	407	PF00514	0.735
TRG_NLS_MonoExtC_3	217	222	PF00514	0.744
TRG_NLS_MonoExtC_3	403	408	PF00514	0.738
TRG_NLS_MonoExtN_4	218	223	PF00514	0.741
TRG_NLS_MonoExtN_4	403	408	PF00514	0.738

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H6M4	Leishmania braziliensis	76%	100%
A4HV07	Leishmania infantum	100%	100%
E9ANP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QGY1	Leishmania major	92%	100%