Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I940_LEIDO

TriTrypDb:

LdBPK_111340.1 , LdCL_110019300 , LDHU3_11.1660

Length:

200

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I940

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I940

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.530
CLV_NRD_NRD_1	14	16	PF00675	0.595
CLV_NRD_NRD_1	143	145	PF00675	0.502
CLV_NRD_NRD_1	191	193	PF00675	0.468
CLV_NRD_NRD_1	2	4	PF00675	0.602
CLV_PCSK_KEX2_1	14	16	PF00082	0.597
CLV_PCSK_KEX2_1	143	145	PF00082	0.622
CLV_PCSK_KEX2_1	2	4	PF00082	0.606
CLV_PCSK_PC7_1	139	145	PF00082	0.524
CLV_PCSK_SKI1_1	65	69	PF00082	0.527
DEG_Nend_UBRbox_1	1	4	PF02207	0.591
DOC_CKS1_1	74	79	PF01111	0.603
DOC_CYCLIN_yCln2_LP_2	71	77	PF00134	0.519
DOC_PP2B_LxvP_1	71	74	PF13499	0.531
DOC_PP2B_LxvP_1	79	82	PF13499	0.512
DOC_PP4_FxxP_1	52	55	PF00568	0.386
DOC_USP7_MATH_1	191	195	PF00917	0.519
DOC_WW_Pin1_4	73	78	PF00397	0.613
DOC_WW_Pin1_4	89	94	PF00397	0.709
LIG_14-3-3_CanoR_1	115	125	PF00244	0.531
LIG_14-3-3_CanoR_1	17	22	PF00244	0.518
LIG_14-3-3_CanoR_1	192	196	PF00244	0.487
LIG_14-3-3_CanoR_1	2	9	PF00244	0.572
LIG_EVH1_1	52	56	PF00568	0.510
LIG_FHA_1	62	68	PF00498	0.613
LIG_FHA_1	74	80	PF00498	0.608
LIG_FHA_1	95	101	PF00498	0.612
LIG_LIR_Apic_2	50	55	PF02991	0.398
LIG_LIR_Gen_1	127	136	PF02991	0.447
LIG_LIR_Gen_1	178	187	PF02991	0.424
LIG_LIR_Gen_1	66	75	PF02991	0.530
LIG_LIR_Nem_3	124	128	PF02991	0.442
LIG_LIR_Nem_3	178	183	PF02991	0.445
LIG_LIR_Nem_3	57	62	PF02991	0.512
LIG_LIR_Nem_3	66	71	PF02991	0.478
LIG_SH3_1	87	93	PF00018	0.631
LIG_SH3_3	19	25	PF00018	0.563
LIG_SH3_3	50	56	PF00018	0.570
LIG_SH3_3	71	77	PF00018	0.592
LIG_SH3_3	87	93	PF00018	0.650
LIG_TRFH_1	52	56	PF08558	0.562
LIG_TRFH_1	59	63	PF08558	0.542
LIG_UBA3_1	169	176	PF00899	0.425
MOD_CK1_1	121	127	PF00069	0.410
MOD_GlcNHglycan	120	123	PF01048	0.449
MOD_GlcNHglycan	189	192	PF01048	0.499
MOD_GlcNHglycan	19	22	PF01048	0.515
MOD_GSK3_1	178	185	PF00069	0.472
MOD_GSK3_1	187	194	PF00069	0.555
MOD_GSK3_1	29	36	PF00069	0.680
MOD_GSK3_1	63	70	PF00069	0.526
MOD_N-GLC_1	33	38	PF02516	0.651
MOD_NEK2_1	116	121	PF00069	0.471
MOD_NEK2_2	63	68	PF00069	0.565
MOD_PKA_2	1	7	PF00069	0.581
MOD_PKA_2	191	197	PF00069	0.500
MOD_PKB_1	15	23	PF00069	0.585
MOD_Plk_1	178	184	PF00069	0.445
MOD_Plk_1	47	53	PF00069	0.642
MOD_Plk_2-3	96	102	PF00069	0.533
MOD_Plk_4	54	60	PF00069	0.580
MOD_Plk_4	63	69	PF00069	0.575
MOD_ProDKin_1	73	79	PF00069	0.615
MOD_ProDKin_1	89	95	PF00069	0.704
MOD_SUMO_for_1	103	106	PF00179	0.479
MOD_SUMO_rev_2	147	154	PF00179	0.497
MOD_SUMO_rev_2	172	177	PF00179	0.452
MOD_SUMO_rev_2	4	9	PF00179	0.561
TRG_DiLeu_BaEn_1	165	170	PF01217	0.394
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.471
TRG_ENDOCYTIC_2	128	131	PF00928	0.461
TRG_ENDOCYTIC_2	59	62	PF00928	0.547
TRG_ER_diArg_1	1	3	PF00400	0.798
TRG_ER_diArg_1	13	15	PF00400	0.564
TRG_ER_diArg_1	143	146	PF00400	0.632
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P412	Leptomonas seymouri	49%	98%
A4H6Q7	Leishmania braziliensis	78%	100%
A4HV41	Leishmania infantum	100%	100%
D0A7A7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9ANS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QGU7	Leishmania major	93%	100%