Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I937_LEIDO

TriTrypDb:

LdBPK_110760.1 , LdCL_110013000 , LDHU3_11.0960

Length:

205

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I937

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I937

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	58	60	PF00675	0.545
CLV_PCSK_KEX2_1	47	49	PF00082	0.594
CLV_PCSK_KEX2_1	58	60	PF00082	0.513
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.504
CLV_PCSK_SKI1_1	48	52	PF00082	0.572
CLV_PCSK_SKI1_1	58	62	PF00082	0.505
DEG_APCC_DBOX_1	58	66	PF00400	0.487
DOC_CKS1_1	185	190	PF01111	0.665
DOC_CYCLIN_yCln2_LP_2	139	145	PF00134	0.647
DOC_MAPK_MEF2A_6	75	82	PF00069	0.512
DOC_MAPK_NFAT4_5	75	83	PF00069	0.509
DOC_PP2B_LxvP_1	139	142	PF13499	0.699
DOC_PP2B_LxvP_1	199	202	PF13499	0.740
DOC_USP7_MATH_1	83	87	PF00917	0.552
DOC_WW_Pin1_4	184	189	PF00397	0.744
LIG_14-3-3_CanoR_1	32	41	PF00244	0.557
LIG_APCC_ABBA_1	69	74	PF00400	0.468
LIG_APCC_ABBAyCdc20_2	68	74	PF00400	0.471
LIG_BIR_II_1	1	5	PF00653	0.633
LIG_BIR_III_3	1	5	PF00653	0.560
LIG_EVH1_2	107	111	PF00568	0.609
LIG_FAT_LD_1	192	200	PF03623	0.716
LIG_FHA_1	185	191	PF00498	0.690
LIG_FHA_2	34	40	PF00498	0.475
LIG_LIR_Apic_2	170	175	PF02991	0.659
LIG_SH2_SRC	161	164	PF00017	0.619
LIG_SH2_STAP1	34	38	PF00017	0.543
LIG_SH2_STAP1	9	13	PF00017	0.528
LIG_SH2_STAT3	9	12	PF00017	0.583
LIG_SH2_STAT5	172	175	PF00017	0.647
LIG_SH2_STAT5	34	37	PF00017	0.467
LIG_SH3_2	142	147	PF14604	0.560
LIG_SH3_3	139	145	PF00018	0.670
LIG_SH3_3	182	188	PF00018	0.673
LIG_Sin3_3	76	83	PF02671	0.509
MOD_CK1_1	129	135	PF00069	0.808
MOD_CK1_1	43	49	PF00069	0.594
MOD_CK2_1	33	39	PF00069	0.466
MOD_CK2_1	64	70	PF00069	0.665
MOD_GlcNHglycan	112	115	PF01048	0.800
MOD_GlcNHglycan	150	153	PF01048	0.674
MOD_GlcNHglycan	85	88	PF01048	0.578
MOD_GlcNHglycan	98	102	PF01048	0.626
MOD_GSK3_1	148	155	PF00069	0.747
MOD_GSK3_1	157	164	PF00069	0.741
MOD_GSK3_1	97	104	PF00069	0.718
MOD_N-GLC_1	83	88	PF02516	0.566
MOD_NEK2_1	110	115	PF00069	0.681
MOD_PIKK_1	152	158	PF00454	0.748
MOD_Plk_1	97	103	PF00069	0.607
MOD_ProDKin_1	184	190	PF00069	0.745
MOD_SUMO_rev_2	159	167	PF00179	0.630
TRG_DiLeu_BaEn_1	74	79	PF01217	0.507
TRG_ER_diArg_1	58	60	PF00400	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I225	Leptomonas seymouri	59%	100%
A0A1X0NDQ9	Trypanosomatidae	43%	100%
A0A3R7KJF9	Trypanosoma rangeli	39%	100%
A4H6K0	Leishmania braziliensis	74%	98%
A4HUY5	Leishmania infantum	100%	100%
E9ANM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QH03	Leishmania major	92%	100%