LeishMANIAdb
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Methylcrotonoyl-CoA carboxylase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Methylcrotonoyl-CoA carboxylase
Gene product:
3-methylcrotonoyl-CoA carboxylase beta subunit, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8I921_LEIDO
TriTrypDb:
LdBPK_110600.1 , LdCL_110011400 , LDHU3_11.0790
Length:
536

Annotations

Annotations by Jardim et al.

Amino acid metabolism, 3-methylcrotonoyl-CoA carboxylase beta subunit

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 1
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1
GO:1902494 catalytic complex 2 1
GO:1905202 methylcrotonoyl-CoA carboxylase complex 3 1

Expansion

Sequence features

A0A3Q8I921
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I921

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 12
GO:0006520 amino acid metabolic process 3 12
GO:0006551 leucine metabolic process 5 12
GO:0006552 leucine catabolic process 6 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009056 catabolic process 2 12
GO:0009063 amino acid catabolic process 4 12
GO:0009081 branched-chain amino acid metabolic process 4 12
GO:0009083 branched-chain amino acid catabolic process 5 12
GO:0009987 cellular process 1 12
GO:0016054 organic acid catabolic process 4 12
GO:0019752 carboxylic acid metabolic process 5 12
GO:0043436 oxoacid metabolic process 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044248 cellular catabolic process 3 12
GO:0044281 small molecule metabolic process 2 12
GO:0044282 small molecule catabolic process 3 12
GO:0046395 carboxylic acid catabolic process 5 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:1901565 organonitrogen compound catabolic process 4 12
GO:1901575 organic substance catabolic process 3 12
GO:1901605 alpha-amino acid metabolic process 4 12
GO:1901606 alpha-amino acid catabolic process 5 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004485 methylcrotonoyl-CoA carboxylase activity 5 8
GO:0016421 CoA carboxylase activity 4 8
GO:0016874 ligase activity 2 12
GO:0016885 ligase activity, forming carbon-carbon bonds 3 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 265 267 PF00675 0.301
CLV_NRD_NRD_1 376 378 PF00675 0.443
CLV_NRD_NRD_1 42 44 PF00675 0.485
CLV_NRD_NRD_1 488 490 PF00675 0.447
CLV_PCSK_KEX2_1 265 267 PF00082 0.292
CLV_PCSK_KEX2_1 488 490 PF00082 0.459
CLV_PCSK_PC1ET2_1 488 490 PF00082 0.323
CLV_PCSK_SKI1_1 107 111 PF00082 0.443
CLV_PCSK_SKI1_1 443 447 PF00082 0.301
CLV_PCSK_SKI1_1 470 474 PF00082 0.421
DEG_Nend_UBRbox_2 1 3 PF02207 0.482
DOC_CYCLIN_RxL_1 40 48 PF00134 0.515
DOC_MAPK_gen_1 265 273 PF00069 0.447
DOC_MAPK_gen_1 377 384 PF00069 0.460
DOC_MAPK_MEF2A_6 181 190 PF00069 0.358
DOC_MAPK_MEF2A_6 344 352 PF00069 0.309
DOC_MAPK_MEF2A_6 377 384 PF00069 0.301
DOC_PP2B_PxIxI_1 417 423 PF00149 0.301
DOC_PP4_FxxP_1 446 449 PF00568 0.301
DOC_USP7_MATH_1 176 180 PF00917 0.316
DOC_USP7_MATH_1 204 208 PF00917 0.290
DOC_USP7_MATH_1 29 33 PF00917 0.549
DOC_USP7_UBL2_3 484 488 PF12436 0.316
LIG_14-3-3_CanoR_1 177 183 PF00244 0.364
LIG_14-3-3_CanoR_1 452 456 PF00244 0.316
LIG_Actin_WH2_2 460 475 PF00022 0.421
LIG_EH1_1 311 319 PF00400 0.408
LIG_EVH1_2 221 225 PF00568 0.335
LIG_FHA_1 178 184 PF00498 0.241
LIG_FHA_1 213 219 PF00498 0.302
LIG_FHA_1 253 259 PF00498 0.316
LIG_FHA_1 412 418 PF00498 0.301
LIG_FHA_1 419 425 PF00498 0.301
LIG_FHA_1 499 505 PF00498 0.287
LIG_FHA_1 513 519 PF00498 0.287
LIG_FHA_1 64 70 PF00498 0.335
LIG_LIR_Gen_1 325 334 PF02991 0.301
LIG_LIR_Gen_1 441 451 PF02991 0.358
LIG_LIR_Gen_1 66 75 PF02991 0.287
LIG_LIR_Nem_3 121 125 PF02991 0.301
LIG_LIR_Nem_3 165 171 PF02991 0.301
LIG_LIR_Nem_3 325 330 PF02991 0.301
LIG_LIR_Nem_3 66 71 PF02991 0.287
LIG_Pex14_2 168 172 PF04695 0.301
LIG_Pex14_2 440 444 PF04695 0.301
LIG_Rb_pABgroove_1 286 294 PF01858 0.421
LIG_SH2_SRC 199 202 PF00017 0.301
LIG_SH2_SRC 396 399 PF00017 0.335
LIG_SH2_STAP1 360 364 PF00017 0.301
LIG_SH2_STAP1 88 92 PF00017 0.421
LIG_SH2_STAT5 14 17 PF00017 0.479
LIG_SH2_STAT5 146 149 PF00017 0.287
LIG_SH2_STAT5 199 202 PF00017 0.301
LIG_SH2_STAT5 262 265 PF00017 0.399
LIG_SH3_3 284 290 PF00018 0.421
LIG_SH3_3 506 512 PF00018 0.301
LIG_SUMO_SIM_anti_2 184 190 PF11976 0.408
LIG_SUMO_SIM_par_1 463 468 PF11976 0.301
LIG_TRAF2_1 22 25 PF00917 0.490
LIG_WRC_WIRS_1 309 314 PF05994 0.311
LIG_WW_1 289 292 PF00397 0.386
MOD_CK1_1 179 185 PF00069 0.447
MOD_CK1_1 32 38 PF00069 0.509
MOD_CK2_1 19 25 PF00069 0.471
MOD_CK2_1 31 37 PF00069 0.533
MOD_CK2_1 473 479 PF00069 0.413
MOD_Cter_Amidation 392 395 PF01082 0.358
MOD_GlcNHglycan 149 152 PF01048 0.301
MOD_GlcNHglycan 21 24 PF01048 0.515
MOD_GlcNHglycan 246 249 PF01048 0.301
MOD_GlcNHglycan 362 365 PF01048 0.296
MOD_GlcNHglycan 92 95 PF01048 0.335
MOD_GSK3_1 177 184 PF00069 0.399
MOD_GSK3_1 456 463 PF00069 0.445
MOD_GSK3_1 493 500 PF00069 0.308
MOD_N-GLC_1 153 158 PF02516 0.447
MOD_N-GLC_1 212 217 PF02516 0.316
MOD_N-GLC_1 385 390 PF02516 0.301
MOD_N-GLC_1 473 478 PF02516 0.447
MOD_NEK2_1 147 152 PF00069 0.301
MOD_NEK2_1 333 338 PF00069 0.421
MOD_NEK2_1 410 415 PF00069 0.434
MOD_NEK2_1 45 50 PF00069 0.386
MOD_NEK2_1 456 461 PF00069 0.337
MOD_NEK2_1 465 470 PF00069 0.247
MOD_NEK2_1 523 528 PF00069 0.358
MOD_NEK2_1 69 74 PF00069 0.301
MOD_PIKK_1 181 187 PF00454 0.408
MOD_PIKK_1 372 378 PF00454 0.386
MOD_PIKK_1 456 462 PF00454 0.447
MOD_PIKK_1 69 75 PF00454 0.291
MOD_PKA_2 176 182 PF00069 0.364
MOD_PKA_2 244 250 PF00069 0.301
MOD_PKA_2 451 457 PF00069 0.316
MOD_PKA_2 523 529 PF00069 0.386
MOD_Plk_1 113 119 PF00069 0.301
MOD_Plk_1 204 210 PF00069 0.275
MOD_Plk_1 512 518 PF00069 0.421
MOD_Plk_1 69 75 PF00069 0.301
MOD_Plk_4 118 124 PF00069 0.301
MOD_Plk_4 204 210 PF00069 0.309
MOD_Plk_4 212 218 PF00069 0.311
MOD_Plk_4 334 340 PF00069 0.310
MOD_Plk_4 460 466 PF00069 0.307
MOD_SUMO_rev_2 278 288 PF00179 0.374
MOD_SUMO_rev_2 323 333 PF00179 0.301
TRG_DiLeu_BaEn_2 295 301 PF01217 0.316
TRG_DiLeu_BaLyEn_6 377 382 PF01217 0.301
TRG_DiLeu_BaLyEn_6 57 62 PF01217 0.447
TRG_ENDOCYTIC_2 122 125 PF00928 0.301
TRG_ER_diArg_1 8 11 PF00400 0.390
TRG_ER_diLys_1 533 536 PF00400 0.502

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4K5 Leptomonas seymouri 31% 100%
A0A0N1IIF0 Leptomonas seymouri 85% 80%
A0A0S4IW40 Bodo saltans 69% 79%
A0A0S4J7G9 Bodo saltans 31% 100%
A0A1X0NV46 Trypanosomatidae 72% 86%
A0A3R7M923 Trypanosoma rangeli 72% 86%
A0A3S7X171 Leishmania donovani 32% 100%
A4H6I5 Leishmania braziliensis 93% 100%
A4HG89 Leishmania braziliensis 32% 98%
A4HUX0 Leishmania infantum 100% 100%
D0A7I1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 75% 88%
E9ANK4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
E9AZL0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
I3R7F1 Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4) 32% 100%
I6YDK7 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 59% 100%
O31825 Bacillus subtilis (strain 168) 37% 100%
O53578 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 29% 100%
O54028 Propionigenium modestum 33% 100%
O86318 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 48% 100%
P05166 Homo sapiens 31% 99%
P07633 Rattus norvegicus 32% 99%
P34385 Caenorhabditis elegans 58% 88%
P53002 Mycobacterium leprae (strain TN) 31% 98%
P53003 Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338) 33% 98%
P54541 Bacillus subtilis (strain 168) 32% 100%
P63408 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 32% 100%
P79384 Sus scrofa 31% 99%
P9WQH4 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 32% 100%
P9WQH5 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 32% 100%
P9WQH6 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 31% 98%
P9WQH7 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 31% 98%
Q06101 Rhodococcus erythropolis 33% 100%
Q06700 Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / CCUG 9996 / CIP 106432 / VR4) 27% 91%
Q168G2 Roseobacter denitrificans (strain ATCC 33942 / OCh 114) 32% 100%
Q2TBR0 Bos taurus 31% 99%
Q3J4E3 Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) 33% 100%
Q3ULD5 Mus musculus 61% 95%
Q4Q8M1 Leishmania major 31% 100%
Q4QH21 Leishmania major 98% 100%
Q57079 Veillonella parvula 32% 100%
Q5XIT9 Rattus norvegicus 61% 95%
Q8GBW6 Propionibacterium freudenreichii subsp. shermanii 34% 100%
Q8T2J9 Dictyostelium discoideum 61% 91%
Q99MN9 Mus musculus 30% 99%
Q9HCC0 Homo sapiens 59% 95%
Q9LDD8 Arabidopsis thaliana 56% 91%
Q9V9A7 Drosophila melanogaster 65% 93%
V5BWB7 Trypanosoma cruzi 71% 87%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS