Inhibitor_of_serine_peptidase_(ISP)_putative/Gene DB:LmjF.15.0300

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ecotin-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8I919_LEIDO

TriTrypDb:

LdBPK_150350.1 , LdCL_150008400 , LDHU3_15.0450

Length:

146

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I919

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I919

Function

Biological processes
Term	Name	Level	Count
GO:0009605	response to external stimulus	2	1
GO:0009607	response to biotic stimulus	2	1
GO:0042783	evasion of host immune response	6	1
GO:0042784	evasion of host immune response via modulation of host complement system	7	1
GO:0043207	response to external biotic stimulus	3	1
GO:0044403	biological process involved in symbiotic interaction	2	1
GO:0044419	biological process involved in interspecies interaction between organisms	1	1
GO:0050896	response to stimulus	1	1
GO:0051701	biological process involved in interaction with host	3	1
GO:0051707	response to other organism	2	1
GO:0052173	response to defenses of other organism	3	1
GO:0052200	response to host defenses	4	1
GO:0052572	response to host immune response	5	1
GO:0075136	response to host	3	1

Molecular functions
Term	Name	Level	Count
GO:0004857	enzyme inhibitor activity	3	14
GO:0004866	endopeptidase inhibitor activity	5	14
GO:0004867	serine-type endopeptidase inhibitor activity	6	14
GO:0030234	enzyme regulator activity	2	14
GO:0030414	peptidase inhibitor activity	4	14
GO:0061134	peptidase regulator activity	3	14
GO:0061135	endopeptidase regulator activity	4	14
GO:0098772	molecular function regulator activity	1	14
GO:0140678	molecular function inhibitor activity	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	49	53	PF00656	0.321
CLV_NRD_NRD_1	100	102	PF00675	0.422
CLV_PCSK_KEX2_1	18	20	PF00082	0.328
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.325
CLV_PCSK_SKI1_1	19	23	PF00082	0.294
CLV_PCSK_SKI1_1	79	83	PF00082	0.445
DOC_CYCLIN_yClb3_PxF_3	107	115	PF00134	0.192
DOC_MAPK_gen_1	115	124	PF00069	0.369
DOC_MAPK_MEF2A_6	115	124	PF00069	0.340
DOC_PP1_RVXF_1	16	23	PF00149	0.325
DOC_USP7_MATH_1	113	117	PF00917	0.337
LIG_APCC_ABBA_1	89	94	PF00400	0.306
LIG_BIR_II_1	1	5	PF00653	0.567
LIG_deltaCOP1_diTrp_1	69	76	PF00928	0.254
LIG_LIR_Gen_1	2	11	PF02991	0.487
LIG_LIR_Nem_3	2	6	PF02991	0.504
LIG_Pex14_1	71	75	PF04695	0.354
LIG_REV1ctd_RIR_1	73	83	PF16727	0.306
LIG_SH2_STAT3	36	39	PF00017	0.354
LIG_SH2_STAT5	123	126	PF00017	0.281
LIG_SH2_STAT5	3	6	PF00017	0.569
LIG_SH3_2	110	115	PF14604	0.265
LIG_SH3_3	101	107	PF00018	0.395
LIG_SH3_3	119	125	PF00018	0.282
LIG_TRAF2_1	31	34	PF00917	0.213
LIG_TRFH_1	22	26	PF08558	0.279
LIG_UBA3_1	20	27	PF00899	0.367
MOD_GSK3_1	55	62	PF00069	0.336
MOD_NEK2_1	46	51	PF00069	0.372
MOD_Plk_2-3	64	70	PF00069	0.369
MOD_Plk_4	84	90	PF00069	0.379
TRG_ENDOCYTIC_2	3	6	PF00928	0.481
TRG_ER_diArg_1	114	117	PF00400	0.281

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIL0	Leptomonas seymouri	52%	99%
A0A0N1PE50	Leptomonas seymouri	40%	98%
A0A1X0NTQ2	Trypanosomatidae	40%	92%
A0A1X0NV40	Trypanosomatidae	39%	96%
A0A3R7KH31	Trypanosoma rangeli	33%	99%
A0A422N3M7	Trypanosoma rangeli	39%	100%
A1JL79	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	32%	87%
A4H804	Leishmania braziliensis	81%	100%
A4H823	Leishmania braziliensis	42%	100%
A4HWD2	Leishmania infantum	99%	100%
A4HWE9	Leishmania infantum	40%	100%
A4TNJ2	Yersinia pestis (strain Pestoides F)	36%	86%
A5W3S6	Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)	37%	92%
A7FKF8	Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)	36%	86%
A7ZP31	Escherichia coli O139:H28 (strain E24377A / ETEC)	35%	90%
A8A271	Escherichia coli O9:H4 (strain HS)	35%	90%
A8GCA1	Serratia proteamaculans (strain 568)	36%	86%
A9MJZ3	Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)	32%	90%
A9R289	Yersinia pestis bv. Antiqua (strain Angola)	36%	86%
B0KU25	Pseudomonas putida (strain GB-1)	38%	92%
B1IY63	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	35%	90%
B1J8K6	Pseudomonas putida (strain W619)	36%	92%
B1JSA0	Yersinia pseudotuberculosis serotype O:3 (strain YPIII)	36%	86%
B1LKV6	Escherichia coli (strain SMS-3-5 / SECEC)	35%	90%
B1X8A5	Escherichia coli (strain K12 / DH10B)	35%	90%
B2K9A0	Yersinia pseudotuberculosis serotype IB (strain PB1/+)	36%	86%
B2TV26	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	35%	90%
B5BDZ1	Salmonella paratyphi A (strain AKU_12601)	34%	89%
B5R236	Salmonella enteritidis PT4 (strain P125109)	33%	89%
B5RC88	Salmonella gallinarum (strain 287/91 / NCTC 13346)	33%	89%
B5YX01	Escherichia coli O157:H7 (strain EC4115 / EHEC)	34%	90%
B6I1A7	Escherichia coli (strain SE11)	35%	90%
B7LAN3	Escherichia coli (strain 55989 / EAEC)	35%	90%
B7LJV0	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	33%	90%
B7M5Q0	Escherichia coli O8 (strain IAI1)	35%	90%
B7MFC2	Escherichia coli O45:K1 (strain S88 / ExPEC)	35%	90%
B7MXP0	Escherichia coli O81 (strain ED1a)	35%	90%
B7N5H1	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	35%	90%
B7NN20	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	35%	90%
B7UFM3	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	35%	90%
B7UZW2	Pseudomonas aeruginosa (strain LESB58)	34%	94%
C4ZU52	Escherichia coli (strain K12 / MC4100 / BW2952)	35%	90%
C9ZNX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	88%
C9ZNZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	95%
E9AQ32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
P23827	Escherichia coli (strain K12)	35%	90%
Q02NQ8	Pseudomonas aeruginosa (strain UCBPP-PA14)	34%	94%
Q0T2R6	Shigella flexneri serotype 5b (strain 8401)	35%	90%
Q0TFN2	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	35%	90%
Q1C9H9	Yersinia pestis bv. Antiqua (strain Antiqua)	36%	86%
Q1CFY7	Yersinia pestis bv. Antiqua (strain Nepal516)	36%	86%
Q1H1S3	Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)	33%	91%
Q1R9K8	Escherichia coli (strain UTI89 / UPEC)	35%	90%
Q31Z32	Shigella boydii serotype 4 (strain Sb227)	35%	90%
Q3KCZ4	Pseudomonas fluorescens (strain Pf0-1)	34%	91%
Q3YZZ8	Shigella sonnei (strain Ss046)	35%	90%
Q4D4Y5	Trypanosoma cruzi (strain CL Brener)	42%	99%
Q4KC31	Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)	30%	92%
Q4QFD4	Leishmania major	40%	100%
Q4QFF0	Leishmania major	91%	100%
Q4UMT9	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	31%	90%
Q57M90	Salmonella choleraesuis (strain SC-B67)	34%	90%
Q57ZP2	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	36%	88%
Q57ZQ7	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	31%	95%
Q5PI36	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	34%	89%
Q66CZ8	Yersinia pseudotuberculosis serotype I (strain IP32953)	36%	86%
Q821B1	Shigella flexneri	35%	90%
Q88IC7	Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)	38%	92%
Q8CVW3	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	35%	90%
Q8EEQ7	Shewanella oneidensis (strain MR-1)	30%	80%
Q8XE46	Escherichia coli O157:H7	34%	90%
Q8Z568	Salmonella typhi	33%	89%
Q8ZGS0	Yersinia pestis	36%	86%
Q8ZNH4	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	33%	89%
Q9I088	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	34%	94%