Pyruvate, phosphate dikinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pyruvate phosphate dikinase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I917_LEIDO

TriTrypDb:

LdBPK_111000.1 , LdCL_110015800 , LDHU3_11.1230

Length:

914

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I917

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I917

Function

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Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	1
GO:0006082	organic acid metabolic process	3	12
GO:0006090	pyruvate metabolic process	7	12
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006096	glycolytic process	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006165	obsolete nucleoside diphosphate phosphorylation	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016781	phosphotransferase activity, paired acceptors	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.639
CLV_C14_Caspase3-7	596	600	PF00656	0.578
CLV_NRD_NRD_1	126	128	PF00675	0.359
CLV_NRD_NRD_1	140	142	PF00675	0.320
CLV_NRD_NRD_1	229	231	PF00675	0.353
CLV_NRD_NRD_1	317	319	PF00675	0.369
CLV_NRD_NRD_1	74	76	PF00675	0.371
CLV_PCSK_FUR_1	315	319	PF00082	0.414
CLV_PCSK_KEX2_1	126	128	PF00082	0.363
CLV_PCSK_KEX2_1	140	142	PF00082	0.320

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I112	Leptomonas seymouri	87%	100%
A0A0S4IJT3	Bodo saltans	71%	100%
A0A1X0NUY0	Trypanosomatidae	79%	100%
A0A3R7KK46	Trypanosoma rangeli	77%	100%
A4H6M6	Leishmania braziliensis	93%	100%
A4HV09	Leishmania infantum	100%	100%
D0A7D9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	100%
E9ANP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O23404	Arabidopsis thaliana	53%	95%
O27190	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	28%	100%

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