Pyruvate, phosphate dikinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pyruvate phosphate dikinase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I917_LEIDO

TriTrypDb:

LdBPK_111000.1 , LdCL_110015800 , LDHU3_11.1230

Length:

914

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I917

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I917

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	12
GO:0006090	pyruvate metabolic process	7	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019752	carboxylic acid metabolic process	5	12
GO:0032787	monocarboxylic acid metabolic process	6	12
GO:0043436	oxoacid metabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044281	small molecule metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0005975	carbohydrate metabolic process	3	1
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006096	glycolytic process	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006165	obsolete nucleoside diphosphate phosphorylation	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006757	obsolete ATP generation from ADP	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009056	catabolic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009132	nucleoside diphosphate metabolic process	5	1
GO:0009135	purine nucleoside diphosphate metabolic process	6	1
GO:0009141	nucleoside triphosphate metabolic process	5	1
GO:0009144	purine nucleoside triphosphate metabolic process	6	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009179	purine ribonucleoside diphosphate metabolic process	7	1
GO:0009185	ribonucleoside diphosphate metabolic process	6	1
GO:0009199	ribonucleoside triphosphate metabolic process	6	1
GO:0009205	purine ribonucleoside triphosphate metabolic process	7	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0016052	carbohydrate catabolic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0046031	ADP metabolic process	7	1
GO:0046034	ATP metabolic process	7	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046939	obsolete nucleotide phosphorylation	6	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016781	phosphotransferase activity, paired acceptors	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0050242	pyruvate, phosphate dikinase activity	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.639
CLV_C14_Caspase3-7	596	600	PF00656	0.578
CLV_NRD_NRD_1	126	128	PF00675	0.359
CLV_NRD_NRD_1	140	142	PF00675	0.320
CLV_NRD_NRD_1	229	231	PF00675	0.353
CLV_NRD_NRD_1	317	319	PF00675	0.369
CLV_NRD_NRD_1	74	76	PF00675	0.371
CLV_PCSK_FUR_1	315	319	PF00082	0.414
CLV_PCSK_KEX2_1	126	128	PF00082	0.363
CLV_PCSK_KEX2_1	140	142	PF00082	0.320
CLV_PCSK_KEX2_1	229	231	PF00082	0.353
CLV_PCSK_KEX2_1	315	317	PF00082	0.365
CLV_PCSK_KEX2_1	368	370	PF00082	0.353
CLV_PCSK_KEX2_1	558	560	PF00082	0.353
CLV_PCSK_KEX2_1	904	906	PF00082	0.689
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.403
CLV_PCSK_PC1ET2_1	368	370	PF00082	0.353
CLV_PCSK_PC1ET2_1	558	560	PF00082	0.353
CLV_PCSK_PC1ET2_1	904	906	PF00082	0.705
CLV_PCSK_SKI1_1	141	145	PF00082	0.353
CLV_PCSK_SKI1_1	19	23	PF00082	0.545
CLV_PCSK_SKI1_1	214	218	PF00082	0.414
CLV_PCSK_SKI1_1	255	259	PF00082	0.348
CLV_PCSK_SKI1_1	303	307	PF00082	0.336
CLV_PCSK_SKI1_1	415	419	PF00082	0.658
CLV_PCSK_SKI1_1	507	511	PF00082	0.326
CLV_PCSK_SKI1_1	533	537	PF00082	0.595
CLV_PCSK_SKI1_1	618	622	PF00082	0.373
CLV_PCSK_SKI1_1	773	777	PF00082	0.458
CLV_PCSK_SKI1_1	79	83	PF00082	0.435
CLV_PCSK_SKI1_1	845	849	PF00082	0.378
CLV_Separin_Metazoa	770	774	PF03568	0.564
DEG_APCC_DBOX_1	870	878	PF00400	0.658
DEG_APCC_KENBOX_2	70	74	PF00400	0.639
DEG_Nend_UBRbox_2	1	3	PF02207	0.629
DOC_CKS1_1	290	295	PF01111	0.553
DOC_MAPK_gen_1	386	396	PF00069	0.631
DOC_MAPK_gen_1	735	741	PF00069	0.575
DOC_MAPK_gen_1	845	855	PF00069	0.580
DOC_MAPK_MEF2A_6	450	457	PF00069	0.557
DOC_PP1_RVXF_1	862	869	PF00149	0.635
DOC_PP2B_LxvP_1	645	648	PF13499	0.553
DOC_PP4_FxxP_1	882	885	PF00568	0.578
DOC_USP7_MATH_1	100	104	PF00917	0.553
DOC_USP7_MATH_1	129	133	PF00917	0.658
DOC_USP7_MATH_1	824	828	PF00917	0.578
DOC_USP7_UBL2_3	168	172	PF12436	0.590
DOC_USP7_UBL2_3	418	422	PF12436	0.565
DOC_USP7_UBL2_3	533	537	PF12436	0.612
DOC_USP7_UBL2_3	79	83	PF12436	0.636
DOC_USP7_UBL2_3	848	852	PF12436	0.578
DOC_WW_Pin1_4	196	201	PF00397	0.658
DOC_WW_Pin1_4	262	267	PF00397	0.551
DOC_WW_Pin1_4	289	294	PF00397	0.549
DOC_WW_Pin1_4	424	429	PF00397	0.526
DOC_WW_Pin1_4	457	462	PF00397	0.553
DOC_WW_Pin1_4	565	570	PF00397	0.553
DOC_WW_Pin1_4	87	92	PF00397	0.658
DOC_WW_Pin1_4	877	882	PF00397	0.578
LIG_14-3-3_CanoR_1	118	122	PF00244	0.639
LIG_14-3-3_CanoR_1	140	146	PF00244	0.553
LIG_14-3-3_CanoR_1	477	487	PF00244	0.555
LIG_14-3-3_CanoR_1	539	544	PF00244	0.602
LIG_14-3-3_CanoR_1	694	700	PF00244	0.601
LIG_14-3-3_CanoR_1	773	781	PF00244	0.573
LIG_AP2alpha_2	204	206	PF02296	0.639
LIG_AP2alpha_2	823	825	PF02296	0.578
LIG_APCC_ABBA_1	143	148	PF00400	0.553
LIG_APCC_ABBA_1	379	384	PF00400	0.658
LIG_APCC_ABBA_1	652	657	PF00400	0.594
LIG_APCC_ABBA_1	811	816	PF00400	0.589
LIG_CtBP_PxDLS_1	461	465	PF00389	0.553
LIG_deltaCOP1_diTrp_1	204	210	PF00928	0.639
LIG_EH1_1	762	770	PF00400	0.564
LIG_FHA_1	233	239	PF00498	0.553
LIG_FHA_1	47	53	PF00498	0.461
LIG_FHA_1	525	531	PF00498	0.614
LIG_FHA_1	790	796	PF00498	0.578
LIG_FHA_2	169	175	PF00498	0.548
LIG_FHA_2	176	182	PF00498	0.542
LIG_FHA_2	351	357	PF00498	0.562
LIG_FHA_2	386	392	PF00498	0.560
LIG_FHA_2	457	463	PF00498	0.553
LIG_FHA_2	566	572	PF00498	0.555
LIG_FHA_2	59	65	PF00498	0.642
LIG_FHA_2	696	702	PF00498	0.564
LIG_FHA_2	765	771	PF00498	0.592
LIG_Integrin_RGD_1	625	627	PF01839	0.378
LIG_LIR_Apic_2	219	223	PF02991	0.564
LIG_LIR_Apic_2	880	885	PF02991	0.578
LIG_LIR_Gen_1	144	153	PF02991	0.553
LIG_LIR_Gen_1	187	193	PF02991	0.546
LIG_LIR_Gen_1	204	213	PF02991	0.578
LIG_LIR_Gen_1	823	833	PF02991	0.578
LIG_LIR_Nem_3	137	142	PF02991	0.553
LIG_LIR_Nem_3	144	149	PF02991	0.553
LIG_LIR_Nem_3	187	192	PF02991	0.546
LIG_LIR_Nem_3	204	209	PF02991	0.578
LIG_LIR_Nem_3	226	231	PF02991	0.611
LIG_LIR_Nem_3	328	333	PF02991	0.550
LIG_LIR_Nem_3	544	550	PF02991	0.564
LIG_LIR_Nem_3	627	631	PF02991	0.554
LIG_LIR_Nem_3	698	702	PF02991	0.553
LIG_LIR_Nem_3	784	790	PF02991	0.566
LIG_LIR_Nem_3	823	828	PF02991	0.578
LIG_LYPXL_yS_3	319	322	PF13949	0.564
LIG_LYPXL_yS_3	699	702	PF13949	0.553
LIG_PCNA_yPIPBox_3	633	645	PF02747	0.631
LIG_PDZ_Class_1	909	914	PF00595	0.730
LIG_Pex14_1	206	210	PF04695	0.639
LIG_Pex14_2	628	632	PF04695	0.564
LIG_SH2_CRK	228	232	PF00017	0.564
LIG_SH2_CRK	330	334	PF00017	0.550
LIG_SH2_SRC	146	149	PF00017	0.560
LIG_SH2_STAP1	146	150	PF00017	0.553
LIG_SH2_STAT3	703	706	PF00017	0.553
LIG_SH2_STAT5	189	192	PF00017	0.553
LIG_SH2_STAT5	272	275	PF00017	0.578
LIG_SH2_STAT5	277	280	PF00017	0.550
LIG_SH2_STAT5	763	766	PF00017	0.564
LIG_SH2_STAT5	820	823	PF00017	0.642
LIG_SH2_STAT5	876	879	PF00017	0.578
LIG_SH2_STAT5	9	12	PF00017	0.488
LIG_SH3_3	199	205	PF00018	0.553
LIG_SH3_3	38	44	PF00018	0.461
LIG_SH3_3	85	91	PF00018	0.526
LIG_SH3_4	418	425	PF00018	0.539
LIG_SH3_4	848	855	PF00018	0.578
LIG_SUMO_SIM_par_1	520	525	PF11976	0.639
LIG_TRAF2_1	311	314	PF00917	0.571
LIG_TRAF2_1	321	324	PF00917	0.528
LIG_TRAF2_1	388	391	PF00917	0.518
LIG_TRAF2_1	659	662	PF00917	0.600
LIG_TRAF2_2	622	627	PF00917	0.553
LIG_TRAF2_2	824	829	PF00917	0.578
LIG_TYR_ITIM	697	702	PF00017	0.405
LIG_TYR_ITSM	142	149	PF00017	0.405
LIG_UBA3_1	728	736	PF00899	0.421
LIG_WRC_WIRS_1	787	792	PF05994	0.440
MOD_CDC14_SPxK_1	880	883	PF00782	0.440
MOD_CDK_SPxK_1	877	883	PF00069	0.440
MOD_CK1_1	265	271	PF00069	0.421
MOD_CK1_1	789	795	PF00069	0.440
MOD_CK1_1	95	101	PF00069	0.405
MOD_CK2_1	308	314	PF00069	0.413
MOD_CK2_1	318	324	PF00069	0.392
MOD_CK2_1	385	391	PF00069	0.513
MOD_CK2_1	456	462	PF00069	0.485
MOD_CK2_1	597	603	PF00069	0.535
MOD_CK2_1	695	701	PF00069	0.479
MOD_CK2_1	764	770	PF00069	0.460
MOD_Cter_Amidation	366	369	PF01082	0.421
MOD_Cter_Amidation	733	736	PF01082	0.421
MOD_GlcNHglycan	254	258	PF01048	0.406
MOD_GlcNHglycan	440	443	PF01048	0.507
MOD_GlcNHglycan	496	499	PF01048	0.402
MOD_GlcNHglycan	656	660	PF01048	0.554
MOD_GlcNHglycan	669	672	PF01048	0.466
MOD_GlcNHglycan	97	100	PF01048	0.405
MOD_GSK3_1	168	175	PF00069	0.421
MOD_GSK3_1	520	527	PF00069	0.405
MOD_GSK3_1	789	796	PF00069	0.424
MOD_GSK3_1	835	842	PF00069	0.549
MOD_N-GLC_1	308	313	PF02516	0.496
MOD_NEK2_1	10	15	PF00069	0.604
MOD_NEK2_1	107	112	PF00069	0.380
MOD_NEK2_1	237	242	PF00069	0.405
MOD_NEK2_1	332	337	PF00069	0.487
MOD_NEK2_1	46	51	PF00069	0.571
MOD_NEK2_1	524	529	PF00069	0.473
MOD_NEK2_1	695	700	PF00069	0.405
MOD_NEK2_1	739	744	PF00069	0.440
MOD_NEK2_1	835	840	PF00069	0.539
MOD_NEK2_1	909	914	PF00069	0.755
MOD_NEK2_1	92	97	PF00069	0.367
MOD_PIKK_1	65	71	PF00454	0.475
MOD_PIKK_1	793	799	PF00454	0.440
MOD_PK_1	597	603	PF00069	0.475
MOD_PKA_1	168	174	PF00069	0.440
MOD_PKA_2	117	123	PF00069	0.507
MOD_PKA_2	385	391	PF00069	0.660
MOD_PKA_2	612	618	PF00069	0.506
MOD_PKB_1	316	324	PF00069	0.417
MOD_Plk_1	129	135	PF00069	0.455
MOD_Plk_1	298	304	PF00069	0.442
MOD_Plk_1	350	356	PF00069	0.405
MOD_Plk_1	737	743	PF00069	0.440
MOD_Plk_1	793	799	PF00069	0.440
MOD_Plk_2-3	520	526	PF00069	0.405
MOD_Plk_2-3	862	868	PF00069	0.526
MOD_Plk_4	107	113	PF00069	0.400
MOD_Plk_4	764	770	PF00069	0.421
MOD_ProDKin_1	196	202	PF00069	0.552
MOD_ProDKin_1	262	268	PF00069	0.402
MOD_ProDKin_1	289	295	PF00069	0.400
MOD_ProDKin_1	424	430	PF00069	0.517
MOD_ProDKin_1	457	463	PF00069	0.405
MOD_ProDKin_1	565	571	PF00069	0.405
MOD_ProDKin_1	87	93	PF00069	0.552
MOD_ProDKin_1	877	883	PF00069	0.440
MOD_SUMO_rev_2	16	24	PF00179	0.592
MOD_SUMO_rev_2	164	171	PF00179	0.479
MOD_SUMO_rev_2	176	185	PF00179	0.329
MOD_SUMO_rev_2	542	550	PF00179	0.477
MOD_SUMO_rev_2	78	84	PF00179	0.514
TRG_DiLeu_BaEn_1	328	333	PF01217	0.421
TRG_DiLeu_BaEn_1	831	836	PF01217	0.552
TRG_DiLeu_BaLyEn_6	640	645	PF01217	0.405
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.394
TRG_ENDOCYTIC_2	139	142	PF00928	0.405
TRG_ENDOCYTIC_2	146	149	PF00928	0.405
TRG_ENDOCYTIC_2	189	192	PF00928	0.405
TRG_ENDOCYTIC_2	228	231	PF00928	0.405
TRG_ENDOCYTIC_2	319	322	PF00928	0.414
TRG_ENDOCYTIC_2	330	333	PF00928	0.381
TRG_ENDOCYTIC_2	344	347	PF00928	0.367
TRG_ENDOCYTIC_2	699	702	PF00928	0.405
TRG_ENDOCYTIC_2	814	817	PF00928	0.440
TRG_ER_diArg_1	139	141	PF00400	0.473
TRG_ER_diArg_1	228	230	PF00400	0.405
TRG_ER_diArg_1	315	318	PF00400	0.440
TRG_ER_diArg_1	336	339	PF00400	0.526
TRG_ER_diArg_1	674	677	PF00400	0.421
TRG_NES_CRM1_1	181	194	PF08389	0.527
TRG_NES_CRM1_1	596	608	PF08389	0.526
TRG_Pf-PMV_PEXEL_1	679	683	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	708	712	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	752	756	PF00026	0.436
TRG_PTS1	911	914	PF00515	0.686

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I112	Leptomonas seymouri	87%	100%
A0A0S4IJT3	Bodo saltans	71%	100%
A0A1X0NUY0	Trypanosomatidae	79%	100%
A0A3R7KK46	Trypanosoma rangeli	77%	100%
A4H6M6	Leishmania braziliensis	93%	100%
A4HV09	Leishmania infantum	100%	100%
D0A7D9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	100%
E9ANP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O23404	Arabidopsis thaliana	53%	95%
O27190	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	28%	100%
O29548	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	27%	100%
O57830	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	27%	100%
O83026	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	25%	100%
O83728	Treponema pallidum (strain Nichols)	33%	100%
P11155	Zea mays	53%	97%
P22221	Flaveria trinervia	54%	96%
P22983	Clostridium symbiosum	57%	100%
P23538	Escherichia coli (strain K12)	24%	100%
P37213	Entamoeba histolytica	49%	100%
P42850	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	28%	100%
P46893	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	25%	100%
P51776	Giardia intestinalis	51%	100%
P56070	Helicobacter pylori (strain ATCC 700392 / 26695)	24%	100%
Q1RH78	Rickettsia bellii (strain RML369-C)	46%	100%
Q39734	Flaveria brownii	54%	96%
Q39735	Flaveria bidentis	54%	96%
Q42368	Zea mays	53%	100%
Q42736	Flaveria pringlei	54%	96%
Q42910	Mesembryanthemum crystallinum	53%	96%
Q4QGX9	Leishmania major	99%	100%
Q4ULI7	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	46%	100%
Q55905	Synechocystis sp. (strain PCC 6803 / Kazusa)	23%	100%
Q59754	Rhizobium meliloti (strain 1021)	55%	100%
Q68WP2	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	46%	100%
Q6AVA8	Oryza sativa subsp. japonica	54%	97%
Q75KR1	Oryza sativa subsp. japonica	53%	100%
Q92HI8	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	47%	100%
Q9K0I2	Neisseria meningitidis serogroup B (strain MC58)	25%	100%
Q9V2H7	Pyrococcus abyssi (strain GE5 / Orsay)	27%	100%
Q9YEC5	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	25%	100%
Q9ZD55	Rickettsia prowazekii (strain Madrid E)	46%	100%
Q9ZMV4	Helicobacter pylori (strain J99 / ATCC 700824)	24%	100%
V5BBD4	Trypanosoma cruzi	79%	100%