Leucine-rich repeat protein (LRRP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I916_LEIDO

TriTrypDb:

LdBPK_110440.1 , LdCL_110009300 , LDHU3_11.0540

Length:

581

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3Q8I916

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I916

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0019900	kinase binding	4	1
GO:0019901	protein kinase binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	532	536	PF00656	0.639
CLV_NRD_NRD_1	180	182	PF00675	0.481
CLV_NRD_NRD_1	240	242	PF00675	0.562
CLV_NRD_NRD_1	340	342	PF00675	0.664
CLV_NRD_NRD_1	438	440	PF00675	0.466
CLV_NRD_NRD_1	445	447	PF00675	0.454
CLV_NRD_NRD_1	562	564	PF00675	0.681
CLV_NRD_NRD_1	7	9	PF00675	0.450
CLV_PCSK_KEX2_1	182	184	PF00082	0.473
CLV_PCSK_KEX2_1	340	342	PF00082	0.664
CLV_PCSK_KEX2_1	438	440	PF00082	0.466
CLV_PCSK_KEX2_1	445	447	PF00082	0.454
CLV_PCSK_KEX2_1	562	564	PF00082	0.598
CLV_PCSK_KEX2_1	6	8	PF00082	0.442
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.448
CLV_PCSK_PC7_1	434	440	PF00082	0.460
CLV_PCSK_SKI1_1	182	186	PF00082	0.443
CLV_PCSK_SKI1_1	340	344	PF00082	0.605
DEG_APCC_DBOX_1	444	452	PF00400	0.527
DEG_Nend_UBRbox_3	1	3	PF02207	0.437
DEG_SPOP_SBC_1	210	214	PF00917	0.641
DEG_SPOP_SBC_1	221	225	PF00917	0.703
DEG_SPOP_SBC_1	315	319	PF00917	0.685
DEG_SPOP_SBC_1	550	554	PF00917	0.642
DOC_CYCLIN_RxL_1	179	186	PF00134	0.454
DOC_CYCLIN_RxL_1	26	40	PF00134	0.411
DOC_MAPK_gen_1	127	137	PF00069	0.448
DOC_MAPK_gen_1	181	190	PF00069	0.448
DOC_MAPK_gen_1	438	444	PF00069	0.458
DOC_MAPK_gen_1	445	453	PF00069	0.451
DOC_MAPK_HePTP_8	180	192	PF00069	0.449
DOC_MAPK_MEF2A_6	183	192	PF00069	0.447
DOC_MAPK_MEF2A_6	446	455	PF00069	0.456
DOC_PP1_RVXF_1	450	456	PF00149	0.401
DOC_PP2B_LxvP_1	190	193	PF13499	0.473
DOC_USP7_MATH_1	221	225	PF00917	0.666
DOC_USP7_MATH_1	306	310	PF00917	0.641
DOC_USP7_MATH_1	373	377	PF00917	0.633
DOC_USP7_MATH_1	471	475	PF00917	0.552
DOC_USP7_MATH_1	520	524	PF00917	0.724
DOC_USP7_MATH_1	534	538	PF00917	0.618
DOC_USP7_MATH_1	545	549	PF00917	0.722
DOC_USP7_MATH_1	550	554	PF00917	0.668
DOC_USP7_MATH_1	94	98	PF00917	0.340
DOC_WW_Pin1_4	287	292	PF00397	0.669
DOC_WW_Pin1_4	349	354	PF00397	0.775
DOC_WW_Pin1_4	358	363	PF00397	0.629
DOC_WW_Pin1_4	367	372	PF00397	0.629
DOC_WW_Pin1_4	391	396	PF00397	0.672
DOC_WW_Pin1_4	505	510	PF00397	0.635
DOC_WW_Pin1_4	530	535	PF00397	0.702
LIG_14-3-3_CanoR_1	183	192	PF00244	0.528
LIG_14-3-3_CanoR_1	211	220	PF00244	0.649
LIG_14-3-3_CanoR_1	253	262	PF00244	0.641
LIG_14-3-3_CanoR_1	300	308	PF00244	0.670
LIG_14-3-3_CanoR_1	364	370	PF00244	0.756
LIG_14-3-3_CanoR_1	380	389	PF00244	0.684
LIG_14-3-3_CanoR_1	429	437	PF00244	0.517
LIG_14-3-3_CanoR_1	8	14	PF00244	0.436
LIG_Actin_WH2_2	441	456	PF00022	0.417
LIG_BRCT_BRCA1_1	168	172	PF00533	0.452
LIG_Clathr_ClatBox_1	134	138	PF01394	0.461
LIG_FHA_1	116	122	PF00498	0.454
LIG_FHA_1	221	227	PF00498	0.659
LIG_FHA_1	324	330	PF00498	0.698
LIG_FHA_1	382	388	PF00498	0.600
LIG_FHA_2	120	126	PF00498	0.452
LIG_FHA_2	71	77	PF00498	0.411
LIG_Integrin_isoDGR_2	378	380	PF01839	0.651
LIG_LIR_Gen_1	104	111	PF02991	0.312
LIG_LIR_Gen_1	122	131	PF02991	0.394
LIG_LIR_Nem_3	104	108	PF02991	0.312
LIG_LIR_Nem_3	122	126	PF02991	0.392
LIG_NRBOX	24	30	PF00104	0.457
LIG_RPA_C_Fungi	452	464	PF08784	0.483
LIG_SH2_CRK	398	402	PF00017	0.627
LIG_SH2_SRC	123	126	PF00017	0.355
LIG_SH2_STAT5	123	126	PF00017	0.355
LIG_SH2_STAT5	310	313	PF00017	0.634
LIG_SH2_STAT5	42	45	PF00017	0.388
LIG_SH3_3	285	291	PF00018	0.642
LIG_SH3_3	399	405	PF00018	0.644
LIG_SH3_3	493	499	PF00018	0.590
LIG_SUMO_SIM_anti_2	164	169	PF11976	0.350
LIG_SUMO_SIM_anti_2	51	57	PF11976	0.312
LIG_SUMO_SIM_par_1	512	517	PF11976	0.639
LIG_SUMO_SIM_par_1	70	76	PF11976	0.414
LIG_TYR_ITIM	121	126	PF00017	0.391
LIG_WRC_WIRS_1	10	15	PF05994	0.431
MOD_CDC14_SPxK_1	361	364	PF00782	0.600
MOD_CDK_SPK_2	287	292	PF00069	0.651
MOD_CDK_SPxK_1	358	364	PF00069	0.612
MOD_CDK_SPxxK_3	505	512	PF00069	0.711
MOD_CK1_1	161	167	PF00069	0.468
MOD_CK1_1	209	215	PF00069	0.637
MOD_CK1_1	225	231	PF00069	0.622
MOD_CK1_1	274	280	PF00069	0.749
MOD_CK1_1	290	296	PF00069	0.641
MOD_CK1_1	309	315	PF00069	0.560
MOD_CK1_1	322	328	PF00069	0.660
MOD_CK1_1	332	338	PF00069	0.570
MOD_CK1_1	357	363	PF00069	0.655
MOD_CK1_1	37	43	PF00069	0.416
MOD_CK1_1	382	388	PF00069	0.646
MOD_CK1_1	413	419	PF00069	0.567
MOD_CK1_1	474	480	PF00069	0.637
MOD_CK1_1	519	525	PF00069	0.617
MOD_CK1_1	554	560	PF00069	0.671
MOD_CK1_1	97	103	PF00069	0.345
MOD_CK2_1	191	197	PF00069	0.579
MOD_CK2_1	233	239	PF00069	0.703
MOD_CK2_1	70	76	PF00069	0.414
MOD_GlcNHglycan	168	171	PF01048	0.454
MOD_GlcNHglycan	173	176	PF01048	0.410
MOD_GlcNHglycan	247	250	PF01048	0.791
MOD_GlcNHglycan	255	258	PF01048	0.566
MOD_GlcNHglycan	304	307	PF01048	0.782
MOD_GlcNHglycan	311	314	PF01048	0.668
MOD_GlcNHglycan	321	324	PF01048	0.619
MOD_GlcNHglycan	354	357	PF01048	0.671
MOD_GlcNHglycan	476	479	PF01048	0.579
MOD_GlcNHglycan	517	521	PF01048	0.600
MOD_GlcNHglycan	542	545	PF01048	0.825
MOD_GlcNHglycan	547	550	PF01048	0.647
MOD_GSK3_1	115	122	PF00069	0.506
MOD_GSK3_1	201	208	PF00069	0.608
MOD_GSK3_1	216	223	PF00069	0.693
MOD_GSK3_1	225	232	PF00069	0.702
MOD_GSK3_1	245	252	PF00069	0.514
MOD_GSK3_1	261	268	PF00069	0.768
MOD_GSK3_1	274	281	PF00069	0.580
MOD_GSK3_1	286	293	PF00069	0.664
MOD_GSK3_1	302	309	PF00069	0.676
MOD_GSK3_1	315	322	PF00069	0.580
MOD_GSK3_1	352	359	PF00069	0.758
MOD_GSK3_1	379	386	PF00069	0.653
MOD_GSK3_1	516	523	PF00069	0.631
MOD_GSK3_1	530	537	PF00069	0.660
MOD_GSK3_1	545	552	PF00069	0.572
MOD_GSK3_1	573	580	PF00069	0.663
MOD_GSK3_1	97	104	PF00069	0.348
MOD_N-GLC_1	101	106	PF02516	0.312
MOD_N-GLC_1	115	120	PF02516	0.458
MOD_N-GLC_1	56	61	PF02516	0.285
MOD_NEK2_1	101	106	PF00069	0.329
MOD_NEK2_1	229	234	PF00069	0.642
MOD_NEK2_1	265	270	PF00069	0.667
MOD_NEK2_1	278	283	PF00069	0.567
MOD_NEK2_1	34	39	PF00069	0.391
MOD_NEK2_1	374	379	PF00069	0.692
MOD_NEK2_1	383	388	PF00069	0.674
MOD_NEK2_1	551	556	PF00069	0.714
MOD_NEK2_1	56	61	PF00069	0.285
MOD_NEK2_1	568	573	PF00069	0.488
MOD_NEK2_1	77	82	PF00069	0.404
MOD_NEK2_2	471	476	PF00069	0.557
MOD_PIKK_1	183	189	PF00454	0.515
MOD_PIKK_1	413	419	PF00454	0.497
MOD_PIKK_1	457	463	PF00454	0.456
MOD_PIKK_1	523	529	PF00454	0.665
MOD_PK_1	507	513	PF00069	0.656
MOD_PKA_2	210	216	PF00069	0.640
MOD_PKA_2	265	271	PF00069	0.712
MOD_PKA_2	299	305	PF00069	0.669
MOD_PKA_2	306	312	PF00069	0.599
MOD_PKA_2	347	353	PF00069	0.743
MOD_PKA_2	379	385	PF00069	0.689
MOD_PKA_2	428	434	PF00069	0.497
MOD_PKB_1	181	189	PF00069	0.519
MOD_Plk_1	101	107	PF00069	0.312
MOD_Plk_1	221	227	PF00069	0.628
MOD_Plk_1	229	235	PF00069	0.621
MOD_Plk_1	362	368	PF00069	0.627
MOD_Plk_4	119	125	PF00069	0.395
MOD_Plk_4	130	136	PF00069	0.376
MOD_Plk_4	163	169	PF00069	0.468
MOD_Plk_4	258	264	PF00069	0.668
MOD_Plk_4	306	312	PF00069	0.630
MOD_Plk_4	37	43	PF00069	0.366
MOD_Plk_4	383	389	PF00069	0.614
MOD_Plk_4	51	57	PF00069	0.363
MOD_ProDKin_1	287	293	PF00069	0.669
MOD_ProDKin_1	349	355	PF00069	0.777
MOD_ProDKin_1	358	364	PF00069	0.629
MOD_ProDKin_1	367	373	PF00069	0.623
MOD_ProDKin_1	391	397	PF00069	0.674
MOD_ProDKin_1	505	511	PF00069	0.632
MOD_ProDKin_1	530	536	PF00069	0.701
TRG_DiLeu_BaEn_1	23	28	PF01217	0.469
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.377
TRG_DiLeu_BaLyEn_6	180	185	PF01217	0.426
TRG_ENDOCYTIC_2	123	126	PF00928	0.383
TRG_ENDOCYTIC_2	398	401	PF00928	0.626
TRG_ER_diArg_1	180	183	PF00400	0.500
TRG_ER_diArg_1	339	341	PF00400	0.656
TRG_ER_diArg_1	437	439	PF00400	0.472
TRG_ER_diArg_1	444	446	PF00400	0.459
TRG_ER_diArg_1	5	8	PF00400	0.411
TRG_Pf-PMV_PEXEL_1	144	149	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	341	346	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	446	450	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	512	517	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBI0	Leptomonas seymouri	51%	92%
A4H6G0	Leishmania braziliensis	70%	100%
A4HUV5	Leishmania infantum	99%	100%
E9ANJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QH36	Leishmania major	93%	100%