Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8I910_LEIDO

TriTrypDb:

LdBPK_110460.1 , LdCL_110009500 , LDHU3_11.0560

Length:

643

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I910

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I910

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	354	358	PF00656	0.536
CLV_C14_Caspase3-7	405	409	PF00656	0.679
CLV_C14_Caspase3-7	579	583	PF00656	0.565
CLV_MEL_PAP_1	69	75	PF00089	0.618
CLV_NRD_NRD_1	151	153	PF00675	0.570
CLV_NRD_NRD_1	2	4	PF00675	0.672
CLV_NRD_NRD_1	277	279	PF00675	0.549
CLV_NRD_NRD_1	296	298	PF00675	0.541
CLV_NRD_NRD_1	585	587	PF00675	0.532
CLV_NRD_NRD_1	590	592	PF00675	0.521
CLV_NRD_NRD_1	606	608	PF00675	0.479
CLV_PCSK_KEX2_1	150	152	PF00082	0.581
CLV_PCSK_KEX2_1	2	4	PF00082	0.657
CLV_PCSK_KEX2_1	277	279	PF00082	0.549
CLV_PCSK_KEX2_1	296	298	PF00082	0.541
CLV_PCSK_KEX2_1	590	592	PF00082	0.578
CLV_PCSK_KEX2_1	608	610	PF00082	0.465
CLV_PCSK_PC1ET2_1	608	610	PF00082	0.571
CLV_PCSK_PC7_1	586	592	PF00082	0.464
CLV_PCSK_SKI1_1	560	564	PF00082	0.590
CLV_PCSK_SKI1_1	590	594	PF00082	0.683
CLV_PCSK_SKI1_1	602	606	PF00082	0.557
CLV_PCSK_SKI1_1	608	612	PF00082	0.474
DEG_APCC_DBOX_1	559	567	PF00400	0.548
DEG_Nend_UBRbox_1	1	4	PF02207	0.629
DEG_SPOP_SBC_1	182	186	PF00917	0.630
DEG_SPOP_SBC_1	19	23	PF00917	0.618
DOC_CYCLIN_RxL_1	586	597	PF00134	0.576
DOC_MAPK_gen_1	222	231	PF00069	0.598
DOC_MAPK_gen_1	290	300	PF00069	0.630
DOC_MAPK_MEF2A_6	293	302	PF00069	0.537
DOC_PP1_RVXF_1	589	596	PF00149	0.677
DOC_PP1_SILK_1	582	587	PF00149	0.473
DOC_PP2B_LxvP_1	171	174	PF13499	0.653
DOC_PP2B_LxvP_1	554	557	PF13499	0.642
DOC_SPAK_OSR1_1	180	184	PF12202	0.615
DOC_USP7_MATH_1	111	115	PF00917	0.672
DOC_USP7_MATH_1	176	180	PF00917	0.611
DOC_USP7_MATH_1	187	191	PF00917	0.630
DOC_USP7_MATH_1	19	23	PF00917	0.593
DOC_USP7_MATH_1	38	42	PF00917	0.544
DOC_USP7_MATH_1	428	432	PF00917	0.611
DOC_USP7_MATH_1	450	454	PF00917	0.557
DOC_USP7_MATH_1	496	500	PF00917	0.706
DOC_USP7_MATH_1	535	539	PF00917	0.599
DOC_USP7_MATH_1	627	631	PF00917	0.485
DOC_USP7_MATH_1	84	88	PF00917	0.671
DOC_WW_Pin1_4	183	188	PF00397	0.782
DOC_WW_Pin1_4	204	209	PF00397	0.641
DOC_WW_Pin1_4	30	35	PF00397	0.679
DOC_WW_Pin1_4	389	394	PF00397	0.748
DOC_WW_Pin1_4	421	426	PF00397	0.643
DOC_WW_Pin1_4	440	445	PF00397	0.423
DOC_WW_Pin1_4	613	618	PF00397	0.582
LIG_14-3-3_CanoR_1	133	138	PF00244	0.645
LIG_14-3-3_CanoR_1	180	188	PF00244	0.621
LIG_14-3-3_CanoR_1	2	7	PF00244	0.575
LIG_14-3-3_CanoR_1	225	229	PF00244	0.605
LIG_14-3-3_CanoR_1	297	303	PF00244	0.523
LIG_14-3-3_CanoR_1	351	360	PF00244	0.557
LIG_14-3-3_CanoR_1	432	440	PF00244	0.553
LIG_14-3-3_CanoR_1	590	596	PF00244	0.682
LIG_14-3-3_CanoR_1	607	617	PF00244	0.479
LIG_14-3-3_CanoR_1	67	72	PF00244	0.579
LIG_Actin_WH2_2	261	279	PF00022	0.569
LIG_BRCT_BRCA1_1	113	117	PF00533	0.597
LIG_BRCT_BRCA1_1	629	633	PF00533	0.611
LIG_BRCT_BRCA1_1	69	73	PF00533	0.606
LIG_CaM_IQ_9	295	310	PF13499	0.560
LIG_FHA_1	183	189	PF00498	0.671
LIG_FHA_1	362	368	PF00498	0.586
LIG_FHA_1	399	405	PF00498	0.631
LIG_FHA_1	432	438	PF00498	0.591
LIG_FHA_1	52	58	PF00498	0.552
LIG_FHA_1	537	543	PF00498	0.579
LIG_FHA_1	595	601	PF00498	0.583
LIG_FHA_1	635	641	PF00498	0.620
LIG_FHA_1	73	79	PF00498	0.595
LIG_FHA_2	352	358	PF00498	0.566
LIG_FHA_2	577	583	PF00498	0.756
LIG_FHA_2	609	615	PF00498	0.558
LIG_IRF3_LxIS_1	294	301	PF10401	0.566
LIG_LIR_Gen_1	227	235	PF02991	0.562
LIG_LIR_Gen_1	461	471	PF02991	0.560
LIG_LIR_Nem_3	215	220	PF02991	0.530
LIG_LIR_Nem_3	227	231	PF02991	0.539
LIG_LIR_Nem_3	461	466	PF02991	0.587
LIG_LIR_Nem_3	630	636	PF02991	0.559
LIG_MYND_1	169	173	PF01753	0.583
LIG_NBox_RRM_1	615	625	PF00076	0.530
LIG_PCNA_PIPBox_1	269	278	PF02747	0.572
LIG_Pex14_1	213	217	PF04695	0.536
LIG_PTAP_UEV_1	105	110	PF05743	0.604
LIG_SH2_GRB2like	547	550	PF00017	0.553
LIG_SH2_NCK_1	253	257	PF00017	0.587
LIG_SH2_PTP2	228	231	PF00017	0.565
LIG_SH2_SRC	547	550	PF00017	0.433
LIG_SH2_STAP1	636	640	PF00017	0.584
LIG_SH2_STAT5	228	231	PF00017	0.565
LIG_SH2_STAT5	368	371	PF00017	0.630
LIG_SH2_STAT5	436	439	PF00017	0.587
LIG_SH2_STAT5	547	550	PF00017	0.468
LIG_SH2_STAT5	636	639	PF00017	0.536
LIG_SH3_1	172	178	PF00018	0.614
LIG_SH3_2	175	180	PF14604	0.605
LIG_SH3_2	62	67	PF14604	0.571
LIG_SH3_3	103	109	PF00018	0.618
LIG_SH3_3	167	173	PF00018	0.619
LIG_SH3_3	205	211	PF00018	0.586
LIG_SH3_3	244	250	PF00018	0.571
LIG_SH3_3	390	396	PF00018	0.583
LIG_SH3_3	59	65	PF00018	0.565
LIG_SH3_5	249	253	PF00018	0.567
LIG_SUMO_SIM_par_1	456	462	PF11976	0.510
LIG_TRAF2_1	255	258	PF00917	0.562
LIG_TRAF2_1	337	340	PF00917	0.695
LIG_WRC_WIRS_1	460	465	PF05994	0.615
LIG_WW_3	290	294	PF00397	0.613
MOD_CDK_SPK_2	204	209	PF00069	0.523
MOD_CK1_1	127	133	PF00069	0.666
MOD_CK1_1	136	142	PF00069	0.493
MOD_CK1_1	18	24	PF00069	0.644
MOD_CK1_1	224	230	PF00069	0.541
MOD_CK1_1	326	332	PF00069	0.610
MOD_CK1_1	392	398	PF00069	0.701
MOD_CK1_1	4	10	PF00069	0.654
MOD_CK1_1	431	437	PF00069	0.643
MOD_CK1_1	459	465	PF00069	0.542
MOD_CK1_1	594	600	PF00069	0.567
MOD_CK1_1	87	93	PF00069	0.756
MOD_CK2_1	224	230	PF00069	0.536
MOD_CK2_1	251	257	PF00069	0.564
MOD_CK2_1	283	289	PF00069	0.622
MOD_CK2_1	421	427	PF00069	0.638
MOD_CK2_1	496	502	PF00069	0.560
MOD_GlcNHglycan	106	109	PF01048	0.618
MOD_GlcNHglycan	17	20	PF01048	0.590
MOD_GlcNHglycan	189	192	PF01048	0.668
MOD_GlcNHglycan	243	246	PF01048	0.685
MOD_GlcNHglycan	252	256	PF01048	0.580
MOD_GlcNHglycan	261	264	PF01048	0.473
MOD_GlcNHglycan	285	288	PF01048	0.759
MOD_GlcNHglycan	330	333	PF01048	0.648
MOD_GlcNHglycan	413	416	PF01048	0.770
MOD_GlcNHglycan	450	453	PF01048	0.553
MOD_GlcNHglycan	488	491	PF01048	0.579
MOD_GlcNHglycan	498	501	PF01048	0.567
MOD_GlcNHglycan	6	9	PF01048	0.709
MOD_GlcNHglycan	86	89	PF01048	0.755
MOD_GSK3_1	15	22	PF00069	0.646
MOD_GSK3_1	183	190	PF00069	0.627
MOD_GSK3_1	319	326	PF00069	0.593
MOD_GSK3_1	431	438	PF00069	0.586
MOD_GSK3_1	492	499	PF00069	0.716
MOD_GSK3_1	67	74	PF00069	0.680
MOD_GSK3_1	79	86	PF00069	0.627
MOD_N-GLC_1	118	123	PF02516	0.634
MOD_N-GLC_1	124	129	PF02516	0.594
MOD_N-GLC_1	133	138	PF02516	0.470
MOD_N-GLC_1	327	332	PF02516	0.678
MOD_N-GLC_1	351	356	PF02516	0.623
MOD_NEK2_1	1	6	PF00069	0.713
MOD_NEK2_1	181	186	PF00069	0.632
MOD_NEK2_1	298	303	PF00069	0.558
MOD_NEK2_1	448	453	PF00069	0.551
MOD_NEK2_1	50	55	PF00069	0.618
MOD_NEK2_1	79	84	PF00069	0.605
MOD_NEK2_2	368	373	PF00069	0.469
MOD_NEK2_2	636	641	PF00069	0.586
MOD_PIKK_1	320	326	PF00454	0.622
MOD_PK_1	133	139	PF00069	0.608
MOD_PK_1	67	73	PF00069	0.623
MOD_PKA_1	2	8	PF00069	0.576
MOD_PKA_1	608	614	PF00069	0.546
MOD_PKA_2	1	7	PF00069	0.653
MOD_PKA_2	221	227	PF00069	0.523
MOD_PKA_2	283	289	PF00069	0.651
MOD_PKA_2	350	356	PF00069	0.585
MOD_PKA_2	431	437	PF00069	0.590
MOD_PKA_2	576	582	PF00069	0.625
MOD_PKA_2	608	614	PF00069	0.546
MOD_PKA_2	71	77	PF00069	0.617
MOD_Plk_1	124	130	PF00069	0.618
MOD_Plk_1	133	139	PF00069	0.650
MOD_Plk_1	144	150	PF00069	0.441
MOD_Plk_4	124	130	PF00069	0.634
MOD_Plk_4	144	150	PF00069	0.563
MOD_Plk_4	224	230	PF00069	0.571
MOD_Plk_4	450	456	PF00069	0.740
MOD_Plk_4	459	465	PF00069	0.518
MOD_Plk_4	522	528	PF00069	0.595
MOD_Plk_4	636	642	PF00069	0.588
MOD_ProDKin_1	183	189	PF00069	0.780
MOD_ProDKin_1	204	210	PF00069	0.636
MOD_ProDKin_1	30	36	PF00069	0.675
MOD_ProDKin_1	389	395	PF00069	0.752
MOD_ProDKin_1	421	427	PF00069	0.638
MOD_ProDKin_1	440	446	PF00069	0.424
MOD_ProDKin_1	613	619	PF00069	0.580
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.532
TRG_DiLeu_BaLyEn_6	588	593	PF01217	0.537
TRG_ENDOCYTIC_2	228	231	PF00928	0.565
TRG_ER_diArg_1	1	3	PF00400	0.663
TRG_ER_diArg_1	149	152	PF00400	0.745
TRG_ER_diArg_1	276	278	PF00400	0.522
TRG_ER_diArg_1	296	298	PF00400	0.420
TRG_ER_diArg_1	47	50	PF00400	0.520
TRG_ER_diArg_1	590	592	PF00400	0.537
TRG_ER_diArg_1	606	609	PF00400	0.481
TRG_NLS_Bipartite_1	590	611	PF00514	0.482
TRG_NLS_MonoExtN_4	605	611	PF00514	0.512
TRG_Pf-PMV_PEXEL_1	93	98	PF00026	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P315	Leptomonas seymouri	35%	100%
A4H6G2	Leishmania braziliensis	75%	100%
A4HUV7	Leishmania infantum	100%	100%
E9ANJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QH34	Leishmania major	92%	100%